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[Pathology of the Cervix. Introduction to the focal topic "Pathology of the cervix - future developments"].

The incidence of cervical cancer has decreased distinctly. Since the causal connection between HPV infection and cervical cancer was proved, new diagnostic and therapeutic methods have become available. New diagnostic possibilities, in certain situations the determination of HPV, a new vaccination as well as molecular-bio-logical tests will shape the future. However, it must not be forgotten that the number of participants in cervical cancer screening has a bigger impact on the decreasing incidence of cervical cancer than any special diagnostic methods.

Cervix Uteri↗

Neuropeptide Y, its localization in the human cervix and possible effect on the contractile activity of cervix smooth muscle.

Immunochemical methods were used to identify neuropeptide Y (NPY) in the cervical tissue of women at early and term pregnancy. NPY-containing fibers could not be demonstrated in the upper and lower uterine segments at term, but the cervical innervation persisted during labor. Moreover, NPY alone did not affect cervical contractile activity, although the stimulatory effect of noradrenaline was enhanced.

Cervix Uteri↗

[Follow-up in cervix intra-epithelial neoplasia and condylomatous lesions of the uterine cervix].

77 women with colposcopic and/or cytologic suspicious signs had been followed up 6 to 46 months. In 23 (44 per cent) out of 52 women with CIN we could observe progredience, in 19 (37 per cent) cases dysplasias and carcinoma in situ remained unchanged and in 10 (19 per cent) there was a regression. From 18 benign condylomatous lesions 8 were regredient and sones were progredient. Only in 1 out of 7 cases with benign lesions without papilloma virus infection a CIN II developed. Follow up of pregnant women demonstrated twofold more regredient findings compared with nonpregnant women. Follow up over a period of several years with colposcopic, cytologic and histologic examination in young women with CIn and childwish is possible without risk if definite management will be secured.

Biopsy↗