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The thread-like worms removed from the right eye of a 10 month-old boy in North Sumatra were shown to be female Thelazia callipaeda, by the shape of the buccal capsule and the position of the vulva. This is the first report of human infection of Thelazia callipaeda in Indonesia.
Selective age group treatment and village scale chemotherapeutic malaria control operation were carried out in east-coast villages in North Sumatra, Indonesia in 1987/1988. A single dose of Fansidar plus primaquine was adopted as the drug regimen to cut the transmission of malaria at the gametocyte stage. After the treatment on day seven, the gametocyte positive rate was reduced to only 2.7% in 72 Plasmodium falciparum gametocyte carriers. A significant reduction of P. falciparum prevalence in the community was observed after successive selective age group treatment in primary school, however P. vivax prevalence persisted. Village scale active case detection was carried out by one health center staff and two village health volunteers. After eight months P. falciparum prevalence was reduced from 14% to 1%. As the result of the chemotherapeutic control activities covering high-prevalence villages in the coastal area, malaria prevalence in 1988 became very low, as compared with the status in 1985/1986.
A survey was carried out among persons residing in 8 villages in the Province of West Kalimantan, Indonesia to determine the prevalence of filariasis. Finger tip blood smears were obtained at night from over 3,000 people and microfilariae of Brugia malayi were found in 108 (3.5%) and Wuchereria bancrofti in 10 (0.3%). Most B. malayi (96 carriers) was found in Kakap, a village near the coast, 20 km from the provincial capital of Pontianak. Nine of 10 cases of W. bancrofti were located in Pahauman, a village 130 km northeast of the provincial capital. Periodicity studies indicate the strain of B. malayi to be subperiodic. In Kakap 18% of 226 persons examined had a clinical history of filariasis and elephantiasis was seen in 13%. This is the first report of rural bancroftian filariasis in the area. A few Mansonia species of mosquitoes were examined but none were infected with filarial larvae.
Indonesia is an archipelago, the largest in the world, stretching 3,200 miles from east to west. It straddles the equator between the Asian and Australian continents. The climate is tropical and has two seasons, the dry season from June to October; and the wet season from November to March. The total population is currently estimated as only 165 million and Indonesian is the national language.
Studies on the occurrence of early symptoms of filariasis have been conducted in two transmigration Units in the valley of the Wae Apu river, Buru island, Maluku Province, Indonesia. In both Units, higher disease rates were found in areas, where there was a closer contact with positive natives, higher density of the vector mosquito, and higher infective rates in the mosquitoes.
Hepatocellular carcinoma (HCC) in Indonesia ranks as the 9th most common of cancers. The ratio of male and female in HCC 2.5:1. HCC were found mostly in the 4th to 7th decade of life. HCC is frequently accompanied with cirrhosis and close relationship with HBV. The positivity of HBV marker is 60% in CLD and 67% in HCC. The patients usually come late to the doctors, and early detection is still a problem. Ultrasonography every 4 months and serologic test every month in CLD is recommended. Ultrasonically guided fine needle aspiration biopsy is quite promising for diagnosis and early detection of HCC.
There are essentially no reports on the use of modern biotechnological methods on the study of cestode parasites in the Philippines, Indonesia or Malaysia. The only recent reports of cestode studies in these countries have been on reports of new species in animals and on prevalence rates of cestode parasites in humans; Taenia solium and cysticercosis, Taenia saginata and Hymenolepis nana, etc. Reports on the use of biotechnology has emanated from outside the area on cestodes of humans and animals, and some of these methods could be used to study cestodes in this part of the world.
Over 1,000 stool specimens from residents of the Napu and Besoa Valleys, Central Sulawesi, Indonesia were examined. Schistosoma japonicum was detected in 31% of Napu Valley residents while in only 2% of the Besoa Valley residents. Hookworm infections were the most frequently encountered helminth parasitisms in both valleys. Other helminth parasites encountered were: Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Strongyloides stercoralis, Physaloptera sp., Diphyllobothrium sp., echinostome and heterophyid trematodes. Intestinal protozoa endemic to the area were: Entamoeba histolytica, E. coli, E. hartmanni, Iodamoebe bütschlii, Giardia lamblia, Chilomastix mesnili and Trichomonas hominis. Plasmodium falciparum was responsible for malaria parasitaemias in 5% of 1353 specimens examined and Brugia malayi microfilaraemias were detected in 10% of 972 specimens examined.
In order to assess the prevalence of the traits of alpha- and beta-thalassaemia as well as of haemoglobin E among Indonesians a survey was conducted in Surabaya, a city of over 3 million inhabitants in one of the most densely populated areas of Indonesia. 450 medical students representing healthy adults were examined with the following results: 18 persons (4%) harboured the beta-thalassaemia trait and 28 (6.2%) had the Hb E trait giving a gene frequency of 0.0202 and 0.0315, respectively. 10 persons (2.2%) had the alpha-thalassaemia trait.
The Asmat are a population of about 35,000 people living on the South-West coast of Irian-Jaya (Indonesia; New Guinea). This paper presents the results of enzyme group and serum protein group typings in a sample of Asmats living in the coastal region around Agats. Red cell enzyme polymorphisms (EaP, PGM1, 6-PGD, EsD, ADA and AK) could be typed in 154 blood samples, serum protein polymorphisms (Ge, alpha 1-AT, PLG, Tf and Hp) in 160 blood samples. The results of this study are discussed in detail.
The early impact of the expanded programme on immunization (EPI) in reducing morbidity from diphtheria was evaluated in the province of Yogyakarta, Java, Indonesia. Since 1980, coverage of two doses of diphtheria-tetanus-pertussis (DTP) immunization has been greater than 60% in Yogyakarta. The morbidity rate for diphtheria for children aged 0-4 years decreased from 4.3 per 100 000 population in 1978-79 to 1.7 per 100 000 in 1981-82, a reduction of 60%. In contrast, the morbidity rate for children aged 5-9 years remained relatively constant over the 5-year period. The EPI programme has therefore had a demonstrable effect on 0-4-year-olds in Yogyakarta.
A screening test for glucose-6-phosphate dehydrogenase (G6PD) deficiency was carried out in North Sumatra, Indonesia by using a simple agar plate method. The prevalence of G6PD deficiency in male was 6.0% (9/151) in Nias prefecture, 3.9% (12/307) in Asahan prefecture and 0.9% (1/110) in Medan city (average 3.9%). The prevalence of malaria was investigated at the same time in Nias and Asahan. It was 8.6% (13/151) and 10.4% (32/307) in males. The parasite rate of Plasmodium falciparum in normal and G6PD deficient groups was 4.1% and 9.5%, respectively. There was no statistical significance between them. The usefulness of the system of detecting malaria and G6PD deficiency at the same time was discussed in relation to malaria control.
A biomedical survey was conducted in 9 villages in the Malili area of South Sulawesi, Indonesia. Blood specimens were examined for malaria and microfilariae; stool specimens were examined for intestinal parasites. Malaria parasitemias were rare; Plasmodium falciparum was detected in 10 and P. vivax in 11 of 985 blood smears. Malayan filariasis was endemic to all villages surveyed. The overall prevalence of detectable microfilaremias was 15%, varying from 34% in Kawata to 1% in Nuha. Microfilarial densities, expressed as MfD50 averaged 8.0 and varied from 1.1 in Timampu to 16.0 in Karabbe. Intestinal parasites were common. Although Schistosoma japonicum was not found, 97% of the examined had one or more intestinal parasites as follows: Ascaris lumbricoides (74%), Trichuris trichiura (65%), hookworm (62%), Entamoeba coli (38%), Endolimax nana (10%), Entamoeba histolytica (6%), Iodamoeba bütschlii (4%), Entamoeba hartmanni (3%), Giardia lamblia (2%) Chilomastix mesnili (1%) and Enterobius vermicularis (1%). Strongyloides stercoralis larvae and Hymenolepis nana eggs were detected once each and heterophyid-like eggs were detected twice.
A controlled field trial comparing the effectiveness of a plain cholera vaccine with that of a vaccine adsorbed to aluminium hydroxide was carried out in a cholera-endemic area of Indonesia during 1973-75. Tetanus toxoid adsorbed to aluminium phosphate was used as the control. In vaccinees aged 1-4 years, the adsorbed cholera vaccine provided about 88% protection for 6 months following vaccination and still provided about 50% protection between 11 and 14 months after vaccination. In the same age group, the plain vaccine provided only 53% protection during the first 6 months and no appreciable protection beyond that period. In those aged 5 years and over, both vaccines provided 50-60% protection throughout the period of observation (14 months). Neither vaccine caused any serious side effects.
Blood smear surveys were conducted in principal villages on the major islands of Indonesia to determine the microfilarial rates presently existing in the populations. A total of 163,454 persons were examined and 10.8 percent found positive for microfilariae of Wuchereria bancrofti, Brugia malayi or Brugia timori. The highest prevalence rates were found in Nusatenggara-Maluku-Irian Jaya (15.5%) followed by Sulawesi (13.7%) Kalimantan (10.8%) Sumatera (8.9%) and Jawa and Bali (1.7%). Many areas endemic for filariasis are used for the settlement of transmigrants from non-filarial endemic areas. Control program must therefore be implemented to prevent filarial infections in these new susceptible population groups.
Limited experience with adverse drug reaction (ADR) monitoring in Indonesia is one of the difficulties faced in the developing programme. Problems which arise are related to data collection, quality of reporting, reaction-type reported, and assessment of cause-effect relationships, in addition to problems related to personnel and other factors.
In a 10-year period (1970-1979) 6,111 cancer cases in males and 7,646 cases (55.3%) in females were registered. The female genital tract cancers occurred in 23.8% of all malignancies in the female. The relative frequency of the gynecological tumors was: cervix 60.3%, ovarium 25.5%, corpus uteri 6.9%, chorioca 5.1% and vulva/vagina 2.2%. A comparison is made with former reports and with other places in Indonesia.
Fecal specimens from 89 orangutans (36 captive, 34 rehabilitant, and 19 wild) at different locations in Indonesia were examined. Strongyloides spp, Balantidium coli, and strongylid nematodes were the most common infestations detected. A syngamid nematode, Mammomonogamus sp, is reported for the first time in orangutans.