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PubMed1985

Immunoelectron microscope demonstration of the basement membrane components laminin and type IV collagen in the dermal cylindroma.

Specific antisera to the human laminin P1 fragment and the 7S domain of type IV collagen were used to investigate the ultrastructural location of these main basement membrane (BM) components in a dermal cylindroma. Thick frozen sections were treated by the immunoperoxidase method, postfixed, embedded in epon and then sectioned for electron microscopic examination. Laminin and type IV collagen were detected in all layers of the cylindroma BM, together with non-specifically stained, diffusely distributed fibrillar structures, possible microfibrils and anchoring fibrils or residual stromal collagen fibres. The mixed presence of the BM components indicates that these substances codistribute rather than occurring as separate layers even when forming neoplastic basement membranes.

Aged↗
PubMed1975

[Cylindroma of the breast. A histochemical and histogenetic study (author's transl)].

The histochemical study of mucopolysaccharide components of the ground substance of the cylindroma lends force to their epithelial origine. The myoepithelial cell, which is ectodermal in origin, plays an essential role in their secretion. Silver impregnation of normal and dysplastic breast illustrates the secretory function of myoepithelial cells and their possible implication in the histogenesis of cylindroma.

Adult↗
PubMed1984

Multifocal dermal-type basal cell adenomas of parotid glands with co-existing dermal cylindromas.

A basal cell adenoma of the parotid gland accompanied by multiple developing microadenomas of the same type and three dermal cylindromas, all observed in a 54-year-old woman, were examined by light microscopy. The histological structure of the basal cell adenomas shows striking similarities to co-existing dermal cylindromas, suggesting a common histogenesis of both tumors. We suggest that the term "basal cell adenoma of dermal type" should be used for these lesions. Multifocal ductal proliferations with nascent adenomas in the glandular parenchyma allow us to trace the development of these tumors. Studies of the literature reveal four additional cases in which there are co-existing basal cell adenomas of salivary glands and dermal adnexal tumors.

Adenoma↗
PubMed1992

Multiple linear cylindromas.

We report a case of multiple cylindromas with a linear arrangement on the lower right extremity. The patient had more than 100 tumors, but the scalp was spared. Some tumors showed overlapping features with eccrine spiradenoma. We believe this is the first report of multiple linear cylindromas.

Adenoma, Sweat Gland↗
PubMed1994

Eccrine cylindroma of the ear canal--report of a case.

Eccrine cylindroma is a benign tumour arising from sweat glands in the skin. It favours the face, forehead and scalp involving the turban area and hence is called a turban tumour. Amongst a variety of tumours originating from adnexal skin structures, which may appear in the ear canal, eccrine cylindroma forms a very rare entity. We present such a case and discuss its pathological and clinical features.

Adenoma↗
PubMed1995

Well-differentiated malignant cylindroma with partially preserved hyaline sheaths. A locally invasive neoplasm?

Light microscopic and ultrastructural features of a well-differentiated malignant cylindroma are described. The tumor was locally invasive but it neither recurred nor metastasized during the 3 years after surgery. This fact, together with the similar biologic behavior of two previously described, well-differentiated malignant cylindromas, suggests that these tumors possess either low or no metastatic potential.

Adenoma↗
PubMed1989

Total scalp excision and auricular resurfacing for dermal cylindroma (turban tumor).

Dermal cylindroma is a benign neoplasm of the eccrine sweat glands, which presents in the head and neck area in 91% of cases. In its most florid presentation, the entire scalp can be involved, leading to the descriptive label turban tumor. We present the case of a 30-year-old woman with dermal cylindroma extensively involving her forehead and scalp and whose family was affected in three consecutive generations. She underwent total scalp and forehead excision with coverage by split-thickness skin grafts from the thigh. Seven years later, because of progressive external ear involvement, auricular resurfacing was performed. Her scalp and forehead have remained tumor free in the eight-year follow-up period and the auricles at one year. Total excision has led to a cosmetic and functional improvement, and the possibility of malignant degeneration is theoretically decreased.

Adult↗
PubMed2005

Carcinosarcoma arising in a patient with multiple cylindromas.

Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas. Malignant tumors may occur, usually with the features of a cylindrocarcinoma. The authors describe the case of a 75-year-old woman with the Brooke-Spiegler syndrome who presented with multiple nodules of the scalp, face, and trunk. In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting. Histologic examination revealed multiple cylindromas, some with areas of spiradenoma and one with an extensive adenomatous component; some trichoepitheliomas were also evident. In 2002, a nodule of the trunk suddenly increased in size and became painful. The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells. Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome. The authors discuss the morphogenesis of the folliculosebaceous-apocrine unit from which the tumors in this syndrome derive, and the pivotal role of mesenchymal cells in determining the process. Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.

Aged↗
PubMed2006

Malignant cylindroma of the external auditory canal.

OBJECTIVE: This report describes a case of a malignant cylindroma arising in the external auditory canal. STUDY DESIGN: Retrospective surgical case review. SETTING: Tertiary care teaching hospital. INTERVENTION: Wide local excision with margin control. RESULTS: Local control of disease at 2-year follow-up. CONCLUSION: To our knowledge, this is the first report describing a malignant degeneration of cylindroma in the external auditory canal. This tumor represents an extremely rare cutaneous neoplasm, thus raising diagnostic and therapeutic challenges.

Carcinoma, Adenoid Cystic↗
PubMed2004

Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma.

Brooke-Spiegler syndrome is a rare, autosomally dominant disease characterized by the development of multiple cylindromas, trichoepitheliomas, and occasional spiradenomas. We report herein a case of Brooke-Spiegler syndrome in a 55-year-old woman associated with multiple cylindromas, spiradenomas, trichoepitheliomas, and syringomas that developed on her face. Her 52-year-old sister also suffered from multiple trichoepitheliomas. Although there is variable clinical and histological expression in Brooke-Spiegler syndrome, all of the tumors encountered in our case were related to folliculosebaceous-apocrine units.

Biopsy, Needle↗
PubMed1991

Cylindroma treated by Mohs micrographic surgery.

Cylindroma, a rare benign adnexal neoplasm, may occur in areas in which simple excision is either not possible or severely disfiguring. We present a case of cylindroma that was treated by Mohs micrographic surgery. Postsurgical evaluation of the tumor showed that the tumor had invaded a larger area than was initially suspected based on clinical examination alone.

Aged↗
PubMed1983

Eccrine spiradenoma and dermal cylindroma.

The homologous nature and morphological similarities between cutaneous and salivary gland tumors have been well documented. This is especially true of the monomorphic adenoma, eccrine spiradenoma and cylindroma. Prior to the first full clinical and pathological description, about twenty-five years ago, the lesion of eccrine spiradenoma had been given multiple synonyms. This report is of a patient with an eccrine spiradenoma in the buttock and dermaltype cylindroma of the parotid gland. This may represent the transformation of pleuripotential basal cells originating in the parotid and eccrine sweat gland.

Adenoma, Sweat Gland↗
PubMed2000

Malignant cylindroma in Brooke-Spiegler syndrome.

A 68-year-old female patient presented with a history of gradual appearance of multiple nodules situated predominantly on the scalp and neck, with a few nodules on the trunk. The nodules began to appear at the age of 30. Family history revealed that the patient's brother, son, father and grandmother had similar cutaneous lesions. The dominant histopathological pattern was that of a cylindroma. Features of both cylindroma and spiradenoma (spiradenocylindroma) were present within the same lesion in some biopsies. Most lesions on the scalp were skin-colored with a smooth surface. The largest tumors located on the neck were tender and ulcerated. Histopathologically, these tumors had the morphology of a high-grade malignant solid neoplasm with epithelioid features.

Aged↗
PubMed2002

[Adenoid cystic carcinoma (cylindroma) of the nasopharynx with extension into the cavernous sinus].

INTRODUCTION: The adenoid cystic carcinoma or cylindroma of the nasopharynx is a rare tumour characterised by its slow progression, high risk of local recurrence and prolonged survival, even in the locally advanced and/or metastatic forms. Treatment is pluridisciplinary. OBSERVATION: In a 30 year-old man consulting for right retroauricular pain, hypoacousia and epistaxis, diagnosis of a nasopharyngeal cylindroma was made in 1994. Treatment consisted first line surgery combined with loco-regional radiotherapy. Twenty-six months after complete remission had been obtained, a loco-regional relapse was revealed, combined with pulmonary metastases. The treatment combining radiotherapy, surgery and chemotherapy led to the stabilisation of the disease. COMMENTS: The adenoid cystic carcinoma of the nasopharynx a rare neoplasia of the head and neck, characterised by its slow progression over time, a high risk of relapse and the progression of metastases at distance. The corner stone of its therapeutic management is surgery. Radiotherapy improves the local control of the disease and chemotherapy is helpful in treating the metastatic disease.

Adult↗
PubMed1991

[Adenoid cystic carcinoma or cylindroma of the breast. General review in light of one case report].

Cystic adenoid carcinoma or cylindroma of the breast is a rare tumour, and until new only 140 cases have been described in the literature. The clinical criteria are not very specific: tumour in a woman of 50 years of age, with slow growth, unilateral, well delimited, firm, peri-areolar, painless and not adherent to the skin nor the deep tissues. The diagnosis is made by histological examination which shows the presence of pseudo-cysts encased in cellular masses heaped up, composing epithelium and myo-epithelial elements. These are sometimes visible with optic microscopy, and if necessary confirmed by electron microscopy and using immunohistochemical techniques. It is now realised that the myo-epithelial cell plays a role in the histogenesis of the cylindroma. The outcome is usually good after simple surgical removal which has to be sufficient to avoid local recurrences. All the same there have been rare cases of metastases in the literature which means that these cases should be followed up carefully.

Aftercare↗
PubMedDate not supplied

[A case of cylindroma of the nasal cavity. Surgery].

The authors presented on this paper one case with a cylindroma in a 33 year old male. The clinical background are the nasal obstruction only; with rhinoscopy they can looked a tumoral masse that full up nasal lumen. Histological diagnostic confirmed cylindroma. During surgical operation prove that it come from nasal septum.

Adult↗
PubMed1989

[Cylindroma of the parotid gland. Apropos of 11 cases].

Few studies have been exclusively devoted to date to parotid cylindromas, essentially because of their rarity and their very slow progression. However, these tumours have a serious prognosis. Although local control appears to be better with complementary radiotherapy, the vital prognosis depends entirely on the presence or absence of distant metastases, essentially pulmonary. The analysis of 11 cases of parotid cylindroma leads the authors to propose a rational management. When the tumour is localised, particularly to the superficial lobe, careful total parotidectomy with preservation of the facial nerve is performed; neck dissection is only performed in the presence of obvious lymph node involvement. Postoperative irradiation is not systematically indicated. In the case of a voluminous tumour or in an obviously incomplete resection, deliberate sacrifice of the facial nerve is not essential, as radiotherapy allows good local control. Extensive mutilating operations do not appear to be justified. Chemotherapy requires the use of more effective drugs than those used at the present time. The complete remission rate in the present series was 60% at six years, but a much longer observation period is required, as the very delayed appearance of metastases is always possible.

Adult↗
PubMed1986

[Poncet-Spiegler cylindroma. Apropos of a recent case].

The authors describe a new case of multiple cutaneous cylindromas (Poncet-Spiegler cylindroma), and discuss the clinical and histopathological characteristics of this rare affection. Treatment is exclusively surgical, with plastic surgery being required for advanced cases. In the case presented, a free flap from the forearm was used to cover the area of extensive loss of cutaneous matter in the parotid region.

Carcinoma, Adenoid Cystic↗