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At least 73 records · Page 4Linked to original sources

[Esophageal rupture with aortic-esophageal fistula due to ingestion of foil packaged drugs].

A 78-year-old man was admitted because of haematemesis. A week before, the patient was admitted for prostate resection. During that admission he ingested an analgesic tablet complete with foil packaging. Since then, he suffered from dysphagia. Endoscopic examination revealed the foil packaging, but during the procedure massive bleeding in the oesophagus occurred. Despite initial haemodynamic stabilisation, fatal bleeding occurred a short while later. Post mortem examination revealed an aortic-oesophageal fistula which was ascribed to the foil packaging. One other oesophageal rupture was thought to be due to the packaging and a third rupture was ascribed to the inserted Sengstaken-Blakemore tube. Ingestion of a foil packaging warrants active medical intervention, as is stated elsewhere in the literature.

Aged↗

The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China.

A study conducted in 1994 showed that the use of blister packs containing antimalarial drugs significantly increased patients' compliance, compared with traditional means of dispensing drugs in a paper envelope. The present study assessed patients' compliance and compared the difference between 3-day chloroquine and 8-day primaquine courses of treatment for vivax malaria. The level of real compliance was determined by making the drugs with phenobarbital, and measuring its level in the blood following treatment. The results show that blister packaging significantly improved patients' compliance (p < 0.001) over traditional means of dispensing antimalarial drugs; there was no difference in treatment compliance between 3-day and 8-day courses when the drugs were in blister packs. However, with ordinary packaging the treatment compliance rate for an 8-day course was significantly less than for a 3-day course (P < 0.05).

Adolescent↗