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At least 73 records · Page 4Linked to original sources
PubMed2006

Effect of lateral meniscal allograft sizing on contact mechanics of the lateral tibial plateau: an experimental study in human cadaveric knee joints.

BACKGROUND: A mismatch of the original lateral meniscus and a lateral meniscus allograft by inaccurate preoperative radiographic sizing can have significant consequences on ultimate function. HYPOTHESIS: The size of a lateral meniscal allograft affects the contact mechanics of the femoral condyle on the tibial plateau. STUDY DESIGN: Controlled laboratory study. METHODS: Four right and 2 left knees were tested as intact joints, after meniscectomy, and after replantation with the original menisci and 16 right or 9 left human, fresh-frozen lateral meniscal allografts, respectively. The allografts were allocated into 7 groups according to their outer and inner anteroposterior and mediolateral diameters. Biomechanical testing was performed as compressive loadings with constrained motions in extension and 30 degrees of flexion. Measurements were done with Fuji pressure-sensitive films for contact parameters of the direct femorotibial and meniscotibial contact. RESULTS: Oversized lateral meniscal allografts led to greater forces across the articular cartilage, whereas undersized allografts resulted in normal forces across the articular cartilage but greater forces across the meniscus. Two undersized transplants failed. Most of the contact parameters of allografts 10% smaller or larger than the original menisci were in the range of the intact knees. The knees after meniscectomy showed greater forces of the direct femorotibial contact areas than did the intact knees and the knees with the replanted original menisci. The contact mechanics of the knees with the replanted original menisci were close to normal. CONCLUSION: The size of a lateral meniscal allograft has a significant effect on the contact mechanics of the tibial plateau. CLINICAL RELEVANCE: Preoperative radiographic sizing needs to be performed precisely to identify a suitable lateral meniscal allograft. A mismatch may be the reason for failure of the allograft or subsequent development of degenerative changes. A mismatch on graft selection of less than 10% of the size of the original meniscus may be acceptable.

Aged↗
PubMed1995

[Study on relationship between anterior components of lateral occlusion and muscle activity. Part 1. Anterior components of lateral occlusion].

a) Angle of frontal and horizontal inclination b) position c) numbers and d) area of the contact points at several lateral occlusions which have different distances from the intercuspal position (ICP) were examined on 12 normal subjects to suggest the normal form of lateral occlusion. Each lateral contact point was different due to the LED jaw tracing device with which the angle was measured, and the position, numbers and the area were measured using black silicon methods. The results were as follows: 1. On the angle of frontal inclination, 70% of the subjects showed 25-45 degrees, and especially at the canine's edge to the edge lateral position (EDGE position), C.P. group and G.F. group had significantly different frontal angles. The angle of horizontal inclination had a negative correlation to the frontal inclination, 70% of the subjects showed 20-35 degrees for this angle. 2. The angle of frontal and horizontal inclination was not affected by the balancing contacts. 3. At a 2 mm lateral position from the ICP, the correlation between the angle of frontal inclination with the numbers and area of lateral occlusal contact was more negative than that at another lateral position.

Adult↗
PubMed1986

Evidence for cerebellar efferents to the ventral lateral geniculate nucleus and the lateral terminal nucleus of the accessory optic system in the rabbit. A morphological study with comments on the organizational features of visuo-oculomotor-trunco-cerebellar loops.

The efferent ascending connections of the cerebellar nuclei and afferent optic projections to the ventral lateral geniculate nucleus and the terminal nuclei of the accessory optic tract were traced in the 26 rabbits using the technique of experimental anterograde degeneration. Following eyeball enucleation, within the ventral lateral geniculate nucleus terminal degeneration was found mostly contralaterally and was restricted to both the sublayers (external and internal) of the lateral division, while ipsilaterally only scanty and confined to the dorsal region of the external sublayer of the lateral (sector alpha) division. After cerebellar lesions degeneration was found within the ventral region of the medial division (sector gamma) of the contralateral LGv and within contralateral LTN. From the localization of the lesions in the cerebellar nuclei, as well as from the distribution of degenerations in the area of the LGv, it was postulated that the parent neurons for the cerebello-LGV fibers are located in the contralateral posterior interposed nucleus, although the anteroventral lateral cerebellar nucleus, the Y group and the infracerebellar nucleus have been not excluded. Within the all terminal nuclei of the accessory optic tract the retinal fibers were found to terminate bilaterally with contralateral preponderance, mostly in the MTN, while ipsilateral fibers terminate most extensively in the lateral terminal nucleus of the accessory optic tract (LTN). In this means the retinal afferents of both sides seem to subserve the contralateral lateral cerebellar nucleus control. Taken together, the findings indicate that the extrageniculate visual inputs might be subjected to direct reciprocal cerebello-nuclear control. The visual extrageniculate cerebellopetal pathways and their correlations with the vestibulo-ocular and optokinetic reflex loops are discussed.

Animals↗
PubMed1978

[The development of urogenital organs after lateral mesoblast heterotopic graft in the toad (Bufo bufo) neurula. I. Distinct inversions of anteroposterior and dorsoventral axis of the lateral plate (author's transl)].

Anteroposterior inversion of lateral mesoblast of early toad neurula is followed by differentiation of diverse urogenital blastema, according to the transplant position before the graft. Anteroposterior polarity of lateral mesoderm is thus perfectly determined in young neurula. On the contrary, dorsoventral inversion of lateral mesoblast leads to mesodermic blastema formation according to the transplant position after the graft. Particularly, the dorsal region of the lateral plates displaced to ventral position does not form blastema. On the other hand, the ventral region which shows a dorsal position after the graft develops and produces a typical blastema. Thus, in the young neurula, the dorsoventral polarity is not yet determined in the lateral plate of the mesoblast. Such a result shows also that the ventral and posterior regions of the lateral mesoblast are competent to form blastema. Moreover, factors from dorsal origin and external to lateral mesoblast take part in urogenital organ anlagen formation.

Animals↗
PubMed1990

A neuronal projection from the lateral geniculate nucleus to the lateral hypothalamus of the rat demonstrated with Phaseolus vulgaris leucoagglutinin tracing.

Iontophoretic injections of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L), were placed in different portions of the rat lateral geniculate nucleus, and the tracer was localized by immunohistochemistry. The efferent projections of the lateral geniculate to limbic areas were analysed with special reference to projections of the lateral hypothalamic area. Only in animals, in which neurons in the intergeniculate leaflet were labeled were PHA-L-immunoreactive axons in the lateral hypothalamic area observed. The nerve fibers were mostly located in the ventral and anterior parts of the lateral hypothalamic area. This tracing study suggests that the optic system probably mediating information about the photoperiod influences not only the suprachiasmatic nucleus, but also the lateral hypothalamic area.

Animals↗
PubMed1985

Motoric indicators of laterality and determination of lateral dominance in schizophrenia.

The literature suggests that schizophrenics exhibit reduced or reversed cerebral lateral dominance relative to normal control subjects. An hypothesis which predicted reduced or reversed cerebral laterality for schizophrenics was tested on 60 young, familially right-handed males, with 20 men in each of the following three groups: schizophrenic inpatients, nonschizophrenic psychiatric inpatient controls, and normal controls. The subjects were administered a battery of seven measures of cerebral laterality. The application of multivariate statistical techniques showed groups did not differ significantly in the degree or the direction of their cerebral lateral dominance. Also there were no significant correlations between the measures of laterality. The findings suggest that cerebral lateral dominance is not necessarily altered concomitantly with psychopathology but rather that it is a complex phenomenon which may not be reliably determined on the basis of simple behavioral characteristics.

Adolescent↗
PubMed1988

Lateral orbitotomy without removal of the lateral orbital rim.

Lateral orbitotomy is used for the removal of orbital tumors and for orbital decompression. Most surgeons make saw cuts through the lateral orbital rim and remove and rewire the bone. This procedure is time-consuming and requires repair of the lateral canthal structures. We describe a technique using an air-driven "acorn-tipped" bur that removes the posterolateral lip of the frontal process of the zygomatic bone and effectively straightens the external surface of the lateral orbital wall. This permits removal of the bone without serious injury to the periorbita. The technique creates a trapezoidal orbitotomy measuring approximately 20 mm anteroposterior, 25 mm at the anterior vertical base, and 6 mm at the posterior base. The orbital soft tissues can thus be safely exposed without removal of the lateral rim. We operated on one patient with cavernous hemangioma (27 X 21 X 19 mm) and three patients with bilateral Graves' ophthalmopathy. We discuss anatomic considerations for the prevention of complications, including injury to the frontotemporal branches of the facial nerve, injury to the superior head of the lateral pterygoid muscle, and inadvertent penetration of the dura.

Dissection↗
PubMed2006

Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: the partial lateral pharyngectomy.

BACKGROUND: Although the lateral pharyngotomy is a well-known surgical procedure, to our knowledge, no published reports have described the results achieved with a lateral pharyngectomy approach in patients with isolated and previously untreated selected invasive squamous cell carcinoma of the lateral wall of the pyriform sinus. METHODS: The medical files and operative charts of 30 patients with an isolated, and previously untreated, squamous cell carcinoma of the pyriform sinus, treated for cure by lateral partial pharyngectomy and primary closure, as well as postoperative radiotherapy (n = 22), and preoperative chemotherapy (n = 8), were retrospectively studied. Sixteen tumors were classified as T1 and 14 as T2. All patients but one were followed until death. RESULTS: Three patients (9%) died in the immediate postoperative period (two from medical complications and one from a surgery-related complication). Overall, 29 patients died, resulting in a 77.7%, 40%, 23.3%, and 15% 1-, 3-, 5- and 10-year Kaplan-Meier actuarial survival estimate, respectively. Only one patient had a serious postoperative complication develop. All patients were decannulated. No patients required a gastrostomy and/or completion total laryngectomy for functional reasons. Local recurrence occurred in four patients (13%). The 3-and 5-year Kaplan-Meier actuarial local control estimates were 88.5% and 79.6%, respectively. The use of a platin-based induction chemotherapy (p = .05) regimen was the only variable that was significantly statistically related to local recurrence. Overall, a 93.3% laryngeal preservation rate was achieved. CONCLUSION: Partial pharyngectomy by means of the lateral pharyngotomy combined with postoperative radiation therapy is an efficient and function-sparing approach to control selected invasive squamous cell carcinomas of the lateral wall of the pyriform sinus.

Aged↗
PubMed1979

A comparison of the organization of the projections of the dorsal lateral geniculate nucleus, the inferior pulvinar and adjacent lateral pulvinar to primary visual cortex (area 17) in the macaque monkey.

Both anterograde and retrograde transport tracing methods were used to study the organization of the projections of the dorsal lateral geniculate (DLG), the inferior pulvinar and subdivisions of the lateral pulvinar to primary visual cortex (striate cortex or area 17). The DLG projects only to striate cortex. These projections are retinotopically organized, and do not extend to any cortical layers above layer IVA. In contrast the inferior pulvinar (PI) and the immediately adjacent portion of the lateral pulvinar (PL alpha 48) project to both striate and prestriate cortex. The projections from these two thalamic areas to the striate cortex are also retinotopically organized and exist in parallel with those from the DLG. In contrast to the DLG, the projections from PI and PL alpha terminate above layer IVA in striate cortex, i.e. layers I, II and III. In prestriate cortex the layers of termination include layers IV, III and I. The pulvinar terminations in layers II and III of area 17 occur in segregated patches as do the geniculate terminations in layers IVC and IVA. On the other hand the pulvinar terminations in layer I which overlie those in layers II and III of area 17 appeared to be continuous. Control studies show that the remainder of the lateral pulvinar overlying PL alpha does not project to striate cortex. It is concluded that there are 3 visuotopically organized inputs from the lateral thalamus to primary visual cortex and that each of these inputs have different layers of termination. The inputs from PI and DLG can convey direct retinal inputs while those from PI and PL alpha can also be involved in intrinsic cortico-thalamocortical connection with prestriate cortex. It remains, then that it cannot be tacitly assumed that the ascending inputs which influence the response properties of the primary cortical neurons arise solely from the dorsal lateral geniculate nucleus. It is also argued that these inputs to the supragranular layers may be excitatory as those from the DLG to the IVth layer.

Animals↗
PubMed1986

Geniculotectal neurons of the lateral part of the ventral lateral geniculate nucleus in the hereditary microphthalmic rat: a retrograde WGA-HRP study.

The distribution and morphological characteristics of the geniculotectal neurons from the lateral part of the ventral lateral geniculate nucleus in the hereditary microphthalmic rat were examined by the WGA-HRP method. Unilateral injection of the tracer into the microphthalmic superior colliculus showed that WGA-HRP-positive neurons were present in the ipsilateral lateral part of the ventral lateral geniculate nucleus. However, the number of labeled geniculotectal neurons of the microphthalmia was about 50% that of the normal rats. Furthermore, the size of labeled geniculotectal neurons of the microphthalmia was smaller and their dendrites were shorter than those of normal rats. These results demonstrated that, although geniculotectal neurons of the microphthalmic lateral part of the ventral lateral geniculate nucleus could differentiate just as in the normal rat, the size and number of microphthalmic geniculotectal neurons were remarkably smaller and fewer than those of normal rats. Moreover, the dendrites of microphthalmic geniculotectal neurons were less branched than usual.

Animals↗
PubMed2005

Activity of inferior head of human lateral pterygoid muscle during standardized lateral jaw movements.

OBJECTIVE: (a) To describe the changes in electromyographic (EMG) activity from selected jaw muscles during a standardized lateral jaw movement with the teeth together, and (b) to investigate the effects on jaw muscle activity of changes in both the rate of lateral jaw movement and the relative magnitude of jaw-closing force. DESIGN: In 16 healthy volunteers, recordings were made using a jaw-tracking system, of mid-incisor point (MIPT) movements, as well as EMG activity from the contralateral inferior head of the lateral pterygoid muscle (IHLP), and bilateral anterior and posterior temporalis, masseter and submandibular muscles, during lateral jaw movement tasks at two speeds and two closing force levels with the teeth together. RESULTS: The IHLP was the only muscle to show a consistent increase in activity in association with the outgoing phase of the task and a decrease during the return phase. Under high closing force at slow speed, the EMG activities of the IHLP and bilateral anterior temporalis and masseter muscles were significantly (p < 0.05) higher than those under a low closing force, while there was no significant change (p > 0.05) in bilateral posterior temporalis and submandibular muscles. The change from slow to fast lateral movement at low force did not significantly (p > 0.05) alter the mean activity except for the IHLP (increase in activity) and the contralateral anterior temporalis (decrease in activity). CONCLUSIONS: The data suggest that the IHLP is one of the principal jaw muscles involved in a lateral jaw movement with the teeth together while the other jaw muscles may play a contributory or facilitatory role.

Adolescent↗
PubMed2005

Locked lateral patella dislocation with generalized ligamentous laxity after arthroscopic lateral release of the knee.

We describe the case of a 14-year-old boy with patellar instability on both sides resulting from ligamentous hyperlaxity and dysplasia of the lateral femoral condyle who had previously undergone an arthroscopic lateral release as well as plication of the medial capsule. The patient presented to our clinic 2 years after surgery with a locked lateral patella dislocation on the left side. The surgical correction involved a substantial open lateral release including an excision of the scar tissue and stabilization of the patella in the patellofemoral groove by tibial tubercle medialization and plication of the medial capsule. Six months after surgery, the patient achieved a Lysholm score of 90 points and clinical examination indicated a stable knee with a centralized patella without any evidence of subluxation or dislocation. Open lateral release with partial resection of the lateral retinaculum, medial reconstruction, and tibial tubercle osteotomy was the procedure of choice in this patient with habitual patella dislocation caused by generalized ligamentous laxity.

Adolescent↗
PubMed2005

Spontaneous vacuum phenomenon in the lateral compartment of the knee associated with a lateral tibial plateau fracture.

A case of spontaneous vacuum phenomenon in the lateral compartment of the knee is presented in an 83-year-old woman who attended the Accident and Emergency department two weeks after a twisting injury to the left knee. At the time of examination she still had a marked effusion in the knee with lateral joint line tenderness. X-rays showed a lateral tibial plateau fracture involving the entire lateral condyle and extending into the opposite compartment beneath the intercondylar eminence. The X-rays also demonstrated the presence of gas in the lateral joint line. This is the first reported case of vacuum phenomenon occurring on the same side as a lateral tibial plateau fracture. It is also demonstrated that the phenomenon may occur in the presence of an effusion.

Aged, 80 and over↗
PubMed1996

Patellofemoral complications following total knee arthroplasty. Effect of a lateral release and sacrifice of the superior lateral geniculate artery.

Between 1987 and 1989, 1,205 Anatomic Graduated Component (AGC, Biomet, Warsaw, IN) total knee arthroplasties were performed by three surgeons using the same prosthesis and same technique. Four hundred twenty-eight total knee arthroplasties (35%) had lateral releases; in 107 (75%) of these, the superior lateral geniculate artery was saved. Lateral release had no effect on patellar subluxation, dislocation, or loosening, but was associated with significantly more patellar fractures. Conversely, patellar radiolucency was more common in knees without a lateral release. Furthermore, saving the superior lateral geniculate artery during a lateral release had no effect on patellar dislocation, radiolucency, loosening, or fracture.

Aged↗
PubMed2001

Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb.

In the mammalian main olfactory bulb (MOB), the release of glutamate from lateral dendrites of mitral cells onto the dendrites of granule cells evokes recurrent and lateral inhibition of mitral cell activity. Whole-cell voltage recordings in the mouse MOB in vivo and in vitro show that recurrent and lateral inhibition together control the number, duration, and onset of odor-evoked action potential (AP) firing in mitral cells. APs in mitral cells propagate into the lateral dendrites and evoke a transient increase in dendritic calcium concentration ([Ca2+]), which is decremental with distance from the soma, and increases with AP number. These results suggest that the extent of AP propagation in lateral dendrites of mitral cells, along with the concomitant dendritic Ca(2+) transient, controls the amplitude of lateral and recurrent inhibition and thus is a critical determinant of odor-specific AP patterns in the MOB.

Action Potentials↗
PubMed2002

Surgical treatment of a displaced lateral malleolus fracture: the antiglide technique versus lateral plate fixation.

OBJECTIVES: To assess the outcomes of the surgical management of "isolated" displaced lateral malleolar fractures, comparing the techniques of lateral plating and antiglide plating as described previously. DESIGN: This is a retrospective review, being largely a surgeon-randomized comparative study. SETTING: The study was carried out at a university teaching hospital that serves as a provincial trauma referral service and provides local community care. The senior surgeons are all orthopaedic trauma subspecialists. PATIENTS: A total of 193 patients meeting our inclusion criteria, with isolated lateral malleolus fractures surgically treated at the Vancouver General Hospital between 1987 and 1998, were studied. INTERVENTION: Eighty-five were treated with antiglide plating, whereas the remaining 108 patients underwent traditional lateral plating. MAIN OUTCOME MEASURES: The functional results were evaluated with the ankle scoring system described previously. We also compared the complication rates, including failure of fixation, infection, wound dehiscence, and need for hardware removal. RESULTS: Both groups were comparable for age, sex distribution, mechanism of injury, and occupation. There was no difference in ankle score, function, and infection rate. The incidence of wound dehiscence and reoperation for hardware removal was slightly higher in the lateral plate group, but the difference was not statistically significant. CONCLUSIONS: The outcome of the surgical management of a displaced lateral malleolus fracture is comparable with both techniques. Although few studies have reported some advantages using the antiglide technique, our data do not support one technique over the other.

Adolescent↗
PubMed2006

Use of anterolateral thigh and lateral arm fasciocutaneous free flaps in lateral skull base reconstruction.

Lateral skull base defects following tumor ablation are ideally reconstructed with microvascular free tissue transfer. Although the rectus abdominis free flap is the workhorse in skull base reconstruction, it has a number of drawbacks. Anecdotal reports have indicated that fasciocutaneous free flaps may be useful alternatives in selected cases. Patients undergoing lateral arm (4 cases) or anterolateral thigh (8 cases) fasciocutaneous free flap reconstruction of lateral skull base defects between 1999 and 2005 were therefore reviewed. Twelve consecutive patients (4 males, 8 females) with a mean age of 63 years (range, 39 to 74) underwent such reconstruction following resection of lateral (11 cases) and anterolateral (1 case) skull base lesions. Eight patients had squamous cell carcinoma, 3 had infection or osteoradionecrosis, and 1 had adenoid cystic carcinoma. The duration of surgery (from induction of anesthesia to exit from the operating room) averaged 14.5 hours (range, 10 to 19.5 hours). All donor sites were closed directly. All the flap transfers were successful, with minimal reconstructive and donor site morbidity. During the follow-up period (average, 18 months; range, 2-48 months), 2 patients died of metastatic disease, and another 2 died of other unrelated causes. The remaining 8 patients are alive and disease free. It is concluded that lateral arm and anterolateral thigh fasciocutaneous free flaps should be considered as viable reconstructive options for lateral skull base ablative defects.

Adult↗