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At least 73 records · Page 4Linked to original sources
PubMed1990

An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure--a multicentre general practice study.

A total of 71 patients with cardiac failure requiring diuretic treatment were randomly allocated to receive either 20 mg frusemide/2.5 mg amiloride or 0.25 mg cyclopenthiazide/8.1 mmol sustained release potassium once daily for 12 weeks. Of the 35 patients treated with cyclopenthiazide/potassium, in 47% of patients the daily dose was doubled compared with in only 30% of the 36 patients treated with frusemide/amiloride. Both treatments significantly improved crepitations, oedema, orthopnoea and patient self-assessments of dyspnoea on effort; there were no significant differences between the two treatments. Plasma potassium concentrations were unaffected by either treatment and there were no clinically significant changes in laboratory data. Of the five patients receiving frusemide/amiloride and of the eight receiving cyclopenthiazide/potassium who withdrew from the trial, three and four, respectively, were due to possible drug-related effects. It is concluded that frusemide/amiloride is efficacious and acceptable for the treatment of congestive heart failure.

Aged↗
PubMed1987

[The stability of hydrochlorothiazide and cyclopenthiazide in various dosage forms. 4. Stability of hydrochlorothiazide injection solutions II].

The hydrolytic decomposition of hydrochlorothiazide (1) in an optimized dispensing with polyethyleneglycol 400/ethanol as solvent led to an equilibrium in the isothermic short-term test as well as in the long-term stability test. Corresponding equilibrium concentrations were obtained for forward and back reaction. When comparing the precalculated equilibrium values with the long-term results the evaluation after Van't Hoff proved superior compared with an evaluation after the Arrhenius plot which is only applicable when the equilibrium concentrations are taken into consideration. By adding the decomposition product aminodisulfamide (2) the hydrolysis of 1 can be inhibited completely.

Cyclopenthiazide↗
PubMed1986

[The stability of hydrochlorothiazide and cyclopenthiazide in various dosage forms. 3. Stability of hydrochlorothiazide injection solutions].

Studies of the stability of hydrochlorothiazide (1) in N-methylacetamide prove that a temperature dependent equilibrium is found in the isothermic short-term test as well as in the longterm stability test. Whereas the kinetic reaction evaluation after Arrhenius doesn't allow a forecast, the 25 degrees C-values, extrapolated after the Van't Hoff-equation, were confirmed using the long-term test. By adding the decomposition product aminodisulfamide (2) the hydrolysis is restricted.

Cyclopenthiazide↗
PubMed1985

[The stability of hydrochlorothiazide and cyclopenthiazide in various drug forms. 2. The stability of Disalunil tablets].

Checking-up the stability of hydrochlorothiazid tablets (Disalunil), chemical and especially pharmaceutical-technological analyses were forming part of the adequate test programme. The pharmaceutical and chemical properties of the Disalunil tablets will be regarded as sufficient ones at normal conditions of their storage. In case the tablets will be stored, however, in their original packing under conditions of an increased humidity or with additional water, the water sorption will result in prolonged disintegration rates as well as in a reduced radial breaking strength and dissolution rate. This significant depreciation of the drug cannot be recognized by chemical-analytical methods.

Cyclopenthiazide↗