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Socio-political aspects of mental health practice with Arabs in the Israeli context.

Since the 1948 establishment of the Israeli state, an event described by Arab peoples as "Al-Nakbah" (catastrophe), the Arab minority in Israel has experienced oppression, trauma and social exclusion; they feel defeated, disempowered and poorer. There are huge gaps in quality of life between Arab and Jewish Israelis. Such social inequities, as well as other issues such as polygamy, have been identified as risk factors for psychological distress. This situation puts the Israeli Arab, like other post-colonial peoples, in an attitude of ambivalence towards modern mental health services. On the one hand, certain forms of intervention, particularly medicinal, may improve peoples' lives. On the other, mental health services, as part of the colonial process, continue to present limited cultural sensitivity towards Arab peoples. A cultural gap leading to mistrust is a given when a non-Arab mental health provider comes into contact with an Arab client. Religious beliefs, the importance of the family and the stigma attached to mental health problems have substantial influence on the Arab's perception and reaction toward mental health problems and their treatment. The expression of conflict and negative feelings are not well accepted within Arab culture. For this reason, mental illness is often denied and kept away from professional help or expressed as a physical illness. There is also a difficulty for a male being treated by a female and for the individual to ask for help outside his family or community. Arab Muslims also generally have a tendency to resign themselves to God's care and thus may neglect or deny symptoms. Another tendency is the preference for using traditional healers and folk medicine. Other problems in mental health work are the passive attitude of the patient and the degree of authority vested in the therapist. To facilitate bridging this cultural gap, the therapist's first task is that of educating him/her self about the religious, cultural and national background of the client. Cultural competence and self-reflection are key components to effective cultural practice.

Arabs↗

Jewish-Arab relations in Israel: a psychology of adolescence perspective.

Jewish and Arab high school seniors (61 Jewish boys and 51 Jewish girls, 57 Arab boys and 49 Arab girls) participated in a study of future orientation and described their hopes and fears for the future. The present analysis focuses on part of the data pertaining to the respondents' cross-ethnic references. More Arab than Jewish adolescents referred to the other ethnic group. The cross-ethnic references contained hope for peace and fear of war; the Arab statements, however, also showed discontent with Israeli authorities. More Arab than Jewish adolescents referred to collective issues (the people, the state, the world). The percentage of Jewish and Arab adolescents concerned with Jewish-Arab relations relative to the number addressing other aspects of collective concerns were similar (12% for Jews and 16% for Arabs). For Jews, this small number was related to adolescents' egocentrism and for Arabs, to adolescents' ethnocentrism.

Adolescent↗

An Arabic validation of a depression inventory.

The present study describes an Arabic cross-cultural validation of the Beck Depression Inventory. An Arab sample of 53 cases was subjected to the original validation procedures which involved a preliminary exercise and a translation from English to Arabic. Acceptable equivalent meanings of Beck's depth-of-depression criteria were established by the Arab clinicians so that independent and valid clinical ratings could be made. Statistical analyses of the internal consistency and stability of the Arabic-BDI indicated a high degree of reliability. Correlations between Arabic-BDI scores and Arab clinicians' ratings indicated a high degree of validity. The results of the cross-cultural validation study agree favorably with those of the original American validation. Although the Arabic inventory makes possible an assessment of the level and intensity of a reactive type depression suffered by Saudi Arab psychiatric outpatients living in the Eastern Province, it must be adapted dialectically for other Arab-speaking regions.

Adolescent↗

Hospitalizations due to falls in Jewish and Arab children in northern Israel.

In Israel, there are no epidemiological data regarding nonfatal childhood falls. A retrospective survey was conducted in order to find epidemiological characteristics of childhood falls among the different populations of northern Israel. During the years 1993 through 1995, 3082 children were hospitalized in Rambam Medical Center (RMC) due to injury. The children were subdivided into the four main populations: Jewish and Arab residents of Haifa region (the main metropolitan area) and Jewish and Arab residents of the Galilee region (the rural region). All of the children who suffered injury that required mechanical ventilation and careful assessment were admitted to the PICU. The charts of the children admitted to the PICU were then further studied. The demographic characteristics of all the cases of falls were statistically analyzed and the annual admission rates due to falls were calculated using the national statistical registrations of children in Israel. Falls were responsible for 1049 admissions due to injury, one third of the total number of children who were admitted due to an injury. Most of the children were five years of age or younger. Two thirds of the total childhood falls were of Arabs. The majority of the admissions were of two major sub-populations of northern Israel: Arab residents of Galilee region (66%) and Jewish residents of Haifa region (34%). Higher admission rate was found among Arab children of the Western Galilee district in comparison with Jewish children of the Haifa district. Most of the children who were admitted to the PICU were Arabs: nearly all of these children were from the rural region. More Arab than Jewish children who fell were admitted to the PICU and the majority of these cases were falls from buildings (private houses). Arab children of the rural region were responsible for 95% of the cases. These falls were mainly in staircases (46%) and from balconies (21%), roofs (11%) and windows (11%). The findings of the present study suggest that young Arab rural children in northern Israel are at high risk to a severe injury due to fall. Possible causes are discussed and a preventative intervention is suggested.

Accidental Falls↗

Providing mental health services to Arab Americans: recommendations and considerations.

Arab Americans are an extremely heterogeneous and frequently misunderstood group whose unique characteristics and cultural heritage have received little attention in the mental health literature. To effectively address the needs of Arab Americans, mental health professionals need to be aware of their own biases and misperceptions regarding Arab Americans, have an accurate understanding of Arab cultural and sociopolitical backgrounds, and be able to identify culturally appropriate interventions for use with Arab American clients. This article reviews common stereotyped beliefs many Americans have about Arab Americans and the negative impact these stereotypes can have on the development of a positive Arab American ethnic identity. It also provides detailed information about the cultural and sociopolitical experiences of Arab Americans and offers specific recommendations for providing culturally relevant mental health services to Arab American clients.

Arabs↗

A change in human faecal flora in response to inclusion of gum arabic in the diet.

1. Gum arabic is a water-soluble polysaccharide resistant to human gut enzymes and thus can be described as dietary fibre. 2. Using a most-probable-number technique, estimates were made of total anaerobes and of gum-arabic fermenters in the faeces of a volunteer during a control period and during addition of 10 g gum arabic/d to the diet. Using an enrichment technique, the principal bacteria able to utilize gum arabic as the only carbohydrate source were isolated and characterized. 3. Faecal samples were analysed for undegraded gum arabic and, following acid-hydrolysis, for total sugars. 4. The proportion of the faecal flora able to degrade the gum arabic polymer rose from an initial level of 6.5% to more than 50% during gum-arabic ingestion, and subsequently returned to the control level after ingestion ceased. The principal gum-arabic fermenters were species of Bacteroides and Bifidobacterium. 5. Undegraded gum arabic was not detected in any faecal sample nor were there significant differences in the level of total sugars in acid-hydrolysed faeces between gum arabic and control periods. 6. The results presented indicate a direct and rapid change in faecal flora in response to a specific change in the diet of a human volunteer.

Adult↗

CTGA: the database for genetic disorders in Arab populations.

The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the 'Catalogue of Transmission Genetics in Arabs' (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA (http://www.cags.org.ae).

Arabs↗

Proabsorptive action of gum arabic: regulation of nitric oxide metabolism in the basolateral potassium channel of the small intestine.

BACKGROUND: Gum arabic, a high-molecular-weight natural polysaccharide, has been shown to have proabsorptive properties in animal models of gastrointestinal disease that involve nitric oxide (NO). Gum arabic may indirectly regulate NO metabolism by creating an outward NO gradient, thus altering other intracellular NO-dependent mechanisms such as gating of the potassium (K+) channel. This hypothesis was further investigated using the K+ channel blocker, glybenclamide. METHODS: Following intraperitoneal injection of 4.5 mg/kg glybenclamide or saline, the jejunum of anesthetized rats was perfused with a standard oral rehydration solution in the presence or absence of 2.5 g/L gum arabic, as well as 1 mmol/L l-arginine to enhance NO production. Sodium, net water, and glucose absorption and unidirectional water movement were determined. RESULTS: Gum arabic showed regulatory capacity for NO-dependent metabolism by reducing net water absorption in the absence of arginine, and sodium absorption after arginine stimulation, in the absence of glybenclamide. Addition of gum arabic to oral rehydration solution, in glybenclamide pretreated animals, and in the absence of arginine, normalized sodium absorption, but was less effective in restoring net water transport. Injection of glybenclamide sharply decreased all absorption markers in arginine supplemented oral rehydration solution, which were at least partially restored by addition of gum arabic to the oral rehydration solution. In the presence of glybenclamide, the effects of arginine became antiabsorptive, as had those observed in preceding studies with high arginine concentration. Gum arabic partially or fully reversed alterations produced by perfused 1 mmol/L arginine. CONCLUSIONS: Some of the effects of gum arabic on the small intestine are likely caused by its ability to remove NO as it diffuses into the lumen, thus reducing NO concentration in the enterocyte and indirectly affecting the absorptive/secretory response of the gut, which leads to normalization of absorptive function. These findings are consistent with the previously shown gum arabic-scavenging properties of NO and support a potential therapeutic role for this product.

Animals↗

Validation of an Arabic translation of the Zung Self-Rating Depression Scale.

BACKGROUND: Depression is a common condition in primary care medicine in all population groups. We wanted to validate an Arabic translation Zung Self-Rating Depression Scale for Arabic speakers as it has been validated in a number of other languages. METHODS: The hospital translation service translated the English version into Arabic, which was verified by back translation. This version was tested in a pilot study with 40 bilingual Arabic-English clinicians and Arabic linguistic experts. Revised questions were subjected to another translation-back translation and the final version tested in a clinical trial with 240 consenting bilingual English-Arabic speakers. The subjects were randomly assigned to answer either the English or Arabic version of the Zung questionnaire first, ensuring that subjects had no access to previous answers when answering the questionnaire in the other language. The scores obtained were tested for agreement using the kappa statistic. RESULTS: We found substantial agreement between the scores obtained from the two questionnaires. The kappa measurement of agreement was 0.652 (95% confidence interval, 0.571-0.732) CONCLUSION: We believe the Arabic translation of the English Zung Self-Rating Depression Scale is valid and reliable, and will be useful to practitioners who would like to use this tool in Arabic-speaking patients.

Arabs↗

Reading, syntactic, orthographic, and working memory skills of bilingual Arabic-English speaking Canadian children.

This study assessed the reading, language, and memory skills of 56 bilingual Arab-Canadian children age's 9-14. English was their main instructional language, and Arabic was the language spoken at home. All children attended a Heritage Language Program in Toronto where they were taught to read and write Arabic. The children were administered word and pseudo-word reading, language, and working memory tests in English and Arabic. The majority of the children showed at least adequate proficiency in both languages. There was a significant relationship between the acquisition of word and pseudo-word reading working memory, and syntactic awareness skills in the two languages. The poor readers in Arabic had lower scores on all linguistic tasks, except the visual task. There were no significant differences between bilingual English Arabic children and monolingual English-speaking children on the reading, language, and memory tasks. However, bilingual English Arabic children who had reading problems in English had higher scores on English pseudo-word reading and spelling tasks than monolingual English-speaking children with reading disabilities, probably because of positive transfer from the regular nature of Arabic orthography. In this case, bilingualism does not appear to have negative consequences for the development of language reading skills in both languages--Arabic and English--despite the different nature of the two orthographies.

Adolescent↗

Different structures of selected and unselected araB-lacZ fusions.

Formation of araB-lacZ coding-sequence fusions is a key adaptive mutation system. Eighty-four independent araB-lacZ fusions were sequenced. All fusions carried rearranged MuR linker sequences between the araB and lacZ domains indicating that they arose from the standard intermediate of the well-characterized Mu DNA rearrangement process, the strand transfer complex (STC). Five non-standard araB-lacZ fusions isolated after indirect sib selection had novel structures containing back-to-back inverted MuR linkers. The observation that different isolation procedures gave rise to standard and non-standard fusions indicates that cellular physiology can influence late steps in the multi-step biochemical sequence leading to araB-lacZ fusions. Each araB-lacZ fusion contained two novel of DNA junctions. The MuR-lacZ junctions showed 'hot-spotting' according to established rules for Mu target selection. The araB-MuR and MuR-MuR junctions all involved exchanges at regions of short sequence homology. More extensive homology between MuR and araB sequences indicates potential STC isomerization a resolvable four-way structure analogous to a Holliday junction. These results highlight the molecular complexity of araB-lacZ fusion formation, which may be thought of as a multi-step cell biology process rather than a unitary biochemical reaction.

Bacteriophage mu↗

Reliability of an Arabic version of the RAND-36 Health Survey and its equivalence to the US-English version.

OBJECTIVES: The objectives of this research were to: (1) evaluate the reliability and equivalence of the Arabic and English versions of the RAND-36 Health Survey (RAND-36) in a sample of Saudi Arabian citizens; and (2) assess the health status of a sample of Saudi Arabian citizens using both the Arabic and English versions. METHODS: Both the Arabic and English versions of the survey were administered to a convenience sample of bilingual (English and Arabic) Saudi citizens (n = 415) at Saudi ARAMCO Company, Dhahran, Saudi Arabia. Internal consistency, equivalent-forms, and test-retest reliability were estimated for the eight multi-item scales in the Arabic and English versions. Mean scale scores were calculated for each version and compared with the general US populations. RESULTS: The median Cronbach's alphas for the Arabic RAND-36 in multiple subgroups exceeded 0.70 for every scale except one. Two of the English RAND-36 scales had median Cronbach's alphas that exceeded 0.70; the remainder exceeded 0.50. Two-week test-retest correlations were all statistically significant for both versions. Product-moment correlations to test the equivalence of the corresponding Arabic and English versions of the RAND-36 ranged from 0.73 to 0.92. Saudi citizens reported significantly higher vitality scores, but significantly lower physical functioning, social functioning, and general health perception scores than the general US population. CONCLUSIONS: The results provide support for the reliability and equivalence of the Arabic and English versions of the RAND-36. Additional studies need to be conducted in a representative sample of the general Saudi population to further assess the psychometric properties of the Arabic version.

Adult↗

An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome.

OBJECTIVE: To investigate genetic susceptibility to recurrent fevers, generalized severe myalgia, and migratory erythema in an Israeli Arab child with no family history of similar disease. METHODS: DNA sequencing of exons 1-6 of the TNFRSF1A gene (formerly TNFR1) was performed in the patient and his parents to determine the presence of the autosomal-dominant tumor necrosis factor receptor-associated periodic syndrome (TRAPS); informative markers spanning the TNFRSF1A locus were used to genotype all available members of the patient's family. The TNFRSF1A gene was subsequently screened in 69 healthy Arab controls and 96 Caucasian controls. Formal forensic paternity testing was performed on the child. RESULTS: We found a de novo missense mutation in exon 3 of the TNFRSF1A gene, involving a novel C-->T transition encoding a Cys70Arg (C70R) variant, in the Israeli Arab patient. Eight of the common familial Mediterranean fever (FMF) gene MEFV mutations were excluded. This mutation was not present in the parents or siblings, or among the 69 healthy Arab controls. However, another TNFRSF1A variant, Pro46Lys (P46L), was present in 1 of the Arab controls. CONCLUSION: We have identified a TNFRSF1A mutation associated with periodic fever in an Arab patient, and a TNFRSF1A variant, which is variably pathogenic in Caucasians, in an Arab control. This is the first report of a de novo mutation in periodic fevers in general, and also of TRAPS in the Arab population. These findings demonstrate the need to include TRAPS in the differential diagnosis of recurrent fevers in this population.

Adolescent↗

Acculturation and well-being among Arab-European mixed-ethnic adolescents in Israel.

PURPOSE: To examine the relationship between two ethnic dimensions (Arab and European), and between a modified version of Berry's four acculturation styles (integration, assimilation into the Arab heritage, assimilation into the European heritage, and marginalization) and measures of psychological well-being among adolescents born to European mothers and Israeli Arab fathers. METHODS: A total of 127 Arab-European adolescents (aged 13 to 18 years; 64 males and 63 females) in Israel completed ethnic identification and well-being measures. RESULTS: Arab and European ethnic identifications emerged as being uncorrelated among the participants, providing a basis to use four acculturation styles to describe participants' variations in ethnic identification. The study found that integration and assimilation into the Arab heritage were connected with higher levels of desirable well-being correlates (self-esteem and positive relations with others) and with lower levels of undesirable correlates (depression and anxiety). The study also found that although assimilation into the European heritage was linked with high levels of self-esteem and low levels of depression, this style was linked with high levels of anxiety and low levels of positive relations with others. The marginalization style was consistently positively associated with high levels of poor mental health. CONCLUSIONS: The underlying assumption of Berry's four-fold model, notably the independence of ethnic identifications, tends to be borne out among mixed-ethnic individuals. On the basis of this independence the study revealed that a modified version of Berry's four acculturation styles could prevail among Arab-European individuals over the period of adolescence and that these styles play a predictive role in well-being measures of the individuals. Specifically, integration and assimilation into the Arab heritage emerged to be the best options for individuals' well-being; individuals' assimilation into their European heritage seemed to be simultaneously connected with high and low well-being outcomes; and ethnic marginalization of individuals was consistently correlated with poor well-being.

Acculturation↗

Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice.

Overdose of acetaminophen, a widely used analgesic drug, can result in severe hepatotoxicity and is often fatal. This study was undertaken to examine the effects of arabic gum (AG), which is commonly used in processed foods, on acetaminophen-induced hepatotoxicity in mice. Mice were given arabic gum orally (100 g l(-1)) 5 days before a hepatotoxic dose of acetaminophen (500 mg kg(-1)) intraperitoneally. Arabic gum administration dramatically reduced acetaminophen-induced hepatotoxicity as evidenced by reduced serum alanine (ALT) and aspartate aminotransferase (AST) activities. Acetaminophen-induced hepatic lipid peroxidation was reduced significantly by arabic gum pretreatment. The protection offered by arabic gum does not appear to be caused by a decrease in the formation of toxic acetaminophen metabolites, which consumes glutathione, because arabic gum did not alter acetaminophen-induced hepatic glutathione depletion. Acetaminophen increased nitric oxide synthesis as measured by serum nitrate plus nitrite at 4 and 6 h after administration and arabic gum pretreatment significantly reduced their formation. In conclusion, arabic gum is effective in protecting mice against acetaminophen-induced hepatotoxicity. This protection may involve the reduction of oxidative stress.

Acetaminophen↗

The learning of Hebrew by Israeli Arab students in Israel.

The relationship was investigated between the attitudes and cultural backgrounds of Israeli Arab students and their reading comprehension of Jewish and Arab stories. The participants were 210 Israeli Arab students in the 10th grade. An attitude questionnaire, Arab and Jewish stories, multiple-choice questions about each story, and a semantic differential test for evaluating the stories' characters were used. The students scored higher on reading comprehension of texts from their own (Arab) culture than of texts from the unfamiliar (Jewish) culture. The motivation of the Arab students to learn Hebrew was primarily instrumental rather than integrative. The participants evaluated Jewish characters and their roles more negatively than they evaluated Arab characters in both the Jewish and Arab stories.

Adolescent↗

Commitment among Arab adolescents in Israel.

Arab adolescents' commitments to their own self-development, their family, their extended family, the Arab people, and their village were explored. The sample consisted of 662 Arab adolescents in 12th grade in 7 high schools in Arab villages, Arab towns, and mixed towns (Jews and Arabs) in Israel. The findings reflect the unique situation of Arab adolescents living in Israel. The polarity found between individualistic and collectivistic ideas, in terms of commitment, illustrates the cultural transformation that Arab society in Israel is currently undergoing.

Acculturation↗

IgE antibodies specific for carbohydrates in a patient allergic to gum arabic (Acacia senegal).

The present study deals with the detailed investigation of the IgE antibody response of a gum arabic-allergic patient. The patient showed multiple serologic and skin test sensitizations to a range of pollen, other inhalants and foods, and bee venom, and to the recombinant allergens Bet v 1 and Bet v 2. Moreover, the patient's serum reacted strongly to gum-arabic extract. The NaIO4-treated and thus deglycosylated extract showed no binding to IgE. In contrast, removal of the protein backbone by basic hydrolysis did not deplete the IgE reactivity. Therefore, it is concluded that the gum arabic-specific IgE antibodies of this patient were mainly directed against the carbohydrate fraction of this material. In IgE-inhibition assays, cross-reactions occurred in the range of 60% between gum arabic and known immunogenic N-glycans containing alpha1-3-linked fucose. Since the inhibition graphs were not parallel and the inhibition was not complete with heterologue antigens, the cross-reacting epitopes of gum arabic appeared to be different from the latter well-known cross-reactive carbohydrate determinants (CCD). Inhibition may have been caused by a partial immunologic identity of the investigated carbohydrate moieties. A strong IgE response to the fucose-containing glycan from bromelain was measured in a glycan ELISA that utilizes purified glycopeptides at the solid phase. This response, which may explain the multiple sensitizations without clinical significance diagnosed in the patient, could originate from inhalation of pollen, which is known to contain similar glycans, or from occupational sensitization during work as a baker and confectioner. Since the gum-arabic protein showed only very weak participation in the IgE reactivity, the clinical symptoms of the patient caused by gum arabic may be attributed to carbohydrate epitopes. Due to the repetitive polysaccharide sequence of gum arabic, several epitopes for the cross-linking of IgE should exist.

Allergens↗