The influence of bis-dequalinium acetate on bone regeneration induced by grafts of combined inorganic heterologous bone and autologous marrow.
The present study was undertaken in order to determine the influence of BDA on bone regeneration and remodeling. Pieces of Kiel bone soaked with autologous bone marrow were implanted in the axial area of rats. The implantation sites were injected with 0.3 cc of 0.005% BDA 3 to 14 days after grafting; the control group was injected with Hartmann solution. Results indicated that BDA does not interfere with the bone-remodeling process. It does, however, have an inhibitory effect on the early stage of mesenchymal cell proliferation, that is, the development of osteoblasts from bone marrow stromal cells. Extrapolation of these findings to earlier evidence regarding the mode of action of this material is currently being investigated.
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