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At least 73 records · Page 4Linked to original sources
PubMed2004

Effect of Ferula assafoetida on experimental murine Schistosoma mansoni infection.

Ferula assafoetida is a hard, resinous, oily herbaceous gum belonging to plant family Umbelliferae. It is used as a traditional medicine in many parts of the world and its wide use in medicine was listed by many authors. In the current study, the effect of F. assafoetida on Schistosoma mansoni in experimentally infected mice is investigated. F. assafoetida was given orally via intragastric tube in an oil-form and a powder-form in different concentrations. Four test groups of 30 mice each were studied. Gs I & II mice were given F. assafoetida in an oil-form in different concentrations at 4 and 6 weeks post infection (PI) respectively. Mice in Gs III & IV were given re-constituted F. assafoetida powder in different concentrations (conc.) at 4 & 6 weeks PI. respectively like the previous groups. Oil-form F. assafoetida was given at conc. of 50, 25 & 15 mg/ml. Powder-form was given at conc. of 32, 16 & 8 mg/ml. A highly significant statistical difference between the test Gs (I, II, III & IV) was recorded in comparison to the infection control G with p value < 0.0001 and also between powder and oil forms of F. assafoetida (p < 0.0001) as regards the mean worm burden and tissue egg count. The highest reduction in worm burden and egg counts was found with powder form of F. assafoetida (Gs III & IV) when compared to oil form (Gs I & II), as confirmed histopathologically and by ultrastructural profile alteration.

Animals↗
PubMed2006

[Karyotypes analysis of Ferula fukanensis].

OBJECTIVE: Study on the karyotypes analysis of Ferula fukanensis. METHOD: The young roots were treated with 0.000 2 mol x L(1) 8-Hydroxyquinoline for 3 h, carnoy's for 3 h, 1 mol x L(-1) HCl in 5 min,carbol fuchsin coloration for 2 min and the treated roots were utilizied to make the plate for observation. RESULT: The fukanensis is diploid. The chromosome number of somatic cells was 2n = 22. The karyotype formula is 2n = 2x = 20 = 16m + 4sm. The 4th and 10th are submetacentric, and the others are metacentric. CONCLUSION: The karyotype of F. fukanensis belongs to "2A" type of stebbins', and it is a primitive species.

Centromere↗
PubMed1994

Ferula communis variety brevifolia intoxication of sheep.

Sheep given powdered Ferula communis variety brevifolia at dosage of 2.5 g/kg of body weight/d for 15 days developed classical clinical signs of intoxication: anorexia, somnolence, apparent weakness, and hemorrhage. Marked reduction of vitamin K-dependent coagulation factors and prolongation of prothrombin time and activated partial thromboplastin time were consistent with presence of ferulenol, a toxic coumarinic factor in the plant. Changes induced in the coagulation system developed by the second day of plant administration and were normal within 4 days after dosing was stopped. There was no evidence of primary liver damage or platelet malfunction. Of 6 intoxicated sheep, 2 died with only minimal evidence of hemorrhage.

Animals↗
PubMed1994

Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication.

Dynamics of plasma ferulenol concentration and its effect on the vitamin K-dependent coagulation factors, prothrombin time (PT), and activated partial thromboplastin time (APTT) were determined in 4 sheep intoxicated individually with 600 g of powdered Ferula communis variety brevifolia (FCb) given in 8 doses at intervals of 6 hours. Ferulenol was detected in the plasma of all sheep at initial blood sample collection, 6 hours after the first dose of approximately 75 g of FCb was placed in the rumen. The last observed peak of approximately 20 micrograms/ml was detected at about 12 hours after the last of 8 doses, and the mean concentration then decreased to < 1 microgram/ml during the next 70 hours. Maximal concentration of ferulenol and time for plasma clearance varied with individual sheep. The PT increased steadily to a maximum of 6 times normal about 70 hours after the last peak plasma ferulenol concentration and about 80 hours after FCb administration was stopped. The PT then returned to almost normal (ratio of 1.12) from the maximum (ratio of 6.12) within approximately 5 days. The APTT results generally paralleled the PT results, but the change was not as marked. Maximal PT and APTT ratios were animal-dependent and not always related to plasma ferulenol concentration. The activity of all the vitamin K-dependent coagulation factors was depressed, but the variations were unique to each factor. Factor V, a vitamin K-independent coagulation factor actually had a brief period of increased plasma activity.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1990

Effects of an aqueous extract of Ferula ovina on rabbit and guinea pig smooth muscle.

The effects of an aqueous extract of Ferula ovina were tested in vitro using isolated segments of rabbit and guinea pig intestine, trachea and aorta. The extract inhibited the spontaneous movements of rabbit jejunum and guinea pig ileum and the contractions induced by acetylcholine. The aqueous extract also inhibited the contractions of rabbit trachealis muscle induced by acetylcholine and the contractions of guinea pig trachealis muscle induced by histamine. These inhibitions were dose-dependent and reversible. However, the aqueous extract did not inhibit the contractions of rabbit and guinea pig aortic rings induced by norepinephrine. These data suggest that this plant has non-specific anticholinergic and antihistaminic antispasmodic effects.

Animals↗
PubMed1991

Effects of a Ferula sinaica root extract on the uterine smooth muscle of rat and guinea pig.

The effects of an ethanolic extract of Ferula sinaica roots on the uterine smooth muscles of rats and guinea pigs were tested in vitro using isolated uterine horns. The extract inhibited the spontaneous movements of rat and guinea pig uterine smooth muscle and also the contractions induced by oxytocin stimulation. These effects were concentration-dependent and reversible by tissue washing. These data suggest that this plant extract may have some antioxytocic potential.

Animals↗
PubMed1991

Relaxant effects of Ferula sinaica root extract on rabbit and guinea pig smooth muscle.

The effects of an ethanol extract of Ferula sinaica roots on the smooth muscles of rabbit and guinea pig were tested in vitro using isolated segments of intestine, trachea and aorta. The extract inhibited the spontaneous movements of rabbit jejunum and guinea pig ileum and acetylcholine-induced contractions. The extract also inhibited the contractions of rabbit tracheal smooth muscle induced by acetylcholine stimulation and the contractions of guinea pig tracheal smooth muscle induced by histamine stimulation. Furthermore, the extract inhibited the contractions of rabbit aorta induced by norepinephrine stimulation. These inhibitions were concentration-dependent and reversible.

Animals↗
PubMed2000

Sesquiterpenoids from Ferula kuhistanica.

Methanol extracts of the air-dried roots and stems of Ferula kuhistanica afforded seven daucane-type sesquiterpenes, called kuhistanicaol A-G, together with 13 known daucane esters. Their structures were established on the basis of spectroscopic evidence and the results of chemical reactions.

Apiaceae↗
PubMed2000

Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.

The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.

Anti-HIV Agents↗
PubMedDate not supplied

New daucane esters from Ferula tingitana.

In addition to the three known daucane esters (2,3,8) and one phenylpropanoid (9), the petroleum ether extract of the roots of Ferula tingitana yielded four new daucane esters: 14-p-anisoyloxy-dauc-4,8-diene (1), acetyltingitanol (4), acetyldesoxodehydrolaserpitine (5), and 4-beta-hydroxy-6-alpha-p-hydroxybenzoyloxy-10-alpha-angeloyloxy dauc-8-ene (6). A possible biogenetic pathway for 1,5-cis- and 1,5-trans-daucanes is presented.

Chemical Phenomena↗
PubMedDate not supplied

New sesquiterpenes from Ferula sinaica.

The CH2Cl2 extract of Ferula sinaica afforded twelve sesquiterpenes including three new daucanes, 14-hydroxyvaginatin, 4 beta, 8 beta, 9 alpha-trihydroxy-6 alpha-p-hydroxy-benzoyloxydaucane, and isolancerotriol.

Magnetic Resonance Spectroscopy↗
PubMed1993

New jaeschkeanadiol derivatives from Ferula jaeschkeana.

Two new jaeschkeanadiol derivatives have been isolated from Ferula jaeschkeana rhizomes. These have been identified as a dichloro compound, jaeschkenol [1], and 2 alpha,3 alpha-dihydroxy-4-keto-5 alpha-p-hydroxybenzoyl-jaeschkeanadiol [2], on the basis of spectral data and the X-ray analysis of the former.

Coumarins↗
PubMed2000

Prenylated benzoic acid derivatives from Ferula kuhistanica.

Four new prenylated benzoic acid derivatives, kuhistanols A-D (1-4), along with one known compound, 3-farnesyl-p-hydroxybenzoic acid (5), have been isolated from the roots of the Uzbekistan medicinal plant, Ferula kuhistanica. Their structures were established on the basis of chemical and spectral evidence. Compound 4 showed a significant inhibitory effect on cytokine production in lipopolysaccharide-stimulated human peripheral mononuclear cells.

Apiaceae↗
PubMed2001

Farnesyl hydroxybenzoic acid derivatives from Ferula kuhistanica.

Four new farnesyl hydroxybenzoic acid derivatives, kuhistanols E-H (1-4), were isolated from the roots of the Uzbekistan medicinal plant Ferula kuhistanica. The structures of the new compounds were elucidated based on spectroscopic and chemical evidence.

Apiaceae↗
PubMed2000

Effect of Piper longum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats.

Use of Dipaniya Mahakasaya, a group consisting of 10 herbal drugs, has been suggested in Charaka Samhita to improve digestion. Out of these 10 plants, three, viz. P. longum (water decoction), Z. officianalis (water decoction) and Ferula species (colloidal solution) were studied for their antiulcer and mechanism of antiulcer effects in rats. All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation. The antiulcerogenic effect seemed to be due to the augmentation of mucin secretion and decreased cell shedding rather than offensive acid and pepsin secretion which however, were found to be increased by them.

Animals↗
PubMed1995

Timely administration of extract of Ferula jaeschkeana causes luteolysis in the ovary of cyclic guineapig.

Effect of hexane extract of Ferula jaeschkeana has been studied on corpora lutea of adult cyclic guinea-pigs. Administration of extract showed duration dependent luteolytic changes in the corpora lutea. Its administration for first three days from the onset of estrus caused significant decrease in the diameter of corpora lutea in the ovary at day 10 of cycle. Ovarian wet weight, proteins and glycogen contents were decreased while the activity of acid phosphatase in the ovary was increased. These luteolytic changes in the ovary have also been observed in the histological findings. Administration of extract for other durations (4-6, 7-9 or 10-12 of cycle) did not cause any change at 10th and 16th day.

Acid Phosphatase↗