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PubMed1995

The Nebraska experience.

Autologous peripheral stem cell transplantation was initiated at the University of Nebraska Medical Center to provide hematopoietic rescue for patients who were candidates for high-dose therapy but had marrows that were unfit for autografting. From 1984 until 1991, the cells were collected during steady state without mobilization. These cells restored hematopoietic function at a rate similar to that of autologous marrow in patients not treated with total body irradiation. Patients who received total body irradiation experienced slower hematopoietic recovery. When growth factors became generally available in the United States in 1991, mobilization with cytokines became standard at Nebraska. In recent years, the function of cells other than hematopoietic progenitors contained in a peripheral stem cell apheresis product has been studied. Detection of tumor cells using cell culture, immunocytochemical and polymerase chain reaction techniques has revealed that such collections are less likely to contain, or contain fewer, tumor cells than autologous bone marrow harvests. More antitumor cytotoxic activity was found in cells in peripheral stem cell collections than in marrow cell collections. The immunocompetent lymphocyte population is larger in peripheral stem cell collection than in marrow harvests, and immunologic recovery after peripheral stem cell transplant has differed compared to recovery following bone marrow transplantation. The future of peripheral stem cell transplantation is likely to include engineering of the graft products specific for the patient and disease being treated. Determining the function of accessory cells in a peripheral stem cell collection will be important to provide the best engineered product for the patient.

Blood Specimen Collection↗
PubMed1996

Population genetics and gene variation of stable fly populations (Diptera:Muscidae) in Nebraska.

Genetic variation in stable fly, Stomoxys calcitrans (L.), populations from Nebraska, Canada, and Texas was sampled. Four of 12 allozyme loci were polymorphic, with an average of 1.7 alleles per locus. Observed and expected heterozygosities were 0.086 and 0.070, respectively. Nei's genetic distance between populations averaged 0.001 and ranged from 0.000 to 0.005. Wright's F statistics revealed greater variation within than among populations. Allele frequencies were homogeneous among temporal samples from a single population. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of 6.4 kb of the mitochondrial DNA genome with 16 restriction enzymes revealed no variation in stable fly populations from Canada, Nebraska, and Texas. PCR-RFLP analysis of a 2.0-kb fragment of the nuclear ribosomal DNA internally transcribed spacer region also revealed no variation. The lack of genetic differentiation among stable fly populations indicates high levels of gene flow among populations. The low levels of variation observed with biochemical and molecular techniques are consistent with a genetic bottleneck during stable fly colonization of North America.

Animals↗
PubMedDate not supplied

Designing and building new local public health agencies in Nebraska.

Prior to 2001, the local public health system in Nebraska was weak, fragmented, and severely under funded. Local public health departments covered only 22 of the state's 93 counties. The Turning Point project provided the impetus for change by allowing a diverse group of public health stakeholders to develop a strategic plan for strengthening and transforming the public health system. The plan acted as a catalyst to use some of the Nebraska Tobacco Settlement Funds to provide dedicated state funding to build the local public health system. By June 2002, 16 new local public health departments had been organized, ultimately covering all of the 93 counties in the state. Some of the keys to long-term sustainability are creating a network of community health partners that support collaborative decision making, continually seeking input from the community, developing and implementing an education and training plan for public health professionals and local board of health members, and demonstrating accountability by documenting results and communicating them to policy makers and the general public.

Community Health Planning↗
PubMedDate not supplied

Regional estimation of total recharge to ground water in Nebraska.

Naturally occurring long-term mean annual recharge to ground water in Nebraska was estimated by a novel water-balance approach. This approach uses geographic information systems (GIS) layers of land cover, elevation of land and ground water surfaces, base recharge, and the recharge potential in combination with monthly climatic data. Long-term mean recharge > 140 mm per year was estimated in eastern Nebraska, having the highest annual precipitation rates within the state, along the Elkhorn, Platte, Missouri, and Big Nemaha River valleys where ground water is very close to the surface. Similarly high recharge values were obtained for the Sand Hills sections of the North and Middle Loup, as well as Cedar River and Beaver Creek valleys due to high infiltration rates of the sandy soil in the area. The westernmost and southwesternmost parts of the state were estimated to typically receive < 30 mm of recharge a year.

Altitude↗
PubMed1999

Parent expectations of the school health program in Nebraska.

This article presents findings from the first phase of a comprehensive evaluation plan for the school health program in Nebraska public schools. The evaluation utilized the Targeting Outcomes of Programs (TOP) framework to gather parents' perspectives about the benefits of the school health program, and a ranking of important health activities and role providers. A survey was distributed to 1,200 parents randomly selected from 60 school districts. Of these, 450 (38%) were returned: 96% supported funding of health programs; 88% believed families benefited from school health; 92% viewed the health programs as "essential" to the educational mission; 64% preferred a ratio of 1 nurse/500 students; and 89% believed all students needed access to a professional school nurse. The nurse was the only clearly defined role in the health program and had activities rated as "extremely important." Results were reported to the Nebraska legislature for support of state funding for school health nursing.

Adolescent↗
PubMed1997

Bioventing pilot test results at the low point drain area, Offutt AFB, Nebraska.

The purpose of this paper was to describe the application of bioventing technology at the LPD site at Offutt AFB, Nebraska and present the results of the 15-month pilot test. The preliminary tests indicated sufficient hydrocarbon contamination was present with the necessary soil characteristics to warrant an extended bioventing pilot test. The six month in situ respiration test indicated that progress was being made in reducing the TVH concentrations and biological activity was still occurring. Laboratory analysis of the final soil samples confirmed the reduction in TRPH and BTEX concentrations indicating that the site is close to complete remediation. However, owing to reduced air flow at greater distances from the VW, more biodegradation is still needed near MPB. The reduced biodegradation at MPB could also be due to the high water tables resulting from heavy rains during the summer and fall of 1993. The local water table was above the VW and MP screens for several months. The operation of the blower will continue until the site is completely remediated. The single VW pilot test at the LPD site at Offutt AFB has proven the effectiveness of bioventing in reducing TRPH and BTEX contamination in the subsurface. The installation, operation and maintenance costs were minimal. The effectiveness of this application has resulted in three additional bioventing applications at Offutt AFB including the first, full-scale system located in the state of Nebraska.

Biodegradation, Environmental↗
PubMed2005

Agricultural pesticide use and risk of glioma in Nebraska, United States.

BACKGROUND: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. METHODS: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. RESULTS: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (> or =55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32). CONCLUSION: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern.

Adult↗
PubMedDate not supplied

Herbicides in ground water beneath Nebraska's Management Systems Evaluation Area.

Profiles of ground water pesticide concentrations beneath the Nebraska Management Systems Evaluation Area (MSEA) describe the effect of 20 yr of pesticide usage on ground water in the central Platte Valley of Nebraska. During the 6-yr (1991-1996) study, 14 pesticides and their transformation products were detected in 7848 ground water samples from the unconfined water table aquifer. Triazine and acetamide herbicides applied on the site and their transformation products had the highest frequencies of detection. Atrazine [6-chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4,-diamine] concentrations decreased with depth and ground water age determined with 3H/3He dating techniques. Assuming equivalent atrazine input during the past 20 yr, the measured average changes in concentration with depth (age) suggest an estimated half-life of >10 yr. Hydrolysis of atrazine and deethylatrazine (DEA; 2-chloro-4-amino-6-isopropylamino-s-triazine) to hydroxyatrazine [6-hydroxy-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine] appeared to be the major degradation route. Aqueous hydroxyatrazine concentrations are governed by sorption on the saturated sediments. Atrazine was detected in the confined Ogallala aquifer in ultra-trace concentrations (0.003 microg L(-1)); however, the possibility of introduction during reverse circulation drilling of these deep wells cannot be eliminated. In fall 1997 sampling, metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] was detected in 57% of the 230 samples. Metolachlor oxanilic acid [(2-ethyl-6-methylphenyl)(2-methoxy-1-methylethyl) amino]oxo-acetic acid] was detected in most samples. In ground water profiles, concentrations of metolachlor ethane sulfonic acid [2-[(ethyl-6-methylphenyl)(2-methoxy-1-methylethyl)amino]-2-oxo-ethanesulfonic acid] exceeded those of deethylatrazine. Alachlor [2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide] was detected in <1% of the samples; however, alachlor ethane sulfonic acid [2-[(2,6-diethylphenyl)(methoxymethyl)amino]-2-oxoethanesulfonic acid] was present in most samples (63%) and was an indicator of past alachlor use.

Adsorption↗
PubMed1994

Process evaluation of Nebraska's Team Training Project.

BACKGROUND: A process evaluation of the Nebraska Drug Free School/Community Residential Team Training Project is described. This training project utilizes a "system approach" in the formation and implementation of localized strategic (action) plans targeting alcohol and other drug (AOD) abuse prevention. METHODS: In June of 1990, training participants completed a pre-post survey in conjunction with the four-day training. The majority of the participants (51.2%) were teachers, 19.2 percent were parents, 13.6 percent administrators, and 9.6 percent were counselors. RESULTS: Although the overall attitudes of the participants (N = 125) were positive initially, they became even more so by the end of the training (N = 121). Prior to training participants felt they could have a significant impact on their local AOD abuse problem, and this attitude became more positive by the completion of training (p < 0.05). CONCLUSIONS: The Nebraska team training process immerses team members in an active planning process allowing teams to develop a plan of action for their school and community. During this process, participants experience a positive growth in attitudes reflecting not only the training experience itself, but even more importantly their ability to meaningfully affect AOD abuse and related destructive behaviors in their homes, schools, and community.

Adult↗
PubMed2002

Attendance problems and disciplinary procedures in Nebraska schools.

STUDY PURPOSE: School principals were surveyed in rural and urban Nebraska schools to compare policies and procedures on school attendance, and to contrast the use of disciplinary procedures for attendance, violence and substance abuse. METHODS: A survey was sent to a 50 percent random sample of Nebraska schools. Respondent school addresses in metropolitan statistical areas (MSA) areas were categorized as urban, and non-MSA respondents were classified as rural area schools. RESULTS: Of the 680 surveys mailed, 464 (68.2 percent) completed surveys were returned. Overall, 86.2 percent of respondents were from rural schools and 13.8 percent from urban schools. A list of disciplinary problems and procedures was reported for a first-time offense by rural and urban schools. Both an "occasional attendance problem" and a "chronic attendance problem" were most frequently addressed through parent contact in both urban and rural areas. For "fighting with another student," rural schools most commonly reported discipline by teacher, followed by discipline by principal and parent contact. In urban schools, discipline by principal was most common. For "using drugs other than alcohol or tobacco at school" in both areas, disciplinary procedures included parent contact and short-term suspension. A list of disciplinary problems and procedures was also reported for a second-time offense and third-time offense. For "fighting with another student," the most commonly reported procedure was discipline by principal and parent contact for a second-time offense, followed by short-term suspension and long-term suspension for a third-time offense. For "using drugs other than alcohol or tobacco at school," for a second time offense was long-term suspension and semester expulsion for a third-time offense. Principals were also asked in an open-response format, what program or procedures were currently in place to prevent violence in their school. Common responses were "conflict resolution training," followed by "the Boys Town social skills and behaviors model" and "a zero tolerance policy." CONCLUSIONS: School principals generally reported similar disciplinary actions for most disciplinary problems. For recurrent offenses and for serious problems, principals generally used tougher disciplinary procedures. Some of the discrepancies in disciplinary actions, however, suggest the need for consistent enforcement and communication of policies for both urban and rural schools.

Absenteeism↗
PubMed1993

WISC-R IQ estimates from the Luria-Nebraska Neuropsychological Battery.

Multiple regression equations predicting WISC-R IQs from Luria-Nebraska T scores and subjects' chronological age were developed and cross-validated on a total sample of 152 adolescent psychiatric patients. Data from a randomly drawn subsample of 100 subjects were entered into three stepwise multiple-regression analyses to derive equations predicting WISC-R IQs. These equations were applied to the remaining subsample (n = 52) as were the equations developed by McKay, et al. (1981) for estimating adult WAIS IQs. Mean differences, correlations, and classification hit rates between the two sets of predicted IQs and the actual WISC-R IQs were examined. Findings were similar to those of previous studies examining the predictive relationship between the Luria-Nebraska and adult intelligence. As expected, chronological age entered significantly into all three stepwise multiple-regression analyses. The newly derived equations had significantly higher correlations with the WISC-R for Verbal and Full Scale IQs and significantly better predictive accuracy for Full Scale IQ. Rates of IQ misclassification warrant caution in the use of these methods, but it is concluded that the equations derived here predict about as well as do short forms of the WISC-R.

Adolescent↗
PubMed1995

Relationship between the Luria-Nebraska Neuropsychological Battery and Woodcock-Johnson Tests of Achievement-Revised in children with psychiatric impairment.

This study was conducted to estimate the relationship between the Luria-Nebraska Neuropsychological Battery and the Woodcock-Johnson Tests of Achievement-Revised at two ages in a child psychiatric sample (N = 113). Analysis showed significant correspondence between scores on the Luria-Nebraska and the Woodcock-Johnson tests at both ages; however, the former tended to show greater impairment than the latter, particularly for the older group.

Achievement↗
PubMed1990

Ectoparasites of ring-necked pheasants in Nebraska.

In 1971, 1983 and 1984, ectoparasites were identified on 61 ring-necked pheasants (Phasianus colchicus) from Nebraska. Birds were collected throughout the state from 11 of 93 counties. Four species of chewing lice (Mallophaga) were collected: Lipeurus maculosus, Goniodes colchici, Lagopoecus colchicus and Amyrsidea megalosoma. One species of analgid mite, Megninia sp. was collected. Apparently, this species is new and undescribed. The four mallophagan species have not been reported from Nebraska.

Animals↗
PubMed1999

Meningeal worm in free-ranging deer in Nebraska.

The meningeal worm (Parelaphostrongylus tenuis) was found in 22 (7%) of 300 white-tailed deer (Odocoileus virginianus) (257 adults, 43 fawns) examined from Nebraska (USA) during November 1996. None of 53 mule deer (Odocoileus hemionus) (47 adults and 6 fawns) examined were infected. Twenty-two white-tailed deer from 18 counties in eastern Nebraska were infected with Parelaphostrongylus tenuis. This is the first record of P. tenuis in white-tailed deer from this state.

Animals↗
PubMed1982

Hazardous waste management program: phase I interim authorization for Nebraska--Environmental Protection Agency, region VII. Phase I interim authorization.

The State of Nebraska has applied for interim authorization of its hazardous waste program under Subtitle C of the Resource Conservation and Recovery Act and EPA guidelines for the approval of State hazardous waste programs [40 CFR Part 123]. EPA has determined that the State's program meets all applicable statutory and regulatory requirements and is granting Phase I interim authorization to Nebraska to operate in its jurisdiction a hazardous waste program in lieu of Phase I of the Federal hazardous waste program.

Environmental Health↗
PubMed1992

The impact of transplantation on the clinical laboratory. Experience at the University of Nebraska with bone marrow and liver transplantation.

The number of both bone marrow and solid organ transplantation programs has increased significantly during the past several years. The implementation of these programs and their growth have had a significant impact on the clinical laboratories that are involved in the support of these programs. Between 1983 and 1985, two major organ transplantation programs were implemented at the University of Nebraska Medical Center, Omaha. The clinical laboratories at the University of Nebraska Medical Center have seen a 217% increase in procedure volume and a 165% increase in full-time equivalents during an 8-year period from 1983 to 1991 as a result of these programs. The laboratory procedures that are performed on patients who are undergoing transplantation currently generate approximately $9 million in charges per year. In the present article, I discuss the effect of bone marrow and liver transplantation programs on the entire laboratory and individual laboratory sections.

Academic Medical Centers↗
PubMed1990

Distributions of genetic markers in a Nebraska population.

Seven genetic marker systems were analyzed from liquid blood and dried bloodstain specimens submitted to the Nebraska State Patrol Crime Laboratory from various law enforcement agencies throughout Nebraska. The phenotypic and genotypic frequencies for the ABO, Lewis, esterase D (ESD), phosphoglucomutase (PGM), adenylate kinase (AK), adenosine deaminase (ADA), and haptoglobin (HP) systems were calculated. The results indicate that the phenotypic frequencies are generally in agreement with frequencies reported in other populations in the United States.

Blood Group Antigens↗
PubMed1989

Progress in lipid reporting practices and reliability of blood cholesterol measurement in clinical laboratories in Nebraska. Efforts to align results with the Centers for Disease Control, and feasibility of meeting National Cholesterol Education Program Guidelines.

The National Cholesterol Education Program has recommended that all laboratories be consistent, precise, and accurate in the reporting and measurement of blood cholesterol levels. In a follow-up to a 1984 survey study, we assessed the changes in reporting procedures for measurements of blood lipid levels in 16 clinical laboratories in Nebraska. Using human serum reference materials of known cholesterol concentrations provided by the Centers for Disease Control, we also assessed the precision and accuracy of measurement of blood cholesterol levels in clinical laboratories in Nebraska. Fourteen of the 16 laboratories restudied in 1987 had altered the reference range for total serum cholesterol since 1984, 86% of whom lowered the upper limit of the reference range. Eleven of 16 laboratories expressed reference ranges for total serum cholesterol in terms of patient age in 1987, while only 7 of 20 did in 1984. Gender-based reference ranges increased from 0 to 5 from 1984 to 1987. Similar trends were seen in the reporting of high-density lipoprotein cholesterol and triglyceride concentrations. Reporting procedures varied greatly; only 1 laboratory used National Cholesterol Education Program risk levels for measuring total serum cholesterol levels. Fifteen laboratories met the National Cholesterol Education Program recommendation for precision (coefficient of variation, less than or equal to 5%) and 78% of laboratories obtained results that satisfied the current recommendation for accuracy (within 5% of "true value," as determined by the Centers for Disease Control).

Adult↗