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[The surgical treatment of hemorrhoids. Their suturing ligation without excision].

Analysis is made of the results of application of a modified method offered by the author "suturing ligature without excision" in hemorrhoids. It consists of suturing ligature of the vascular bundle, including ligation of the hemorrhoid node itself without excision. For the period 1981-1988 the method was applied on 32 patients. The results were compared with those in a control group of 105 patients operated by the method of Milligan, Morgan. The mean postoperative hospital treatment lasted 3.2 days, vs. 11.4 days in the control group. It was moreover characterized by minimal pain, good state of well-being and hygiene, normal intestinal passage from the first day with flatulence and defecation. Pain lasting more than 24 hours had only 2 patients, vs. 97 in the control group. There was no constrained retention of bowel movement, which in the control group led to difficult flatulence in 101 patients and exacerbation of colitic complaints. The method is pathogenetically substantiated. It provides ligation of the terminal branchings of a. rectalis sup. averts relapses and postoperative bleeding, preserves a sufficient mucosal surface to ensure the physiologic act of flatulence.

Hemorrhoids↗

[Male-female transsexualization with glandular preservation].

The choice of the tissue to build up the neovagina is an important step in the surgical treatment of transsexualism. Both the penile skin and an intestinal segment are possible solutions to the problem. However intestinal segments have some defects like continuous secretions and painful intercourse. For these reasons the authors prefer the penile skin with the neuro-vascular bundle preserved. One hundred cases of this surgery are presented.

Female↗

[The postresuscitation changes in the permeability of the hemato-encephalic barrier and their possible pathogenetic significance].

Experiments were conducted on rats with temporary (10-min) clamping of the thoracic vascular bundle and subsequent resuscitation to study the permeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period. Mild increase of BBB permeability was detected 3 minutes after the beginning of recirculation. Permeability increased markedly in 24 hours and continued growing by the 72nd hour. At a 1-3-hour interval in recirculation the BBB was closed. The obtained results disclose the mechanisms of the development of autoimmune cerebral disorders in an organism that experienced cardiac arrest and resuscitation.

Animals↗

[Neurovascular sparing radical prostatectomy].

Radical prostatectomy means a surgical removal of the whole prostate gland with its capsule and seminal vesicles. The fact that this operation is not performed frequently is usually due to late diagnosis of this condition rather than to involvement indicated for radical prostatectomy. The paper describes a technique which helps to spare the sphincter and posterolateral nervous and vascular bundles, as these are responsible for continence and erectile potency. The experience acquired is based on good results obtained in 13 patients, and the author stresses the importance of early diagnosis of carcinoma of the prostate using preventive per rectum examinations in male patients over 45 years.

Aged↗

Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy.

Much recent work has focused on the progressive nature of renal injury, and hemodynamic alterations have been implicated in the pathogenesis of the predominant lesion, focal glomerulosclerosis. Despite the well-documented atherogenic toxicity of lipids in cardiovascular morbidity, little is known about lipid-associated renal injury. However, lipids are toxic to endothelium, and the glomerulus is a vascular bundle. Several authors participating in this symposium have presented evidence for an association between hyperlipidemia and glomerulosclerosis in animal models. This association is particularly significant given the expanded therapeutic armamentarium now available to treat hyperlipidemia. In fact, glomerular injury may be moderated by pharmacologic treatment of hyperlipidemia in a rat renal ablation model. Very little evidence exists, however, for a similar association in human renal disease. We have, in the course of clinical practice, made certain observations in renal biopsy specimens that may for the first time link atherogenesis and lipid deposition to human glomerular injury.

Arteriosclerosis↗

[Magnetic resonance tomography of the heart in healthy persons].

Potentialities of MR-tomography of the heart were studied in 20 healthy persons. Synchronization with the cardiac cycle on ECG was used in 15 cases. The VMT-1100 MR-tomograph (Brucker, FRG) was employed. The spinecho technique was used. MR-tomography of the heart was performed in axial, sagittal, frontal and oblique planes with relation to the anatomical heart axes. All major heart structures and mediastinal vascular bundles were clearly visualized on MR-images obtained by means of synchronization with the cardiac cycle. In some cases pericardial zones and fragments of coronary arteries were seen. MR-tomography permitted imaging of the heart in a desired phase of the cardiac cycle. This method was shown to be highly informative, providing quality images of the cardiac chambers and walls in different planes, permitting their quantitative and qualitative assessment. Further improvement of the method and programs for it will permit raising its diagnostic potentialities in studies on the heart.

Adult↗

Ultrastructural evidence for alterations of pituicytes in reanimated rats in connection with experimentally induced clinical death.

This work was undertaken to elucidate some ischaemic and postischaemic changes appearing in the neurohypophysial pituicytes of rats which underwent the incident of clinical death. The incident was experimentally induced by compression of the vascular bundle of the heart for 2.5 min. The ultrastructural organization of pituicytes was investigated directly after reanimation and 3 days after surviving the clinical death. These studies provided evidence for numerous alterations in pituicytes indicating a high sensitivity of the cells to the ischaemic conditions. Thus, four varieties of pituicytes were revealed based on their ultrastructural characteristic, namely: "swollen", "dark", "vacuolated" and "intermediate". Except for the "intermediate" pituicytes (abounding in liposomes), embedding of neurosecretory axons in pituicytes was commonly observed, and thus, several phases of axon degeneration due to pituicytes were noted, including disintegrated axolemma and appearance of a peculiar arrangement of microtubules. These findings strongly support the hypothesis of neuronal-glial interaction in the neurohypophysis under physiological and/or pathophysiological conditions. Thus, the results of the present study are discussed in terms of pituicytes involvement in the mechanisms of control (restriction) of neurohypophysial hormones release in reanimated rats.

Animals↗

[Morphofunctional evaluation of the condition of the brain in rats with different degrees of recovery of neurological status following arrest of systemic blood circulation].

The brain status was studied for four days after resuscitation of rats with different degrees of recovery of the neurological status after systemic circulatory arrest induced by the occlusion of vascular bundles of the heart. Morphometric analysis of the population of Purkinje cells from the two different functional zones of the cerebellum revealed that in comparison with completely recovered rats, the animals with disturbed neurological status were characterized by loss of neurons, disturbed composition of the neuronal population, development of severe dystrophic cell changes. The lateral zone of the cerebellum hemisphere was most affected. Four days after resuscitation all the animals showed a sharp increase in the size of the nucleus of Purkinje cells, which is considered to be one of the mechanisms of neuronal adaptation to hypoxia.

Animals↗

The vascularization of the peripheral nerve of chicken and rat.

The vascular system of the sciatic nerve of chicken and rats was examined by means of the microcorrosion casting technique and freeze-broken specimens. The main epineural vessels form two lateral and interfascicular vascular bundles which anastomose with one another and also with the peri- and endoneural plexuses. On epi- and perineural vessels one can find morphological correlates for regulative means such as sphincters. Even the endoneural vessels depict numerous anastomoses. The proximity of the vessels as well as the great number of anastomoses suggests a considerable compensatory potential with an adaptable perfusion rate in case of a partial breakdown of a plexus.

Animals↗

[Ventral approach to the cervical spine].

Since they were introduced in 1950, ventral approaches for surgical operations on the cervical spine have become widely used. The most frequently used is the anteromedian approach, passing along the anterior border of the sternocleidomastoideus muscle and then between the upper gastrointestinal tract and the vascular bundle to give access to the spine. This approach allows access to practically every segment of the cervical spine. The significance of the transoral approach is stressed in the literature, and we ourselves are also convinced of its importance. In this paper, however, the combined anteroposterior procedures and the cervicothoracic methods used for the transitional zone are also described. Complications affecting the upper gastrointestinal tract, the vessels or the nerves are always possible, and to reduce their likelihood to a minimum it is essential to make a detailed study of the complicated anatomy of the neck region.

Cervical Vertebrae↗

[High-dose preoperative radiotherapy of primary inoperable oropharyngeal cancer].

Despite the great progress made by tumor therapy in recent years, it has not yet been possible to obtain a decisive improvement in the five-year survival of about 20% and the five-year recurrence-free survival of about 30% of patients suffering from advanced T3 oropharynx carcinomas. A new way to improve the poor prognosis of these patients is only offered by the possibilities of modern radiotherapy with ultrahard X-radiation as well as by the progress of microsurgery. Up to now, the recurrence-free survival of our patient's group suffering from primarily inoperable T3 oropharynx carcinomas has reached 60% (increase of about 40%). This was achieved by preoperative high-dose irradiation and subsequent implantation of myocutaneous skin flaps with the vascular bundle supplying the flap with blood. As is shown by the communications of literature and our own experience, about 80% of all recurrences will appear within the first 24 months after the end of therapy. In our preoperatively high-dose irradiated group, the observation period is meanwhile 48 months, and the recurrence-free survival is still by 40% higher than that of the control groups. Although a new formation of local recurrences cannot be excluded for the further observation time and despite the small number of patients, the rate of recurrence-free patients suffering from tumors of stage T3N+ signifies a most promising therapeutic approach.

Carcinoma, Squamous Cell↗

[Conditioned reflexes in rats after 5-minute arrest of blood circulation].

Neurological recovery and conditioned activity were studied in rats resuscitated after five-minute circulation cessation caused by intrathoracal clamp of the heart vascular bundle. The dynamics of disappearance of neurological deficit was evaluated according a scale of 19 parameters of the general state of animals where number 100 meant the death of the brain and number 0 meant recovery. In the course of 8 months after resuscitation, in reanimated rats and simultaneously in intact (control) ones, an alimentary instrumental conditioned reflex was elaborated and then changed to a defensive one; passive and acute extinction of both reflexes was also carried out. In most of the rats the neurological recovery was completed rapidly within 3-4 hours. In reanimated animals, both instrumental conditioned reflexes were acquired in the same way as in the intact rats. Quantitative evaluation of the dynamics of conditioning and extinction allowed to see that elaboration of the alimentary reflex in reanimated rats proceeded faster and its change to the defensive one, and acute extinction of both kinds of conditioned reflexes went slower than in intact animals. A conclusion is drawn that even a short-term circulation cessation compatible with complete and rapid compensation of visible neurological disorders causes long-term disturbances of conditioned activity manifested in weakening of inhibitory processes.

Animals↗

[Use of vascular complexes in orthopedics].

In the treatment of 38 patients with aseptic necrosis of the femur head, wrist bones and trophic ulcers the authors have successfully used the vascularization of tissues for the improvement of their feeding by means of transplantation of isolated vascular bundles.

Adult↗

[Contribution to the study of "wet lung". Radiological and clinico-functional changes induced by depletion therapy in 5 patients with chronic bronchopulmonary disease].

The Authors consider the global evaluation of clinical and functional data in patients with the following radiological features: 1) X-ray thoracic aspects characterized by marked broncho-vascular bundles and diffusion of reticular nodulation as in diffuse interstitial pulmonary fibrosis; 2) lack of ECG and clinical signs of heart failure. Since a reversibility of radiological alterations was considered a favourable reply to bleeding and diuretic acute and long term therapy the Authors suggest that these patterns should be related to a different distribution of hydric and haematic masses with a decreasing of interstitial pulmonary oedema which contributes to a full interlobar septa like "D" lines shadows, according to Kreel, (1975). The Authors, moreover, relate these clinical, functional and radiological aspects to the patterns of "wet lung" distinguished from the cardiac lung caused by congestive heart failure and from interstitial lung fibrosis.

Bloodletting↗

[Experimental anatomic basis for tentorium cerebelli incisions].

The histotopographic features of the structure of the upper and lower layers of the tentorium cerebelli and the range of the age and individual variability of its dimensions were studied on 152 preparations. The main neuro-vascular structures are located in the lower layer of the tentorium. Two extreme forms of the structure of the neuro-vascular bundle are distinguished: main-line and spreading. Various localizations of the tentorial bundle are described: lateral, medial, and separate bilateral. A zone of the tentorium cerebelli that is relatively poor in vessels and nerves and comparatively favourable for incision is established. Measurements of the tentorium cerebelli according to age and sex made it possible to determine the optimum length of its incisions.

Adolescent↗

Free muscle graft as applied to brachial plexus injury-case report and experimental study.

Active flexion of the elbow was restored in a case with complete brachial plexus injury of ten years' standing, by using free gracilis muscle graft with restoration of its vascular pedicle and the 3rd and 4th intercostal nerves for reinnervation of the graft. Experimental studies on the anterior tibial muscle of rats showed that the major bulk of the proximal part of the muscle by preservation of neuro-vascular bundle survived and was histologically viable, whereas, the major bulk of the distal part of the muscle replaced as a free graft necrosed and was replaced by fibrosis. A free graft with its intact circulation and neural supply could therefore provide a good proportion of viable muscle bulk for functional restoration in properly selected cases.

Animals↗

[Effect of phosphorylation on glycolysis in the cells of assimilating millet leaf tissues].

The effect of phosphorylation on glycolysis reactions was studied in respect with the rate of 1-14C-glucose metabolization and the composition of synthesized labelled products in isolated cells of assimilating millet leave tissues incapable to reassimilation of respiratory CO2. Data on oxygen metabolism in mesophyll protoplasts and in cells of parenchymal facing of vascular bundle sheaths in the absence and in the presence of electron acceptors (3,5-dichlorophenolindophenol and methylviologen) show that they retain adenylate pool and energy charge characteristic of photosynthetizing tissues. The glycolysis rate decreased in illuminated cells, which did not remove carbon products from chloroplasts. Analysis of compounds produced from 1-14C-glucose exogenous ADP effect on their ration and the change of adenylate energy charge in the presence of methylviologen demonstrates that the acting factor is a decrease of Pi and ADP concentrations in cytoplasm because of their use chloroplast phosphorylation. It is suggested, that a short-cut chain of glycolysis reactions may take place in intact cells assimilating CO2 in photosynthesis, and the capacity of this chain is determined by the type of carbon metabolism and photorespiration mechanism.

Adenosine Diphosphate↗