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At least 73 records · Page 4Linked to original sources
PubMed1999

Catalog-library approach for the rapid and sensitive structural elucidation of oligosaccharides.

We obtained the nearly complete structural elucidation of oligosaccharide components, including sequence, linkage, and even stereochemistry in the picomolar levels. The "catalog-library" approach is used for elucidating the structures of minor components in a mixture of oligosaccharides. Oligosaccharides released from a family of glycoproteins are often composed of a small finite set of monosaccharides. In this regard, the numerous oligosaccharide species are analogous to the products found in syntheses involving combinatorial libraries. The great structural diversity in the library is the result of the nearly infinite combinations in which even a small number of monosaccharides can be arranged. Fortunately, structural similarities exist between different oligosaccharides, as specific substructural motifs are preserved among different compounds. We propose that a catalog of substructural motifs can be identified and characterized by collision-induced dissociation mass spectrometry. The catalog is constructed from a set of known compounds that have been fully structurally elucidated by, for example, nuclear magnetic resonance. The catalog consists of the characteristic fragmentation patterns belonging to a set of specific substructural motifs. Collision-induced dissociation is used to determine the presence of these motifs and reconstruct the structures of less abundant components.

Carbohydrate Conformation↗
PubMed2002

A catalogue of described genera and species of microsporidians parasitic in fish.

A complete list of microsporidians parasitic in fish is presented; in each species, the host(s), site of infection and the known geographical distribution is given. Species of a total of 14 genera can be found in fish hosts. These genera do not occur in other hosts and include 80 named species plus 29 records only designated as 'sp.' The collective group Microsporidium includes 15 species plus 30 records only designated as 'sp.' Described species with incorrect generic assignment number seven species and there are six hyperparasitic species infecting other fish parasites. Thus the total number of microsporidians which may be encountered in fish is 108 named and 59 innominate species.

Animals↗
PubMed1997

Nonverbal memory assessment with designs: construct validity and clinical utility.

The evaluation of memory is often a principal objective in psychological testing, especially for older adults. Differentiation between subtypes of memory functioning is critical in making differential diagnoses and in predicting everyday functioning. In this paper, 23 tests using memory for designs and developed for clinical or research applications are reviewed. Overall, reliabilities are low, normative samples varied in size, and findings regarding the construct validity of design memory testing are mixed. Tests with higher reliability, large numbers of designs, and recognition formats may be more specific to nonverbal memory. A series of studies that systematically establishes construct validity for design memory tests will enhance clinical utility.

Adult↗
PubMed1989

Computerized information sources in toxicology and their use in a poisons centre.

The increasing volume of calls received by a poisons centre, such as the National Poisons Unit, Guy's Hospital, London is placing the present information services under escalating pressure. Recent developments in the technologies used to store and manipulate data have resulted in a number of public and private computerized systems being made available. In order to maximize the benefit of the new technologies to a Poisons Centre Information Service it would be desirable to create an integrated system to link the currently unrelated systems. Such an integrated system would be capable of retrieving bibliographic information from bibliographic files similar to MEDLINE and EMBASE and data from source information files such as RTECS and ECDIN, with the user only having to make one enquiry. This paper examines the current position with regard to computerized information sources in toxicology and discusses how an integrated system might improve the efficiency of a poisons centre's information retrieval service and outlines some of the obstacles to the development of such a system.

Catalogs as Topic↗
PubMed2003

Dupuytren's disease or Cooper's contracture?: Kenneth Fitzpatrick Russell Memorial Lecture.

In his position as curator of the Cowlishaw collection of historical medical books in the Library of the College, Kenneth Russell prepared the definitive catalogue of the collection. This catalogue is comprehensive and for almost all entries there is an annotation that demonstrates his meticulous attention to detail and the love of the book collection that he managed to secure for the College. It is from this catalogue that I have chosen two books in particular that bring together two great surgeons of the turn of the 19th century. Although he was a pupil of the great John Hunter, the young Astley Cooper possessed good manners and a gift of oratory of which the Scot, his teacher, was devoid. After his apprenticeship with Henry Cline senior, Cooper came to share the podium with Cline at Guy's and St Thomas' hospitals and the two dominated surgical teaching in London for some 22 years, until Cline's retirement in 1811. It was the latter who was first to recognize the true nature of the condition now known as Dupuytren's disease. Later, in 1822, Cooper wrote a detailed description of the contracture of the palmar aponeurosis and recommended fasciotomy as being curative. His book A Treatise on Dislocations and Fractures of the Joints, which contains this description of Dupuytren's contracture, is held in the Cowlishaw Collection. On the other side of the English Channel, M. le Baron Dupuytren repeatedly misquoted Cooper and stated that Cooper believed that the disease was incurable. In his famous lecture given to the staff of the Hôtel Dieu in Paris on 5th December 1931, he admitted to having seen 30 or 40 cases over 20 years of practice. It seems likely that he was not aware of the true cause of the condition before 1831 when he treated his first case. This lecture, along with others, are recorded in his Leçons Orales de Clinique Chirurgicale, a copy of which is also to be found in the Cowlishaw Collection.

Catalogs as Topic↗
PubMed2005

[The catalogue of ambulatory sickness benefits -- realistic? Feasible? Put into practice?].

Ambulatory surgery at German hospitals is an underdeveloped field. New legal regulations allow contracts between hospitals and insurance companies which will improve this situation. Besides the establishment of quality parameters and a fixed payment for the operations the contract lists 307 operations which can be performed on an outpatient basis. However, only few operations need to be done obligatory as ambulatory surgery. This reflects just incompletely what is already operated ambulatory outside the hospitals. Due to altered financial structures in case of in-patient treatment and because of a decrease of hospital beds, the listed operations in the contract may be reviewed and ambulatory surgery at the hospitals will increase in the future. The hospitals need to change their structure to establish successfully ambulatory surgery within the hospital setting. Finally, German patients need to be convinced that operations done on an out-patient basis show the same quality standards like procedures under in-patient conditions.

Ambulatory Surgical Procedures↗
PubMed2003

BioWareDB: the biomedical software and database search engine.

UNLABELLED: A wealth of bioinformatics tools and databases has been created over the last decade and most are freely available to the general public. However, these valuable resources live a shadow existence compared to experimental results and methods that are widely published in journals and relatively easily found through publication databases such as PubMed. For the general scientist as well as bioinformaticists, these tools can deliver great value to the design and analysis of biological and medical experiments, but there is no inventory presenting an up-to-date and easily searchable index of all these resources. To remedy this, the BioWareDB search engine has been created. BioWareDB is an extensive and current catalog of software and databases of relevance to researchers in the fields of biology and medicine, and presently consists of 2800 validated entries. AVAILABILITY: BioWareDB is freely available over the Internet at http://www.biowaredb.org/

Abstracting and Indexing↗