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PubMed1991

Human regional cerebral blood flow during rapid-eye-movement sleep.

Owing to the coupling between CBF and neuronal activity, regional CBF is a reflection of neural activity in different brain regions. In this study we measured regional CBF during polysomnographically well-defined rapid-eye-movement (REM) sleep by the use of single photon emission computerized tomography and the new tracer 99mTc-dl-hexamethylpropyleneamine. Eleven healthy volunteers aged between 22 and 27 years were studied. CBF was measured on separate nights during REM sleep and during EEG-verified wakefulness. On awakening from REM sleep, all subjects reported visual dreams. During REM sleep CBF increased by 4% (p less than 0.01) in the associative visual area, while it decreased by 9% (p less than 0.01) in the inferior frontal cortex. The CBF increase in the associative visual area suggests that activation of cerebral structures processing complex visual material is correlated to visual dream experiences. On the other hand, the reduced involvement of the inferior frontal cortex observed during REM sleep might explain the poor temporal organization and bizarreness often experienced in dreams.

Adult↗
PubMedDate not supplied

One possible function of sleep: to produce dreams.

Among the various functions of sleep, one is particularly significant for our mental life: that of producing dreams. This specifically human experience, which takes place only during sleep, is closely related with neurophysiological events. The coincidence between mental and biological events raises a complex epistemological question concerning the close relationship between dreams, viewed as a subjective experience and sleep, viewed as a vegetative experience which is possible to define from a behavioural, electrical, neurochemical and neurobiological viewpoint. In this presentation, the author criticizes Hobson and McCarley's internal generator theory, according to which the pons activates the limbic structures responsible for the recovery of memory in dreams, on account of physiological and psychological reasons. The author puts forward a cognitive hypothesis, which considers dreams as a symbolic process of elaborating, interpreting and reorganizing in narrative sequences all the material accumulated in the memory during waking hours. The author proposes, therefore, a psychoanalytical model of dreaming, in which dreams constitute a way of representing the individual's inner world with internal objects related with one another and with the Self.

Animals↗
PubMed1983

The use of dreams in couples therapy.

Spouses and family members communicate in complex, highly developed patterns which are largely out of awareness (Wynne 1961; Martin 1976; Cavenar 1979; Satir 1964). The therapist's grasp of these patterns of unconscious relatedness is essential to effective couples therapy or family therapy. This becomes a basis for interventions designed to help change those patterns destructive to a mutually satisfying relationship. A dream which one member of a couple presents in the setting of conjoint therapy is an important moment in which unconscious communication becomes manifest. Awareness and effectiveness can be enhanced when a therapist emphasizes the interpersonal dimension of the dream rather than treating it as a purely intrapsychic event. We examine meanings and uses of dreams shared in the context of couples psychotherapy, via literature review, clinical examples, and discussion. We suggest an approach which highlights interpersonal dimensions of dream-sharing and incorporates a concept of unconscious resonance.

Adult↗
PubMed1998

Erik Erikson's dream specimen paper. A classic revisited.

This paper offers an overview of Erik Erikson's contribution to psychoanalysis, contrasting the humanistic perspective from which he viewed psychoanalysis with the biological perspective adopted by Heinz Hartmann. The vehicle for this comparison and for the explication of Erikson's extension of the work of Freud and Hartmann is Erikson's analysis of Freud's Irma dream, as presented in his Dream Specimen paper. I hope to show that: (1) Erikson's analysis of Freud's Irma dream provides a masterful illustration of the richness and complexity of past and current life themes and conflicts that inform the dreamer's construction of the manifest surface of the dream. (2) Erikson's examination of the relationship between the manifest content of the dream and the current life context of the dreamer leads him to propose a connection between trauma and the origins of the dream. This view complements Freud's discovery of the instinctual motivation for dreaming and anticipates subsequent discoveries concerning the role of dreams and REM sleep in defensive ego functioning and adaptation. (3) The Dream Specimen paper presents readers with a humanistic ego psychology that rests upon--but is subtly different from--the work of Hartmann and the other biologically oriented analysts of his day. In this sense, Erikson's paper is an elegant "specimen" of ego psychology carried to its most creative heights.

Dreams↗
PubMed2001

The dream's navel between chaos and thought.

The authors begin by drawing attention to the problem of the transition from the biological to the psychic, noting that Freud himself, with his background in the neurosciences, grappled with it throughout his career. Certain recent paradigms more commonly applied to the natural sciences, such as in particular chaos and complexity theory, can in their view prove fruitful in psychoanalysis too, and it is shown how these notions are inherent in some of Freud's conceptions. The unconscious is stated to operate like a neural network, performing the kind of parallel processing used in the computing of highly complex situations, whereas the conscious mind is sequential. Dreams, in the authors' opinion, are organisers of the mind, imparting order to the turbulence of the underlying wishes and unconscious fantasies and structuring them through the dream work. Through dreams, the structured linearity of conscious thought can emerge out of the non-linear chaos of the drives. The dream's navel can be seen as the chaotic link, or interface, between the unconscious wish, which constitutes an attractor, and the conscious thought. The attractor may be visualised as having an hourglass or clepsydra shape, the narrow section being the dream's navel, and, being the same at any scale of observation, has the property of fractality.

Dreams↗
PubMed2000

Dreaming and REM sleep are controlled by different brain mechanisms.

The paradigmatic assumption that REM sleep is the physiological equivalent of dreaming is in need of fundamental revision. A mounting body of evidence suggests that dreaming and REM sleep are dissociable states, and that dreaming is controlled by forebrain mechanisms. Recent neuropsychological, radiological, and pharmacological findings suggest that the cholinergic brain stem mechanisms that control the REM state can only generate the psychological phenomena of dreaming through the mediation of a second, probably dopaminergic, forebrain mechanism. The latter mechanism (and thus dreaming itself) can also be activated by a variety of nonREM triggers. Dreaming can be manipulated by dopamine agonists and antagonists with no concomitant change in REM frequency, duration, and density. Dreaming can also be induced by focal forebrain stimulation and by complex partial (forebrain) seizures during nonREM sleep, when the involvement of brainstem REM mechanisms is precluded. Likewise, dreaming is obliterated by focal lesions along a specific (probably dopaminergic) forebrain pathway, and these lesions do not have any appreciable effects on REM frequency, duration, and density. These findings suggest that the forebrain mechanism in question is the final common path to dreaming and that the brainstem oscillator that controls the REM state is just one of the many arousal triggers that can activate this forebrain mechanism. The "REM-on" mechanism (like its various NREM equivalents) therefore stands outside the dream process itself, which is mediated by an independent, forebrain "dream-on" mechanism.

Acetylcholine↗
PubMed2004

[Mechanism and function of dreams].

Man has been fascinated by his dreams for ages. The discovery of rapid eye movement (REM) sleep revived the interest in dream research. The objective study of dream content allowed the characterization of the main features of human dreams: its perceptual content, its pervasive emotional background, its oddity. The particular pattern of cerebral activity observed during REM by functional neuroimaging seems to match these features. Firstly, the perceptual aspects of dreams would be related to the activation of posterior (occipital and temporal) cortices. Accordingly, patients with occipito-temporal lesions may report a cessation of visual dreams imagery. Secondly, emotional features in dreams would be related to the activation of amygdalar complexes, orbito-frontal cortex and anterior cingulate cortex. Thirdly, the activation of mesio-temporal areas would account for the memory content commonly found in dreams. Fourthly, the relative hypoactivation of the prefrontal cortex would explain the alteration in logical reasoning, working memory, episodic memory and executive functions that manifest themselves in dream reports from REM sleep awakenings. Despite these recent results, the precise neural correlates of dreaming remain elusive. Likewise, the functions of dreams are unknown, although usually related to the functions of sleep itself.

Brain Injuries↗
PubMed1996

In the last analysis: archetypal themes in the analysis of an elderly patient with early disintegrative trauma.

Aspects of the analysis of an elderly patient with early disintegrative experiences are described: separation anxiety, an internalized attack upon vitality, and the fear of dependency were prominent features of the transference/countertransference relationship, while the search for meaning as death drew nearer continued to be the central theme. The patient's many dreams reveal a wealth of images whose complex interlinkings provided evidence of a heightened and energized individuation process aiming at the integrity of personality.

Aged↗
PubMed1994

Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia.

Fatal familial insomnia (FFI) is a disease characterized by loss of sleep activity due to selective thalamic degeneration. To assess the secretory pattern of melatonin (MT) in FFI, we studied two cases of overt disease under standardized conditions and polysomnographic control. Each patient underwent repeated 24-h study sessions, and MT was assayed at 30-min intervals. Six healthy volunteers were used as controls. Slow wave sleep was never recorded, whereas occasional episodes of enacted dreaming accompanied by rapid ocular movements and complex muscular activities were documented, with no detectable rhythm. Plasma MT concentrations gradually decreased as the disease progressed. A significant circadian rhythm was detected in the earlier recordings, with decreasing amplitudes with disease progression. Complete rhythm obliteration was achieved in the most advanced stage. Normally placed nocturnal acrophases were detected in the earlier stages, but then a shift toward the daytime hours was observed. Thalamic lesions of FFI appear to determine a progressive disruption of the sleep/wake cycle accompanied by decreased circulating levels of MT, with progressive alterations in the circadian rhythm of this hormone. On the other hand, decreased secretion of MT may contribute to the sleep disturbances of FFI.

Adult↗
PubMed1990

[Artificial blood in 1990: from a lifelong dream to today's reality].

Human blood is a very complex tissue. Therefore the idea of rediscovery its different cellular and plasmatic constituents would seem to be utopic. To be efficient the oxygen carrier, be it natural or by synthesis, must be stripped of antigenicity, be easily stockable and transportable. Thus these properties permit its use in urgent circumstances (accidents, natural disasters, war...), in those countries where there is a non existent or limited transfusional structure. This, under certain conditions, during very specific pathologies (localised ischemia for example). Among several hypotheses, they are two main lines of research that of "hemoglobin solutions" the oldest and the most physiological. This will be developed here in more lengthy terms due to our personal work on the subject. The second line of research concerns fluorocarbons, the most modern and artificial and without doubt better known to doctors and the public. 1. HEMOGLOBIN SOLUTIONS. Other than nephrotoxicity, which has proved affordable, research han revealed four large limitations with hemoglobin solutions (a high affinity for oxygen due to absence or loss of 2.3 DPG, a short half life due to vascular loss, rapid dimerisation and elimination of urine, insufficient concentration of prepared solutions (70 g/L) with as a result a weak oncotic pressure and oxygen supply, oxidation in methemoglobin). In order to overcome the two inconveniences, proposals were made to modify hemoglobin chemically, the idea coming from the putting into operation of potential analogues to or substitutes for 2.3 DPG which it is advisable to bring or to keep--by covalent bonding--near to the fixation site of the natural ligand. Thus our group has already deposed several patents and is now working on a complex hemoglobin-dextran benzine tetracarboxylate which appears promising. Today, due to the quality and reproduction of the results obtained on animals with chemically modified hemoglobin preparations clinical assays should be carried out soon. 2. FLUOROCARBONS. In this very different approach which uses totally synthetic compounds oxygen carrying can only be realised in dissolved form. Due to this fluorocarbons, even though they are remarkable solvents of gas, do not reach their full efficiency unless the patient breathes in a very rich oxygen atmosphere. This is therefore a considerable limiting factor. The other big problem is the insolubility of these compounds and therefore the need to emulsify them, but unfortunately these emulsions are difficult, if not impossible to stabilise.(ABSTRACT TRUNCATED AT 400 WORDS)

Blood Substitutes↗
PubMed2026

DREAMS illuminates spatial DNA and RNA modification landscapes.

DNA and RNA modifications regulate gene expression and RNA processing, but their spatial organization in complex tissues remains elusive. Here we developed DNA RNA Elements Areal Mass Spectrometry (DREAMS), a mass spectrometry imaging platform that spatially maps diverse nucleic acid modifications simultaneously. Applying DREAMS to TET-deficient mouse brains (Tet1Δ/Δ and triple Tet1/2/3Δ/Δ), we uncover TET1's unexpected role in modulating N1-methyladenosine (m1A), a pivotal RNA modification. While DREAMS reveals broad modification landscapes altered across TET knockouts, we identify TET1-mediated changes in m1A that correlate with transcriptome alterations. Our work establishes DREAMS as a transformative tool for spatial epigenomics/epitranscriptomics and suggests that TET enzymes could influence multiple DNA and RNA modifications with potential gatekeeping roles in nucleic acid regulation.

Animals↗
PubMed2001

Determining the structure of biological macromolecules by transmission electron microscopy, single particle analysis and 3D reconstruction.

Single particle analysis and 3D reconstruction of molecules imaged by transmission electron microscopy have provided a wealth of medium to low resolution structures of biological molecules and macromolecular complexes, such as the ribosome, viruses, molecular chaperones and photosystem II. In this review, the principles of these techniques are introduced in a non-mathematical way, and single particle analysis is compared to other methods used for structural studies. In particular, the recent X-ray structures of the ribosome and of ribosomal subunits allow a critical comparison of single particle analysis and X-ray crystallography. This has emphasised the rapidity with which single particle analysis can produce medium resolution structures of complexes that are difficult to crystallise. Once crystals are available, X-ray crystallography can produce structures at a much higher resolution. The great similarities now seen between the structures obtained by the two techniques reinforce confidence in the use of single particle analysis and 3D reconstruction, and show that for electron cryo-microscopy structure distortion during sample preparation and imaging has not been a significant problem. The ability to analyse conformational flexibility and the ease with which time-resolved studies can be performed are significant advantages for single particle analysis. Future improvements in single particle analysis and electron microscopy should increase the attainable resolution. Combining single particle analysis of macromolecular complexes and electron tomography of subcellular structures with high-resolution X-ray structures may enable us to realise the ultimate dream of structural biology-a complete description of the macromolecular complexes of the cell in their different functional states.

Bacteria↗
PubMed2007

Gene expression profiling in pulmonary hypertension.

The application of functional genomics toward the investigation of complex medical conditions has moved from a futuristic dream to a medical reality in less then a decade. The ability to examine the expression level of thousands of genes simultaneously has opened the door for entirely new approaches toward experimental observation and discovery. The resulting data from these genomic studies is being collected at an unprecedented scale. This wealth of data can present its own obstacles in terms of analysis. However, as new and more powerful means of examining these experiments are developed, medical science is reaping significant benefit. The power of microarray gene expression analysis has been directed at a diverse and complex array of diseases. As will be discussed in this article, the investigation of pulmonary hypertension has already benefited greatly from the application of this technology.

Animals↗
PubMed1990

On acting out.

The author sets out to compare her own ideas on the archaic matrix of the Oedipus complex, as opposed to the fully developed Oedipus complex, with Glover's conception of the different developmental stages of the mental apparatus in which historical priority is given to what he calls 'psychosomatic reactions' over later psychoneurotic symptoms. These former result in pure discharge, whereas the latter are characterized by meaningfulness. She also briefly tries to connect some of her views with those of Melanie Klein and Bion.

Acting Out↗
PubMed1988

A woman's attempt at a perverse solution and its failure.

The Programme Committee of the Montreal Congress asked the author to present a case of perversion connected with traumas. Rather than speak about erotization of the effects of the trauma (death or castration anxiety transformed into a source of pleasure) the author relates the first 18 months of analysis of a young woman whose important narcissistic trauma, the result of an inadequate early relationship with her mother, is camouflaged by an avidity for sexual excitations. The aim is to transform narcissistic pain which cannot be worked through into sexuality for which release is possible. Sexuality becomes a means of expressing feelings of hate, revenge and triumph over the primary object. The ensuing perverse solution--an attempt to slip into the primal scene by identification with the sadistic penis--does not succeed. The author advances certain hypotheses concerning the mother-daughter relationship which seem to explain this failure and to explain too the absence of a stable perverse organization in women. There follows a longing to return to the womb, in the shape of the fantasied destruction of the contents of the mother's belly, expressed as the fantasy of the end of the world, and which the author labels as 'the archaic matrix of the Oedipus complex'.

Borderline Personality Disorder↗
PubMed2002

Mental activity during sleep.

Since remote antiquity humankind has believed in the supernatural origin of dreaming. The scientific approach to mental activity during sleep dates back to the eighteenth century. One hundred years ago, psychoanalysis introduced dream analysis for diagnostic and therapeutic purposes. Only 50 years ago psychophysiology made it possible to collect mental sleep activity by means of experimental awakenings while monitoring physiological variables; this approach encouraged investigation into the relationship between the features of sleep activity and sleep state (REM versus NREM). Advances in neurophysiology, in neurochemistry, and recently in brain imaging techniques, have shed light on the roles played by the different cerebral structures in determining specific characteristics of mental activity during sleep. The development of cognitive psychology has enabled investigation of dream generation in terms of output from a complex multilevel system of information processing. In addition to sleep state, other factors, such as the time of the night and the sequence of the NREM-REM cycles, have been shown to influence the characteristics of mental activity. The usefulness of investigation of mental sleep activity as a clinical tool is controversial. The psychophysiological approach to mental sleep activity in clinical contexts has enabled the exploration of adaptation processes and contributed to neuropsychological studies on focal and systemic brain pathology.

Brain↗
PubMed2002

Dream recall frequency in epilepsy patients with partial and generalized seizures: a dream diary study.

PURPOSE: The frequency of dream recall (DR) in patients with brain diseases has proved to be indicative of the relation between sleep disturbances and the functioning of cognitive processes during sleep. In this study we attempted to ascertain whether DR frequency in patients with complex partial seizures (CPSs) is higher than that in those with generalized seizures. METHODS: DR frequency was assessed by means of a 60-day dream diary in patients with CPSs, whose epileptic focus was in the right (n = 12) or left temporal lobe (n = 28), and with idiopathic generalized seizures (n = 21). The patients enrolled in the study were not impaired in global cognitive and memory functioning. RESULTS: The ability to recall dreams was established in nearly all patients with either CPSs or generalized seizures. DR frequency resulted significantly higher (about twice) in patients with CPSs, regardless of (a) the side of the epileptic focus, (b) the presence of a cerebral lesion detectable on a computed tomography (CT) scan, or (c) the occurrence of seizures in the previous day. CONCLUSIONS: These findings indicate that overall, DR occurs in medicated epilepsy patients with CPSs more frequently than reported in previous studies. The high DR frequency observed in these patients, regardless of the side of the epileptic focus, is in agreement with the assumption that tempoparietal areas of both hemispheres are involved in the production and recall of the dream experience.

Adult↗