The natural history of gravitational induced loss of consciousness.
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We have examined the feasibility of using reflectance photoplethysmography to assess Gz acceleration tolerance. Reflectance plethysmograms recorded using a sensor placed on the region of the superficial temporal artery were analysed along with the mean value and the pulsatile component of the Doppler velocity recorded from the opposite temporal artery. The photoplethysmogram signal and pulsatile and mean Doppler velocities were examined as predictors of impending peripheral light loss (PLL) during the experiments. Photoplethysmography correctly predicted a large percentage of the PLL runs (80.5%) and non-PLL runs (98.3%). Mean Doppler velocity predicted a higher percentage of PLL runs (88.1%), but with an unacceptably low rate of non-PLL runs (77.2%). The pulsatile Doppler velocity yielded only 50.7% correct prediction of PLL runs. The results of this preliminary study indicate that, with an improved design of the sensor and the electronics, it may be possible to use reflectance photoplethysmography in acceleration tolerance experiments as a reliable predictor of impending peripheral light loss.
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During 30 days rats were centrifuged at 1.1 and 2.0 G. On centrifugation day 30 the rats showed body mass losses, decrease of plasma ACTH, activation of the renin-angiotensin-aldosterone system (RAAS) and ultrastructural changes in the mossy fiber terminals in the nodulus cortex which were indicative of the state of excitation (at 1.1 G) or excess excitation (at 2.0 G) in the system of the utriculus receptor cell and vestibular ganglion neuron (RCN). On the 2nd day after centrifugation the ultrastructural changes in the terminals pointed to a lower activity of the RCN system which was below the physiological norm. As compared to centrifugation day 30, the RAAS became more active on the 2nd day of recovery. On the 7th day of recovery (after centrifugation at 1.1 G) the RCN ultrastructure, RAAS and ACTH concentrations returned to the normal. The general trends of the RAAS and RCN changes seen on the 2nd day of recovery and identified by other authors at an acute stage of adaptation to microgravity suggest that the data obtained on the 2nd day of recovery may be used to analyze certain effects which develop during an acute stage of adaptation to microgravity in mammalian organs and systems responsible for the perception of modified gravity and their adaptation to a new level of gravity.
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