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PubMed2002

[The course of neonatal period in neonates of epileptic mothers].

In prospective analysis we compared 211 newborns of women with epilepsy (examined group) and 211 random chose newborns of mothers, without neurological and psychical diseases (control group). Newborns were admitted to ICZMP in 1990-1998 years. In the examined group, the percentage of premature birth, hypotrophia and inborn malformations was higher as compared with the control group. Among biochemical abnormalities the most frequent was hypocalcemia. By means of clinical examination we found circuits of head diminished and most frequently fine tremor in the examined group. Analysis of blood morphology showed lower values of haematocrit, a lower level of haemoglobin and lower numbers of erythrocytes.

Adult↗
PubMed2002

Plasma concentration of intestinal- and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates.

Both early diagnostic and prognostic assessment of the acute abdomen in preterm infants are hampered by the lack of a sensitive and specific parameter for intestinal injury. In this prospective clinical study we wanted to estimate the value of intestinal (I-) and liver (L-) fatty acid binding protein (FABP) in diagnosing necrotizing enterocolitis (NEC). Using highly sensitive and specific sandwich ELISAs which employ recombinant human I- and L-FABP as standard proteins (limit of detection 0.1 ng/ml plasma), the L-FABP concentration (median 7.6 ng/ml) was determined to be about 3 fold that of I-FABP (median 2.52 ng/ml) in plasma of healthy preterm infants. I- and L-FABP concentrations significantly increased with birth weight (1.6 and 5.0 ng/ ml per kg, respectively). At onset of symptoms, I-FABP concentration was significantly higher in infants who later developed severe NEC compared to healthy infants and those, whose illness remained confined to stage I or II. L-FABP was significantly elevated compared to the control group at onset of symptoms regardless of the further course of NEC. In conclusion, I-FABP appears to be a specific parameter for early detection of intestinal injury leading to severe NEC stage III. L-FABP, however, is a promising sensitive marker even for stage I of NEC.

Animals↗