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PubMed2006

Imagining inoculation: Smallpox, the body, and social relations of healing in the eighteenth century.

People in colonial New York adopted inoculation for smallpox as quickly and as thoroughly as did people anywhere in the British Atlantic world. Such adoption was not dependent upon the authority of formal medicine, but rather upon everyday epistemology. Inoculation became accepted as local knowledge because ordinary New Yorkers integrated it imaginatively into common ideas about the body and disease, reconceptualized its theological meaning, and incorporated it into familiar social relations of healing.

Culture↗
PubMed2002

Trajectories of aging: imagined pathways in later life.

The model of aging that people construct influences interpretations of and responses to actual situations when they occur, as well as preparatory actions that people take. Thus the question of what people foresee for themselves and the process by which they construct and revise this subjective aging trajectory has implications for such issues as health behavior, retirement planning, migration and residential moves, and advance directives, as well as for overall well-being in old age. This exploratory, hypothesis-generating study found that informants referred frequently to the course of aging and the events they envisioned in their own futures. The analysis delineates 1) types of events that older people see as part of aging in general and their own aging in particular, 2) factors and processes that enter into the construction of the subjective trajectory of aging, and 3) feeling and behavioral responses to the imagined future.

Affect↗
PubMed2004

Moral imagination in long-term care workers.

Our study focused on the cultural construction of dying and death in long-term care facilities. This article centers on direct care workers' perspective of residents' deaths. The data on which this article is based were gathered in a multi-year, multi-site study through formal ethnographic interviews, informal conversations, and on-site observations of residents and staff members. During fieldwork, we noticed an aptitude of direct care workers to deal with residents' deaths, which we named "moral imagination." The term is borrowed from other disciplines to describe a "way of seeing" residents. The case studies presented--that of three direct care workers: a dietary aide, a nurse aide, and an assistant activities director--are suggestive of workers in each category. Our study offers implications for future research concerning direct care workers' value to residents' quality of life. We also propose questions for long-term care facilities about standards of formal caregiving at the end of life.

Aged↗
PubMed1984

The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster.

Six zygotically expressed genomic loci of Drosophila melanogaster, N, bib, mam, neu, Dl and E (spl), have previously been found to be involved in the commitment of ectodermal cells as neuroblasts. We have studied phenotypes induced by various mutant alleles at these 6 loci in imaginal epidermal cells, in order to assess possible implications of the genes in functions other than early neurogenesis. When homozygous, any of these mutations except bib affected the development of bristles and compound eye in various ways. These range from cell death to the production of additional bristles and several defects in ommatidial patterning, depending on the allele used. In contrast clones of bib homozygous cells exhibited wild-type phenotypes. The differences found in the expression of the neurogenic genes are discussed with respect to a hypothesis on the genetic control of neurogenesis.

Alleles↗
PubMed1990

Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginal Drosophila melanogaster.

Mutations at the period (per) locus of Drosophila melanogaster disrupt the circadian rhythm of adult locomotor activity. Molecular studies have shown that this gene is expressed primarily at the embryonic, pupal and adult stages. We have used conditional per mutants to infer the stages of development during which per expression is required for adult rhythmicity. In experiments carried out with germline transformants in which the arrhythmic per01 allele has been transformed with a heat-shock protein 70 promoter-driven per gene (hsp-per transformants) we find that per expression in the adult is both necessary and sufficient for imaginal rhythms. Results obtained with existing per alleles and other per transformant strains that behave as conditional per mutants are consistent with those obtained with these molecularly engineered conditional mutants. Using hsp-per transformants we have found that the per gene product is apparently required only at the time of manifestation of rhythmicity, and can rescue the host's arrhythmic phenotype even when supplied many days after transfer to constant darkness. We present evidence suggesting that it is necessary for pacemaker function itself, rather than being involved in a process that couples the activity of the pacemaker to the output pathway. The levels of per transcript and the abundance and tissue distribution of its protein product observed in hsp-per transformants exposed to different temperature regimes are described. An initial report of some of these results has been published previously (Ewer et al., 1988).

Activity Cycles↗
PubMedDate not supplied

[Comparison of imaginal diets of various Syrphidae (Diptera) species].

The full amount and species composition of pollen from intestines of 11 species of Syrphidae (Arctophila fulva, Eristalis arbustorum, E. nemorum, E. pertinax, Helophilus pendulus, Myiatropa florea, Rhingia campestris, Sericomyia silentis, Syrphus baltheatus, S. ribessii and S. vitripennis), collected at the some place (Torma, Jogeva distr., Estonia) and at the some time (18-20 July 1989) have been studied. Maximum number of pollen grains is different fly species varied from 67,800 (Rh. campestris) up to 240,700 (S. silentis) grains, and average number from 25,560 (Rh. campestris) up to 115,880 (E. pertinax) grains. Maximum volume of pollen in different fly species varied from 1.5 (S. ribesii) up to 23.6 (S. baltheatus) mm3, and average volume from 0.36 up to 7.0 mm3 (the same species). The difference in a imaginal diets of Syrphidae are found, and the degree of difference does not correlate with a degree taxonomic affinity of species. The difference in strategy of a feeding behavior of two Syrphus species, that have similar diet, are marked: in intestines of 80% specimens of S. ribesii we found pollen grains of less that 7 plant species, whereas intestines of more than 88% specimens of S. vitripennis contained more than 8 species of grains. Distinction in alimentary preferences of different species of files can not be explained neither particularities of their morphology, nor their color preferences.

Animals↗
PubMed1999

[The dance of death theme. On the cultural erosion of the figure of imagination].

The Dance of Death theme was the most developed figure of imagination of the late Middle Ages. Its sources were not only rich but also mysterious: oriental influence, pagan customs, Christian religion, and the habits of medieval everyday life. The imagery tendency of religious themes and the invention of wood engraving established the Dance of Death theme as a popular form of death imagery. The modern erosion of the Dance of Death theme has two reasons: 1) dying, death and corpses no longer constitute a sensual experience; 2) medical context of death disintegrated the former sacrum which has established ideological horizons of death imagery.

Death↗
PubMed2001

Nonlinear EEG dynamics during imagined self-paced movements.

The majority of studies devoted to reveal electrophysiological correlates of words and sentences comprehension, imageability and remembering are based on the event-related potentials and frequency synchronization in different narrow frequency bands. These linear methods reveal some patterns of EEG activity in time and frequency domain. Having in mind that the activation of many cortical structures is a result of mass of nonlinearly interconnected neurons, the linear methods seem to be insufficient to discover the complexity of the information transfer. We revealed recently nonlinear dynamic transients in EEG, long before real performance of goal-directed voluntary movements with different temporal and spatial distributions over frontal, sensorimotor and parietal cortical areas (Popivanov and Dushanova, 1999). The aim of this study was to establish whether similar behavior of the nonlinear characteristics exists when the subject imagines movements of a given type. The Kolmogorov entropy computed over time after the sentence end proved to be an useful characteristic that complement the linear methods.

Eidetic Imagery↗
PubMedDate not supplied

Congenital diaphragmatic hernia diagnosed by magnetic resonance imagine in late infancy: Report of one case.

We report the magnetic resonance imagine (MRI) findings of an 11-month-old baby with delay onset of congenital diaphragmatic hernia (CDH). The capability of visualizing diaphragmatic discontinuity, connecting bowel segments between abdomen and chest are clearly demonstrated. The various techniques of diagnosing diaphragmatic hernia are described and we emphasize the potential usefulness of MRI in CDH.

Hernia, Diaphragmatic↗
PubMed2002

Ischemia Management with Accupril post bypass Graft via Inhibition of angiotensin coNverting enzyme (IMAGINE): a multicentre randomized trial - design and rationale.

BACKGROUND: Coronary artery bypass grafting (CABG) remains the revascularization treatment of choice for patients with severely symptomatic or life-threatening coronary artery disease (CAD). However, 9% to 25% of the patients undergoing CABG will suffer a recurrent ischemic event such as death, recurrent infarction, angina or repeat revascularization. The pathophysiological processes particular to the CABG procedure that may affect graft endothelial function are most active in the early phase after surgery. Angiotensin-converting enzyme (ACE) inhibition has been shown to be effective in reducing or preventing ischemic events in patients with and without left ventricular dysfunction, and in those at high risk for CAD. Nonetheless, no large clinical trail has investigated this role of ACE inhibition in preventing ischemic events early after CABG. OBJECTIVE: The Ischemia Management with Accupril post bypass Graft via Inhibition of angiotensin coNverting Enzyme (IMAGINE) study addressed whether ACE inhibition initiated early after CABG improves short and long term outcomes in patients after CABG. PATIENTS AND METHODS: This multicentre, multinational trial recruited 2204 patients with an uncomplicated course early after CABG from 55 to 65 medical care facilities in Canada, The Netherlands, Belgium and France. Eligible patients with normal left ventricular function were randomly assigned to placebo or quinapril (titrated up to 40 mg daily where possible) within seven to 10 days after CABG. All patients were followed up closely for a minimum of 12 months after random placement. The median treatment period is expected to be approximately 27 months.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed2002

[Application of SPOT 4 remote sensing imagine in classification of Qira oasis landscape in China].

The landscape surounding Qira osais at the southern fringe of the Taklamakan Desert in China was analyzed by using the SPOT 4 multispectrum remote sensing data and GPS (global positioning system) data. The SPOT 4 scene was projected into an UTM grid, and a supervised classification by ERDAS IMAGINE software was applied. In total, 13 landscape units could be distinguished, and a "frame of reference" was set up for establishing monitoring system of landscape patterns dynamics. Limitations, possible improvements and further applications of the approach were discussed.

China↗
PubMed1992

Toxicity and residual action of the photoactivated compound, cyano-alpha-terthienyl, and its efficacy for reducing pre-imaginal populations of mosquitoes.

The photoactivated compound, cyano-alpha-terthienyl (cyano-alpha-T), was highly toxic to pre-imagines of the mosquitoes Culex restuans, Cx. tarsalis and Culiseta inornata when synergized with piperonyl butoxide (PBO). Lethal concentrations for 50% mortality, determined during an outdoor trial using caged fourth-instar Culex spp. larvae, were 19.4, 15.4 and 12.9 g/ha at 24, 48 and 72 h after treatment, respectively. No residual activity of cyano-alpha-T was observed beyond 24 h following treatment. In artificial pool tests, greatest population reductions were achieved using dosages of 20 and 40 g/ha; statistically significant reductions were not observed following applications of 5 g/ha. Cyano-alpha-T plus PBO was more effective for reducing mosquito populations than alpha-terthienyl (alpha-T) plus PBO at comparable dosages, although it exhibited slightly lower insecticidal activity at a dosage of 20 g/ha than a formulation of Bacillus thuringiensis var. israelensis (Vectobac 12 AS, 0.12 ml/m2). Greatest effectiveness of cyano-alpha-T plus PBO was observed in pools with low organic content relative to pools high in organic content.

Animals↗
PubMed2003

Body dysmorphic disorder--a fear of imagined ugliness.

BACKGROUND: Body dysmorphic disorder (BDD) is a distressing and impairing illness characterised by an intense time consuming preoccupation with an imagined or slight defect in appearance of a body part or parts. OBJECTIVE: This article outlines the characteristic features and treatment approaches for BDD and suggests screening techniques that can be usefully applied in the general practice setting. DISCUSSION: Body dysmorphic disorder has been shown to be common and chronic yet goes under recognised as the patient is often secretive about their distress. In an endeavour to alleviate the distress, time consuming rituals are performed that are either without effect or paradoxically may exacerbate the distress. Recent treatment studies show that the selective serotonin reuptake inhibitors and cognitive behavioural therapy, used simultaneously or alone, can be beneficial in alleviating the distress and impairment associated with the condition.

Australia↗
PubMed1989

[Reaction of the cerebral vertebrae in imagined changes in the shape of the cervical spine].

Postural reaction of the cervical vertebrae on imagined, but actually not performed changes in the shape of the cervical spine in the sagittal plane are described. The percentage of reacting vertebrae is relatively high. The findings seem to indicate, that 1.) the described phenomena belong to the constant features of the spinal dynamics, 2.) that there, probably, exist residual traces of preceding activities and 3. that these changes are due to the activation of the polymetameric system of the intrasegmental muscles.

Cervical Vertebrae↗
PubMed1987

Postembryonic neurogenesis in the CNS of the tobacco hornworm, Manduca sexta. II. Hormonal control of imaginal nest cell degeneration and differentiation during metamorphosis.

The nervous system of an adult moth is comprised of retained larval neurons that are remodeled during metamorphosis and a set of new adult specific neurons. The new neurons arise from a stereotyped array of stem cells (neuroblasts) that divide during larval life to generate nests of up to 100 arrested postmitotic immature neurons, the imaginal nest (IN) cells. At the onset of metamorphosis, some of the IN cells die while the remainder differentiate into mature functional neurons. Metamorphosis in insects is regulated by 2 classes of hormones, the ecdysteroids and the juvenile hormones. The transition from larva to pupa requires the disappearance of juvenile hormones followed by 2 releases of ecdysteroids: a small "commitment peak" and a larger "prepupal peak." Through a series of endocrine manipulations, we demonstrate that the death and differentiation observed among the abdominal IN cells at metamorphosis are both influenced by these hormonal cues. If the abdomen was isolated from the hormonal sources in the anterior half of the larva before the onset of metamorphosis, death and differentiation of the IN cells were prevented. Infusion of ecdysteroids into such abdomens, to mimic the prepupal peak, resulted in the IN cells showing the same fate as seen in control animals during the early phases of metamorphosis. The response of the IN cells to the small commitment peak of ecdysteroids was heterogeneous. Exposure to this small peak of steroids caused some cells to become committed to resume their development, making them resistant to juvenile hormone application.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster.

We have followed the formation of neuronal pathways in different imaginal discs of Drosophila. The pattern is highly reproducible for a given disc type but distinct for each type of discs: in leg discs, several neurons are present before metamorphosis and provide two major pathways that are joined by later neurons; in the wing and haltere discs, a few pairs of neurons appear after the onset of metamorphosis and pioneer the major pathways; in antenna discs, no pioneers are detected before massive neuronal differentiation begins. The mechanisms used for axonal guidance seem common to all discs, and the differences between discs can be accounted for simply by differences in the arrangement and birth time of pioneer neurons. Different subsets of pioneer neurons are deleted by mutations such as scute and engrailed.

Animals↗
PubMed1977

The eversion and differentiation of Drosophila melanogaster leg and wing imaginal discs cultured in vitro with an optimal concentration of beta-ecdysone.

The stages of the eversion and differentiation of prothoracic leg and wing discs of Drosophila melanogaster, in Shields and Sang's medium 3, are described. The range of specific imaginal structures produced, including patterns of sensilla trichodea and sensilla campaniformia, are noted, and the relationship of these structures to those differentiated in situ is discussed.

Animals↗
PubMed1977

Active ion transport and beta-acdysone induced differentiation of Drosophila melanogaster imaginal discs cultured in vitro.

The theory that beta-ecdysone initiates developmental changes during insect metamorphosis by causing an increase in intranuclear levels of potassium, together with a concomitant decrease in sodium levels, has been investigated by two methods. First, imaginal discs from late third instar larvae have been cultured with 0-2 microng/ml of beta-ecdysone together with inhibitors of active ion transport. Non-specific inhibitors, which may have general effects on sulphydryl groups, such as iodoacetic acid, N-ethylmaleimide ethacrinic acid and furosemide, inhibit both eversion and differentiation at concentrations of from 10(-3) M to 2 X 10(-3) M. Ouabain, the only specific inhibitor of the active transport of Na+ and K+ across membranes, had no effect on development even at a concentration of 10(-2) M. Second, a medium containing raised levels of K+, and reduced concentrations of Na+, neither initiated disc development in the absence of beta-ecdysone, nor stimulated development induced by suboptimal levels (0-02 microng/ml) of beta-ecdysone, either in the presence or absence of ouabain. These results suggest that beta-ecdysone induced morphogenesis is not dependent upon Na+ and K+ concentrations, or on the activity of an ouabain-sensitive ion pump.

Animals↗