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Searching the literature and computerized services in ophthalmology.

The individual searching the literature of ophthalmology should not find this a time-consuming or frustrating activity. The basic guides to the literature are described, and methods for obtaining information are outlined. The value of orienting oneself to each guide before using it is stressed. Special attention in this communication is given to locating current material; however, guides for searching the older literature are presented also. Since several computerized searching services can be helpful, their programs are briefly described; addresses are given for current prices and additional information. Some of the online services may be accessible in your local or regional medical library. When you become conversant with these guides and methods you will be able to find more information than before, and you will be able to find it more quickly.

Abstracting and Indexing↗

Sample size calculations for ophthalmologic studies.

Sample size calculations are shown for some common ophthalmologic study designs in which two treatments are to be compared. Included are the following three designs: 1, only one eye per subject; 2, both eyes, with each eye assigned to a different treatment; and 3, both eyes undergoing a common treatment. Continuous and binary outcomes are considered. The correlation between eyes is accounted for in the computations using a simple correction factor. For design 3, the formulas allow for a mixture of single-eye and double-eye eligible subjects. A computer program that performs the calculations is available.

Humans↗

Whither ophthalmology in the era of health care system reform?

Ophthalmology as a specialty finds itself at the center of change in health care delivery. During the Bush Administration, concerns for the profession mounted as the administration constrained ophthalmic surgical fees, limited surgical assistants, and experimented with cataract preferred provider organizations. Now, the Clinton Administration's proposed Health Security Act magnifies such concerns. This article discusses some of the specific worries that trouble ophthalmologists within the context of health system reform.

Health Care Reform↗

Statistical inference for correlated data in ophthalmologic studies.

In ophthalmologic studies, each subject usually contributes important information for each of two eyes and the values from the two eyes are generally highly correlated. Previous studies showed that test procedures for binary paired data that ignore the presence of intraclass correlation could lead to inflated significance levels. Furthermore, it is possible that asymptotic versions of these procedures that take the intraclass correlation into account could also produce unacceptably high type I error rates when the sample size is small or the data structure is sparse. We propose two alternatives for these situations, namely the exact unconditional and approximate unconditional procedures. According to our simulation results, the exact procedures usually produce extremely conservative empirical type I error rates. That is, the corresponding type I error rates could greatly underestimate the pre-assigned nominal level (e.g. (empirical type I error rate/nominal type I error rate) 0.8). On the other hand, the approximate unconditional procedures usually yield empirical type I error rates close to the pre-chosen nominal level. We illustrate our methodologies with a data set from a retinal detachment study.

Biometry↗

A likelihood approach to estimating sensitivity and specificity for binocular data: application in ophthalmology.

Binocular data typically arise in ophthalmology where pairs of eyes are evaluated, through some diagnostic procedure, for the presence of certain diseases or pathologies. Treating eyes as independent and adopting the usual approach in estimating the sensitivity and specificity of a diagnostic test ignores the correlation between eyes. This may consequently yield incorrect estimates, especially of the standard errors. The paper proposes a likelihood-based method of accounting for the correlations between eyes and estimating sensitivity and specificity using a model for binocular or paired binary outcomes. Estimation of model parameters via maximum likelihood is outlined and approximate tests are provided. The efficiency of the estimates is assessed in a simulation study. An extension of the methodology to the case of several diagnostic tests, or the same test measured on several occasions, which arises in multi-reader studies, is given. A further extension to the case of multiple diseases is outlined as well. Data from a study on diabetic retinopathy are analysed to illustrate the methodology.

Canada↗

Mail consultations in ophthalmology. The Tenth Richard E. Hoover Lecture.

BACKGROUND: Although a number of diagnostic and therapeutic methods are available to assist the ophthalmologist, relatively little attention has been given to mail consultations. By this method, a clinical summary and photographs, fluorescein angiograms, ultrasonograms, and/or other relevant materials are mailed to a consultant who then renders an opinion by telephone and/or return mail. MATERIALS AND METHODS: The records of all mail consultations that were sent to the senior author and his colleagues during a 20 year period were reviewed to determine the total number of mail consultations, the reasons for the consultations, and the diagnoses and therapeutic recommendations that were made by the consultant. RESULTS: A total of 1357 mail consultations were received during the 20 year period, with a progressively increasing number of consultations each year. Consultations were received from 757 physicians representing all 50 states in the United States and 32 other countries. Because of the authors' subspecialty in ocular oncology and medical retinal diseases, the majority of the consultations received were related to those topics. In many cases, the initial diagnosis and treatment plan were altered based on our opinion through mail consultation. Based on the material received, the recommendations that we made included observation in 635 cases, enucleation in 152, surgical excision of a lesion in 120, plaque radiotherapy in 102, laser photocoagulation in 81, systemic evaluation in 40, external beam irradiation in 36, fine needle aspiration biopsy in 33, orbital exenteration in 25, chemotherapy in 21, and cryotherapy in 14. CONCLUSION: Although not as ideal as direct patient examination, mail consultation can be an effective method of making or confirming a diagnosis and obtaining a therapeutic opinion. Although the authors have received mail consultations related to ocular oncology, this method may be applicable to other subspecialties in ophthalmology and to general medicine.

Adult↗

S.I. units in ophthalmological practice.

The introduction of S.I. units internationally means that an adaptation of the use of certain units in ophthalmological practice will have to be considered. This has important consequences, especially for the measurement of intra-ocular pressure. A survey is given and some suggestions are made for the practical use of an adapted unit for intra-ocular pressure measurement.

Humans↗

The French Egyptian campaign and its effects on ophthalmology.

Almost all soldiers of the armies involved in the Egyptian campaign fell victim to what was later called the ophthalmia militaris which we now know to be caused by Haemophilus aegyptius, N. gonorrhoea and possibly to some extent by Chlamydia trachomatis but more likely by the adenoviruses. Because of the enormous incidence of ocular infection and the controversy generated by speculation on the nature of the disease--English surgeons considered this ophthalmia to be of a contagious nature, whereas the French surgeons violently opposed this view-, the interest in diseases of the eye increased, which eventually resulted in the acceptance of ophthalmology as a separate branch of medicine.

Egypt↗

Some Byzantine chroniclers and historians on ophthalmological topics.

Byzantine historians and chroniclers recorded events not only of national importance, but also of daily life. The authors present various aspects in relation to ophthalmology. A selection of subjects including eye disorders and injuries, as well as visual problems discussed in myths, narratives and religious dogmas are presented.

Eye Diseases↗

Miraculous ophthalmological therapies in Byzantium.

A series of cures for ophthalmological diseases practised by saints are described, particularly the Saints Cosmas and Damian and the Saints Cyrus and John, the famous 'Anargyroi'. In the xenones of the Byzantine churches and in the hospitals connected to these, therapeutic regimes, cures and surgical interventions took place at night during incubation, following the example of the ancient Asclepieia. This conclusion stands in spite of the fact that the authors describing the lives of the saints were often clergy who frequently cloak the true therapeutical cures by presenting them in a supernatural manner in order to stress the divine intervention of the saints. From the operations mentioned, it is clear that cataract surgery was among the operations most frequently practised.

Eye Diseases↗

The ophthalmology of Fabricius Hildanus in the 17th century.

Wilhelm Fabricius, born in Hilden, near Düsseldorf, (Fabricius Hildanus) lived from 1560 until 1634. He had been working as physician and surgeon in Switzerland. He left a voluminous literature posthumously edited as 'Opera observationum et curationum medicochirurgicarum'. It is a compendium of 600 extremely interesting pathological cases, some of them in form of letters to close colleagues. Ophthalmology is represented by quite a big chapter, one of them reports a successfully performed exenteratio orbitae because of a tumor. Further parts, for example, describe special ophthalmic twizzers with certain fixing mechanisms and some kind of an operation table equipped by an adjustable prop for the operator's arm. Fabricius points out that after perforation of the eye the loss of aqueous humour is not consequently noxious. He, too, demonstrates the treatment of a symblepharon and describes amongst other therapies the first successful magnetic extraction of an iron foreign body out of the eye in ophthalmic history.

Germany↗

Computer-aided teaching in ophthalmology.

Computer-aided teaching is of a growing importance in ophthalmology. The following problems are particularly reviewed: sequential, ramified and tutorial teaching, exercises in simulation and the checking of knowledge. Most of the technical obstacles have now been resolved. The aim of this paper is to overcome some psychological obstacles due to partial ignorance of the subject by most lecturers in our field.

Computer-Assisted Instruction↗

A new ultrasonic apparatus for ophthalmology using manuel compound scanning.

A new ultrasonic equipment for ophthalmological diagnosis has been developed. Manual compound scanning using water immersion made acurate representation of cross-section of the orbital structure possible. A large, focused transducer brought resolution and sensitivity. Gray scale display of the ultrasonogram increased information concerning intensity of echoes. Ultrasonograms of retinoblastoma, vitreous hemorrhage, melanocytoma, optic disc coloboma and unilateral exophthalmos are presented.

Child↗

Patient data storage and retrieval using dBASE III in a pediatric ophthalmology department.

Ashton Tate's dBASE III has been adapted to store patient data for both medical and administrative purposes by the Department of Ophthalmology of Children's Hospital National Medical Center. The program is run on an IBM-PC microcomputer and stored on twin Iomega 10 megabyte cartridge disks. The advantages of this system include ready availability of both software and hardware, relative ease of customization, simplicity of use, and modest cost.

Hospital Departments↗

Military ophthalmology in the Vietnam War.

This overview of the practice of military ophthalmology by US army ophthalmologists during the Vietnam War focuses on administrative management of eye and adnexal injuries, care of the wounded military and of Vietnamese civilians, and research activities. It concludes with improvements that have been subsequently adopted.

History, 20th Century↗

Sushruta: the father of Indian surgery and ophthalmology.

Sushruta is the most celebrated physician and surgeon in India. Though he practiced during the 5th century B.C., many of his contributions to medicine and surgery preceded similar discoveries in the Western world. Sushruta devotes a complete volume of his experiences to ophthalmologic diseases. In the Uttar Tantrum, Sushruta enumerates a sophisticated classification of eye diseases complete with signs, symptoms, prognosis, and medical/surgical interventions. In particular, Sushruta describes what may have been the first extracapsular cataract surgery using a sharply pointed instrument with a handle fashioned into a trough. His ability to manage many common eye conditions of the time with limited diagnostic aids is a testament to his virtuosity.

General Surgery↗

[Current practice of immune prophylaxis and therapy in perforating keratoplasty. A survey of members of the Cornea Section of the German Ophthalmological Society].

PURPOSE: Different strategies are currently used for prophylaxis and therapy of immunological transplant reactions. The aim of the present study was to evaluate clinical practice in planning and treatment of perforating keratoplasty (KPL) in Germany. METHOD: A questionnaire was sent out to 148 members of the cornea section of the German Ophthalmological Society. The return consisted of 69 (47%) questionnaires representing 69% of institutions, 39% of responses returned from institutions performing <50 KPL/year, 15% from institutions operating >100 KPL and 4% from centres performing >300 KPL/year. RESULTS: Of the responders 13% currently never use HLA-matched grafts, 22% choose matched grafts in every risk KPL and 1.5% always use matched grafts. In normal risk situations 1.5% treat less than 2 weeks with topical steroids, 66% 3-12 months, 6.5% >1 year, 35% additionally treat with systemic steroids. Cyclosporine A (CsA) (92%) is besides steroids (80%) the most common systemic immunomodulatory agent in high risk situations, while methotrexate is used by only 9.5%. The duration of immunosuppressive therapy varies from <3 months (9%) up to >12 months (14%). The postoperative therapy after KPL in herpes includes topical (51%) and systemic aciclovir <3 (26%) and >3 weeks (67%) and additional systemic immunomodulatory agents (37%). The acute immune reaction is treated predominantly with steroids: topical (95%), subconjunctival (29%), intracameral (1.5%). Systemic steroids are given orally (48%) and intravenously (42%), 12% treat with topical CsA. CONCLUSIONS: Besides therapeutic options that are accepted as common practice (e.g. systemic CsA) clinical practice varies widely. This may reflect the lack of evidence-based clinical observations.

Adjuvants, Immunologic↗