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Results for “MOUTH NEOPLASMS”

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At least 703 records · Page 39Linked to original sources
PubMed1985

[Enzymatic studies on human carcinoma tissues,--especially, study on beta-N-acetylhexosaminidases in oral and pulmonary carcinomas].

Activities of beta-hexosaminidase A and B were measured in both human lung and oral carcinomas. The specific activities of total beta-hexosaminidase were increased in both tissues, irrespective of histological types. In isoelectric focusing experiments, beta-hexosaminidase B from normal lung exhibited a single peak with an isoelectric point (pI) of 7.9, while beta-hexosaminidase B from adenocarcinoma contained two forms with pI of 7.6 and 7.9. With respect to heat stability, beta-hexosaminidase B from normal lung was very stable at 52 degrees, while tumor beta-hexosaminidase B was unstable. After treatment of the enzyme with dithiothreitol, the heat stability was restored. When the tumor pI 7.6 form was treated with dithiothreitol and subjected to polyacrylamide gel electrophoresis, the enzyme converted to pI 7.9 form, which was similar to that of the normal lung. Determination of the sulfhydryl group of the tumor pI 7.6 form under non-denaturing conditions showed that the enzyme did have some easily reducible disulfide bonds on its surface. These findings indicated that the formation of mixed disulfide bonds in the tumor beta-hexosaminidase B increased the net negative charge and resulted in the appearance of a heat-stable form.

Adenocarcinoma↗
PubMed1988

[Experiences with percutaneous endoscopy controlled gastrostomy in patients with neck and otolaryngologic tumors].

Most patients with head and neck tumours need supportive long-term nutrition. To guarantee enteral food intake we implanted a nasogastric tube percutaneously without any complications in 108 patients. The advantage of this method of feeding is that the direct percutaneous route avoids any mechanical irritation of the upper gastro-intestinal tract; this could be important, for example, during radiotherapy, because the mucous membranes are already damaged. In addition the gastric tube is invisible below the patient's clothing so that he can move about without embarrassment.

Endoscopy↗