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Some radical implications of Bach-y-Rita's discoveries.

Bach-y-Rita's clinical results in restoring lost sensory function are based on several phenomena not widely appreciated in cognitive science. First, there is volume transmission. Extensive laboratory observation has shown that the brain is much more than a network of synaptically connected neurons. Bach-y-Rita has found that a key implication of volume transmission is that it is a functional component in adult brain plasticity, also widely observed experimentally. Plasticity has led him to conclude that the structure of brain dynamics is beyond the scope of algorithmic computation. If the brain is not a computer, this insight would have a significant impact on the development of new technologies based on brain function. Bach-y-Rita's work is being extended from restoration of lost senses to the creation of new senses. This in turn could lead to a new technology of "wiring a human-in-the-loop" that would be utterly unlike any computationally based technology. Instead of mere interaction with a machine, the human "becomes one" with it.

Brain↗

[Complexity of land ecosystem].

In recent years, complexity studies has become a new research region and been widely applied in engineering, biology, economy, management, military, police and sociology. In this paper, from the view of complex science, the main complexity characteristics of land ecosystem were described, furthermore, the application of fractal, chaos, and artificial neural network on the complexity of land ecosystem were also discussed.

Conservation of Natural Resources↗

Articles with authors affiliated to Brazilian institutions published from 1994 to 2003 with 100 or more citations: I - the weight of international collaboration and the role of the networks.

Articles with 100 citations or more in the scientific literature and with at least one author with Brazilian affiliation, were identified in the Thomson-ISI (Institute for Scientific Information) Web of Science bibliometric database, covering a 10-year period, from 1994 to 2003; 248 (0.23%) out of a total of 109,916 articles with Brazilian affiliation were identified. This study was primarily carried out to identify thematic nuclei of excellence in research that had major impact in the international literature (Meneghini and Packer 2006). The regional and institutional affiliation distributions of these articles follow approximately that of the total of Brazilian articles in the ISI database. However, some significant deviations are observed derived from the outstanding performance of a few groups responsible for the publication of the HC-ISI (Highly cited ISI) papers. The international collaboration and the network organization of work played a fundamental role in these results. It is evident that the role played by organizations in research networks as well as the international collaborations exerted strong influence in the impact of these articles, although with distinct amplitude in the different fields.

Academies and Institutes↗

A method for finding communities of related genes.

We present a method for creating a network of gene co-occurrences from the literature and partitioning it into communities of related genes. The way in which our method identifies communities makes it likely that the component genes of each community will be related by their function. The method processes a large database of article abstracts, synthesizing information from many sources to shed light on groups of genes that have been shown to interact. It is a tool to be used by researchers in the biomedical sciences to swiftly search for known interactions and to provide insight into unexplored connections. The partitioning procedure is designed to be particularly applicable to large networks in which individual nodes may play a role in more than one community. In this paper, we explain the details of the method, in particular the partitioning process. We also apply the method to produce communities of genes related to colon cancer and show that the results are useful.

Colonic Neoplasms↗

Reliable multicast for the Grid: a case study in experimental computer science.

In its simplest form, multicast communication is the process of sending data packets from a source to multiple destinations in the same logical multicast group. IP multicast allows the efficient transport of data through wide-area networks, and its potentially great value for the Grid has been highlighted recently by a number of research groups. In this paper, we focus on the use of IP multicast in Grid applications, which require high-throughput reliable multicast. These include Grid-enabled computational steering and collaborative visualization applications, and wide-area distributed computing. We describe the results of our extensive evaluation studies of state-of-the-art reliable-multicast protocols, which were performed on the UK's high-speed academic networks. Based on these studies, we examine the ability of current reliable multicast technology to meet the Grid's requirements and discuss future directions.

Computer Simulation↗

Curriculum for the new college of health sciences: A departure from the traditional medical education.

As an outgrowth of the Report of the Imperial Commission on the Study of Health and Medical Problems, The College of Health Sciences was established as the basic educational unit to provide comprehensive health care education within the framework of a team approach to Iranian national health care. The programs are to nonrestrictive, thereby demonstrating the principles of the concept and practice. Because of this, the College is a multidiscipline institution, and will expand to include programs of study in all health care specialties. The program of study for the equivalent of the baccalaureate degree in the College is based on functional analysis of the tasks to be performed by the primary care workers called behdars. The curriculum is task oriented and is made up to two sections, each of 33 months instruction. The first year concentrates on basic functional science and medicine in an academic setting, and the following two years are spent in clinical training in geographically diverse dispensaries and health care facilities. The second stage of the academic program will be available to graduate behdars who have successfully completed two or more years of work in the health care network and who display academic and professional excellence. Through a unit system approach these candidates for doctor of medicine will complete eleven months or more of comprehensive instruction in functional basic sciences, and this will be followed by two years in comprehensive hospital internship.

Allied Health Personnel↗

New perspectives in EEG/MEG brain mapping and PET/fMRI neuroimaging of human pain.

With the maturation of EEG/MEG brain mapping and PET/fMRI neuroimaging in the 1990s, greater understanding of pain processing in the brain now elucidates and may even challenge the classical theory of pain mechanisms. This review scans across the cultural diversity of pain expression and modulation in man. It outlines the difficulties in defining and studying human pain. It then focuses on methods of studying the brain in experimental and clinical pain, the cohesive results of brain mapping and neuroimaging of noxious perception, the implication of pain research in understanding human consciousness and the relevance to clinical care as well as to the basic science of human psychophysiology. Non-invasive brain studies in man start to unveil the age-old puzzles of pain-illusion, hypnosis and placebo in pain modulation. The neurophysiological and neurohemodynamic brain measures of experimental pain can now largely satisfy the psychophysiologist's dream, unimaginable only a few years ago, of modelling the body-brain, brain-mind, mind-matter duality in an inter-linking 3-P triad: physics (stimulus energy); physiology (brain activities); and psyche (perception). For neuropsychophysiology greater challenges lie ahead: (a) how to integrate a cohesive theory of human pain in the brain; (b) what levels of analyses are necessary and sufficient; (c) what constitutes the structural organisation of the pain matrix; (d) what are the modes of processing among and across the sites of these structures; and (e) how can neural computation of these processes in the brain be carried out? We may envision that modular identification and delineation of the arousal-attention, emotion-motivation and perception-cognition neural networks of pain processing in the brain will also lead to deeper understanding of the human mind. Two foreseeable impacts on clinical sciences and basic theories from brain mapping/neuroimaging are the plausible central origin in persistent pain and integration of sensory-motor function in pain perception.

Brain↗

Neural network adaptive control for nonlinear nonnegative dynamical systems.

Nonnegative and compartmental dynamical system models are derived from mass and energy balance considerations that involve dynamic states whose values are nonnegative. These models are widespread in engineering and life sciences and typically involve the exchange of nonnegative quantities between subsystems or compartments wherein each compartment is assumed to be kinetically homogeneous. In this paper, we develop a full-state feedback neural adaptive control framework for adaptive set-point regulation of nonlinear uncertain nonnegative and compartmental systems. The proposed framework is Lyapunov-based and guarantees ultimate boundedness of the error signals corresponding to the physical system states and the neural network weighting gains. In addition, the neural adaptive controller guarantees that the physical system states remain in the nonnegative orthant of the state-space for nonnegative initial conditions.

Adaptation, Physiological↗

Reinventing a health sciences digital library--organizational impact.

What is the organizational impact of becoming a digital library, as well as a physical entity with facilities and collections? Is the digital library an add-on or an integrated component of the overall library package? Librarians see sweeping environmental and technological changes. The staff members feel exhilarated and challenged by the pressures to adapt quickly and effectively. Librarians recognize that a Web presence, like other technology components, must be continuously enhanced and regularly re-engineered. The Health Sciences Library, University of North Carolina at Chapel Hill, is reinventing its digital presence to better meet the needs of the community. This paper provides a case study focusing on major changes in planning processes, organizational structure, staffing, budgeting, training, communications, and operations at the Health Sciences Library.

Computer Communication Networks↗

Information management through integration of distributed resources.

Duke University Medical Center conducted a strategic planning process focused on information management needs beginning in 1983 and ending in 1985. That effort concluded that the institution was ready to establish an Integrated Academic Information Management System (IAIMS). A model was proposed in which information management was to be achieved through integrated distributed resources. The elements of the IAIMS model are ongoing policy development and planning; communications; an electronic library or resource inventory; coordination of the development or selection of the end-user function; user support; and ongoing evaluation. This model is being tested to determine its effectiveness in meeting the administrative, patient care, research, and educational needs of a basic science department and a clinical science department at Duke University.

Academic Medical Centers↗

Telemedicine: history, applications, and impact on librarianship.

This paper traces the uses of telecommunications in health care from the Civil War era to the present. Topics include the National Aeronautics and Space Administration's involvement in the origins of current telemedicine systems and the impact of television. Applications of telemedicine discussed include remote consultation and diagnosis, specialty clinical care (including examples from anesthesia, dermatology, cardiology, psychiatry, radiology, critical care, and oncology), and others (including examples of patient education, home monitoring, and continuing education). The concluding section highlights how telemedicine affects health sciences librarianship, beginning with the development of online computerized literature searching. This section also discusses the medical resources available to health sciences librarians as a result of the Internet.

Computer Communication Networks↗

Neural networks, nativism, and the plausibility of constructivism.

Recent interest in PDP (parallel distributed processing) models is due in part to the widely held belief that they challenge many of the assumptions of classical cognitive science. In the domain of language acquisition, for example, there has been much interest in the claim that PDP models might undermine nativism. Related arguments based on PDP learning have also been given against Fodor's anti-constructivist position--a position that has contributed to the widespread dismissal of constructivism. A limitation of many of the claims regarding PDP learning, however, is that the principles underlying this learning have not been rigorously characterized. In this paper, I examine PDP models from within the framework of Valiant's PAC (probably approximately correct) model of learning, now the dominant model in machine learning, and which applies naturally to neural network learning. From this perspective, I evaluate the implications of PDP models for nativism and Fodor's influential anti-constructivist position. In particular, I demonstrate that, contrary to a number of claims, PDP models are nativist in a robust sense. I also demonstrate that PDP models actually serve as a good illustration of Fodor's anti-constructivist position. While these results may at first suggest that neural network models in general are incapable of the sort of concept acquisition that is required to refute Fodor's anti-constructivist position, I suggest that there is an alternative form of neural network learning that demonstrates the plausibility of constructivism. This alternative form of learning is a natural interpretation of the constructivist position in terms of neural network learning, as it employs learning algorithms that incorporate the addition of structure in addition to weight modification schemes. By demonstrating that there is a natural and plausible interpretation of constructivism in terms of neural network learning, the position that nativism is the only plausible model of acquisition can no longer be defended. Indeed, I briefly discuss a number of learning-theoretic reasons indicating that constructivist models so characterized uniquely possess a number of important learning characteristics.

Cognition↗

The contribution of Acadia PRIMENet research to science and resource management in the National Park Service.

Acadia National Park was one of the 14 sites included in the Park Research and Intensive Monitoring of Ecosystems network (PRIMENet). For eight years the EPA monitored ultraviolet (UV) radiation at this site, with the National Park Service (NPS) sponsoring a total climate and air monitoring station. Under the auspices of PRIMENet, research projects were initiated that investigated the effects of UV on amphibians, determined watershed mass balances, and developed a model of deposition along an elevational gradient. The monitoring data and research results have been used by park management to protect vegetation and water resources from ozone and deposition. These data are now being used to develop a "vital signs" monitoring program under the NPS' Inventory and Monitoring Program. These data sets have been used in regional, national and international programs to protect human health and resources from air pollution. Public outreach has been accomplished through web site resources and via the Schoodic Education and Research Center.

Air Pollution↗

IAIMS development at Harvard Medical School.

The long-range goal of this IAIMS development project is to achieve an Integrated Academic Information Management System for the Harvard Medical School, the Francis A. Countway Library of Medicine, and Harvard's affiliated institutions and their respective libraries. An "opportunistic, incremental" approach to planning has been devised. The projects selected for the initial phase are to implement an increasingly powerful electronic communications network, to encourage the use of a variety of bibliographic and information access techniques, and to begin an ambitious program of faculty and student education in computer science and its applications to medical education, medical care, and research. In addition, we will explore means to promote better collaboration among the separate computer science units in the various schools and hospitals. We believe that our planning approach will have relevance to other educational institutions where lack of strong central organizational control prevents a "top-down" approach to planning.

Boston↗

The structure of medical informatics journal literature.

OBJECTIVE: Medical informatics is an emergent interdisciplinary field described as drawing upon and contributing to both the health sciences and information sciences. The authors elucidate the disciplinary nature and internal structure of the field. DESIGN: To better understand the field's disciplinary nature, the authors examine the intercitation relationships of its journal literature. To determine its internal structure, they examined its journal cocitation patterns. MEASUREMENTS: The authors used data from the Science Citation Index (SCI) and Social Science Citation Index (SSCI) to perform intercitation studies among productive journal titles, and software routines from SPSS to perform multivariate data analyses on cocitation data for proposed core journals. RESULTS: Intercitation network analysis suggests that a core literature exists, one mark of a separate discipline. Multivariate analyses of cocitation data suggest that major focus areas within the field include biomedical engineering, biomedical computing, decision support, and education. The interpretable dimensions of multidimensional scaling maps differed for the SCI and SSCI data sets. Strong links to information science literature were not found. CONCLUSION: The authors saw indications of a core literature and of several major research fronts. The field appears to be viewed differently by authors writing in journals indexed by SCI from those writing in journals indexed by SSCI, with more emphasis placed on computers and engineering versus decision making by the former and more emphasis on theory versus application (clinical practice) by the latter.

Abstracting and Indexing↗

An overview of neural networks.

Some of the world's leading researchers in neural networks submitted their most recent results concerning their research in neural networks to the author for inclusion in this survey. Descriptive accounts of their collective papers are presented as well as a list of sources of information concerning neural networks, such as journals, books, and technical reports. The material is broken into categories related to established areas in computer science, robotics, neural modeling, and engineering.

Algorithms↗

HAVNET: A New Neural Network Architecture for Pattern Recognition.

A new artificial neural network architecture, specifically designed for two-dimensional binary pattern recognition, is introduced. The network employs a unique similarity metric, based on the Hausdorff distance, to determine the degree of match between an input pattern and a learned representation. Use of this metric in the network leads to behaviour that is more consistent with human performance than that generated by similarity metrics currently in use in other artificial neural networks. A detailed description of the architecture, the learning equations, and the recall equations for the network are presented. An extension of the network is also described in which each class of learned objects is represented by multiple two-dimensional aspects. This extension greatly increases the utility of the network for tasks like character recognition and three-dimensional vision. The network is employed on an example pattern recognition task to demonstrate its application, with very good results. Copyright 1996 Elsevier Science Ltd.

Journal Article↗