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PubMed2002

A rare case of mucoepidermoid carcinoma of the nasal cavity.

Mucoepidermoid carcinoma of the nasal cavity is rare. We report the case of a 57-year-old man who was evaluated for a rapidly enlarging subcutaneous mass on the nasal bridge. The tumor was diagnosed as a mucoepidermoid carcinoma. The patient underwent extensive surgical resection and postoperative radiotherapy, but 5 months later he required orbital exenteration for persistent disease. Despite these radical measures, the patient died with persistent disease 9 months following the initial evaluation. The aggressive behavior of this tumor highlights the need for physicians to be aware of the differential diagnosis, symptoms, and signs of neoplasms that originate in the nasal cavity so that prompt treatment can be instituted.

Biopsy, Needle↗
PubMed1993

Osteoblastoma of the nasal cavity.

The clinicopathological features of a rare case of osteoblastoma of the nasal cavity arising from the nasal turbinate are reported and compared with four reported cases of osteoblastoma with nasal cavity involvement. Two of the five tumours involved the nasal cavity and paranasal sinuses. The remaining three tumours were confined in the nasal cavity; one arose from nasal bone and two from nasal turbinate periosteum. Four tumours were successfully treated with local excision. One tumour recurred locally after excision; the recurrence was apparently controlled by further local excision.

Adult↗
PubMedDate not supplied

Microbiology of the canine nasal cavities.

The microbiota of both nasal cavities were investigated in 37 dogs by both aerobic and anaerobic techniques. The predominant microorganisms were composed of enterococci and staphylococci. A surprisingly high incidence (46%) of Gram-negative rods was noted from the inferior portion of the nose. Microorganisms from the superior region of the nose, as obtained with a surgical approach, differed both qualitatively and quantitatively from the respective transnasal cultures. Thus, it appears that different bacterial populations are present within various anatomic regions of the nose and a routine transnasal culture cannot accurately reflect the microbiology of the entire nasal cavity.

Animals↗
PubMedDate not supplied

Nasal nitric oxide is independent of nasal cavity volume.

This study was performed to evaluate the relationship between nasal nitric oxide (NO) and changes in nasal cavity volume resulting from the topical application of xylometazoline and saline and between upright and supine posture. Nasal NO was measured using a fixed high flow technique that avoids contamination with lower airways NO. In nine healthy subjects nasal NO concentration was measured by a rapid response chemiluminescent analyzer. A tapered tube was inserted in one nostril, into which room air was insufflated to produce a constant flow of 100 mL/second; another tube was inserted into the opposite nostril for NO sampling (air exit side). Subjects were instructed to keep the vellum closed while NO was sampled through a sideport connected to the analyzer. Nasal cavity volume was measured by acoustic rhinometry from a segment of the acoustic pathway, 2 to 5 cm from the nostril. Nasal cavity volume and NO measurements were made at baseline, 15 minutes, and 60 minutes after intervention (administration of saline 0.9%, xylometazoline or posture changes on 3 consecutive days). Xylometazoline produced a significant increase in nasal cavity volume, together with a significant reduction in NO level at 15 and 60 minutes after intervention. In addition, the change from seated to supine position decreased the total nasal volume significantly, but without changes in nasal NO. No correlation was found between the magnitudes of changes in nasal NO and the changes in nasal volume. Topical application of xylomethazoline resulted in increased nasal cavity volume and reduced NO output. In contrast to previous published reports, a technique using high flow rate insufflation demonstrated an abscence of correlation between the magnitudes of changes in nasal NO and nasal cavity volume brought about by decongestant, saline, or posture.

Acoustic Stimulation↗
PubMed1998

Large molecule and particulate uptake in the nasal cavity: the effect of size on nasal absorption.

One of the characteristics influencing the increased interest in the nasal cavity as a site for systemic drug delivery is the ability of large molecules to permeate through the nasal mucosa into the systemic circulation. Compilations of data regarding the absorption of large therapeutic agents, peptides and proteins in particular, along with more systematic studies using polymeric compounds have shown that for compounds larger than 1000 Da, bioavailability can be directly predicted from a knowledge of molecular weight. In general, the bioavailability of these large molecules ranges from 0.5 to 5%. Particulate uptake also occurs in the nasal mucosa, and particles up to approximately 1 µm have been shown to rapidly enter the bloodstream following intranasal administration. The unique barrier properties of this mucosal delivery site give it great promise as a route for the systemic administration of large molecules.

Journal Article↗
PubMed2000

Resident aerobic microbiota of the adult human nasal cavity.

Recent evidence strongly suggests that the microbiota of the nasal cavity plays a crucial role in determining the reaction patterns of the mucosal and systemic immune system. However, little is known about the normal microbiota of the nasal cavity. The purpose of this study was to determine the microbiota in different parts of the nasal cavity and to develop and evaluate methods for this purpose. Samples were collected from 10 healthy adults by nasal washes and by swabbing of the mucosa through a sterile introduction device. Both methods gave results that were quantitatively and qualitatively reproducible, and revealed significant differences in the density of the nasal microbiota between individuals. The study revealed absence of gram-negative bacteria that are regular members of the commensal microbiota of the pharynx. Likewise, viridans type streptococci were sparsely represented. The nasal microbiota was dominated by species of the genera Corynebacterium, Aureobacterium, Rhodococcus, and Staphylococcus, including S. epidermis, S. capitis, S. hominis, S. haemolyticus, S. lugdunensis and S. warneri. These studies show that the microbiota of the nasal cavity of adults is strikingly different from that of the pharynx, and that the nasal cavity is a primary habitat for several species of diphtheroids recognized as opportunistic pathogens. Under special circumstances, single species, including IgA1 protease-producing bacteria, may become predominant in a restricted area of the nasal mucosa.

Actinomycetales↗
PubMed1991

The effects of neonatal capsaicin administration on trigeminal nerve chemoreceptors in the rat nasal cavity.

Trigeminal nerve fibers in the nasal cavity respond to a variety of volatile chemical stimuli. Some of these trigeminal nerve fibers have been suggested to be capsaicin-sensitive and thus belong to a class of pain receptor rather than constituting a separate class of chemoreceptor. Our current results confirm this suggestion. Trigeminal nerve responses to volatile chemical stimuli were eliminated in rats which were injected with capsaicin on the second day of life. Animals whose nerves were unresponsive to chemical stimuli also exhibited a loss of intraepithelial peptide-immunoreactive fibers in their nasal cavities. The results of this study suggest that trigeminal nerve fibers in the nasal cavity which respond to chemical stimuli may be polymodal nociceptors which contain substance P, calcitonin gene-related peptide, or perhaps other neuropeptides.

Animals↗
PubMed2006

[Three dimensional reconstruction of the nasal cavity structure and numerical simulation of airflow].

The nasal cavity structure of one patient was reconstructed by the method of surface rendering based on his CT images. In a respiratory period the change of air flux in the nasal cavity was supposed based on the tidal volume and the respiratory period gained by statistical method. The digital simulation and the analysis of the airflow in the nasal cavity was made by the FEA method and the result was compared with the data from literatures. The comparison indicates that the result is confident. From the result we can observe the airflow distribution quantitatively in the nasal cavity in the period of respiration.

Adult↗
PubMed1986

The bacterial flora of the nasal cavity in healthy young men.

The nasal cavity of 97 young healthy men (applicants for the pilot education in the Finnish Air Force) was examined. Bacterial culture demonstrated one or more species of aerobic bacteria in all 194 nasal cavities examined and anaerobic bacteria in 76.5%. In ten per cent of the cultures bacteria were detected after enrichment only. The most common aerobic bacteria were Staphylococcus epidermidis (79%), diphtheroids (41%) and Staphylococcus aureus (34%). Haemophilus influenzae was found in 5% and Streptococcus pneumoniae in 0.5%. Anaerobic culture yielded Propionibacterium acnes in 74.5% and Peptococcus magnus in 3.5%.

Adolescent↗
PubMed2000

Humidity and temperature profile in the nasal cavity.

OBJECTIVES/HYPOTHESIS: Adequate air conditioning in the nasal airways is mandatory for respiration and gas exchange in the lower respiratory tract. The aim of the present study was to measure relative humidity and temperature in the airstream at different sites within the nasal cavity for mapping of relative humidity and temperature in the upper airways. STUDY DESIGN: Intranasal relative humidity and temperature of 23 volunteers was measured during respiration at different locations in the nasal cavity. METHODS: The end-inspiratory temperature and humidity data, obtained with a miniaturized thermocouple and a capacitive humidity sensor, were determined. RESULTS: A high increase of humidity and temperature at the end of inspiration, in relation to the environmental conditions, was found in the anterior nasal segment. The further increase of both parameters between turbinate area and nasopharynx was less pronounced in spite of the longer distance. CONCLUSIONS: The anterior part of the nasal cavity contributes within a short nasal passage to air conditioning of inspired air.

Adult↗
PubMed2003

Antioxidant status of the rat nasal cavity.

Despite extensive interest in the rodent nasal cavity as a target organ for toxicity, there is very limited information regarding nasal defenses against oxidative stress and xenobiotic-derived oxidants. Using immunohistochemistry, we have examined the distribution of Cu,Zn and Mn superoxide dismutase (SOD), catalase, glutathione (GSH) peroxidase, and DT-diaphorase in rat nasal tissues. In addition, we have determined the concentrations of ascorbate and alpha-tocopherol and the activities of SOD (combined Cu,Zn and Mn forms), catalase, GSH peroxidase, GSH reductase, and DT-diaphorase in nasal respiratory epithelium (RE), olfactory epithelium (OE), and in lung. Immunohistochemistry demonstrated that all four enzymes were similarly distributed, with the greatest staining intensity in dorsal-medial regions of the nasal cavity. In respiratory epithelium, ciliated columnar cells and subepithelial glands stained positively, while in olfactory tissue the enzymes were detected in the sustentacular cells and Bowman's glands. With the exception of SOD, enzyme activities were higher in RE than OE, while concentrations of ascorbate and alpha-tocopherol were higher in OE than RE. With the exception of catalase, nasal activities were either higher than or comparable to those of the lung. Thus, the rat nasal cavity appears to be well protected against oxidative damage.

Animals↗
PubMed1992

[Experimental study of airflow in the main nasal cavity of the human using a nose model].

Airflow patterns of nasal cavities in a human nasal fossa model were examined in this study. Our 1:1 model of the whole nose (both nasal fossae were moulded) gives a good insight into all parts of the nasal cavities. Staining of flow paths visualised that the main stream of air flow passes through the inferior nasal duct in inspiration and expiration. All regions of the nasal fossa were reached by fluid movements and could be marked with staining solution. Under static conditions laminar flow without turbulent profiles was seen in all sections of the nasal cavities. This technique of detection of flow characteristics in the nasal cavities provides a good tool for further research on flow and deposition characteristics of aerosols.

Humans↗
PubMedDate not supplied

Histopathologic examination of the rat nasal cavity.

A method for preparation of the rat nasal cavity for histopathologic examination is presented, and the anatomic features of the sections obtained are described. The method results in four tissue sections which are selected because of their reproducibility based on landmarks on the dorsal aspect of the mouth and because of the anatomic features of each section which contribute to a thorough examination of the nasal cavity. The four areas examined include transverse sections taken at the following points: (1) immediately posterior to the upper incisor teeth, (2) at the incisive papilla, (3) at the second palatal ridge, and (4) at the level of the first upper molar teeth. The value of each section to the overall evaluation of the nasal cavity and adjacent structures is also discussed. The method described is applicable to both short-term and chronic toxicity studies, and allows for a thorough examination of the nasal cavity without destructive invasion at the time of necropsy.

Animals↗
PubMed1995

Surgical diseases of the nasal cavity and paranasal sinuses.

Nasal diseases in small animals range from simple foreign bodies to invasive malignancies, yet the patients may present with identical clinical signs. As is true in many situations in veterinary medicine, one of the first questions a clinician ponders is: does this animal have a good disease or a bad disease? Recent advances in diagnostic methods have improved our ability to answer that question using noninvasive techniques. However, surgical intervention remains a viable option for exploring the nasal cavity and sinuses to establish and possibly treat the cause. If a malignant process is found, owners should be advised that surgery alone is not helpful and that radiation therapy can improve survival. Complications of all treatment options must be thoroughly outlined to owners because they are common.

Animals↗
PubMedDate not supplied

Transport phenomena in the human nasal cavity: a computational model.

Nasal inspiration is important for maintaining the internal milieu of the lung, since ambient air is conditioned to nearly alveolar conditions (body temperature and fully saturated with water vapor) on reaching the nasopharynx. We conducted a two-dimensional computational study of transport phenomena in model transverse cross sections of the nasal cavity of normal and diseased human noses for inspiration under various ambient conditions. The results suggest that during breathing via the normal human nose there is ample time for heat and water exchange to enable equilibration to near intraalveolar conditions. A normal nose can maintain this equilibrium under extreme environments (e.g., hot/humid, cold/dry, cold/humid). The turbinates increase the rate of local heat and moisture transport by narrowing the passageways for air and by induction of laminar swirls downstream of the turbinate wall. However, abnormal blood supply or mucous generation may reduce the rate of heat or moisture flux into the inspired air, and thereby affect the efficacy of the process.

Biological Transport↗
PubMed1987

Is endonasal insufflation of xenon133 a fiable functional assessment of nasal cavities?

The ventilation of nasal cavities has been examined according to the method of Bisschop et al. (1983). The test was performed on 32 healthy volunteers, free of symptoms with normal standard X-rays of their sinuses. Half-times of the wash-out curves were calculated and adopted as a measure of ventilation. For sitting persons these values were lower than other authors reported, the values in sitting or lying persons were comparable. We did not find a significant difference between values of sitting or lying We did not find a significant difference between values of sitting or lying persons. There was no significant difference neither in the half-times obtained in persons with normal clinical background and persons with septal deviations. The experiment was not optimally reproducable.

Humans↗
PubMed1992

[Usefulness of 0.02 percent epinephrine solution to widen the nasal cavity].

There are many reports describing how to use epinephrine solution before nasal intubation, but there are few reports showing how much of the nasal cavity is widened by using epinephrine solution. The purpose of this study is to examine the usefulness of epinephrine solution to widen the nasal cavity before nasal intubation by measuring the decrease of the nasal concha. Twenty patients who were scheduled for nasal intubation were divided into two groups: 0.02 percent (1:5000) epinephrine solution (0.02 group, n = 10). 0.033 percent (1:3000) epinephrine solution (0.033 group, n = 10). The solutions were instilled on long cotton-tipped applicators that were slowly inserted until they reached posterior wall of the nasopharynx. We examined the area of the inferior nasal concha on X-P before and after inserting applicators in two groups. The area of the inferior nasal concha on X-P decreased 25 percent and 27 percent after using epinephrine solution in 0.02 group and 0.033 group, respectively and the decreases of the area were significant. But there was no significant difference between two groups. We conclude that 0.02 percent epinephrine solution is useful and adequate to widen the nasal cavity before nasal intubation.

Adolescent↗
PubMed2005

Primary lymphoma arising in the nasal cavity among Japanese.

AIMS: Most lymphomas arising in the nasal cavity are thought to be of natural killer (NK) cell origin. However, some reports indicate that T- and B-cell lymphomas may also primarily arise in the nasal cavity. We therefore studied lymphomas arising in the nasal cavity both histologically and immunohistochemically. METHODS AND RESULTS: Of the 32 cases investigated, 20 cases were also available as fresh frozen specimens. We diagnosed 31 cases as extranodal NK/T-cell lymphoma and one as plasmacytoma. The neoplastic cells were immunoreactive for CD3 (polyclonal) 31/31, LMP-1 12/31, CD20 (L26) 0/31, granzyme B 30/31, TIA-1 30/30, CD56 (123C3) 29/31, CD4 0/31 and CD8 3/31. In situ hybridization for Epstein-Barr virus-encoded small RNA-1 (EBER-1) was detected in 31/31. In frozen tissue sections, neoplastic cells mostly showed CD3 (Leu4)-, CD4 (Leu3a)-, CD5 (Leu1)-, CD8 (Leu2)-, CD16 (Leu11)-, CD56 (Leu19)+, betaF1-, TCRdelta1-, perforin+, CD94+ phenotypes. These immunohistochemical findings indicate their NK cell origin. In three cases, neoplastic cells were positive for CD8. In one of these cases, neoplastic cells were positive for CD8beta and Valpha24, suggesting their NKT-cell origin. CONCLUSIONS: Our present study indicates that primary lymphomas arising in the nasal cavity are mostly of NK cell derivation. Our present study also suggests that a small number of cases are derived from NKT-cells.

Adult↗