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PubMedDate not supplied

[Neonatal dermatoses of relevant medical significance: their report in the newborn's file]

OBJECTIVE: To check the report of neonatal dermatoses of medical relevance (congenital melanocytic nevus, sebaceous nevus, cafe-au-lait spots, Port-wine stain, ash leaf maculas) in the newborn's file. METHODS: The authors carried out a cross-sectional study in two hospitals in the city of Belo Horizonte. All children born during a consecutive period of 4 months were examined within their 36 first hours of life by a dermatologist who reported all clinically relevant dermatoses (congenital melanocytic nevus, sebaceous nevus, cafeau- lait spots, Port-wine stain, ash leaf macules). Simultaneously, the dermatologist's report was cross checked with the pediatrician's. RESULTS: Neonatal dermatoses of clinical relevance were found in 42 (5.6%) out of 752 children examined during this period. However, the report in the neonate's file could be detected only in 5 (11,9%) out of 42 children. CONCLUSIONS: Clinically relevant dermatoses were underreported in the neonate's file in this study. There is a clear need to stimulate the detection and report of these skin disorders so that parental advice, treatment and genetic counseling can be adequately indicated.

Journal Article↗
PubMed1995

Dermatoses determined in a population of farmers in a questionnaire-based clinical study including methodology validation.

OBJECTIVES: The study analyzed skin diseases in a population sample of Finnish farmers descriptively and in the process validated the question "Do you have a skin disease now?" METHODS: All farmers from one Finnish municipality were surveyed for dermatoses, first with a questionnaire and then with a clinical examination of those who reported dermatoses. Another population of farmers answered a set of questions immediately before a clinical examination, and the self-report of current dermatosis was validated. RESULTS: Eczema was diagnosed for 66% of the women and 53% of the men who had reported dermatosis in the questionnaire study 6 to 12 months earlier. Toe-web maceration, psoriasis, folliculitis, and acne were, after eczema, the most frequent diagnoses (in that order). In more than 50% of the cases, the location of clinically determined dermatoses corresponded with the skin disease areas reported 6 to 12 months earlier. In the validation study, everyone who reported a skin disease immediately before the clinical examination were found to have a skin disease. In addition 22% of those not reporting dermatosis were found to have a skin disease. Toe-web maceration was the most common dermatosis not reported by the farmers. CONCLUSIONS: Finnish farmers suffered from the same type of dermatoses as other populations. The prevalence of eczema and hand eczema was similar to that of other risk populations. A self-report of current dermatosis is probably a good indicator of the point prevalence of explicit skin diseases in populations.

Adolescent↗
PubMed1999

Acquired blaschkolinear dermatoses.

Congenital and/or nevoid skin disorders following the lines of Blaschko may have a delayed onset after birth. They have to be differentiated from acquired dermatoses exhibiting the same linear pattern. In common dermatoses, such as psoriasis or lichen planus, lesions in a blaschkolinear distribution most often occur together with scattered lesions, but occasionally they may be isolated. Less common self-limited dermatoses such as lichen striatus and adult blaschkitis always present in a blaschkolinear fashion. In these diseases, or some other conditions occasionally distributed along these lines (chronic graft versus host reaction, fixed drug eruption, lupus erythematosus, atopic dermatitis, etc.), the cause of the disease may lead to the unmasking of tolerance to an abnormal keratinocyte clone that remained hidden in these lines. In addition to epithelial cells, other cells may be involved in the occurrence of acquired blaschkolinear dermatoses. In linear atrophoderma and linear fibromatosis, the histogenesis seems to involve hypothetic dermal clones. The extension of an acquired dermatosis on a preexisting linear nevoid disorder is an argument in favor of an early embryonic somatic mutation of a skin cell line.

Adult↗
PubMed1999

Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses.

Azathioprine is employed for its immunosuppressive properties, as a steroid-sparing agent or as monotherapy. Its most traditional clinical indications are connective tissue diseases, vasculitis, post-transplant, and immunobullous dermatoses. The main disadvantages of azathioprine therapy are a delayed onset of action (6-8 weeks), and rare profound bone marrow toxicity. Susceptibility to bone marrow toxicity is due to a genetically determined metabolic defect (1 in 300). Patients at risk of such toxicity may be identified by a Thiopurine methyltransferase enzyme assay. We have undertaken a retrospective study, looking at the use of azathioprine as monotherapy for non-bullous inflammatory dermatoses. We studied a total of 24 patients (10 male, 14 female). The dermatoses comprised: atopic eczema (10), pompholyx (6), plaque psoriasis (6), and chronic actinic dermatitis (2). All patients had severe refractory disease warranting systemic second line therapy. The mean age was 49.4 years (range 17-86 years). The starting dose of azathioprine was 100-150 mg/day, and the maintenance dose 50-100 mg/day. The mean duration of treatment was 33.5 months(range 1-132 months). Eighteen patients (75%) showed a good to excellent sustained clinical response to azathioprine. This response rate was evenly represented in the 4 dermatoses studied. The adverse reactions encountered were raised MCV (6), leucopenia (2), raised hepatic enzymes (6), and dyspepsia (4). Azathioprine had to be discontinued due to adverse reactions in 2 patients (dyspepsia, raised hepatic enzymes) followed by normalization. Other factors that potentially contributed to the observed adverse events were present in 5 patients: alcoholism (2), erythromycin toxicity (1), and malabsorption (2). Our study demonstrates the efficacy of azathioprine monotherapy for severe atopic eczema, pompholyx, plaque psoriasis, and chronic actinic dermatitis. Furthermore, azathioprine is a low cost and generally well tolerated drug.

Adolescent↗
PubMed2002

[Paraneoplastic dermatoses].

Paraneoplastic dermatoses are important cutaneous markers of internal malignancies. They form a heterogenous group of skin diseases, where tumor induced immunologic factors, hormones, metabolic disorders and epidermal growth factor may play a role in the onset of the symptoms. The paraneoplastic skin disorder frequently refers to the type, localization and prognosis of the underlying tumor. The course of the tumor and that of the skin disease is generally parallel, which means that the cutaneous symptoms disappear when the tumor is treated and reappear in case of recurrence or metastasis. Seven rare obligate paraneoplastic dermatoses are known, where the skin marker is associated with neoplasia in almost 100% of the cases. The facultative paraneoplastic dermatoses are more common skin disorders, with a wider spectrum, and they are only associated with tumors in 3-30% of the cases. Authors present an overview of the clinical characteristics, etiopathogenesis and the underlying tumor of the most important paraneoplastic dermatoses.

Humans↗
PubMed2004

Pattern of pediatric dermatoses in a referral center in South India.

This study was undertaken to determine the pattern of dermatoses in children in south India. All children <14 years presenting to us between May 2001 and June 2002 were recruited. A total of 2100 children (males -995; females- 1105) with 2144 dermatoses were recorded. Infections and infestations were the most common dermatoses (54.5%) followed by dermatitis and eczema (8.6%), pigmentary disorders (5.7%), insect bite reaction (5.27%), hair and nail disorders (5.2%), miliaria (4.1%), nutritional deficiency disorders (2.8%), urticaria (2.5%), genetic disorders (2.1%), psoriasis (1.4%), collagen vascular disorders (0.5%), hemangiomas (0.5%), drug eruptions (0.3%), pityriasis rosea (0.2%) and others (5.8%). Pyodermas were the most common dermatoses (47.13%) followed by scabies (30.6%) amongst infections and infestations. Atopic dermatitis was noticed only in 3 patients. Insect bite reactions (papular urticaria) (5.27%) and miliaria (4.1%) were attributed to the tropical weather conditions in this coastal area. Genetic disorders including ichthyosis and palmoplantar keratoderma contributed to 2.1% of cases and could be due to the high incidence of consanguinous marriages in this society.

Adolescent↗
PubMed2006

[Specific dermatoses of pregnancy].

Dermatoses related to pregnancy or the postpartum period are known as the specific dermatoses of pregnancy. These dermatoses include (a) pemphigoid gestationis (synonym: herpes gestationis), (b) polymorphic eruption of pregnancy (synonym: pruritic urticarial papules and plaques of pregnancy; PUPPP), (c) prurigo of pregnancy and (d) pruritic folliculitis of pregnancy. Of these disorders, only pemphigoid gestationis has a known cause: an allogeneic immune reaction of the mother to the placental basal membrane. Itching or an itchy skin eruption is often the main symptom ofa dermatosis of pregnancy. During the diagnostic process, the possibility of a pre-existing or de novo skin disorder unrelated to the pregnancy should be considered. Correct diagnosis is important for the choice of treatment and for the prognosis of mother and child, because some dermatoses of pregnancy, such as pemphigoid gestationis, constitute a health risk.

Diagnosis, Differential↗
PubMed1989

[Clinico-immunologic characteristics and prevention of occupational allergic dermatoses due to molybdenum exposure].

Occupational diseases of the skin have been detected in 19.6% of 352 workers engaged in molybdenum production. These diseases are characterized by a relatively low incidence on the dermatitis transformation into eczema and a considerable length of this process, by weak skin reactions to molybdenum tests (with 20% aqueous solution of ammonium paramolybdate), by the predominance of skin itching in the clinical picture, by a secondary pyococcic infection, and by frequent combination of eczema with allergic involvement of the ENT organs. Experimental and clinical immunologic studies have revealed that mostly humoral immune mechanisms with a relatively weak involvement of the T-lymphocytes contribute to the pathogenesis of the dermatoses due to molybdenum exposure; this fact is responsible for poor clinical manifestation of the delayed type hypersensitivity reactions and at the same time a manifest IgE-dependent pattern of allergic reactions. A clear-cut correlation between the frequency of the dermatoses and molybdenum level in environmental dust was detected, as were a considerable molybdenum contamination of the skin and the fact that hot and humid microclimate are conducive to the development of dermatoses. Basing on the results of these studies, the authors have developed recommendations on the diagnosis and prevention of molybdenum-induced dermatoses.

Animals↗
PubMed1995

[Paraneoplastic dermatoses].

Paraneoplastic dermatoses or cutaneous paraneoplastic syndromes are a non neoplastic skin condition closely related to and in their manifestation directly influenced by an underlying malignancy. They are subdivided into two groups: one whose clinical picture reveals the presence of a malignant tumor and an association with a malign internal tumor in nearly 100%, and a second in which the possibility of a malignancy exists. Not included under the heading paraneoplastic dermatoses are changes with neoplastic cells appearing in the skin, tumors involving secondary illnesses, and genetically caused dermatologic syndromes accompanied by internal malignancies. Although the pathogenesis of the paraneoplastic dermatoses is very unclear, knowledge of these conditions is necessary, since it may in rare instances lead to an early diagnosis of a malignant tumor. On the other hand, only treatment of the underlying disease can improve the dermatoses.

Diagnosis, Differential↗
PubMed1996

Distribution and appearance of elastic fibers in the dermis of clinically normal dogs and dogs with solar dermatitis and other dermatoses.

OBJECTIVE: To determine the distribution and amount of elastic fibers in the dermis of clinically normal dogs and dogs with dermatoses, particularly solar dermatitis. DESIGN: Skin specimens from 7 anatomic sites were obtained from 19 clinically normal dogs after euthanasia to evaluate the normal distribution of elastic fibers. Biopsy specimens also were obtained from 34 dogs with dermatoses, including 16 with solar dermatitis. Tissue sections were stained with H&E, Verhoeff-van Gieson, and periodic acid-Schiff. ANIMALS: 19 clinically normal dogs and 34 dogs with dermatoses. PROCEDURE: Numbers of elastic fibers were graded subjectively. Comparisons between clinically normal dogs and dogs with dermatoses were made. RESULTS: Normal elastic fibers were present in low numbers in the dermis of adult dogs, regardless of anatomic site or presence or severity of dermatitis. Condensed elastotic material was visualized in only 2 dogs with solar dermatitis. In both dogs, the elastotic material was Verhoeff-van Gieson and periodic acid-Schiff stain positive but was not visible with H&E stain. The most frequent histopathologic finding in the dermis of dogs with solar dermatitis was superficial dermal fibrosis. CONCLUSIONS: The dermis of clinically normal dogs does not contain abundant elastic fibers. Alterations of elastic fibers in dogs with solar dermatitis are rare. Superficial dermal fibrosis may be a better indicator of solar damage.

Animals↗
PubMed1997

[Vulvar dermatoses].

Vulvar dermatoses are the localizations to the vulva of a great variety of dermatoses. In genodermatoses, the expression of diseases on the vulva is a part of a complex syndrome. It is non indispensable for the diagnosis. In the immuno-allergic dermatoses or in dermatoses where the pathogenesis is not clearly understood, the vulvar disease is very important because the vulva is often the exclusive localization. The vulvar disease can be the first manifestation before the other expressions of the mucocutaneous disease. Sometimes, there is a risk of scars or transformation in epithelioma. So the diagnosis must be soon established. At least, hidradenitis suppurativa is disease where the choice of the must appropriate treatment is difficult.

Female↗
PubMed1995

Facial, pedal, and other regional dermatoses.

This article discusses disorders of the head and face, including feline acne, solar dermatoses, pruritus of the head and neck, and nodular or ulcerative dermatoses of the head. Disorders of the pinna, otitis externa, and nasal diseases are highlighted. In addition, a discussion of pododermatitis and diseases of the claws and ungual fold is presented. Miscellaneous regional dermatoses include midline ulcerative dermatitis, stud tail, and vaccine-induced lesions.

Animals↗
PubMedDate not supplied

Dermatoses among paddy field workers--a descriptive, cross-sectional pilot study.

BACKGROUND: Paddy farming is one of the main occupations in coastal South India. Dermatological problems in paddy field workers have not received much attention. AIM: The purpose of this study was to study the dermatoses of the exposed parts of the body, viz. face, hands, and feet, in paddy field workers. METHODS: Three hundred and forty-one workers were questioned and clinical findings noted. Scrapings for bacterial and fungal examination were taken by random selection. RESULTS: Seventy-three per cent had work-related itching. Melasma was the commonest facial lesion (41.1%). The main problems on the hands were hyperkeratosis (26.4%), nail dystrophy (15.2%) and paronychia (8.8%). Common feet dermatoses included nail dystrophy (57.1%), pitted keratolysis (42.5%) and fissuring (23.5%). Common aerobic and anaerobic bacteria isolated from pitted keratolysis and intertrigo were Klebsiella and Clostridium species. Aspergillus species were the commonest fungus grown from intertrigo. CONCLUSIONS: Occupational dermatoses are common in paddy field workers.

Adolescent↗
PubMed1989

Dermatoses among poultry slaughterhouse workers.

A survey on the incidence of occupational dermatoses among poultry slaughterhouse workers, who, in order to do their work more efficiently, protected their hands only with cotton gloves, revealed that many workers had dermatoses of the hands. Their symptoms included maceration, erosio interdigitalis, paronychia, trichophytia unguium, and eczema, presumably caused by the constant wetness of their hands during work. Candida albicans was detected in the ungual lesions of some patients. A second survey including a skin examination was performed at a plant where preventive measures such as better working gloves and improved sanitary conditions had been implemented because of the high incidence of skin disorders. The results of this survey showed marked improvement in the reduction of the incidence of dermatoses.

Abattoirs↗
PubMed1990

Regional dermatoses in the African race. Papular lesions on the face.

Many diseases are peculiar to the black race and most practicing physicians in Africa have limited access to histopathologists, therefore, diagnosis is largely clinical. A retrospective study of 10,000 consecutive patients seen at the skin clinic of the Lagos University Teaching Hospital, Nigeria, was conducted with the objective of identifying the notable dermatoses affecting various parts of the body. The face and the shins were observed to have a very broad spectrum of dermatoses. Useful clinical descriptions of these dermatoses are highlighted in a three part paper to help practicing physicians.

Adult↗
PubMed1984

Hand dermatoses and sick-leave: relationship between educational level, physical activity at work and housework as main occupation.

In parallel with a coronary risk factor survey in northern Norway, 14,667 men and women answered questions concerning health, life style, and social background. The occurrence of hand dermatoses varied only slightly within groups with different educational level and groups with different physical activity at work. Women with housework as their main occupation had a somewhat higher frequency of hand dermatoses than employed women. Sick leave due to hand dermatoses was 4-5 times more frequent in both sexes in less educated compared to highly educated individuals, and more frequent in men and women with physically active jobs. These differences may partly reflect differences in the over-all frequency of sick leave.

Absenteeism↗
PubMed1997

Occupational dermatoses in cheese makers: frequent association of irritant, allergic and protein contact dermatitis.

BACKGROUND: Few data are available on occupational dermatoses in cheese makers. OBJECTIVE: The purpose of the present study was to investigate occupationally related skin diseases in cheese makers. METHOD: In a retrospective study we analyzed 400 patients with occupational dermatoses which presented for expert opinion evaluation at our institution (1990-1995). RESULTS: Four patients with hand eczema acquired in cheese dairies were identified. All patients had a decreased alkali resistance. Atopy was a further risk factor in 2 patients. Three out of 4 patients were patch test positive for occupationally related substances and demonstrated also immediate skin test reactions to various milk products. Therefore, these patients had concurrent allergic contact and protein contact dermatitis. CONCLUSION: The diagnosis of concurrent allergic and protein contact dermatitis has to be considered in occupational dermatoses related to cheese making.

Adolescent↗
PubMed1992

Dermatoses--an occupational hazard in the canning industry.

Despite the recognition that occupational dermatitis is extremely common, few data exist on the prevalence of skin disorders in South African industry. A cross-sectional prevalence study among 686 female workers in a canning factory in the western Cape showed high rates of dermatoses--in particular, chronic paronychia, intertrigo and dermatitis of the hands. A statistically significant association was found between exposure to 'wet work' in the industry and the prevalence of chronic paronychia and intertrigo. Age was also found to be associated with these dermatoses, irrespective of duration of service. The prevalence of dermatitis of the hands was increased among high-exposure workers, but not significantly. Dermatoses are an important occupational hazard in the canning industry, and there is a need for improved preventive measures.

Adolescent↗