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PubMed2005

Magnesium deficiency is associated with periodontal disease.

In the multifactorial pathogenesis of periodontitis, there are still unknown factors influencing the outcome of the disease. An association between magnesium and periodontitis has been suggested by preliminary studies. However, relevant clinical data are lacking. We investigated the association between magnesium status and periodontal health in a population-based analysis. We conducted a cross-sectional epidemiological investigation involving 4290 subjects aged 20-80 yrs. We recorded periodontal risk factors and determined concentrations of serum magnesium and calcium, relating them to periodontal parameters. In a matched-pair study, 60 subjects using oral magnesium-containing drugs and 120 without were compared. In subjects aged 40 yrs and older, increased serum Mg/Ca was significantly associated with reduced probing depth (p<0.001), less attachment loss (p=0.006), and a higher number of remaining teeth (p=0.005). Subjects taking Mg drugs showed less attachment loss (p<0.01) and more remaining teeth than did their matched counterparts. These results suggest that nutritional magnesium supplementation may improve periodontal health.

Adult↗
PubMed1993

A magnesium-deficient high fructose diet augments bone-sparing action of exogenous oestrogen in ovariectomized rats.

To investigate interactions between circulating oestrogen, high dietary fructose, and low dietary magnesium on bone mineral density and numbers of trabeculae, 10 week old ovariectomized (OVX) and sham-ovariectomized (SOVX) rats were studied. The OVX animals were divided into three groups: one-third of the animals were injected with beta-oestradiol-3-benzoate dissolved in sesame oil twice a week; another one-third were injected with testosterone cypionate; and the remaining OVX and all of the SOVX animals were injected with sesame oil only. One-half of the animals in each group were fed cornstarch without magnesium and the other half, fructose without magnesium. After a 14 week experimental period, a 24 h urine sample was collected for measurements of Ca, Mg, P and cAMP. Blood was collected for determination of Ca, Mg, P, 25-hydroxy- and 1,25-dihydroxy-cholecalciferol. Femurs were used for determination of bone density, and tibiae for numbers of trabeculae. Testosterone-treated and OVX control animals fed cornstarch diets had the lowest bone density, whereas oestrogen-treated and SOVX control rats fed fructose had the greatest bone density. Oestrogen-treated animals fed fructose without magnesium had the highest serum and urinary Ca, whereas testosterone-treated animals fed cornstarch without magnesium had the lowest serum and urinary Ca. Serum alkaline phosphatase was higher in OVX- and testosterone-treated and starch-fed animals as compared to their respective counterparts. High urinary cAMP in OVX- and testosterone-treated animals may reflect the action of increased circulating concentrations of PTH, which could be responsible for bone resorption. The results show that high dietary fructose without magnesium interacts with endogenous or exogenous oestrogen to decrease bone mineral loss significantly in ovariectomized rats.

Animals↗