Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Drug Incompatibility”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed1995

Drug combinations in syringe drivers.

AIMS: Because of widely differing views on the drugs that can be administered in combination, this study was undertaken to record the combination of drugs in syringe drivers that we had found to be compatible. METHODS: The content of syringe drivers in 100 consecutive patients in whom continuous subcutaneous infusion was used, was recorded. The incidence of skin reactions with the different drugs was noted. The efficacy of combinations used was assessed clinically. RESULTS: A wide variety of drugs were used in many different combinations, with no clinical evidence of loss of efficacy. Some drug combinations are incompatible. Drugs known to cause skin reactions were not administered. In this study skin reactions depended on the number of drugs used in combination. CONCLUSIONS: The array of medications that can be used together in syringe drivers enable this method of drug administration to be used successfully in the control of the diverse symptoms that may arise in terminal illness. Further study is needed for quantitative measurement of drug stability.

Anti-Anxiety Agents↗
PubMedDate not supplied

[Physicochemical incompatibility of injectable drugs: practical considerations].

Preservatives and additives are needed to prepare stable solutions for injection. They may provoke physiochemical reactions when these solutions are mixed. End-products may be either inactive or toxic to the patient. Information on allowed mixtures is scarce. Compatibility analyses are difficult to perform in a short time and are usually expensive. The best way would be to inject the drugs separately with 50 or 100 ml infusions. Moreover, some laboratories supply prepared infusion solutions such as buflomedil, pefloxacine, metronidazole.

Chemical Phenomena↗
PubMed1977

Medication procedures in a nursing home: abuse of PRN orders.

Nursing home patients often receive more drugs than needed. Drug incompatibilities frequently are found, and PRN orders are apt to be overused. Regulatory agencies require periodic physician review in the hope of eliminating these loose prescribing habits. A study was made of the drugs prescribed for 98 patients in a proprietary nursing home. The principal findings were that PRN orders can indeed be inappropriate and indiscriminately followed, and that the multiplicity of drugs often prescribed can lead to drug incompatibilities and to additional illness of the patient. Concern is expressed about the medication review process currently in vogue in nursing homes.

Aged↗
PubMed2000

An investigation into the use of stepwise isothermal high sensitivity DSC as a means of detecting drug-excipient incompatibility.

The use of stepwise isothermal high sensitivity differential scanning calorimetry (HSDSC) as a novel means of detecting excipient incompatibility is described using aspirin mixes with magnesium stearate and stearic acid as model systems. Aspirin, magnesium stearate and stearic acid alone and as mixes were studied in scanning mode using conventional DSC and were then subjected to a stepwise heating programme using HSDSC, whereby the samples were heated to temperatures between 45 and 70 degrees C and held for 1 h, during which the heat flow to or from the sample was measured. The data indicated that while no thermal events were detected for the individual components or mixes with stearic acid other than melting of stearic acid, 50% w/w mixes of magnesium stearate showed a marked endothermic response at temperatures above 55 degrees C. The data were fitted to an adaptation of an existing kinetic model for the degradation process and a reasonable correlation found. Mixes of the drug with the two excipients were then studied at 60 degrees C over 6 h at concentrations between 1 and 50% w/w. Incompatibilities with magnesium stearate concentrations as low as 1% w/w could be detected using this approach. Compacts of magnesium stearate and aspirin were also studied, with considerably more pronounced thermal events taking place compared to the powder mixes. It is concluded from these studies that while the study has highlighted certain limitations of the approach, stepwise isothermal DSC represents a potentially highly useful means of detecting excipient incompatibilities.

Aspirin↗
PubMed1983

Adverse drug interactions of importance in veterinary practice.

Multiple drug therapy is often used in veterinary practice; occasionally, inappropriate combinations of drugs may be administered which interact to produce adverse responses. Such interactions may occur in vitro because of physically or chemically incompatible drugs having been mixed before administration or in vivo. A number of important in vitro incompatibilities concerning parenteral drugs are tabulated, consideration having been given both to problems attending the use of intravenous fluids as vehicles for their administration and to incompatibilities between the drugs themselves. Interactions which occur in vivo are also examined; these have been grouped according to the various mechanisms by which they occur.

Absorption↗
PubMed1985

Therapeutic effects of drug-nutrient interactions in the elderly.

The elderly are the major drug users both because they need specific prescription drugs for control of chronic diseases and because they make excessive use of over-the-counter (OTC) drugs. Therapeutic drugs that are required may be discontinued because the individuals suffer side effects or because the drug is ineffective. Adverse drug reactions in the elderly may result from drug overuse or misuse, slowed drug metabolism or elimination secondary to aging or to age-related chronic disease, intake of alcohol, food-drug incompatibilities, or nutrient-drug interactions. The timing of drug intake in relation to food intake is an important determinant of therapeutic efficacy in the elderly. Food-drug interactions in the gastrointestinal tract may reduce drug absorption. Enteral formula feeding may also interfere with drug absorption. Conversely, absorption of certain drugs (e.g., thiazides) may be promoted by meal-induced slowing of gastric emptying time. Therapeutic diet prescription can influence drug responses in the elderly because the protein composition of the diet influences the rate of drug metabolism. Nutrient depletion secondary to the effect of drugs may be recognized as an important and often avoidable type of adverse drug reaction.

Aged↗
PubMed1974

Problems of administering drugs by continuous infusion.

A study of how often drugs were administered by continuous intravenous infusion to patients occupying 110 surgical and 50 medical beds showed that an average of 48 drug additions were made to intravenous fluids each week: 15% of these were of more than one drug and 15% were of drugs incompatible either with each other or with the infusion fluid. As a result of the survey an educational programme was developed to bring these problems to the attention of the staff concerned. After this programme a second survey showed only 18 additives had been given to patients occupying the same 160 beds and none of these were incompatible mixtures.

Ampicillin↗
PubMed2003

Incidence and severity of intravenous drug errors in a German hospital.

OBJECTIVE: To determine the incidence of errors in preparing and administering intravenous (i.v.) drugs, identify the stages in the process at which errors occurred and evaluate their clinical importance. METHODS: A prospective ethnographic study using disguised observation was carried out on two wards in one German non-university hospital. RESULTS: We observed 22 nurses administering 122 i.v. drug preparations and administrations. One or more errors occurred in the preparation and administration of 58 of 122 i.v. drug doses (error rate 48%, 95% confidence interval 39-57%). In total, 65 errors were identified. Of doses, 4 had potentially severe errors (3%), 38 (31%) potentially moderate errors and 16 (13%) potentially minor errors. Common errors included multiple step preparations and the co-administration of potentially incompatible drugs as intermittent infusions. CONCLUSION: A high incidence of i.v. drug errors was found in the study hospital. Effective strategies to reduce potentially harmful errors are urgently needed. Measures could include a reduction in the number of ward-based i.v. drug preparations, improvement of staff training and the introduction of ward-based clinical pharmacy services.

Drug Compounding↗
PubMed1984

The pharmacological studies in central nervous system on the interaction of Taiwanese Veratri Formosani Rhizoma and Sophorae Radix.

The eighteen opposing drugs were to be recognized as absolute incompatibility of Chinese herbs. Ku-Shen (Sophorae Radix) opposed Li-Lu (Veratri Rhizoma) is one of these incompatible drugs. In this study, we attempted to investigate and identify the interactions of these two drugs in the CNS by means of modern pharmacological technics. The results elucidate that toxicity, number of retching movements, change of locomotor activity and the concentration of monoamines' metabolites of Li-Lu can be changed by Ku-Shen. From these results, further evidence was provided that the involvement of Li-Lu and Ku-Shen in the eighteen opposing drugs of Chinese ancient Pentsao are deemed to be significant.

Animals↗