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PubMed2006

The experience is CLEAR.

Conventional amphotericin B has been the 'gold standard' for antifungal efficacy, but nephrotoxicity problems limit its clinical utility. In the late 1990s, three lipid-based formulations of amphotericin B were introduced, all of which offered comparable efficacy and reduced renal complications. However, to date, robust safety and comparative efficacy data have been sparse. This paper briefly reviews the available clinical data on amphotericin B lipid complex (ABLC). Also, in detail, it reviews the findings of Collaborative Exchange of Antifungal Research (CLEAR), the most extensive dataset on systemic antifungal treatment with the lipid-based agent ABLC.

Amphotericin B↗
PubMed1999

Mapping the literature of dental hygiene.

Despite the long history of the dental hygiene profession, little research has been conducted on the characteristics of its literature. In this study, the bibliometric method was used to identify the core journals in the discipline and the extent of indexing of these journals. The study was a part of the Medical Library Association (MLA) Nursing and Allied Health Resources Section's project to map the allied health literature. Five journals were found to provide one-third of all references studied. Forty-two journals yielded an additional one-third of the references. MEDLINE had the best indexing coverage with 87% of the journals receiving indexing for at least one-half of the articles included. Limited coverage was provided by EMBASE/Excerpta Medica (11%) and the Cumulative Index to Nursing and Allied Health Literature (9%). The findings identified titles that should be added by indexing services as well as those that should have more complete coverage.

Abstracting and Indexing↗
PubMedDate not supplied

Research revealed.

AIM: The objective of this study was to investigate nursing research, including topics, funding and publication. METHOD: A database of published biomedical research set up by the Wellcome Trust was analysed for nursing research. RESULTS: Topics covered in nursing research were found to be diverse, with mental health nursing and nurse education the major areas. Multi-authorship is lower than in biomedical research generally. The most prolific areas of publication are London SE postcodes and Manchester. Only about a third of nursing research appears to be funded. CONCLUSION: Nursing research was found to be the fastest growing field of biomedical research during the period analysed (1988-1995).

Authorship↗
PubMed1992

Coverage by four information services of the core journals of rehabilitation and related topics.

In this study, three serials databases were used to identify core journals in rehabilitation and related areas. Simple strategies were used to search SERLINE (Serials Online, National Library of Medicine), Ulrich's International Periodicals Directory and SACHET (British Library serials database). Coverage of the journals identified by four secondary information services was then studied. These were Medline, Excerpta Medica, CINAHL (Cumulative Index to Nursing and Allied Health) and CATS (Current Awareness Topics Services, British Library). The results confirmed and extended the findings of earlier work: the number of core journals in rehabilitation is very large and their coverage by information services is very selective. Of the services studied here, CATS seemed to be most comprehensive for the journals identified.

Databases, Factual↗
PubMed2006

Design and implementation of a library-based information service in molecular biology and genetics at the University of Pittsburgh.

SETTING: In summer 2002, the Health Sciences Library System (HSLS) at the University of Pittsburgh initiated an information service in molecular biology and genetics to assist researchers with identifying and utilizing bioinformatics tools. PROGRAM COMPONENTS: This novel information service comprises hands-on training workshops and consultation on the use of bioinformatics tools. The HSLS also provides an electronic portal and networked access to public and commercial molecular biology databases and software packages. EVALUATION MECHANISMS: Researcher feedback gathered during the first three years of workshops and individual consultation indicate that the information service is meeting user needs. NEXT STEPS/FUTURE DIRECTIONS: The service's workshop offerings will expand to include emerging bioinformatics topics. A frequently asked questions database is also being developed to reuse advice on complex bioinformatics questions.

Computational Biology↗
PubMed1997

Assessing research productivity in an oncology research institute: the role of the documentation center.

An evaluation method used to assess the quality of research productivity and to provide priorities for budget allocation purposes is presented. This method, developed by a working group of the National Institute for Research on Cancer (IST), Genoa, Italy, is based on the partitioning of categories of the Science Citation Index and Journal Citation Reports (SCI-JCR) into deciles, which normalizes journal impact factors in order to gauge the quality of the productivity. A second parameter related to the number of staff of each institute department co-authoring a given paper has been introduced in order to guide departmental budget allocations. The information scientists of the IST Documentation Center who participated in the working group played a pivotal role in developing the computerized database of publications, providing and analyzing data, supplying and evaluating literature on the topic, and placing international bibliographic databases at the working group's disposal.

Documentation↗
PubMed2002

Electronic information resources for food toxicology.

This manuscript provides a brief overview of many useful Internet resources concerning food toxicology. Specific topic areas include pesticide residues, food additives, natural toxins, environmental contaminants, and food allergies; numerous links and evaluative information are provided within each topic area. Several helpful Internet resources have been identified and include government, industry, academic, and consumer sites.

Databases as Topic↗
PubMed2002

A dynamic problem to knowledge linking Semantic Web service based on clinical codes.

Many information needs arise during everyday clinical practice. Problem to knowledge linking aims to answer these needs by providing contextually appropriate medical knowledge in the right place and at the right time. Empirical evidence shows that well-informed physicians and patients are able to make better clinical decisions that positively affect healthcare outcomes. This paper reports on the design and development of a re-usable and flexible Semantic Web problem to knowledge linking service. The service makes use of metadata and clinical codes contextually to link disparate Electronic Patient Record clients to resources in an online medical knowledge service (HealthCyberMap). Clinical codes act as crisp knowledge hooks, providing a reliable common backbone language for communication between Electronic Patient Records and HealthCyberMap. Ideas to improve the service are also discussed. By minimizing irrelevant leads (noise) and reducing the time needed to find relevant information (the right contextually relevant knowledge is linked to real patient data in the Electronic Patient Record), the system is potentially beneficial. The actual success of the system will depend on the quality and granularity of metadata it uses and the topical coverage and quality of resources to which it points.

Databases as Topic↗
PubMed2005

DCCP and DICP: construction and analyses of databases for copper- and iron-chelating proteins.

Copper and iron play important roles in a variety of biological processes, especially when being chelated with proteins. The proteins involved in the metal binding, transporting and metabolism have aroused much interest. To facilitate the study on this topic, we constructed two databases (DCCP and DICP) containing the known copper- and iron-chelating proteins, which are freely available from the website http://sdbi.sdut.edu.cn/en. Users can conveniently search and browse all of the entries in the databases. Based on the two databases, bioinformatic analyses were performed, which provided some novel insights into metalloproteins.

Animals↗
PubMed2003

[Cochrane Anaesthesia Review Group and the Cochrane Library. Useful resources for anaesthetists].

The Cochrane Collaboration is an international non-profit organisation that aims to help clinicians in making well-informed decisions about health care issues. This is done through preparing, maintaining and disseminating systematic reviews on the effects of health care interventions. To facilitate this task, review groups have been established. These groups cover specific health care areas and form the organisational basis of the collaboration. They provide methodological and logistic help to the authors of the systematic reviews. The Cochrane Anaesthesia Review Group (CARG) covers anaesthesia, perioperative medicine, intensive care,pre-hospital medicine, resuscitation, and emergency medicine. Protocols and completed Cochrane reviews are published in a structured format in the electronic Cochrane Library. Beside this Cochrane database of systematic reviews, the Cochrane library contains a database with summaries of non-Cochrane systematic reviews (database of abstracts of reviews of effectiveness), and a comprehensive database with controlled clinical trials (Cochrane central register of controlled trials). Thus the Cochrane library is a useful source of information on health care interventions for anaesthetists.

Anesthesiology↗
PubMed1999

Mapping the literature of perfusion.

Perfusionists select and operate the equipment necessary for monitoring, supporting, or temporarily replacing the patient's circulatory or respiratory function. There are over 3,000 perfusionists working in U.S. hospitals, medical and perfusionist groups, and as independent contractors. The purpose of this study was to identify the core literature of perfusion and to determine which major databases provide the most thorough access to this literature. This paper is part of the Medical Library Association Nursing and Allied Health Resource Section's project to map the literature of the allied health professions. It uses a bibliometric methodology to identify core journals. A group of forty-three journals was determined to make up the core journal literature of perfusion. MEDLINE provided the best overall indexing coverage for these journals, but librarians and perfusionists will wish to supplement its use with the Cumulative Index to Nursing and Allied Health Literature in order to access the journals written primarily for perfusionists. The study results can guide purchasing and database searching decisions of collection development and reference librarians, encourage the database producer to increase coverage of titles that are unindexed or underindexed, and advise perfusionists of the best access to their core literature.

Abstracting and Indexing↗
PubMed2006

Mapping the general literature of American nursing.

OBJECTIVES: As part of a project to map the literature of nursing, sponsored by the Nursing and Allied Health Resources Section of the Medical Library Association, this study identifies core journals cited by general or "popular" US nursing journals and the indexing services that cover the cited journals. METHODS: Three journals were selected for analysis: American Journal of Nursing, Nursing 96-98, and RN. The source journals were subjected to a citation analysis of articles from 1996 to 1998, followed by an analysis of database access to the most frequently cited journal titles. RESULTS: Cited formats included journals (63.7%), books (26.6%), government documents (3.0%), Internet (0.5%), and miscellaneous (6.2%). Cited references were relatively current; most (86.6%) were published in the current decade. One-third of the citations were found in a core of 24 journal titles; one-third were dispersed among a middle zone of 94 titles; and the remaining third were scattered in a larger zone of 694 titles. Indexing coverage for the core titles was most comprehensive in PubMed/MEDLINE, followed by CINAHL and Science Citation Index. CONCLUSIONS: Results support the popular (not scholarly) nature of these titles. While not a good source for original research, they fulfill a key role of disseminating nursing knowledge with their relevantly current citations to a broad variety of sources.

Abstracting and Indexing↗
PubMed2002

Getting to the (c)ore of knowledge: mining biomedical literature.

Literature mining is the process of extracting and combining facts from scientific publications. In recent years, many computer programs have been designed to extract various molecular biology findings from Medline abstracts or full-text articles. The present article describes the range of text mining techniques that have been applied to scientific documents. It divides 'automated reading' into four general subtasks: text categorization, named entity tagging, fact extraction, and collection-wide analysis. Literature mining offers powerful methods to support knowledge discovery and the construction of topic maps and ontologies. An overview is given of recent developments in medical language processing. Special attention is given to the domain particularities of molecular biology, and the emerging synergy between literature mining and molecular databases accessible through Internet.

Abstracting and Indexing↗
PubMed2004

What is the point of databases of reviews for dermatology if all they compile is "insufficient evidence"?

BACKGROUND: The use of review databases for dermatology has been questioned because of the impression that these reviews frequently report finding insufficient evidence to guide therapeutic recommendations. OBJECTIVE: We sought to determine the number of review database entries most relevant to dermatology (addressing diseases with skin manifestations whereby a dermatologist may be the primary caregiver) and the percentage of these entries that report sufficient evidence to guide clinical decision making. METHODS: We conducted computerized searches and analysis of reviews in the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effectiveness. Database entries were categorized using the face value reports of the original reviewers as: (1) finding sufficient evidence to inform clinical decisions; (2) finding insufficient evidence; or (3) unable to classify with regard to degree of evidence found. RESULTS: Of all review database entries, 3% (54/1235 in Cochrane Database of Systematic Reviews and 65/2208 in the Database of Abstracts of Reviews of Effectiveness) were deemed relevant to dermatology. In all, 14 entries from the Database of Abstracts of Reviews of Effectiveness were in the process of being written and not available for further evaluation. Of the remaining entries, 40% (42/105) reported finding sufficient evidence. Of the 10 most common dermatologic diagnoses, 8 were addressed in 30% (31/105) of these reviews. Of entries addressing common dermatologic diagnoses, 32% (10/31) reported finding sufficient evidence. CONCLUSIONS: Although few (3%) entries in review databases currently address dermatology topics, entries address many (8/10) of the top 10 dermatology diagnoses. Contrary to popular belief, a substantial number (40%) of such reviews report sufficient evidence to inform clinical decisions making.

Databases, Bibliographic↗
PubMed1999

Mapping the literature of occupational therapy.

Occupational therapy, formally organized in the United States in 1917, is considered an allied health field. Mapping occupational therapy literature is part of a bibliometric project of the Medical Library Association's Nursing and Allied Health Resources Section's project for mapping the literature of allied health. Three core journals were selected from the years 1995 and 1996 and a determination was made of the extent to which the cited journal references were covered by standard indexing sources. Using Bradford's Law of Scattering three zones were created, each containing approximately one-third of the cited journal references. The results showed that three journals made up the first zone, 117 journals the second, and 657 the third. The most cited journal was the American Journal of Occupational Therapy. In the second zone, journals from twelve disciplines were identified. While MEDLINE provided the best overall indexing, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) was the only database that indexed the three most cited journals plus nine of the currently active titles in occupational therapy. MEDLINE could improve its coverage of occupational therapy by indexing the journals of the British, Canadian, and Australian national associations.

Abstracting and Indexing↗
PubMed2006

Cestode systematics and phylogeny move forward.

This paper represents a meeting report for the Fifth International Workshop on Cestode Systematics and Phylogeny held at the Institute of Parasitology, Academy of Sciences of the Czech Republic, Ceské Budejovice, 18-22 July 2005. The major topics discussed included (i) the progress in cestode systematics during 2002-2005, (ii) the use of the life-cycle data in phylogenetic studies, (iii) the utilisation of new morphological and molecular characters in cestode systematics and phylogeny, and (iv) the ongoing work on the completion of the Global Cestode Database.

Animals↗