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At least 703 records · Page 39Linked to original sources
PubMed1975

Oestradiol receptor levels in the human fallopian tube during the menstrual cycle.

The levels of cytoplasmic high-affinity oestradiol receptor sites were determined in the isthmus, isthmus-ampulla, ampulla and fimbria of human Fallopian tubes obtained from 23 women during the proliferative and secretory phase of the menstrual cycle and after menopause. Each segment was homogenized in 0.25 M sucrose and fractionated by differential centrifugation into an 800 g X 15 min nuclear pellet and a 100,000 g X 1 h cytoplasmic supernatant and pellet. The nuclear and cytoplasmic pellets were extracted with 0.01 M Tris/HCl pH 8.0 containing 0.25 M sucrose, 1 mM EDTA and 0.1 M KCl. The receptor levels were determined in the 100,000 g X 1 h supernatant (free receptors) and in the KCl extracts (bound receptors). Values are expressed per mug DNA. The concentration of receptors (total, free and bound) was significantly greater in the ampulla than in the isthmus in both phases of the menstrual cycle (P less than 0.001). The concentration of free receptors in the isthmus, isthmus-ampulla and ampulla obtained in the proliferative phase was not significantly different from that of the secretory phase. In the fimbria a significantly higher concentration (P less than 0.01) was observed in the proliferative phase. The bound receptors were significantly higher in all regions in the proliferative phase than in the secretory phase (P less than 0.01). As a consequence the concentration of total receptors was significantly greater along the tube in the proliferative phase (P less than 0.01). The levels of oestradiol in the nuclear pellet of each segment as measured by radioimmunoassay were significantly greater in the isthmic region (P less than 0.01) than in other regions of the tube. The inverse relationship between the concentration of oestradiol receptor sites and the nuclear levels of oestradiol along the Fallopian tube is discussed.

Adult↗
PubMed1981

Gestational choriocarcinoma of the fallopian tube.

Review of a world literature of 93 reported cases of choriocarcinoma primary in the fallopian tube yields 58 acceptable cases, to which 18 are added from the files of the Armed Forces Institute of Pathology. Patients ranged from 16 to 56 years old, with a mean age of 33. About 66% presented with acute symptoms consistent with banal ectopic pregnancy. The remainder usually presented with a gradually expanding adnexal mass clinically indistinguishable from an ovarian tumor. Grossly, the tumor is usually a hemorrhagic friable mass, occasionally containing spongy tissue resembling placenta. Smaller tubal choriocarcinomas are difficult to distinguish on gross inspection from common ectopic pregnancy, ruptured or not. Histopathological features and distribution of metastases are similar to gestational choriocarcinoma arising in the uterus. Chorionic villi were found in two cases, an uncommon observation in primary uterine choriocarcinoma. Of 47 acceptable cases treated prior to modern chemotherapy, 41 died, a mortality of 87%. Of 16 cases treated with modern chemotherapy, 15 survive, a salvage of 94%. Five cases in the world literature, plus three in the present series, were cured by unilateral salpingectomy or salpingo-oophorectomy alone.

Adolescent↗
PubMed1993

Use of hydrophilic guide wires in the fallopian tubes: effect on sperm survival and mouse embryo development.

Hydrophilically coated guide wires from two different manufacturers were tested in vitro for potential use in the fallopian tubes. Incubation of the guide wires and scrapings from the guide wires with sperm and with mouse embryos did not show any deleterious effect on sperm survivability or embryo development. These "slippery" guide wires may prove useful for fallopian tube catheterization.

Animals↗
PubMed2002

[Determination of ofloxacin in human fallopian tube, uterus and serum by high performance liquid chromatography].

AIM: To establish a method for determineation of the concentration of ofloxacin in human fallopian tube, uterus and serum. METHODS: The separation was performed on a Spherisob C18 column (Hypersil, 250 mm x 4.6 mm ID, 5 microns) with a mobile phase of acetonitrile-0.01 moL.L-1 potassium dihydrogen phosphate-0.5 mol.L-1 tetrabutylammonium bromide (9:91:4, pH 2.5). The flow rate was 1.0 mL.min-1 and detection was at 294 nm. The samples were homogenated or ground to powder after freezing with liquid nitrogen. 1% triton-100 and certain volume of ethylacetate-isopropanol (10:1) were added, shaken and centrifuged. Then the entire organic layer was transferred to a tube and vacuum dried. The residue was reconstituted in the mobile phase for HPLC. RESULTS: There was a linear relationship between the peak area ratio and the ofloxacin concentration over the range of 0.2-8.0 micrograms.mL-1. The limits of detection was 40 ng.mL-1. Using this method to determine the ofloxacin concentrations in relevant organs as well as in the plasma of patients of the Department of Gynecology, and achieved satisfactary results. CONCLUSION: The method can be applied to assay the ofloxacin concentration in human tissues. Ofloxacin was well distributed in woman fallopian tube, uterus and serum after single oral administration.

Adolescent↗
PubMed1975

Spontaneous motility and distribution of prostaglandins in different segments of human Fallopian tubes.

The "in vitro" spontaneous magnitude and stability with time of the isometric developed tension (IDT) and frequency of contractions of ampullar longitudinal and ampullar circular as well as isthmic longitudinal and isthmic circular muscle, from human Fallopian tubes, were explored. The effects of polyphloretin-phosphate (PPP), an inhibitor of prostaglandins (PG), upon the IDT and frequency of different tubal segments, were also explored. We looked for PGE, and F2alpha in extracts of ampullar and isthmic tubal segments. The initial IDT and frequency (recorded at 10 minutes following equilibration) as well as the stability with time (explored afterward during 40 minutes) were comparable among all the preparations, with the exception of the isthmic longitudinal muscle, which suffered a progressive decrement of IDT. PPP inhibited significantly the IDT of the isthmic circular muscle but had no effect upon the ampullar circular muscle. Whereas PGF2alpha was frequently detected in extracts from the isthmic region, those from the tubal ampullar region showed the consistent presence of PGE1. The results suggested a possible relationship between isthmic PGF2alpha and its spontaneous motility. Also, the peculiar distribution of PGE1 and PGF2alpha could have some bearing on the regulation of the different functions of isthmic and ampullar regions of human Fallopian tubes.

Fallopian Tubes↗
PubMed1996

Modulation of platinum sensitivity and resistance by cyclosporin A in refractory ovarian and fallopian tube cancer patients: a phase II study.

Our objective was to assess the activity of cyclosporin A (CsA) used as a chemomodulator of carboplatin in refractory ovarian and fallopian tube cancer patients. Fifty-one patients (47 epithelial ovarian, 1 ovarian mixed mesodermal tumor, and 3 fallopian tube carcinomas) were enrolled in a prospective Phase II trial of CsA and carboplatin. CsA was infused as a loading dose of 10 mg/kg over 5 h, followed by carboplatin infused over 30 min at an AUC of 6 mg/ml x min, then a 24-h continuous infusion of 11.6 mg/kg CsA. The patients received this protocol as second- to sixth-line therapy and had received between 1 and 3 prior platinum-based regimens. Eight patients received more than six cycles every 28 days, 34 patients received three to six cycles; and 9 patients received only one or two cycles. Thirty-eight patients were evaluable for objective response, and in an additional nine patients, CA-125 was the only marker of response. Four patients had no marker of disease. Of evaluable patients, 74% were platinum resistant. There were nine objective responses (one complete and eight partial responses) for an overall response rate in evaluable patients of 24%, with a median duration of response of 7 months (range, 3-38+ months). No responses were seen in patients who had received only one or two cycles of therapy. Among the strictly defined platinum-resistant patients, there was an overall 14% response rate, including one partial response seen after five prior regimens of chemotherapy including paclitaxel, and one ongoing complete response for 38+ months. Among the rest of the patients (those who were potentially platinum sensitive), there was an overall 50+ response rate; four of five responses were seen in patients with a platinum-free interval of <24 months, with only one response seen in a patient with a platinum-free interval of >24 months. Of evaluable patients, 34% had stable disease for a duration of 3-19 months. The most common grade 3 or 4 toxicity, thrombocytopenia, was seen in 22% of the patients. Hypertension, which responded to medications, was seen in 18% of the patients during the CsA infusion. We concluded that this CsA/carboplatin regimen is active in potentially platinum-sensitive patients and compares well with the expected response rate of 30% in patients with a platinum-free interval <24 months who are retreated with platinum. Moreover, this regimen had modest but real activity in platinum-resistant patients.

Adult↗
PubMed1997

Sonographic hydrotubation using agitated saline: a new technique for improving fallopian tube visualization.

Vaginal sonographic hydrotubation (SHT) was assessed in the evaluation of uterine configuration and tubal patency in 71 women undergoing investigation for infertility. In addition, a new technique using "agitated" saline during transvaginal sonography was evaluated in 50 of the patients. Ultrasound was more sensitive in detecting uterine abnormalities (89% compared with 6% for hysterosalpingography (HSG). Of 142 individual fallopian tubes studied, the diagnosis on SHT and HSG were the same in 120 (85%). Laparoscopic results were available on 15 patients. The findings on all 19 tubes in which the SHT and HSG diagnosis had concurred were confirmed. Of 11 tubes in which the diagnoses had differed, the laparoscopic finding agreed with the diagnosis made with SHT in seven, HSG in three, and neither in one. As shown in previous studies, sonographic hydrotubation is a simple technique with a high degree of accuracy. The use of "agitated" saline improved the ease with which the fallopian tubes were visualized.

Fallopian Tube Patency Tests↗
PubMed1982

Motor activity of the human Fallopian tube in vitro in relation to plasma concentration of oestradiol and progesterone, and the influence of noradrenaline.

The contractile pattern of the human Fallopian tube was studied in preparations from the ampullary and isthmic regions mounted in an organ bath for measurement of longitudinal and circular smooth muscle activity. The material was obtained during the follicular, ovulatory, and luteal phases of the cycle as defined primarily from plasma oestrogen and progesterone values. The frequency of the spontaneous contractions increased progressively during the follicular phase to become maximal around ovulation. There was no consistent difference between isthmus and ampulla; the circular musculature had a higher frequency than the longitudinal during the ovulatory phase. Noradrenaline (3 x 10(-6) M) in general potentiated the difference in frequency seen between the ovulatory phase on the one hand and the follicular and luteal phases on the other. Contractile activity, assessed by planimetric integration of the curve on the pen-recorder trace, increased markedly during the ovulatory phase in all types of smooth muscle preparations. Exogenous noradrenaline inhibited spontaneous motor activity in preparations from pregnant or post-menopausal women or from women taking combined-type oral contraceptives. This effect was most marked in the circular muscle. Thus the different regions of the human Fallopian tube in vitro show various patterns of spontaneous motor activity in relation to the plasma steroid concentrations furing the menstrual cycle. Responses to exogenous noradrenaline also varied, indicating that the effects of endogenous noradrenaline released from sympathetic nerves may vary similarly.

Adult↗
PubMed1988

Experience with diagnosis and treatment of sterility due to abnormality of the infundibulum of the Fallopian tube.

The diagnosis and treatment of sterility due to abnormalities of the infundibulum of the Fallopian tube are reviewed. Knowledge on the physiology of the distal part of the tube explains the mechanisms of sterility when a lesion occurs, although diagnosis is based mainly on hysterosalpingography and laparoscopy. The requisite treatments are either percoelioscopic or surgical, and techniques and results with these treatments are reviewed. Special attention is given to tubal stenosis as a consequence of embryonic cysts of the tube.

Fallopian Tubes↗
PubMed1981

Binding of estrogen and progestin in the human fallopian tube.

The estrogen and progestin receptor concentrations in the human fallopian tube have been investigated. The binding of estrogen and progestin to their cytoplasmic and nuclear receptor proteins were of high affinity and specificity. The cytoplasmic and nuclear receptor concentrations in the isthmus, ampulla, and fimbria did not differ significantly. The nuclear progestin receptor concentrations in the isthmus and fimbriae were significantly higher (P less than 0.05) in the follicular phase than in the luteal phase of the menstrual cycle. In the postmenopausal tubes the receptor concentrations was low, whereas the progestin receptor concentration was quite high.

Cell Nucleus↗
PubMed1992

GIFT or IVF for patients with patent fallopian tubes?

The pregnancy rate in a group of 39 couples who underwent in vitro fertilization (IVF) with donor sperm was compared with that of couples undergoing gamete intra-Fallopian transfer (GIFT) over the same period (31 December 1986 to 30 June 1991). The diagnostic status of the female partners in each group was qualitatively similar. The women had patent Fallopian tubes, mild endometriosis or minor tubal adhesions. The male partners in the GIFT group had normal or marginally abnormal semen parameters which were considered to be comparable to the post-thaw quality of the semen used in donor insemination (DI). The mean age of the women in the DI group was 32 years (range 25-40) which was similar to that in the GIFT group [32 years (24-39)]. The women in the IVF group had undergone a mean of eight cycles of DI before proceeding to treatment with IVF. There was no difference between the pregnancy rate in the two groups (log-rank test). These observations advance the proposition that IVF should be reconsidered as an effective treatment for women with patent Fallopian tubes.

Adult↗
PubMed1988

Capacitation potential of the fallopian tube: a study involving surgical insemination and the subsequent incidence of polyspermy.

In an attempt to demonstrate limitations in the capacitating potential of the Fallopian tube, ejaculated boar spermatozoa were introduced directly into the isthmus at varying intervals before ovulation. The incidence and degree of polyspermy subsequently observed were taken as indicators of the population of capacitated spermatozoa confronting the newly ovulated eggs: the more extensive the condition of polyspermy, the greater the number of capacitated spermatozoa presumed to have been available at the site of fertilization. Results are based on 673 eggs from 53 animals. When suspensions containing 2.21-3.87 x 10(8) sperm per ml were introduced 36-40 hours and 26-30 hours before ovulation, 85% and 61% respectively of the eggs were polyspermic, such eggs exhibiting mainly dispermy and trispermy. By contrast, when comparable sperm suspensions from the same boar were instilled 17-18 hours before ovulation, 70% of the eggs were polyspermic but the degree of polyspermy had increased dramatically: most eggs contained 40 or more sperm heads in the vitellus, invariably forming swollen chromatin aggregates rather than male pronuclei. Surgical insemination at times closer to ovulation significantly reduced the incidence and degree of polyspermy, reaching a low of 2% with insemination 1-2 hours before ovulation. These results therefore support the concept of a limited capacitation potential of the Fallopian tube. In a separate series of observations, mating animals shortly before surgical insemination with sperm suspensions from the same boar markedly reduced the incidence of polyspermy. This latter observation may be of clinical significance in procedures of laparoscopic or transcervical insemination into the tubes to alleviate human infertility. The manner whereby myosalpingeal physiology could be modified in response to coital stimulation is discussed.

Animals↗