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PubMed2005

No difference in lipolysis or glucose transport of subcutaneous fat cells between moderate-fat and low-fat hypocaloric diets in obese women.

The objective of the present study was to evaluate the effect of two different diets on lipolysis and lipogenesis in subcutaneous fat cells from obese women. In a ten-week nutritional intervention study, forty women were randomly assigned to a hypoenergetic-2,514 kJ (- 600 kcal/day) diet of either moderate-fat/moderate-carbohydrate or low-fat/high-carbohydrate content. Body weight was equally reduced by approximately 7.5 % in both diet groups (p = 0.58). A subcutaneous adipose tissue biopsy was obtained for subsequent measurement of triglyceride breakdown (lipolysis) using drugs active at different steps of the lipolytic signaling cascade, and lipid synthesis (glucose transport) before and after intervention. No difference was found between the two diet groups at the maximum rate of either lipolysis or adrenoceptor sensitivity (p-values: 0.14 - 0.97). Inhibition of lipolysis by insulin was also similar in both diet groups before and after intervention. Finally, insulin-stimulated glucose transport did not show any changes that could be attributed to the type of diet. In conclusion, our data suggest that macronutrient diet composition has no major influence on glucose transport or mobilization of triglycerides in human subcutaneous fat cells of obese women.

Adipocytes↗
PubMed1985

Dietary fat and blood pressure: an intervention study on the effects of a low-fat diet with two levels of polyunsaturated fat.

The role of dietary fat in human blood pressure control was studied among 84 middle-aged subjects (mainly couples) in two semirural communities in North Karelia, Finland. The families were randomly allocated into two groups that, after a baseline period of 2 weeks, changed their diet for a 12-week intervention period so that the proportion of energy derived from fats was similarly reduced in both groups, from 38 to 24%, but the polyunsaturated/saturated fatty acid (P/S) ratio was increased--from 0.2 to 0.9 in group I and to 0.4 in group II. After the intervention period, both groups switched back to their usual diet for a period of 5 weeks. During the intervention period, total serum cholesterol was reduced by 16% in group I and 14% in group II. Mean body weight and urinary sodium, potassium, calcium, and magnesium excretion changes were small or nonexistent. Mean systolic blood pressure decreased 4 mm Hg in group I (P less than 0.01) and 3 mm Hg in group II (P less than 0.01), and mean diastolic blood pressure decreased 5 mm Hg (P less than 0.001) and 4 mm Hg (P less than 0.01), respectively. The reductions were reversed during the switch-back period (P less than 0.01). These results confirm previous findings of the blood-pressure-reducing effect of a low-fat/high-P/S diet. Although a number of possible confounding factors can be ruled out, the dietary constituent accounting for the blood pressure change cannot be ascertained definitely. The results showed no significant further blood pressure reduction with more than a moderately increased P/S ratio when the saturated fat intake was markedly reduced.

Adult↗
PubMed1998

A medium-term intervention study on the impact of high- and low-fat snacks varying in sweetness and fat content: large shifts in daily fat intake but good compensation for daily energy intake.

Thirty-six normal-weight, habitual snackers (eighteen males, eighteen females) completed a medium-term intervention study designed to examine the tendency of four different types of snacks, varying in nutrient (low- (LF) or high-fat (HF) and sensory properties (sweet (SW) or non-sweet (NSW)), to influence the control of appetite and to adjust daily energy intake. Subjects were exposed to each snack category for a 3-week period and were asked to consume a minimum number of snacks each day so that at least 25% of their daily energy intake would be derived from the test snacks. Energy and macronutrient intakes from the test snacks were calculated every day and also from other eating episodes (using 3 d food diary records) during the third week of snack exposure. Subjects consumed more energy/d from the SW snacks than from the NSW snacks, with most energy being consumed from the HF/SW snacks (3213 kJ) and least energy from the LF/NSW snacks (1628 kJ). This differential snack intake remained stable across the whole snack exposure period. Total daily energy intake did not differ significantly during exposure to any of the four snack types. Furthermore, the encouragement to eat freely from the test snacks did not lead to daily overconsumption of energy when compared with pre-study intakes. Hence, the level of snack consumption was largely compensated for by the energy consumed from the rest of the eating pattern. Although daily energy intake during exposure to the HF snacks was an average of 364 kJ higher (NS) than that during exposure to the LF snacks, the clearest and most significant effect of snack consumption was on daily macronutrient intake. Appreciable consumption of the HF snacks raised the percentage of total daily energy intake consumed as fat from 37 to 41% (P < 0.01). In contrast, the LF snacks reduced daily fat intake to 33.5% (LF/SW, P < 0.05; LF/NSW, NS) of total daily energy. The results, therefore, suggest that, in habitual snackers, generous consumption of LF snacks, when compared with HF snacks, is an effective strategy to reduce fat intake so that it approaches the recommendations of dietary guidelines without increasing total daily energy intake.

Adolescent↗
PubMed1998

Mirror, mirror on the wall, who's the thinnest one of all? Effects of self-awareness on consumption of full-fat, reduced-fat, and no-fat products.

Two studies tested whether self-focusing situations influence people to avoid fatty food. In Study 1, college students tasted full-, reduced-, and no-fat cream cheese spreads on bagelettes. A large mirror was present in the room for some students and was absent for the remaining students. In Study 2, shoppers at large supermarkets tasted full-, reduced-, and no-fat margarine spread on bread. A large mirror was present on the table top for some shoppers and was absent for the remaining shoppers. In both studies, individuals in the mirror group ate less of the full-fat product than did those in the no-mirror group. The presence of a mirror did not influence consumption of reduced- and no-fat products, perhaps because people thought these products were not unhealthy. These findings support self-awareness theory and suggest that individuals on weight reduction programs may benefit from making food choices in self-focusing situations.

Adolescent↗
PubMed1986

Development of divergent lines of lean and fat broilers using plasma very low density lipoprotein concentration as selection criterion; results over the fourth generation and lack of effect of dietary fat on performance and carcase fat content.

Comparisons were made of the performance and carcase composition of lean and fat broilers from the 4th generation of a breeding experiment which were fed diets containing 25 or 80 g fat/kg. Selection over the 4th generation resulted in continued divergence in the selection trait and the correlated responses of total body lipid and protein contents and the efficiencies of conversion of food and dietary protein. In both lines body weight, efficiency of food utilisation and total body lipid and protein contents were unaffected by dietary fat content. Tissue fatty acid composition was influenced by dietary and genetic factors: dietary fat increased the proportions of linoleic and oleic acids at the expense of palmitic, palmitoleic and stearic acids whilst greater body fatness increased the proportion of palmitoleic at the expense of linoleic acid.

Adipose Tissue↗
PubMed2003

Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis.

Milk composition can be altered by diet, and one example is milk fat depression (MFD) in dairy cows. The biohydrogenation theory of MFD has implicated unique fatty acids formed by altered rumen biohydrogenation of PUFA; one example is trans-10, cis-12 conjugated linoleic acid (CLA). In the present study, we induced MFD with a high concentrate/low forage (HC/LF) diet and examined milk composition, milk fatty acid changes and mammary lipogenic mRNA abundance to determine the mechanism involved. The HC/LF diet reduced milk fat percentage by 25% and yield by 27% with no effect on dietary intake, milk production, protein or lactose. Milk fatty acids synthesized de novo in the mammary gland and fatty acids taken up from circulation were reduced to a similar extent (molar basis). MFD was also characterized by the appearance of trans-10, cis-12 CLA in the milk fat. We analyzed mammary mRNA abundance for lipogenic genes and detected reductions for acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), fatty acyl CoA ligase, glycerol phosphate acyltransferase (GPAT) and acylglycerol phosphate acyltransferase (AGPAT). There was no effect on the milk protein gene, kappa-casein. The reductions in mRNA were also correlated with the appearance of trans-10, cis-12 CLA in the milk fat for ACC, FAS, lipoprotein lipase and GPAT. This study demonstrates that diet-induced MFD involves coordinated effects on mRNA for mammary lipid synthesis pathways, and provides support for a mechanism involving alterations in transcriptional activation of these genes.

Acetyl-CoA Carboxylase↗
PubMed1988

The free autogenous fat graft. A comparison of the fat "pearl" and fat "cell" graft in an animal model.

Adipose tissue is a material successfully utilized in the past for soft tissue augmentation. A comparison of insulin-treated free autogenous fat "pearl" grafts to insulin-treated injected fat "micrografts" was made in a rabbit animal model. Gross and microscopic examinations of free autogenous fat grafts were performed at 2, 6, and 12, weeks. With present techniques, results suggest that greater long-term soft tissue augmentation and graft survival is obtained with insulin-treated free fat "pearl" grafts.

Adipose Tissue↗
PubMed1991

[The fat content in the muscles of three selected lines of German Landrace swine. Effects of graded feeding intensity on muscle fattening. Muscle fat content in relation to parameters of body fat deposits].

Investigations on muscle fat content and intramuscular adipose tissue pattern of 51 male castrated pigs were performed. For each body 4 muscles were collected after slaughter. Breeding lines of swine (German Landrace) had been selected through 8 generations for high ("E(+)-Line") and low ("E(-)-Line") levels of NADPH-generating dehydrogenases including a control group without selection. 42 animals were kept under feeding experiments of various energy levels from 60 kg up to 100 kg body mass. Additionally, out of control line 5 piglets (25 kg) and 4 hogs (135 kg) were examined. Data of ether-extracted total fat content versus data of fat marbling planimetry correlated well with r = 0.9. The average degrees of muscle fattening were: m. semispinalis capitis (11%) much much greater than m. psoas major (1.8%) greater than m. semimembranosus (1.7%) greater than m. long thoracis (1.3%). The specific internal relation of muscle fattening with respect to the collected samples was calculated as r = 0.8. Intramuscular fat showed the tendency to increase with higher levels of dietary energy. The E(+)-Line showed higher (16%) muscle fattening than the E(-)-Line. The control group, however, showed 44% higher levels than the E(+)-Line. So, the results of that K degree-Line could not serve as baseline for interpretations. The criteria of thickness and harmony of marbling scores were used to make statements of meat quality: The samples of m. psoas major and E(+)-Line reached the best, the samples of m. semispinalis capitis and the K degree-Line reached the least values.(ABSTRACT TRUNCATED AT 250 WORDS)

Adipose Tissue↗
PubMedDate not supplied

[Chronic action of the fat-mobilizing fragment of human somatotropin on the fat content of fat depots and the plasma glucose level in rabbits].

The effect was studied of synthetic tetradecapeptide-the fat-mobilizing human somatotropin fragment 31-34--on the fat content in fat depot and glucode concentration in the rabbit blood plasma and urine. A marked decrease in subcutaneous (the nape region), perirenal, mesenteric and epididimal fat content, accompanied by partial replacement of the fatty tissue by the connective one, was seen 3 to 4 weeks after tetradecapeptide injection to rabbits. Peptide effect manifested itself only under condition of the inadequate diet and was especially pronounced in young animals. Clucosuria and hyperglycemia were not observed after chronic tetradecapeptide injection. Tetradecapeptide did not exert an evident hyperglycemic or insulinogenous effect and did not produce a marked glucose tolerance fall after short administration to rabbits and during the glucose tolerance test in rats.

Adipose Tissue↗
PubMed1989

[The effect of microbial protein from a hydrocarbon base (fermosin) with a defined fatty acid composition on fat metabolism and fat composition in slaughter animals. 2. The effect of "fermosin" on the composition of back fat in hogs].

Two tests have been undertaken to investigate the influence of feeding microbial biomasses to pigs. No alterations of the fat parameters characterizing the fat stability were observed. All the values obtained are in a normal range. Increases in heptadecenic acid were detected dependent on the content of microbial biomasses in the feed and its fat content. The alterations are mainly in a normal range or slightly beyond it. In nature odd-numbered fatty acids are ubiquitous. Uptake and storage suggest that the organism reacts to an increased offer of C17-fatty acids with an accelerated decomposition of these fatty acids or/and with inhibition of their endogenous synthesis. The results are discussed in comparison with those of literature.

Adipose Tissue↗
PubMed2001

Effect of high fat diet on insulin resistance: dietary fat versus visceral fat mass.

The purpose of the present study was to determine whether chronic high-fat diet (HF) induces insulin resistance independently of obesity. We randomly divided 40 rats into two groups and fed them either with a HF or with a high-carbohydrate diet (HC) for 8 weeks. Whole body glucose disappearance rate (Rd) was measured using a euglycemic hyperinsulinemic clamp. Firstly, we defined whether insulin resistance by HF was associated with obesity. Plasma glucose and triglyceride concentrations were significantly increased in HF. Rd was decreased (10.6+/-0.2 vs. 9.1+/-0.2 mg/kg/min in HC and HF, respectively) and the hepatic glucose output rate (HGO) was increased in HF (2.2+/-0.3 vs. 4.5+/-0.2 mg/kg/min in HC and HF, respectively). Rd was significantly correlated with %VF (p<0.01). These results implicate that visceral obesity is associated with insulin resistance induced by HF. In addition, to define whether dietary fat induces insulin resistance regardless of visceral obesity, we compared Rd and HGO between groups 1) after matching %VF in both groups and 2) using an ANCOVA to adjust for %VF. After matching %VF, Rd in HF was significantly decreased by 14% (p<0.001) and HGO was significantly increased by 110% (p<0.001). Furthermore, statistical analyses using an ANCOVA also showed Rd for HF was significantly decreased even after adjusting %VF. In conclusion, we suggest that dietary fat per se could induce insulin resistance in rats fed with chronic HF independently of obesity.

Adipose Tissue↗
PubMed1988

[The effect of microbial protein, obtained on a hydrocarbon base (fermosin), with a defined fatty acid composition on fat metabolism and fat composition in slaughter animals. 1. The effect of fermosin on the composition of broiler depot fat].

A study has been undertaken to investigate the influence of fermosin on the depot-fat composition of broilers and the oxidative stability of these fats in parallel with test animals fed yeast conventional produced on carbohydrate base. The data obtained are discussed with reference to literature.

Adipose Tissue↗
PubMed1999

Fat oxidation and adiposity in prepubertal children: exogenous versus endogenous fat utilization.

Fat balance plays an important role in fat mass regulation. The mechanisms by which fat intake and fat oxidation are controlled are poorly understood. In particular, no data are available on the origin, i.e. exogenous (meal intake) or endogenous (adipose tissue lipolysis), of fat oxidized during the postprandial period in children and the proportion between these two components. In this study we tested the hypothesis that there is a relationship between adiposity and the oxidative fate of fat taken with a mixed meal in a group of 15 children with a wide range of fat mass (9-64%). The combination of stable isotope analysis ([13C] enriched fatty acids added to a mixed meal) and indirect calorimetry allowed us to differentiate between the exogenous and endogenous resting fat oxidation rate over the 9-h postprandial period. During the 9 hours of the postprandial period, the children oxidized an amount of fat comparable to that ingested with the meal [26.8 (+/-2.31) g vs. 26.4 (+/-2.3) g, respectively, P = ns]. On average, exogenous fat oxidation [2.99 (+/-3.0) g/9 h] represented 10.8% (+/-0.9) of total fat oxidation. Endogenous fat oxidation, calculated as the difference between total fat oxidation and exogenous fat oxidation, averaged 23.4 (+/-1.9) g/9 h and represented 88.2% (+/-0.9) of total fat oxidation. Endogenous fat oxidation as well as exogenous fat oxidation were highly correlated to total fat oxidation (r = 0.83, P < 0.001; r = 0.84, P < 0.001, respectively). Exogenous fat oxidation expressed as a proportion of total fat oxidation was directly related to fat mass (r = 0.56, P < 0.03), while endogenous fat oxidation expressed as a proportion of total fat oxidation was inversely related (r = -0.57, P < 0.03) to the degree of adiposity. The enhanced exogenous fat oxidation observed when adiposity increases in the dynamic phase of obesity may be viewed as a protective mechanism to prevent further increase in fat mass and hence to maintain fat oxidation at a sufficient rate when the body is exposed to a high amount of dietary fat, as typically encountered in obese children.

Adipose Tissue↗
PubMed2002

Dietary polyunsaturated fatty acids decrease fat deposition in separable fat depots but not in the remainder carcass.

Two experiments were conducted in order to determine the effect of dietary fatty acid profile on deposition of body fat, carcass fat, and separable fat depots. Diets with four types of fat (tallow, olive, sunflower, and linseed oils) at an inclusion level of 10% were administered to female broiler chickens. In Experiment 1, total body fat, carcass fat (total body fat minus abdominal fat), and abdominal fat (AF) were determined. In Experiment 2, several separable fat depots (abdominal, neck, sartorial, and mesenteric fat) were removed and weighed. In general, the analyzed separable fat depots were reduced in broilers fed sunflower or linseed oils with respect to those fed tallow or olive oil (P < 0.05). Percentages of body and carcass fat were also slightly reduced in birds fed sunflower or linseed oil, with respect to those fed tallow; however, the differences were not statistically significant. Regression analysis showed that body fat, carcass fat, and fat depots variability were closely correlated with AF (R2 = 0.69, 0.56, and 0.81, respectively), except for birds fed tallow, in which abdominal and mesenteric fat showed a different growth pattern with respect to the other treatments and to the other fat depots. These results suggest that polyunsaturated fatty acids reduce fat deposition in separable fat depots with respect to monounsaturated and saturated fats but not in the rest of the body fat depots. The growth pattern of fat depots can be modified by dietary fatty acid profile. Broilers fed saturated fat tend to deposit more fat in abdominal and mesenteric depots.

Abdomen↗
PubMed2004

Is dietary fat intake related to liking or household availability of high- and low-fat foods?

OBJECTIVE: Despite the increasing availability of low- and reduced-fat foods, Americans continue to consume more fat than recommended, which may be a contributing factor to the obesity epidemic. This investigation examined relationships between liking and household availability of high- and low-fat foods and their association with dietary fat intake. RESEARCH METHODS AND PROCEDURES: A food frequency questionnaire assessed percent calories from fat consumed over the past year in 85 men and 80 women. Participants reported their degree of liking 22 "high-fat foods" (>45% calories from fat) and 22 "low-fat foods" (<18% calories from fat), and the number and percentage (number of high- or low-fat foods/total number of foods x 100) of these high- and low-fat foods in their homes. RESULTS: Hierarchical regression analyses examined the ability of liking and household availability of low- and high-fat foods to predict percent dietary fat intake. After controlling for age, sex, and BMI, liking ratings for high- and low-fat foods and the interaction of liking for low-fat foods by the percentage of low-fat foods in the household were significant predictors of percent dietary fat consumed. Greater liking of high-fat foods and lower liking of low-fat foods, both alone and combined with a lower percentage of low-fat foods in the home, were predictive of higher dietary fat intake. DISCUSSION: Interventions designed to reduce dietary fat intake should target both decreasing liking for high-fat foods and increasing liking for low-fat foods, along with increasing the proportion of low-fat foods in the household.

Adult↗
PubMed2001

Health benefits of dietary fat reduction by a novel fat replacer: Mimix.

The primary goals of this study were to identify any health benefits of the replacement of dietary fat with a novel fat replacer, Mimix, and to assure that the consumption of this fat replacer did not convey any deleterious health effects. Male, weanling, Fischer 344 rats were fed one of six diets containing between 5 and 20% w/w as fat for 8 weeks. These diets included two high fat diets (safflower oil or lard), a low fat diet and three diets where 15% of the fat in the high fat diets was replaced with various amounts of Mimix. When animals were fed a diet rich in saturated fat they consumed significantly more energy than other diet groups. When 15% saturated fat (lard) was replaced with safflower oil animals adjusted their food intake so that no difference in energy intake was observed between the high safflower diet and the low fat and Mimix diets. When the various Mimix fat replacements were compared to animals fed a high fat lard diet there was incomplete compensation of energy intake. Animals fed the high fat lard diet also had higher glucose and total serum cholesterol than their low fat and fat replacement counterparts. Feeding a high fat safflower oil diet to rats resulted in a significantly lower total serum cholesterol and serum triglyceride than all other diets. Replacement of dietary fat with Mimix demonstrated no deleterious effects on the heart, liver and intestinal tract that were all of normal weight, morphology and colour compared to other diet groups. Body composition analysis demonstrated that animals fed high fat diets had higher body fat mass at the expense of lean body mass. This was most obvious for animals fed high fat lard diets who had heavier epididymal fat pads. These data demonstrate that the replacement of dietary fat with the novel fat replacer Mimix can convey a number of health benefits in the absence of any deleterious effects.

Analysis of Variance↗