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At least 73 records · Page 4Linked to original sources
PubMed1998

[Investigations on hematologic and clinical chemical parameters in blood serum of newborn fallow deer calves (Dama dama L.). 1: Birth weight and hematologic parameters].

59 newborn fallow deer calves were caught, marked, clinically investigated and weighed within 24 hours after parturition. Simultaneously a blood sample was taken from the jugular vein for hematological investigation. Mean birth weight was 4.84 +/- 0.4 kg. Mean number of erythrocytes was 8.91 +/- 0.77 T/l, the hemoglobin concentration was 8.28 +/- 0.77 mmol/l and the PCV was 40.9 +/- 3.0%. A temporary physiological erythropenia as described for neonates of different species during early postnatal development was not found in newborn fallow deer calves. On the other hand the fallow deer calves were born with a remarkable little number of leukocytes (4.5 +/- 1.34 G/l). Granulocytes are dominant among the white blood cells in newborn and adult fallow deer. Only during the 3rd and 4th month of life the number of lymphocytes raised temporarily.

Aging↗
PubMed2003

Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tumors--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

Morbidity and mortality in patients with malignancies, especially leukemia and lymphoma, are increased by invasive fungal infections. Since diagnosis of invasive fungal infection is often delayed, antifungal prophylaxis is an attractive approach for patients expecting prolonged neutropenia. Antifungal prophylaxis has obviously attracted much interest resulting in dozens of clinical trials since the late 1970s. The non-absorbable polyenes are probably ineffective in preventing invasive fungal infections, but may reduce superficial mycoses. Intravenous amphotericin B and the newer azoles were used in clinical trials, but their role in antifungal prophylaxis is still not well defined. Allogeneic stem cell transplant recipients are at particularly high risk for invasive fungal infections. Other well described risk factors are neutropenia >10 days, corticosteroid therapy, sustained immunosuppression, graft versus host disease, and concomitant viral infections. The enormous study efforts are contrasted by a scarcity of risk stratified evidence based recommendations for clinical decision making. The objective of this review accumulating information on about 10.000 patients is to assess evidence based criteria primarily regarding the efficacy of antifungal prophylaxis in neutropenic cancer patients.

Hematologic Neoplasms↗
PubMed2002

[Revisited univariate delta check method for hematologic laboratories (II)--Causes of marked MCV change in identical patients with hematologic disorder].

We have identified causative factors contributing to marked mean corpuscular volume(MCV) change. We selected 38 patients who demonstrated changes in MCV of > or = 10 fl within less than 30 days. Of the 38 patients, 27 had received blood transfusions and 6 had undergone allogeneic bone marrow transplantation within the previous 2 months. No definitive cause was detected in 5 patients. In conclusion, blood transfusion and bone marrow transplantation can result in substantial MCV change in a short time and can represent confounding factors for the MCV delta check method.

Adolescent↗
PubMed1989

[Evaluation of the first program of external quality control in hematology of the Spanish Hematology and Hemotherapy Association. Experience of 1 year's activity].

The External Quality Control Programme in Haematology (EQCP-H) comprises a monthly remittance of two whole-blood control samples for evaluating red cell count (RBC), white cell count (WBC), platelet count (PC), haematocrit (HT), haemoglobin rate (HB) and red cell indices (MCV, MHC, MCHC), as well as lyophilized plasma for prothrombin time (PT), partial thromboplastin time (PTT) and fibrinogen (F) determination. The participant laboratories were classified for each determination in accordance with the methods used. The evaluation was made on the basis of 1986 data, the number of participants being 230, from Public Health (54%) and private 46%) laboratories. A mean (means) or target value, along with the standard deviation (SD), was obtained for the results received in the Organising Centre for each parameter. In order to find deviation of individual results with respect to means, a deviation index (DI) was calculated with regard to the whole group and to those laboratories using the same methods. The graphic evaluation of the results was plotted on a Youden diagram. The active participation was 58.3 +/- 5.7%, ranging from 33% (PC) to 74% (RBC, HB, HT and MCV). Upon evaluating the whole programme, stress was laid on the global variation coefficient (VC%) attained for each parameter and those pertaining to the analytical systems employed, grouped in accordance with the methodological principles. Global VC% ranged between 3.6% (HB) and 31.9% (PTT), and the values corresponding to the analytical procedure used were below 4% for RBC, HB, MCV and MCHC in automatic systems and also for HB and MCV in semiautomatic systems. Although the working period of EQPC-H is too short to draw definitive conclusions on the improvement it may induce in the methodological quality, the high VC% values found for WBC, PC and manual determination of HB, along with the unacceptable values for PT, PTT and F, should be stressed.

Hematologic Tests↗
PubMed1999

Effect of granulocyte-colony stimulating factor on empiric therapy with flomoxef sodium and tobramycin in febrile neutropenic patients with hematological malignancies. Kan-etsu Hematological Disease and Infection Study Group.

The clinical effects of concomitant use of granulocyte-colony stimulating factor (G-CSF) on empiric antibiotic therapy in febrile neutropenic patients were evaluated in a randomized fashion. Two hundred and fourteen neutropenic febrile episodes (neutrophil counts < 1.0 x 10(9)/l) were treated with flomoxef sodium and tobramycin with or without G-CSF. The resolution of fever at day 4 (excellent response) or at day 7 (good response) was deemed effective. Among 157 evaluable episodes, the observed excellent responses were 31 (38.8%) and the good responses were 20 (25.0%) in the G-CSF group; those in the control group were 26 (33.8%) and 25 (32.5%), respectively. The overall efficacy rate was 63.8% (51/80) in the G-CSF group and 66.2% (51/77) in the control group (not significant). The initial neutrophil count was 0.186 +/- 0.249 x 10(9)/l in the G-CSF group and 0.235 +/- 0.290 x 10(9)/l in the control group, and rose to 2.889 +/- 4.198 x 10(9)/l and 0.522 +/- 0.844 x 10(9)/l, respectively, at day 7. These results indicate that G-CSF does not affect the rate of response to empiric antibiotic therapy in febrile neutropenic patients, although a significant effect of G-CSF was observed on neutrophil recovery.

Adolescent↗