Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Discitis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 703 records · Page 39Linked to original sources
PubMed1994

Pyogenic and tuberculous spondylodiskitis (vertebral osteomyelitis) in 80 adult patients.

Bacterial spondylodiskitis--i.e., adjacent vertebral osteomyelitis and diskitis--was studied in 80 adult patients. The infection was due to Mycobacterium tuberculosis in 31 cases (39%) and to pyogenic bacteria in 49 cases (61%). The latter pathogens included gram-negative bacilli in 16 cases (20%), Staphylococcus species in 15 (19%), Streptococcus species in 9 (11%), and Corynebacterium species in 1 (1%); the pathogens in the 8 remaining cases (10%) were not identified. Of the patients with tuberculous spondylodiskitis, 55% came from countries where tuberculosis is endemic (P < .001). Cases due to staphylococci and those due to M. tuberculosis were associated with a high frequency of previous active infection with those respective organisms at any site (47% and 42%, respectively; P < .001) and with a high rate of neurological complications (33% and 32%, respectively; P < .001). Nine patients with pyogenic spondylodiskitis (18%) but only one patient with tuberculous spondylodiskitis (3%) had diabetes mellitus (P < .05). Blood cultures were positive in 23 (56%) of the 41 cases of pyogenic spondylodiskitis due to an identified bacterium. Discovertebral needle biopsy contributed to the bacteriologic diagnosis in 29 (74%) of 39 cases.

Adult↗
PubMed1996

Spondylodiskitis due to Candida albicans: report of two patients who were successfully treated with fluconazole and review of the literature.

We report the cases of two patients with spondylodiskitis due to Candida albicans who were successfully treated with fluconazole. On the basis of findings from these cases and a review of 52 mycologically proven cases in the literature, we describe the main characteristics of candidal spondylodiskitis. In 60% of the cases, candidal spondylodiskitis was a late complication of candidemia (mean delay, 5.2 months) it was determined to be a complication on the basis of the results of previously positive blood cultures (19 cases), and it was presumed to be a complication in iv drug addicts (12 cases). As spondylodiskitis can be a late complication of candidemia, all episodes of candidemia should be treated with systemic antifungal agents. Clinical and radiological signs of candidal spondylodiskitis were nonspecific. Any bone or joint symptoms in a patient who has had candidemia should be considered to be of fungal origin at the time of presentation. The definitive diagnosis of candidal spondylodiskitis was made on the basis of the results of percutaneous puncture in 26 of 30 cases. The overall prognosis for patients with candidal spondylodiskitis was good, with the full recovery rate ranging from 67% to 100%. The preliminary results of treating candidal spondylodiskitis with triazole derivatives, particularly fluconazole, were satisfactory; there was excellent tolerance of this drug.

Antifungal Agents↗
PubMed1996

The epidemiology of spondylodiscitis in ankylosing spondylitis--a controlled study.

UNLABELLED: Spondylodiscitis is well recognized in ankylosing spondylitis (AS), but little is known about its epidemiology. We therefore reviewed 147 consecutive patients with AS using lumbar and thoracic spine radiographs. For each patient with spondylodiscitis, two age- and sex-matched controls were selected. Twelve individuals (8%) had spondylodiscitis, affecting a total of 32 disc spaces: 10 thoracic, 22 lumbar. The mean age at onset was 21 +/- 4.1 yr, significantly younger than that of the controls (28.5 +/- 10.1 yr, P = 0.004). Half of the 12 patients had multiple lesions (between two and six levels). The most common site was the lower thoracic spine with additional lumbar spine involvement. Only two of the 12 patients (17%) had symptoms localized to the lesions. Neither trauma nor infection were considered to be causes of the spondylodiscitis. IN CONCLUSION: (1) spondylodiscitis occurs in approximately 8% of patients with AS; (2) these patients have early onset of disease; (3) multiple-level lesions in the spine are not uncommon among those with spondylodiscitis; (4) lesions are usually asymptomatic.

Adult↗