Effect of dimercaprol on oxygen toxicity in rats.
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The pharmacokinetics of 111 indium-labeled bleomycin were altered in the P-1798 tumor-bearing BALB/c mouse when pretreated with the dithiol 2,3-dimercapto-1-propanol (Bal). 1 mg of BAL administered 1 h prior to 20 microCi of 111In-bleomycin resulted in 2:1 tumor loading and 3:1 liver loading of 111In-bleomycin over controls (p less than or equal to 0.05 at the 2- to 3-hour interval). Muscle uptake during this interval remained at unity.
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