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Results for “RUBIDIUM”

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At least 703 records · Page 39Linked to original sources
PubMed1981

Changes in 86-rubidium uptake in erythrocytes of digoxin-treated patients, in heart failure with sinus rhythm. Relationship to clinical effects.

Previous studies have shown a significant relationship between the clinical effect of digoxin and a tissue response, namely the inhibition of 86Rb uptake by the patients' erythrocytes. In the present study, this relationship is confirmed in patients, in heart failure with sinus rhythm. The slowing of the heart rate but not the QS2 index changes correlates significantly with the 86Rb uptake inhibition.

Adult↗
PubMed1983

GABA uptake by human blood platelets: effects of lithium and rubidium chlorides.

The methodologic and kinetic characteristics of GABA uptake by platelets were determined in blood platelets of volunteer donors. Extrapolation of a reciprocal plot indicate two uptake systems: a high affinity and a passive diffusion mechanism. When LiCl and RbCl were added in vitro, they had no effect on platelet GABA uptake. Our data suggest that platelet GABA and 5-HT uptake are carried out by different systems.

Adult↗
PubMed1983

GABA binding in human blood platelets: in vitro effects of lithium and rubidium chlorides.

Methodologic and kinetic properties of gamma-aminobutyric acid (GABA) binding were studied in platelet materials of different nature. Platelet GABA binding was saturable and specific. LiCl and RbCl added in vitro at concentration of 0.01 mM increased significantly platelet GABA binding. This activator effect, and its kinetic characteristics were different from those obtained for GABA uptake and 5-hydroxytryptamine (5-HT) binding, which suggest that the three processes are different in platelets.

Adult↗
PubMed1984

Myocardial perfusion with rubidium-82: III. Theory relating severity of coronary stenosis to perfusion deficit.

The relation between the quantitative perfusion deficit, as measured by emission computerized tomography, and the severity of coronary artery stenosis is important for the noninvasive clinical evaluation of coronary artery disease in man. Positron emission tomography allows direct noninvasive measurement of myocardial perfusion and quantification of the size of the perfusion defect. Given this important information, a mathematical model has been derived to gauge the severity of a coronary stenosis from quantitative perfusion measurements in the normal and poststenotic regions of the heart. The theoretical basis is presented for relating regional myocardial perfusion and regional perfusion resistance to total coronary blood flow and resistance at normal resting flow and during maximal coronary vasodilation. The concept of perfusion reserve is presented as a clinical measure of the severity of a stenosis.

Coronary Circulation↗
PubMed1982

The influence of the cryopreserving process on rubidium uptake by human spermatozoa.

The effect of cryopreservation and its phases on the netto-Rb+ uptake (analogous to the K+ uptake) of washed human spermatozoa was investigated under different conditions. The Rb+ uptake reached a steady state after almost 50-min incubation both before and after the cryopreserving process. The Rb+ uptake could be reduced to about 30% by ouabain and to about 80% by monoiodoacetate. The cryoprotective agents glycerol (G), ethylene glycol (EG), and particularly dimethylsulfoxide (DMSO) reduced the Rb+ uptake by a factor dependent on its concentration. The comparative cryopreservation with G, EG, DMSO,and dimethylformamide (DMFA) as cryoprotective agents caused an inhibition especially of the ouabain-sensitive netto-Rb+ uptake. This inhibitory effect became stronger from G to EG and from DMSO to DMFA. Within the course of cryopreservation especially the process of pelletation, Rb+ uptake was reduced, whereas the prolongation of the equilibration time up to 180 min moderated the effect of the cryopreservation on the Rb+ uptake. Beside the reduction of the absolute Rb+ uptake, the cryopreservation altered the dependence of the netto-Rb+ uptake on the extracellular Rb+ concentration in a sigmoid manner.

Dimethyl Sulfoxide↗