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PubMed1975

Colposcopy.

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Colposcopy↗
PubMed2002

Association of cervical cryotherapy with inadequate follow-up colposcopy.

OBJECTIVES: We studied the anatomic changes that occur in the ectocervix after cryotherapy and the role these changes play in the adequacy of follow-up colposcopic examination. STUDY DESIGN: We retrospectively reviewed patients' charts. POPULATION: Between January 1, 1991, and December 1, 1995, 268 women underwent 2 colposcopic examinations in 7 state-run public health clinics. OUTCOMES MEASURED: The likelihood that a follow-up colposcopic examination would be inadequate. RESULTS: Of the 268 women who underwent 2 colposcopic examinations during the study period, 83 had cryotherapy, 24 had loop excision of the ectocervical portion or cervical conization, and 96 had no procedure. Sixty-five were excluded because of missing data. Subjects were similar with respect to age, whether endocervical curettage was performed, cervical dysplasia, presence of human papilloma virus, and whether glandular involvement was noted. Patients who had cryotherapy had an increased likelihood of inadequate follow-up colposcopic examination compared with women who had no procedure (adjusted odds ratio = 18.7, 95% confidence interval = 7.0-49.8). CONCLUSIONS: Undergoing cryotherapy of the uterine cervix increases the risk that a follow-up colposcopic examination will be inadequate. Given the reported high rates of regression of mild and moderate cervical dysplasia and the risks posed by possibly unnecessary procedures performed after inadequate colposcopic examination, a trend toward less aggressive therapy and watchful waiting may be appropriate but should be investigated in a controlled clinical trial.

Adult↗
PubMedDate not supplied

Colposcopy, cervical cytology and human papillomavirus detection as screening tools for cervical cancer.

A cohort of 77 women referred for routine screening or investigation of Pap test abnormality underwent colposcopic examination. Pap-stained liquid-based preparations were diagnosed and categorized according to the Bethesda system. Residual material on the sampling device was used to detect high-risk oncogenic human papillomavirus DNA. Although the colposcopic failure rate was higher than that of cytology, no lesion was missed when both methods were used together. High-risk types were recorded in 24% of patients with atypical squamous cells of undetermined significance, 45% with low-grade squamous intraepithelial lesions and 79% with high-grade squamous intraepithelial lesions--indicating that the efficacy of cytological screening can be improved by papillomavirus detection.

Adult↗
PubMed1976

[The value of local application of a vasoconstrictive peptide during colposcopy (author's transl)].

The vasoconstrictive peptide (Ornithin-Vasopressin, experimental name POR 8) was tested regarding its usefulness in colposcopic diagnosis and differential diagnosis. In a concentration of 5 IE/2 ml of normal saline the compound resulted in good hemostasis in 88% of the cases. The differential diagnosis of the atypical transformation zone was much easier because of the difference in constriction between normal and abnormal vessels. The local application of "POR 8" is a valuable aid in the colposcopic diagnosis and differential diagnosis of the bleeding cervix in the cervix with an atypical transformation zone.

Administration, Topical↗