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Results for “Capillary Resistance”

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At least 73 records · Page 4Linked to original sources
PubMed1981

The effect of O-(beta-hydroxyethyl)-rutosides (HR) on the skin capillary resistance of rats.

The effect of three different oral doses of O-(beta-hydroxyethyl)-rutosides (HR, Venoruton) on the skin capillary resistance (CR) of Sprague-Dawley rats aged 8-10 weeks, 6 months or 1 year (and selected because of their low CR) was investigated. The CR was measured over a period of 24 h after a single administration of each dose. The results were compared with a further group aged 6 months who received HR intraperitoneally. The optimal dose was defined in all four groups receiving the drug systemically. In most cases a significant effect could be shown already after 2-4 h, persisting until at least 8 h and in some cases 24 h. Comparative data were also obtained with four different pure hydroxyethyl components (tetra-HR, tri-HR, di-HR and mono-7-HR) in identical experimental conditions. The most active appeared to be the mono-7-HR. Finally, the effect of a single topical application of a gel containing 2% HR was investigated. This produced a significant increase of CR after 1 h, which lasted around 4-5 h. The clinical implications of these results are discussed with special reference to senile, hypertensive and diabetic vascular disease.

Animals↗
PubMed1975

Studies on small intestinal obstruction. II. Blood flow, vascular resistance, capillary filtration, and oxygen consumption in denervated small bowel after obstruction.

Intestinal circulation was studied during in vitro perfusion of denervated small intestine of the cat shortly after release of an in vivo small-bowel obstruction. Blood flow, vascular resistance, capillary filtration, and oxygen consumption were determined. No significant differences were demonstrated between obstructed and non-obstructed intestines. The presently studied facets of small-bowel microcirculation thus exhibit a virtually normal function 30 minutes after decompression of a bowel obstruction. The pertinent literature affords evidence that a distension impairs bowel viability; it would seem that this impairment is rapidly ameliorated following decompression of the bowel.

Animals↗