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Arrested eruption of the permanent lower second molar.

The incidence of retention/impaction of the permanent lower second molar (M2inf) lies between 0.6/1000 and 3/1000. Therefore, the purpose of the present study was to investigate the craniofacial morphology, the frequency of dental anomalies and the inclination of the affected M2inf and the adjacent first molar in patients with arrested eruption of M2inf. The overall goal was to elucidate the aetiology of arrested tooth eruption and to present the characteristics of these patients in order to improve diagnosis and treatment planning. Radiographic material (profile radiographs and orthopantomograms) from 19 patients (nine females and 10 males; 13-19 years of age at the time of referral) were analysed. The ages of the patients when profile radiographs were taken for cephalometric analysis varied from 8 to 16 years. The study shows that this group of patients, compared with a reference group, had an increased sagittal jaw relationship (Class II). Specifically, the mandibular prognathism was less, the mandibular gonial angle smaller, the mandibular alveolar prognathism enlarged and the maxillary incisor inclination less than in the reference group. Furthermore, this group of patients had a more frequent occurrence of morphological tooth anomalies, such as root deflections, invaginations, and taurodontism. However, none of the patients with arrested eruption of M2inf had agenesis of the lower third molar. The study did not reveal an association between the degree of inclination of the M2inf and that of the first molar in the same region. The results of this investigation show that conditions such as the craniofacial morphology and deviations in the dentition are associated with arrested eruption of M2inf. Therefore, it is important to evaluate these conditions in future diagnosis and treatment planning of patients with arrested eruption of M2inf.

Adolescent↗

The relationship between eruption and length of mandibular incisors in young rats.

BACKGROUND: Rat incisor teeth exhibit continuous growth, hence they have frequently been used to study the eruption process. The aim of our study was to investigate changes in the eruption rate of impeded and unimpeded rat incisors and to determine if any relationship existed between eruption rate and length of the clinical crown. MATERIAL/METHODS: An image analysis technique was used to measure the length of the mandibular incisors of 23 young female Sprague-Dawley rats, aged 7 to 8 weeks. Over a four-week period, the mandibular right incisors of the 11 rats in the experimental group were shortened every two or three days. Another group of 12 rats served as the control. RESULTS: The mean unimpeded eruption rate was 1.0+/-0.1 mm/day, while the impeded eruption rate was 0.6+/-0.1 mm/day. On day 2, the eruption rate of the unimpeded mandibular incisors accelerated to 163.9% when compared to the controls. The impeded mandibular incisors increased in length by 8.8% and 12.1% for the experimental and control groups respectively. An inverse relationship was identified between the eruption rate and the length of clinical crown of the impeded mandibular incisors, while the unimpeded eruption rate was unrelated to the length difference between the left and right incisors if the length difference exceeded 0.5 mm after accelerated eruption. CONCLUSIONS: It was found that the mandibular incisors of young rats need to be shortened every two days in order to study unimpeded tooth eruption, and the shorter the tooth is cut the higher the rate of eruption.

Animals↗

The effect of cortisone on the eruption rate of root-resected incisors in the rat.

It is generally thought that the periodontal ligament plays a key--perhaps even exclusive--role in tooth eruption. The present study was designed to test the hypothesis that the fundus also may contribute to the process. To this end the effect of cortisone on the eruption rate of root-resected mandibular incisors was examined in male albino rats. Half of the animals received daily injections of cortisone; the other half were given normal saline. Impeded and unimpeded eruption rates were measured at 3-day intervals and tested for between- and among-means differences by repeated-measures analysis of variance (ANOVA). In contrast to the acceleration commonly seen in intact incisors, cortisone produced no change in the eruption rate of root-resected incisors. It was concluded therefore that the accelerative effect of cortisone is mediated by the fundus, rather than the periodontal ligament. Further, it is hypothesized that early eruption is controlled by cellular proliferation within the fundus; however, once the tooth enters the oral cavity and becomes functional, the periodontal ligament matures and becomes the dominant factor in subsequent eruption.

Alveolar Process↗

Management of nasally erupting deciduous canine in operated cleft lip and alveolus patient.

Nasally erupting tooth is a rare finding seen associated with cleft lip and alveolus. It may be diagnosed as a result of symptoms such as difficulty in breathing, pain on sneezing or blowing the nose or may remain asymptomatic. A case of a 4 year old male child operated for bilateral cleft lip and alveolus with unilateral right sided nasally erupting deciduous canine is presented here.

Child, Preschool↗

[Pre- and post-eruption effects on the functional morphology of the articulating structures].

Profile traces of latero- and protrusive facets of subjects with class-I-occlusion showed characteristic regular patterns in curvature and angle to the occlusal plane. There was no significant correlation between the laterotrusive surface profiles and the corresponding transversal movement of the condyle which was recorded electronically in 3 dimensions. Curvature morphology was plotted as a function of tooth eruption, development of the dental hard tissues, and tooth wear. In conclusion the results were applied to comprehensive occlusal restorations.

Dental Arch↗

Video microscope observations of human premolar eruption.

It is now possible to observe with an accuracy of 1-2 microns the pattern of eruptive movements of a human premolar as it moves from gingival emergence to the occlusal plane. This was accomplished by use of a video microscope to track the position of an optical ruling on the erupting tooth relative to a reference ruling mounted on adjacent teeth that were in occlusion. Net eruptive movements averaging 25-75 microns occurred from one day to the next until the tooth was almost in occlusion; then the eruptive rate slowed. Eruption occurred almost entirely at night. During the day, there was a marked slowing or cessation of eruption and often intrusion, which appeared to be related to masticatory activity.

Adolescent↗

[Genetic analysis of tooth development and eruption in 82 pairs of female-female twins].

OBJECTIVE: To study the heritability of tooth development and eruption. METHODS: 82 pairs of female-female twins between 6-12 years old were collected. Twin zygosity diagnosis were made by DNA-fingerprinting. The number of third molar present, hypodontia, upper lateral incisor malformation and the number of erupted permanent teeth were recorded by oral examination and panoramic radiographs, their heritabilities were calculated. RESULTS: According to the level of heritability, the dental traits were aligned as follows: the number of third molars present, the upper lateral incisor malformation, hypodontia and the number of erupted permanent teeth. CONCLUSION: Though both the tooth development and its eruption were under genetic influence, the heritability of tooth development was far more than tooth eruption.

Adolescent↗

The eruption of permanent incisors and first molars in prematurely born children.

The purpose of this work was to examine whether the clinical eruption of the permanent first molars and incisors is affected by pre-term birth. The data applied to 328 prematurely born white and black children and 1804 control children who participated in the Collaborative Perinatal Project (USA) in the early 1960s and 1970s. The dental examinations had been performed in a cross-sectional manner at ages varying from 6 to 12 years in 95 per cent of cases (range 5-14 years). Dental casts were placed in matched pairs by sex, race and conceptional age for comparison of the four clinical stages of eruption of the permanent incisors and first molars between the pre-term and control children. The results showed significantly (P < 0.05) earlier tooth eruption in the pre-term children. The findings suggest that the eruption process is earlier in those teeth that go through a sensitive period circumnatally, being at the pre-eruptive stages and entering the first phases of mineralization under the influence of various neonatal systemic factors and accelerated growth period (catch-up growth) with related unknown mechanisms, which may influence the eruption of the permanent incisors and first molars in prematurely born children.

Adolescent↗

A histochemical study of apoptosis in the reduced ameloblasts of erupting mouse molars.

Apoptotic reactions were demonstrated with a commercial detection kit in the reduced ameloblasts around the tip of the cusp just before and after exposure to the mouth but, as tooth eruption advanced, they were no longer seen in the remainder of the reduced ameloblasts. Although some of the reduced ameloblasts appear to be expelled as a consequence of apoptosis, the remainder appear to constitute the junctional epithelium.

Ameloblasts↗

Tooth-by-tooth survival analysis of the first caries attack in different age cohorts and health centers in Finland.

The aims of this study were to test the hypothesis that existing patient records serve as a source of data for survival analysis of dental health and to develop a system for routinely conducted survival analysis of dental health from tooth eruption to first caries attack. Patient records for three cohorts were collected from four towns in Finland: Oulu, Turku, Kuopio, and Kemi. The study population comprised 2103 children born and living in these towns. The Kaplan-Meier curves for dental caries were drawn separately for each tooth and for the maxilla and mandible (for each age cohort). Placements of the first restoration of all teeth in each age cohort were investigated. The 1960 cohort had an extremely high post-eruptive morbidity in all teeth. The 1970 cohort had relatively high immediate post-eruptive morbidity in both molars, but much lower than that of the 1960 cohort. The filling increment rates for second molars were lower than those of the first molars in the 1970 cohort. Characteristic of the 1980 cohort was a rapid increase in the caries increment of the premolars and second molars 4 years after eruption. The results indicate a big difference in tooth-by-tooth dental health in Finland. A huge decline in caries attack was seen from the 1960 cohort to the 1980 cohort, but a deterioration of dental health in premolars and second molars is clearly seen in the 1980 cohort in the 1990s.

Adolescent↗

Disturbed enamel mineralization in a rat incisor model.

Possession of full-thickness hard enamel appears to be one of the indispensable life-saving characteristics of rats. Previous studies by Suga and his colleagues and by others demonstrated that various types of malformation are evoked in continuously erupting rat incisors. In the current report, we directed our effort to oversee various types of enamel malformation caused experimentally in rat incisors. We surveyed the specimens collected by Suga and his colleagues, as well as specimens we obtained. From the results, it is conceivable that perturbation of the programmed sequential events during enamel development is a major factor in the establishment of enamel malformation. Animal studies with either 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) or a multidentate phosphonic acid (EDTPO) confirmed that dentin mineralization provides a certain inductive effect on the secretion of enamel matrix and subsequent enamel crystallization. Our recent studies using anti-microtubular agents led to the conclusion that the acceleration of mineralization in outer enamel is a type of enamel malformation, most likely due to disruption of the cellular regulation of calcium transport under severe toxic regimens. In future work, experimental approaches combining measurements of kinetic factors with static observation of enamel lesions are required before we can gain a comprehensive understanding of the pathogenesis of disturbed enamel mineralization. The kinetic factors to be considered include the rates of tissue apposition and tooth eruption which determine the total volume of tooth substance formed, and the rate of mineral accretion. Furthermore, information as to the composition, crystallinity, solubility, and mechanical properties of enamel defects is needed before we can assess the susceptibility of teeth having those lesions to caries and other physico-chemical attacks in the oral environment.

Ameloblasts↗

Factors influencing the susceptibility to gingivitis during childhood--a review.

A variety of biological changes take place during childhood which have an impact on the development of gingival inflammatory disease. This paper reviews the literature concerning changes in the susceptibility to gingivitis during childhood. It is concluded that during certain periods the risk of developing gingivitis is relatively low, while in others the gingival tissues are more susceptible and react to bacterial irritation with inflammation. Factors that may be responsible for these changes include differences in bacterial plaque composition, in immune defence systems and in morphology of the gingival tissues, and also factors related to tooth eruption and puberty.

Adolescent↗

In vivo and in vitro effects of epidermal growth factor on its receptor gene expression in rat dental follicle cells.

Epidermal growth factor receptor (EGFR) is known to be localized early postnatally in the follicle of rat mandibular molars and to decline later. Here, EGFR mRNA present early postnatally in the follicle was revealed by in situ hybridization and reverse transcription-polymerase chain reaction. Injections of epidermal growth factor (EGF) enhanced the expression of EGFR mRNA but not EGF mRNA through day 5 postnatally in the follicle. By day 7 postnatally, the amount of EGFR mRNA was dramatically reduced and EGF injection at that time or later did not enhance its expression. Cultured dental follicle cells were also shown to contain both EGFR mRNA and EGF mRNA, but only EGFR mRNA expression was enhanced after incubation of the cells with EGF. The EGFR mRNA was apparently translated, because the cultured cells could be immunostained for EGFR. This enhancement of EGFR mRNA in the dental follicle cells by EGF may be a necessary prelude to the mitogenic effect of EGF on the cultured cells because incubating the dental follicle cells in EGF over 6 days resulted in almost a doubling in their number as compared to controls. These results indicate that the tissue necessary for eruption to occur, the dental follicle, contains EGFR mRNA in the early postnatal days. In turn, this mRNA is enhanced by EGF, a molecule known to accelerate eruption if injected early postnatally. Whether or not the mitogenic effect of the EGF on the cultured dental follicle cells is a mechanistic factor that contributes to the subsequent tooth eruption is unknown.

Animals↗

The effect of age on morphology and eruption of the lower incisors in mature rats.

OBJECTIVE: This study investigated the effect of age on tooth and periodontium morphology and on tooth eruption in the lower incisors of 28 female rats, initial age 10 weeks. DESIGN: Morphometric data of the incisors in three young mature rats (weight 199+/-2.4 g) were compared to that of three 18-week-old (weight 260+/-5 g) animals. The rate of eruption was monitored during 12 months in 11 rats with all teeth in occlusion and in 11 rats with one lower incisor kept constantly out of occlusion. RESULTS: : The incisors continued to enlarge after the animals reached maturity with the size of the teeth increasing both longitudinally and circumferentially. Tooth volume increased by 21%, while that of the periodontal ligament was enlarged by only 12%. The rate of impeded eruption declined steadily from a mean value of 542+/-49 microm/day during the first experimental month to a mean value of 443+/-25 microm/day during the concluding month (p<0.05). The eruption rate of the teeth exceeded that of attrition rate by 2.4%. The unimpeded eruption proceeded steadily throughout the experimental year, at a mean rate of 811+/-12. CONCLUSIONS: Apparently in mature rats age has no effect on the genetic potential as expressed by the unimpeded eruption. In the impeded teeth age does affect the phenotypic expression of the eruptive function governed by occlusal forces as well as by the form and size ratio of the tooth and its PDL.

Age Factors↗