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At least 73 records · Page 4Linked to original sources

Osmotic swelling effects on neural conduction.

Local anesthetics administered intrathecally seen more effective when in hypobaric solution than when in hyperbaric solution. To test whether an unrecognized osmotic effect might be playing a part in this, sheathed vagus nerves of rabbit were incubated in electrolyte-deficient or electrolyte-free media of various degrees of hypo-osmolarity. The nerves gained weight over a period of 15 min. They lost nearly half their sodium, but very little potassium, within 5 min. Electrolyte depletion by incubation in sucrose solutions depressed the amplitude of the C-fiber component of the compound action potential more rapidly in hypo-osmotic than in iso-osmotic solutions. In iso-osmotic sucrose, 50 per cent depression developed in 61 +/- 12 min (mean +/- SD, n = 5), but in 0.6 iso-osmotic sucrose, 50 per cent depression was reached in 17 +/- 3 min (n = 5). Lidocaine, 100 microM (approximately 0.003 g/100 ml) in iso-osmotic sucrose was without observed effect; lidocaine, 100 microM in 0.6 iso-osmotic sucrose produced 50 per cent depression in 7 +/- 2 min (n = 4). Thus, osmotic swelling plus electrolyte depletion, but not electrolyte depletion alone, markedly intensified inhibition of conduction by lidocaine. All effects were reversible by returning the nerves to isotonic physiologic incubation medium. The results suggest that intrathecal osmotic swelling of neural tissue may contribute to the conduction block in hypobaric spinal anesthesia.

Anesthesia, Spinal↗

[Normal values of neural conduction velocity in a group of 101 subjects].

Motor and sensory nerve conduction velocities were analysed in a group of 101 normal Brazilians. The normal values were obtained considering the group age, the distal and proximal segments of each nerve, the differences in the right and left side for each nerve. A significant decline in the conduction was found for the elderly aged group.

Adolescent↗

[Hoffmann's reflex evoked on the soleus muscle and motor neural conduction velocity of the tibial nerve].

H reflex on the soleus muscle and motor tibial nerve conduction velocity are used to study peripheral nervous system maturation in 68 healthy children, from birth to 4 years of age. Proximal an distal conduction velocities develop in a parallel and approximately exponential way but proximal conduction velocities remain always faster. The latencies slightly decrease during the first 18 months of life and then increase very slowly.

Age Factors↗

[Sensory polyneuropathy and neural conduction block as an initial manifestation of polyarteritis nodosa].

Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis which affects middle calibre arteries and which has a tendency to form aneurysms. It may appear as one of a great variety of clinical forms depending on the vascular territory afflicted. Almost any organ may be involved although the lung is usually unaffected. Neurological manifestations are very frequent in this disease (global incidence being around 80%), especially at the peripheral nervous system level. Multiple mononeuritis is the most usual manifestation classically associated with this type of vasculitis, but it may also appear as distal sensorimotor polyneuropathy, this being its most infrequent form of presentation. The presence of nerve conduction blocks has also been recently described, usually associated with demyelinating processes. However peripheral nerve affectation in vasculitis has its origins in small ischaemic infarcts in the sensorimotor conduction fibres. It may well be that segmentary demyelination and axonal degeneration reflect different levels of ischaemic damage.

Cerebral Angiography↗

[Neural conduction in hand nerves and the physiological factor of age].

Many researchers have established the influence of physiological factors as age, for the parameters of the study of the motor and sensitive conduction. The objective of this study was to analyze the influence of the variable age in the study of the motor and sensitive nervous conduction of the median and ulnar nerves. The data were collected from 92 volunteers: 61 women and 31 men. Their age was from 13 to 74 years old, with a mean of 36.3 years. Most of them were employees at Santa Casa de São Paulo. It was observed that a reduction in the velocity of sensitive and motor nervous conduction takes place with the age. This reduction is associated with a reduction in the amplitude of the evoked potential.

Adolescent↗

[Changes in the neural conduction in spinal muscular atrophy of the Kennedy type].

Sensory conduction velocity of median and sural nerves was examined in 6 patients with spinal muscular atrophy (SMA) of Kennedy type. In all patients, except the youngest one, slight slowing of sensory conduction velocity and marked decrease of potential amplitude was observed. These changes might suggest that the Kennedy type of SMA differs from another types of SMA and, may be, does not fit into "pure" motoneuron disease.

Adult↗

[Neural conduction in workers after long-term exposure to mercury vapors].

36 workers exposed to mercury vapour intoxication were examined to estimate the abnormalities in peripheral nervous system. 18 workers showed on physical examination features of polyneuropathy and in this group 15 workers had on emg examination sensory polyneuropathy. Statistical analysis was performed to show correlations between polyneuropathy on emg and age, time of exposure to mercury vapour and urinary mercury level. No such correlations were demonstrated.

Adult↗

[Method of dissecting peripheral nerve sheaths with an ultrasonic microscalpel that does not disturb neural conduction].

A new method for dissection of the nerve sheaths by an ultrasonic microscalpel was tested in in-vivo experiments with the cat saphenus nerve. The compound nerve action potential consisting of A beta, A delta and C waves did not change after successive one-cm long dissections of the major nerve sheaths, epineurium and perineurium, demonstrating innocuous character of the method. Not deep plunging of the ultrasonic scalpel into the nerve, hemocoagulation when dissecting as well as drastically reduced mechanical efforts are the principal advantages of new method.

Animals↗

[Body building--effect on neural conduction velocity of the median nerve in the carpal tunnel].

The examination of 30 body builders showed that prolonged practice of this sport may lead to exercise-induced carpal tunnel syndrome (CTS). Three of these body builders demonstrated typical symptoms of CTS. It was shown that, especially when training had lasted for more than 6 years, the distal motor latency (DML) of the median nerve increased significantly. A clear correlation between the estimated total duration of training and the DML was found.

Adult↗

[Peripheral and central neural conduction in the rat].

The orthodromic sensory nerve conduction velocity was measured on the tail nerve of 35 male and 14 female Wistar rats. The spinal somatosensory evoked potential also was determined for the excitation of the tail and lower limb over the 5th and 1st lumbar vertebrae. The cervical response and cortical somatosensory evoked potential were determined for the stimuli of the hind and fore paw. Normal values are compared with the latencies evaluated by upper limb stimulus. Differences between both sexes are discussed.

Animals↗