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At least 73 records · Page 4Linked to original sources
PubMed1983

[Functional relations between the adrenal cortex, thyroid gland and pineal body. I. Reactions of the adrenal cortex following interference with the thyroid regulatory cycle].

Histologic-cytological and morphometrical changes were investigated in the adrenal cortex of male Wistar-rats in experimental hypo- and hyperthyroid situation. Under hypothyroid metabolism's situation (methylthiouracil-application or thyroidectomy) a regressive transformation was found: It is a decrease of secretion of the fascicular zone. The glomerular zone was activated. After long-time application of high dosis of thyroxin, the histological findings show some criteria of an increasing function and also of a beginning exhaustion, too. It is evident, that the duration of the hyperthyroid situation is important. Thyroxin is an unspecific stressor. The long-time application of high thyroxin dosis induced a regressive transformation and atrophic changes in the adrenal cortex. The nuclei of the fascicular and the glomerular zone were diminuated significantly.

Adrenal Cortex↗
PubMedDate not supplied

[Process of bile formation and bile composition in albino rats in acute adrenal cortex insufficiency and adrenal gland autologous transplantation].

Experiments were conducted on 84 male albino rats. A study was made of the state of the bile forming process 7, 14 and 30 days after bilateral adrenalectomy and adrenal gland autotransplantation. Investigations carried out showed inhibition of the bile formation with the corresponding changes in the chemical composition of bile to occur both in adrenalectomized animals and the rats with adrenal autotransplantation; in the second case, however, these changes were less pronounced. A gradual suppression of the intensity of bile production, cholate formation, bilirubin- and cholesterol secretion occurred in the adrenalectomized rats, whereas in the animals a significant shift in the direction of restoration took place as soon as in 7 days after autotransplantation. The first to become restored is the cholesterin secretory function in the liver, then the intensity of the cholate formation, particularly the glycocholic and desoxycholic acids, and bilirubin secretion. The intensity of bile secretion, as well as the sum total content of cholates in the bile, chiefly on account of taurocholic acid, failed to reach the initial level even by the 30th day after the adrenal gland autotransplantation.

Acute Disease↗