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At least 703 records · Page 39Linked to original sources
PubMed1997

Late developing supernumerary teeth in the mandible.

This paper presents two cases in which supplemental premolars were an incidental finding. Although anomalies of tooth number and form are quite common, both cases demonstrate late forming supernumeraries with one case illustrating their development in a more unusual site. It is not routine practice to screen for late development of teeth during orthodontic treatment. Therefore the possibility of their interference with occlusal development or orthodontic mechanics such as space closure, should always be kept in mind.

Bicuspid↗
PubMed2001

Mandibular advancement using an intra-oral osteogenic distraction technique: a report of three clinical cases.

Osteogenic distraction has been used for decades to lengthen limbs and now attention is focused upon its use within the craniofacial skeleton. This paper addresses distraction of the mandible. It is proposed that mandibular osteogenic distraction could be a possible adjunct to the orthodontic treatment of those adult patients with skeletal anomalies, who would benefit from combined orthodontic/orthognathic treatment. Three consecutive cases from one unit are presented, where adult patients with severe Class II division 1 malocclusions have undergone orthodontic treatment combined with mandibular osteogenic distraction, instead of conventional bilateral sagittal split osteotomies.

Adolescent↗
PubMed2003

Forestadent Young Specialist Prize (1999).

This paper describes the clinical orthodontic treatment of the three cases that were awarded the 1999 Forestadent Young Specialist Prize. There are two Class II division 1 cases treated by different treatment modalities and a Class II division 2 case complicated by a palatally ectopic maxillary canine. These case reports demonstrate the three main treatment modalities available to the orthodontist for treating skeletally-based malocclusions, i.e. growth modification, orthodontic camouflage, and a combined surgical-orthodontic approach.

Adolescent↗
PubMed1997

In search of the harmonious face: Apollo revisited, with an examination of the indications for retrograde maxillary displacement.

A historical review of our perception of facial flatness and convexity and what constitutes "a pleasing face," both in North America and internationally, is provided. Attractive faces may range from slightly flat ("Apollonian") to mildly bimaxillary protrusive, but marked deviations in either direction, from the dish face to extreme bimaxillary protrusion, constitute a deformation and warrant combined orthodontic and surgical treatment. Technical aspects of segmental and total maxillary setback are presented, along with four representative cases.

Asian People↗
PubMed2006

Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets.

Microarray technologies have come into prominence for the assessment of molecular diagnostic profiles in cancer tissue biopsies. To better understand the effect of sampling bias, we paired image-guided stereotactic biopsy and microarray technology to study regional intratumoral differences in tumor periphery and core regions of untreated glioblastoma. RNA was extracted from serial frozen sections using an integral histopathologic scoring approach. Gene expression analysis was performed using high-density oligonucleotide microarrays (22,283 probe sets). A consensus list of 643 genes (784 probe sets) with greater than 2-fold difference between intratumoral periphery and core samples was obtained using Microarray Suite 5.0, model-based expression indexes, and robust multiarray analysis algorithms. Results were validated using quantitative polymerase chain reaction and Western blotting analyses. Reproducible profiles emerged, in which multiple therapeutic targets significant to glioblastoma [matrix metalloproteinases, AKT1 (v-akt murine thymoma viral oncogene homolog 1), epidermal growth factor receptor, vascular endothelial growth factor] showed significant differences in regional expression that may affect treatment response. This study suggests important intratumoral regional differences in the molecular phenotype of glioblastoma.

Algorithms↗
PubMed1986

RAST inhibition: a collaborative study on its suitability and reproducibility for the assay of cocksfoot pollen extracts.

The suitability and reproducibility of the inhibition mode of the radioallergosorbent test (RAST) as a method for the assay of allergen extracts was examined in a collaborative study involving seven laboratories. Participants assayed five coded extracts of cocksfoot grass (Dactylis glomerata) pollen, including three batches from one manufacturer, both by a common method and by their local methods of RAST inhibition. For the versions of RAST inhibition employed in this study the estimates of relative potencies of the extracts were in agreement. Further, when laboratories used their local methods, the inter-laboratory variation in potency estimates was similar to that found when laboratories used the common method. It was concluded that RAST inhibition has a useful role in the assessment of the potencies of allergen extracts, and of the consistency of serial batches of extracts from individual manufacturers.

Allergens↗
PubMed2005

The minimum number of clones necessary to sequence in order to obtain the maximum information about hepatitis C virus quasispecies: a comparison of subjects with and without liver cancer.

Most studies of hepatitis C virus (HCV) quasispecies have reported the results of sequencing only three to five clones per sample. The possibility that sequencing so few clones might not provide a representative picture of the quasispecies present in a sample has never been evaluated. The present study was conducted to evaluate whether sequencing greater numbers of clones results in better information about the HCV quasispecies number and distribution, and to compare the HCV quasispecies in liver cancer cases and controls. RNA was extracted from serial serum samples from six subjects with HCV-associated liver cancer and 11 age- and sex-matched HCV-infected controls without liver cancer. The hypervariable region 1 (HVR1) of the HCV genome was amplified, cloned, and sequenced. For further studies of 12 serum samples from two liver cancer cases and two matched controls, successive groups of 10 additional clones were sequenced up to a total of 50 clones per serum sample. When only 10 clones were sequenced from each specimen, no consistent differences were seen between the number of HCV quasispecies in the six liver cancer cases and the 11 controls. However, sequencing 40 clones from each of 12 samples from two liver cancer cases and two controls revealed a greater number of quasispecies in liver cancer cases than in controls. Testing an additional 10 clones (50 clones per sample) did not significantly increase the number of quasispecies detected.

Genetic Variation↗
PubMed1975

Cutaneous reactions to pollen extracts in patients with hay fever. Special references to grass pollen recommended for treatment in fixed combination.

Skin reactivity to 8 common grass pollens was investigated in patients with hay fever using commercial, unfractionated extracts in serial dilution technique. The highest degree of sensitivity was observed for cocksfoot, meadow fescue, meadow foxtail, rye grass, timothy and Yorkshire fog. Five of those are included in the Allpyral 5-Grass Mix. The cutaneous responses to rye grass pollen overlap with those to timothy in a high degree.

Adolescent↗