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[Effect of digoxin, strophanthin and isolanid on oxygen absorption, oxidative phosphorylation and the amount of cytochromes in the myocardial mitochondria and their ATPase activity].

A total of 200 nonlinear rats were used to study the release and utilization of energy in the normal myocardium on administration of clinical concentrations of cardiac glycosides. It was found that cardiac glycosides exert no effect on oxidative phosphorylation under utilization of alpha-ketoglutarate. At the same time digoxin and strophanthin ( to a less degree) intensify the phosphorylating activity of mitochondria, while isolanid has no effect on the oxidative and phosphorylating activity under oxidation of succinate. The content of the enzymes in the terminal portion of the respiratory chain, namely the myocardial mitochondria - cytochromes, did not change under the effect of cardiac glycosides. The test animals were shown to have an increased activity of actomyosin ATPase.

Actomyosin↗
PubMed1984

[Curbing of arrhythmias under outpatient polyclinic conditions].

The material has been collected in the course of two years and covers 48 cases with paroxysms of supraventricular paroxysmal tachycardia (28), auricular fibrillation (4) ventricular tachycardia (2), group and polytopic ventricular extrasystoles (14), organic cardiac diseases (30) and 18--inorganic heart diseases. Paroxysms were interrupted by isolamid, tachmalin lidocain via slow intravenous infusion with constant ECG, auscultation and hemodynamic control, monitor follow up. The paroxysms successfully coped were 43. It proved possible to interrupt the rhythm disorders under the conditions of non-integrated polyclinic provided the functional consulting room is well equipped. The problem of early and effective treatment of rhythm disorders even under polyclinical conditions is solved, thus avoiding the unnecessary hospitalization of some of those patients and delay in the effective treatment of the other part of the patients. The early diagnosis and proper therapeutic behaviour of the physician towards the patient from the very first moment of contact to the transportation and hospitalization of the patient is of vital importance. The interruption of rhythm disorders must very cautiously be performed--the ventricular tachycardia and polytopic extrasystoles in particular, that considered only an introductory treatment.

Adult↗
PubMed1984

Intestinal ischemia after a single intravenous injection of deslanoside. A case report.

Nonocclusive intestinal ischemia is closely associated with heart disease and digitalization. Animal experiments and indirect evidence in man suggest that digitalis significantly decrease splanchnic blood flow. A case is described where peroperative intravenous digitalis caused profound intestinal ischemia. The report constitutes the first direct observation relating heart glycosides with intestinal ischemia in man.

Aged↗
PubMed1984

[Arrest of rhythmic disorders in an outpatient polyclinic].

The material has been collected for two years and covers 48 case with paroxysm of supraventricular paroxysmal tachycardia (28), auricular fibrillation (4), ventricular tachycardia (2), group and polytopic ventricular extrasystoles (14), with organic heart diseases (30) and with non-organic heart diseases (18). The paroxysms were coped with isolanid , tachmalin and lidocain , sow intravenous infusion under constant ECG, auscultatory and hemodynamic control and monitors. The number of the successfully coped paroxysms is 43. It proved to be possible to interrupt the rhythm disturbances under the conditions of non-integrated polyclinic in case of properly equipped functional consulting room. In this way the problem of early and effective treatment of rhythm disturbances under polyclinical conditions is solved, hence--avoiding both the unnecessary hospitalization of part of those patients and the delay in the initiation of effective treatment of the other part of them. The early diagnosis and adequate therapeutic behaviour of the physician towards the patient at their first contact till the moment of their transportation and hospitalization proved to be of particular significance. The out-patient department interruption of rhythm disorders should very cautiously be performed, particularly in case of ventricular tachycardia and polytopic extrasystoles, that being only their initial treatment.

Adult↗