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At least 703 records · Page 39Linked to original sources
PubMed1978

[Improved rapid sequence fluorescein angiography for retinal circulation studies (author's transl)].

Investigations of the initial phase of the angiogram and measurements of retinal circulation times require a rapid sequence angiography. Although almost all of the available cameras allow for 2 or 3 exposures per second, such rapid sequence angiograms are not performed routinely. Especially the patient's stress from 2 or 3 flashes per second is considerable making these investigations very difficult. We have introduced 3 modifications of the regular technique of rapid sequence angiography that greatly facilitate the procedure so that large numbers of patients can easily be investigated in clinical routine. 1. The regular fixation target in the Zeiss fundus camera has been replaced by a special diaphragm (Fig. 1) which will exclude part of the fundus from exposure to light. This way pictures are taken only of the disc and the peripapillary area which are most important for circulation studies. After completion of the rapid sequence the diaphragm can easily be removed and further pictures taken of regular size. 2. The fluorescein is injected by means of an automatic injector (Fig. 2) in order to obtain a concentrated dye bolus. 3. The sequence of the angiogram is controlled by an electronic timer (Fig. 3 a and b). The photographer can thus fully concentrate on the camera adjustment without worrying about dye injection or triggering the camera. The perfect standardisation obtained will facilitate the measurement of different circulation parameters later on the film.

Fluorescein Angiography↗
PubMed1994

Plasmapheresis and subsequent pulse cyclophosphamide in severe systemic lupus erythematosus. An interim report of the Lupus Plasmapheresis Study Group.

The rarity with which therapy-free remission is achieved in patients with severe SLE demand the continued search for improved treatment strategies. Possibly, therapeutic results can be improved by means of a "synchronized" combination of plasmaphereses followed by pulse cyclophosphamide (Ctx). If the hypothesis is correct, that plasmapheresis induces a compensatory "rebound" proliferation of pathogenic clones, then pulse Ctx applied immediately after plasmapheresis should attack these activated clones when they are most vulnerable and, ideally, eliminate them. Employing a strict variant of this strategy in a pilot study, treatment-free remission lasting now for up to 7 years were achievable in 8 of 14 SLE patients. The Lupus Plasmapheresis Study Group (LPSG) is currently conducting a randomized international multicenter trial comparing a synchronized procedure with the administration of pulse Ctx alone. The present paper explains the rationale of synchronization and reports on the interim status of the LPSG Study.

Combined Modality Therapy↗
PubMed1994

[The strategy and basic trends in optimizing immunoprophylaxis among the troops].

On the basis of complex analysis of the present situation and problems of immunization in the Armed Forces the authors worked out the scientific substantiation of the principles and trends towards the improvement of immunoprophylaxis among servicemen. The article provides epidemiological evidence concerning the necessity to make a transition to a principle of a complex associated immunization, maintaining unchanged three basic regional schemes, as well as a 2-stage immunization with different approach to the various categories of servicemen, and a 4-5-valent protective vaccine complex for the first-term enlistees. The authors worked out a variant of a calendar and schedules for prophylactic vaccination of personnel in the Armed Forces of Russian Federation in peaceful time.

Adult↗
PubMed1993

[Short-term and long-term effects on glycosylated hemoglobin after transition from conventional insulin treatment to multiple insulin injection regime in a diabetic outpatient clinic].

In order to examine the short- and long term effects of basal/bolus insulin therapy on the metabolic regulation assessed by glycosylated haemoglobin (HbA1c) the first 201 patients in the diabetes out-patient clinic of the Section of Endocrinology, Department of Medicine, Aalborg Hospital, assigned for this treatment were prospectively studied. In all 201 patients a significant decrease in mean HbA1c value was observed after 21 months on multiple injection therapy (8.5% vs 8.1%; p < 0.001). The higher the HbA1c value on conventional therapy, the greater was the observed decrease in HbA1c following six months on basal/bolus therapy (r = 0.57, p < 0.001). According to an anonymous questionnaire completed by the first 140 patients six months after the start of multiple injection therapy, 97% of the patients preferred to continue with basal/bolus therapy with NovoPen, and 87% felt that they had achieved a better general condition and that the basal/bolus regime made their daily life easier. It is concluded that basal/bolus therapy with NovoPen may combine the attainment of improved metabolic control assessed by a decrease in mean HbA1c in many poorly regulated patients and the subjective experience of an improved quality of life.

Adolescent↗