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At least 703 records · Page 39Linked to original sources
PubMed1998

Binding properties of bovine ocular lens zeta-crystallin to right-handed B-DNA, left-handed Z-DNA, and single-stranded DNA.

Bovine zeta-crystallin has the ability to bind with different DNAs. Initially, this protein was named regulatory factor 36 (Kang et al., 1985), but it has been shown to be an ocular lens zeta-crystallin (Jörnvall et al., 1993), which is considered an enzyme-crystallin (Rodakanaki et al., 1989). The enzyme-linked immunosorbent assay (ELISA) was used to quantitate the binding of bovine zeta-crystallin to purified high molecular weight double-stranded (ds-) and single-stranded (ss-) DNA (bovine and synthetic DNA). ELISA quantitation was achieved by the addition of anti-zeta-crystallin antibodies to the DNA-zeta-crystallin complex, using a novel immunochemical avidin-biotin method. Zeta-crystallin shows much greater binding intensity for ss-DNA and for ds-Z-DNA than for ds-B-DNA. It also reacts slightly more with ds-Z-DNA than ss-DNA. Therefore, we speculate that zeta-crystallin may act as a transcriptional enhancer (outer lens cortex), possibly binding to Z-DNA regulatory elements within lens crystallin genes. It may also act to protect DNA from endogenous DNase activity and as a DNA unwinding (destabilizing) protein also involved with transcription, occurring in normal adult bovine lens nucleated secondary fiber cells.

Animals↗
PubMed1999

[Dying through the hand of man or taken by the hand of man? Results of an opinion poll concerning active euthanasia and the Hospice Movement].

BACKGROUND: Opinion polls show a growing support of active euthanasia in Germany. The hospice movement rejects active euthanasia and pleads for a qualified care for the dying. The aim of our study was to evaluate how far the work and the ideas of the hospice movement are known in Germany and to which extend this knowledge influences the attitude towards active euthanasia. METHODS: An interview of 200 people in the pedestrian area of Mainz was undertaken. RESULTS: 73% of all interviewees supported active euthanasia. Significant predictors for opposition to active euthanasia were increasing age and belonging to the roman catholic confession. However, 72% of active euthanasia supporters did not know what a hospice is, and 80% were not aware of the existence of such an establishment in Mainz. Opponents of euthanasia had significantly more knowledge of these items. CONCLUSION: The results of our study indicate that physicians should wherever possible explain the aims and the work of the hospice movement who should be their ally in a qualified commitment for the dying. It can be expected that the hospice movement will find a lot of sympathy in the population as 2 of its major aims--openness in communication and dying at home wherever possible--were shared by the vast majority of all interviewees: in case of incurable disease 92% wanted to be informed on their diagnosis, and 84% wanted to die at home or in their families home.

Euthanasia↗
PubMed2005

Hand movement observation by individuals born without hands: phantom limb experience constrains visual limb perception.

Increasing evidence suggests that the visual analysis of other people's actions depends upon the observer's own body representation or schema. This raises the question of how differences in observers' body structure and schema impact their perception of human movement. We investigated the visual experiences of two persons born without arms, one with and the other without phantom sensations. These participants, plus six normally-limbed control observers, viewed depictions of upper limb movement under conditions of apparent motion. Consistent with previous results (Shiffrar M, Freyd JJ (1990) Psychol Sci 1:257), normally-limbed observers perceived rate-dependent paths of apparent human movement. Specifically, biologically impossible motion trajectories were reported at rapid display rates while biologically possible trajectories were reported at slow display rates. The aplasic individual with phantom experiences showed the same perceptual pattern as control participants, while the aplasic individual without phantom sensations did not. These preliminary results suggest that phantom experiences may constrain the visual analysis of the human body. These results further suggest that it may be time to move beyond the question of whether aplasic phantoms exist and instead focus on the question of why some people with limb aplasia experience phantom sensations while others do not. In this light, the current results suggest that somesthetic representations are not sufficient to define body schema. Instead, neural systems matching action observation, action execution and motor imagery likely contribute to the definition of body schema in profound ways. Additional research with aplasic individuals, having and lacking phantom sensations, is needed to resolve this issue.

Amputees↗
PubMed1988

Recurring loop motif in proteins that occurs in right-handed and left-handed forms. Its relationship with alpha-helices and beta-bulge loops.

A common feature of alpha-helices in proteins is a loop at the C-terminal end, with a characteristic hydrogen bond pattern. It is noted that several loops with the same structural features occur independently of alpha-helices; two are even situated at the loop ends of beta-hairpins. The name paperclip is suggested for loops possessing the appropriate hydrogen bonds. A number of features of paperclips are described: they exist in two classes, depending on the number of residues at the loop end; one class is very much commoner than the other. Two paperclips are found that belong to the common class, except that the main-chain conformation of each is the mirror image of that normally found. The majority of paperclips are shown to have tightly clustered sets of main-chain dihedral angles. These are somewhat similar to, but distinct from, a subgroup of another common family of loops that have been called beta-bulge loops; in the latter, the dihedral angles are also tightly clustered. The high degree of clustering in both cases is likely to be a result of steric constraints associated with hydrogen bond patterns at the ends of loops.

Amino Acid Sequence↗
PubMed2005

Cannabinoids and ceramide: two lipids acting hand-by-hand.

Cannabinoids, the active components of Cannabis sativa (marijuana) and their endogenous counterparts, exert their effects by binding to specific G-protein-coupled receptors that modulate adenylyl cyclase and ion channels. Recent research has shown that the CB1 cannabinoid receptor is also coupled to the generation of the lipid second messenger ceramide via two different pathways: sphingomyelin hydrolysis and ceramide synthesis de novo. Sustained ceramide accumulation in tumor cells mediates cannabinoid-induced apoptosis, as evidenced by in vitro and in vivo studies. This effect seems to be due to the impact of ceramide on key cell signalling systems such as the extracellular signal-regulated kinase cascade and the Akt pathway. These findings provide a new conceptual view on how cannabinoids act, and raise interesting physiological and therapeutic questions.

Apoptosis↗
PubMed2003

From hand maiden to right hand--the birth of nursing in America.

AT THE ONSET of the American Civil War, women were asked to leave their homes and serve as suppliers and caregivers for the armies on both sides of the conflict. MANY WOMEN suddenly found themselves in situations that required real strength, stamina, and fortitude, and some found an inner strength as they organized others to provide care. WOMEN LIKE Dorthea Dix and Clara Barton were among the first to champion the ability of and the need for women to provide nursing care, which until then had been a male bastion. THIS ARTICLE, which is the second in a two-part series on nursing during the Civil War, tells how Dorthea Dix, Clara Barton, and other women worked to establish nursing as a viable career choice for women in the United States.

History of Nursing↗
PubMed2003

From hand maiden to right hand--the Civil War.

Before the onset of the US Civil War, women were expected to take care of individuals in their households who were sick or injured. The Civil War marked the first time the concept of women working as nurses outside of the household was established in the United States. This article, which is the first in a two-part series on nursing during the Civil War, outlines the medical conditions in the United States at the start of the War Between the States. The second article in this series will detail the role of the first female Civil War nurses.

Female↗
PubMed2002

Challenging the widespread assumption that connectionism and distributed representations go hand-in-hand.

One of the central claims associated with the parallel distributed processing approach popularized by D.E. Rumelhart, J.L. McClelland and the PDP Research Group is that knowledge is coded in a distributed fashion. Localist representations within this perspective are widely rejected. It is important to note, however, that connectionist networks can learn localist representations and many connectionist models depend on localist coding for their functioning. Accordingly, a commitment to distributed representations should be considered a specific theoretical claim regarding the structure of knowledge rather than a core principle, as often assumed. In this paper, it is argued that there are fundamental computational and empirical challenges that have not yet been addressed by distributed connectionist theories that are readily accommodated within localist approaches. This is highlighted in the context of modeling word and nonword naming, the domain in which some of the strongest claims have been made. It is shown that current PDP models provide a poor account of naming monosyllable items, and that distributed representations make it difficult for these models to scale up to more complex language phenomena. At the same time, models that learn localist representations are shown to hold promise in supporting many of the core reading and language functions on which PDP models fail. It is concluded that the common rejection of localist coding schemes within connectionist architectures is premature.

Cognitive Science↗
PubMed2001

Meiotic recombination: Making and breaking go hand in hand.

Accurate segregation of homologous chromosomes at the first meiotic division requires the tight coordination of DNA replication, homologous recombination and chromosome organization. Recent studies suggest that the initiation of meiotic recombination is mechanistically coupled to premeiotic DNA replication.

DNA Replication↗