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At least 703 records · Page 39Linked to original sources
PubMed2005

Dilated cardiomyopathy and acute liver injury associated with combined use of ephedra, gamma-hydroxybutyrate, and anabolic steroids.

Anabolic-androgenic steroids are synthetic derivatives of testosterone that some athletes have used to enhance muscle mass and improve their athletic performance. Ephedrine is a potent sympathomimetic agent that can lead to cardiomyopathy similar to that seen with catecholamine excess. Adverse cardiovascular events attributed to anabolic steroid and ephedra use, such as arrhythmias, myocardial infarction, cardiomyopathy, and sudden death, are rarely reported. Bodybuilders have used gamma-hydroxybutyrate, a potent secretagogue of growth hormone, to promote muscle development. Although dilated cardiomyopathy is a known complication of excess growth hormone levels, it has not been associated with use of gamma-hydroxybutyrate. A healthy 40-year-old man was admitted to our hospital for new-onset congestive heart failure and severe acute hepatitis that developed several months after he began using anabolic-androgenic steroids, ephedra, and gamma-hydroxybutyrate supplements. Analysis with an objective causality assessment scale revealed a probable adverse drug reaction between the patient's use of anabolic steroids, ephedra, and gamma-hydroxybutyrate and the development of his cardiomyopathy and acute liver injury.

Adult↗
PubMed2006

Drug-induced hirsutism.

Hirsutism is a symptom or sign, which may have more serious associations than cosmetic and psychological concern alone, such as adrenal hyperplasia and ovarian tumor, particularly if it develops well after puberty. Some medicines having androgenic activity may also cause this problem. Here, we present a case of a young unmarried girl who was given anabolic steroid for the treatment of dysmenorrhoea which resulted in hirsutism.

Adult↗
PubMed1999

[Effect of gravitation loading and retabolil on development of atrophy in muscles and bones of rats due to suspension].

In a 3-wk experiment with tail-suspended rats histological and histomorphometric methods were used to determine the effects of graded gravitational loading (GGL) and anabolic steroid retabolil (nortestosterone decanoate) on the course of atrophy in soleus m. (SM), gastrocnemius m. (GM), tibia and humerus, and functioning of somatotrophic hormones (STH) of the pituitary and thyrocytes of the thyroid. Suspension was found to produce atrophy in SM and, to a less degree, in GM, partial transformation of SM slow fibers into the fast ones, suppression of the tibial longitudinal growth, demineralization of the tibial and humeral spongious metaphyses; besides, functional activities of STH-cells and thyrocytes were inhibited. Graded gravitational loading of rats by intermittence of suspension for 2 hrs slowed down atrophy in both muscles and osteopenia in tibia, stimulated the synthetic and secretory functions of STH-cells without any marked effect on thyrocytes or humeral osteopenia. GGL failed to influence the slow-to-fast transformation of SM fibers. Two injections of retabolil at the total dose of 3 mg/kg of the body mass somewhat interfered with the SM atrophy and humoral osteopenia, and were favorable to the synthetic but not secretory activity of STH-cells. Neither SM and tibial atrophies nor thyroid activity of the gland were improved. The prophylactic action of GGL upon the SM and humeral atrophies was significantly higher when combined with retabolil, whereas GM and tibia were not noticeably cured by retabolil. Inhibition of the SM atrophy and humeral osteopenia in rats treated with GGL and retabolil concurred with elevated activities of STH-cells and thyrocytes indirectly suggesting their more intensive production of the growth hormone and thyroid hormones, respectively.

Anabolic Agents↗
PubMed2000

Reversible hypogonadism and azoospermia as a result of anabolic-androgenic steroid use in a bodybuilder with personality disorder. A case report.

We report a case of reversible hypogonadism and azoospermia resulting from anabolic-androgenic steroid abuse in a body-builder with primary personality disorder. A keen body builder, a 20-year-old man, developed acute aggressive and destructive behavior after 10-month use of Bionabol (mean total dose of 1,120 mg per month), and Retabolil (mean total dose of 150 mg per month). He was found to meet the Diagnostic and Statistical Manual of Mental Disorders-IV ed. (DSM-IV) criteria for Borderline personality disorder. On admission to the hospital the clinical profile of the patient showed extremely low levels of serum testosterone. Values increased to normal levels 10 months after withdrawal of steroids. The semen was azoospermic at the beginning of the study period, oligospermic five months later, and reached 20 x 10(6) sperm per mL ten months after the steroid discontinuation. Anabolic steroids can greatly affect the male pituitary-gonadal axis. A hypogonadal state, characterized by decreased serum testosterone and impaired spermatogenesis, was induced in the patient. This condition was reversible after the steroid withdrawal, but the process took more than ten months. His personal imbalance could be considered a personality trait rather than a result of the anabolic-androgenic steroid use. There were probably dispositional personality characteristics that contributed to anabolic steroid abuse in our patient. The hypogonadal changes which occurred after his long-term steroid abuse were for the most part reversible.

Adult↗
PubMed2001

[Treatment of acute purulent mediastinitis].

Results of treatment of 37 patients with advanced purulent mediastinitis are presented. The cause of mediastinitis in 27 patients was perforation of the esophagus, in 10--purulent diseases of head and neck. Lethal outcome was in 9 (24.3%) cases. Sepsis and progression of mediastinitis were the main causes of lethal outcomes.

Acute Disease↗
PubMed2001

[The combined effect of retabolile and support loads on the post-traumatic reparation process in suspended rat muscles].

Histological and histomorphometric technical were used to determine effects of limited support loads and anabolic steroid retabolite on the time course of the post-traumatic reparation of m. soleus and m. gastrocnemius in tail-suspended rats in the 14-d experiment. One day prior to suspension, the muscles were partly crushed after the rats had been anesthetized with the help of artery clamp. Deprivation of the support loading was shown to cause atrophy of m. soleus and, to a less degree, m. gastrocnemius and inhibit the post-traumatic reparation of m. soleus. Neither retabolite injection (at the total dose of 5 mg per 100 g of the body mass) nor daily limited support loading (the rats were free from suspension and could stand on all four limbs 2 hrs a day) could essentially prevent muscle atrophy and enhance reparation. Nonetheless, combination of the support loads with retabolite injection implicitly slowed atrophy and stimulated healing of m. soleus trauma.

Anabolic Agents↗
PubMed2002

[Morphofunctional changes in the adenohypophysis in suspended rats under the effects of support loads and retabolil].

Histological and histomorphometric methods were used to study morphofunctional changes in adenohypophyseal somatotrophs and gonadotrophs in male rats with the hind limbs deprived of the support load (30 d tail-suspension). Suspension of the rats was found to inhibit the functional activity of somatotrophs and sharply activate the synthetic and secretory functions of gonadotrophs. Injection of retabolil at the total dose of 10 mg per 100 g of the rat's body mass stimulated the somatotrophs activity both in intact and suspended rats suppressing at the same time the functional activity of gonadotrophs. Graded support loads (3 hrs./d) increased the activity of somatotrophs (though to a less degree than retabolil) and activated a little bit the secretory function of gonadotrophs. Combination of the support loads and retabolil was favorable to normalization of the somatotrophs function in the suspended animals. The synthetic activity of gonadotrophs in rats receiving the support loads and retabolil injections was below the control level. Emphasized is the point that morphological criteria of the somatotrophs function normalization in suspended rats as a result of support loading and retabolil injection alone are not sufficient to judge about normalization of the somatotrophic function of the hypophysis, since the growth hormone may not possess the biological activity.

Anabolic Agents↗