Stress and its effects.
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The ultrastructural organization of secretory granules, containing adrenaline (A) or noradrenaline (NA) was studied in chromaffin cells of the rat adrenal gland after 3-, 24- and 48-hour immobilization stress. Using cytochemical electron microscopic Tranzer's method and the method of morphometry, the number of normal dense cores, "empty" and "semiempty" vesicles was calculated. It was shown that the total content of vesicles and the ratio of investigated types of both adrenaline- and noradrenaline-accumulating granules were markedly changed during stress. The degree of such stress-induced reorganization depended on the stage of stress reaction and involved first A-cells and then NA-cells.
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The experiments on rats demonstrated that barbamyl, aminazine, seduxen, haloperidol, apressin, phentolamine, inderal, dopegit, amizil prevent to a large extent the development of morphological and biochemical manifestations in the body of animals during long-term immobilization.
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The bioptic specimens of liver taken from 687 patients with various acute and chronic liver diseases were studied by means of the modern morphological methods. It was found, that structural changes, that reflect the adaptive-compensatory reactions are seen in hepatocytes, in epithelial cells of the interlobular bile ducts and in the connective tissue.
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