[Effects of n-phthalyl-glutamic acid imide (Thalidomide). I. Study of the blastic evolution of human lymphocytes in culture with phytohemagglutinin].
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Using Huntington disease, mental retardation, and schizophrenia, it has been shown that two individuals with identical genotypes or phenotypes have different fitnesses because of affected nuclear family members. Such fitness interaction seems to occur because of cultural and social reactions due to the presence of affected individuals, and the interaction has been termed "social selection." Without assuming any specific genetic control for the social behavior, we can study the effect of social behavior on the incidence of a genetic disease.
There is currently a great interest by many winemakers in making some of their vinifications by means of pure culture yeasts. We describe, in this paper, the problems encountered in operating this way, the corresponding aims, the method of selecting strains and, more particularly, the possibilities offered by applying yeast genetics.
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There were investigated 6967 families from 6 rural regions, under industrialization, and industrialized urban regions. In the grandparents generation there were taken into account 10 traits (an education level, a mating radius, and a stature) and in parents generation 17 traits (the mentioned-above ones and a number of family members, a flat size, incomes, an employees No., a life mode, smoking etc. Numerical characteristics of traits have been calculated jointly and separately in six populations, matrices of correlation have been constructed and moreover factorial analysis have been carried out, as a result of which 8 rotated factors have been obtained. The highest cultural mobility (increase in the level of education) from generation to generation occurs in the population of textile industry town Lódź. The highest improvement of biological status, the increase in mating radius and high incomes are characteristic for this regions, too. On the other side are villages with low culture mobility (not large increase in education level), slight improvement of biological status, almost no migrations, overcrowded flats and low income per family member. The relations between pairs of traits appear to vary largely in several populations. Generally is a high correlation between the education level of the same family members in both generations. The has been stated negative correlation between grandfather stature both of the mother and the father lines, with occurring of positive assortative mating in the couples of two generations. In both investigated generations there is the positive assortative mating, but the negative correlation in the stature between grandfathers of the mother and the father lines. The grandparents education level is correlated with their and their offsprings stature. The duration of holidays is one of the best (closely correlated with others) indicators of life mode, and partially of a given family living conditions, too. 8 hidden factors have been separated: a consciousness, mode of life, a number of family members, a genetic factor (stature), migrations, living conditions, incomes. This 8 factors have different ranks (evaluated as a position in sequence expressing in % the share in being explained variance) in six investigated rural and urban populations, explaining together 54-55% of the total variance of analyzed family traits. The consciousness occurs generally as a first factor. As far, as the mode of life is concerned, the rank of its factor is less in villages than in towns, and reciprocally the ranks of such factors as a number of family members, migrations and living conditions, are greater in villages than in towns.
Pockets of high fertility persisted in some areas of the American South through the Great Depression. Most other areas of the country adopted modern fertility patterns considerably earlier in the century; these "laggard" areas are clear exceptions to the national demographic revolution in family building. In this paper we attempt to identify the factors that account for the persistently high fertility in some southern regions. We use county-level data for 1940 to assess the utility of three theoretical models of fertility: structural, diffusion-innovation, and health. Differences by race are also considered, in view of the distinctly different histories of whites and African-Americans in the south. Our findings suggest that unicausal explanations for the persistence of high fertility are too simplistic; all three theoretical perspectives receive empirical support. Considerable similarity is observed in the findings for blacks and for whites. Yet important differences also emerge, especially the more powerful effects of structural variables on white fertility. We conclude that the evidence indicates the need for "diversity" in the study of demographic behavior. Not only should we examine a variety of causal mechanisms for demographic phenomena; we also should consider the varying utility of those mechanisms across different social groups.
We report an exclusively cutaneous case of cryptococcosis, which is exceptional. He was a 33 years old patient with the acquired immunodeficiency syndrome who presented with an ulcer-necrotic lesion at the nasal wings with a long and torpid evolution. Finally, culture and biopsy were diagnostic of cryptococcosis. We ruled out affection of other organs and the cryptococcal antigen was negative in serum and cerebrospinal fluid. The patient was treated with fluconazole and had a good clinical course. Its emphasized the scarcity of this form of presentation as well as the lack of specificity of its lesions and the necessity of ruling out other locations once the fungus is isolated in the skin. Diagnosis is simple through skin biopsy and culture. Its important to determine the cryptococcal antigen. We comment on the current approaches to treatment during acute and maintenance phases, after the appearance of the new imidazolic compounds such as fluconazole.
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