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Modafinil augmentation in depressed patients with partial response to antidepressants: a pilot study on self-reported symptoms covered by the Major Depression Inventory (MDI) and the Symptom Checklist (SCL-92).

Treatment-resistant depression, i.e. partial or non response to antidepressants in spite of various treatment attempts with optimized doses and combinations, is rather common. With residual symptoms such as tiredness, anhedonia and concentration disturbances, the treatment strategy has often been to use monoamino-oxidase inhibitors (MAOIs). Their use, however, is limited due to interaction problems. Modafinil is recently developed wake-promoting drug with only minor side-effects. Pilot studies indicate that it appears to have an augmentation effect in treatment-resistant depression. This open-label study performed in the private psychiatric practice setting is the first to make a comprehensive evaluation of the target patient profile based on patient-reported symptoms. Modafinil in doses of 100-400 mg was administered as augmentation to ongoing antidepressant therapy in patients with partial response and suffering from hypersomnia. The total number of patients was 21 and 43% of these were responders (i.e. had a score reduction of >50% on the Major Depression Inventory (MDI) as well as remitters, i.e. the remission rate was 43%. At endpoint, the responders had psychological distress scores on the Symptom Checklist (SCL-92) on the level of the general Danish population. Baseline characteristics for responders were lower scores on depression, hostility, anxiety, somatization, obsession and psychoticism. Modafinil thus appears to be an appropriate augmentation to antidepressant treatment, leading to a remission rate of 43%. However, the results from this open-label study need ot be confirmed in a placebo-controlled trial.

Antidepressive Agents↗

Using Rasch analysis to test the cross-cultural item equivalence of the Harvard Trauma Questionnaire and the Hopkins Symptom Checklist across Vietnamese and Cambodian immigrant mothers.

A major challenge in conducting assessments in ethnically and culturally diverse populations, especially using translated instruments, is the possibility that measures developed for a given construct in one particular group may not be assessing the same construct in other groups. Using a Rasch analysis, this study examined the item equivalence of two psychiatric measures, the Harvard Trauma Questionnaire (HTQ), measuring traumatic experience, and the Hopkins Symptom Checklist (HSCL), assessing depression symptoms across Vietnamese- and Cambodian American mothers, using data from the Cross-Cultural Families (CCF) Project. The majority of items were equivalent across the two groups, particularly on the HTQ. However, some items were endorsed differently by the two groups, and thus are not equivalent, suggesting Cambodian and Vietnamese immigrants may manifest certain aspects of trauma and depression differently. Implications of these similarities and differences for practice and the use of IRT in this arena are discussed.

Adolescent↗

[Association between substance abuse problems and antisocial tendencies in male juvenile delinquents: A study using the Psychopathy Checklist, Youth Version].

AIMS: We examined an association between substance abuse problems and antisocial tendencies in male juvenile delinquents. METHODS: Subjects were 57 male adolescents consecutively incarcerated between December 2004 and February 2005 in a juvenile classification home. A self-reporting questionnaire was used to assess substance abuse problems in the subjects: Drug abuse problems were assessed by the Drug Abuse Screening Test (DAST-20), and alcohol abuse problems were assessed by the Quantities-Frequencies Scale (QFS). A semi-structured interview was also preformed according to the Psychopathy Checklist, Youth Version (PCL: YV). Associations between questionnaire responses and interview findings were examined using Pearson's correlation or Spearman's rank correlation test. RESULTS: Of our subjects, the 17.5% were recognized as a problematic drug abuser, and the 52.6% as a problematic drinker. Neither of the total DAST-20 nor QFS score was significantly correlated with the total PCL: YV score, and also with each score of the four PCL: YV subfactors. However, significant correlations were found between some items on the PCL: YV and the DAST-20 or QFS score. The DAST score was significant correlated with the PCL: YV item, "impression management" (rs=0.35, p<0.001), and the QFS score was significant correlated with "serious violations of conditional release" (rs=0.33, p<0.05) and "criminal versatility" (rs=0.48, p<0.001). CONCLUSION: More than a half of male juvenile delinquents had alcohol abuse problems. Alcohol intake may be considered to promote repetition and diversification of their antisocial behaviors, although overall antisocial tendencies were not associated with drug and alcohol abuse problems in male juvenile delinquents.

Adolescent↗

A checklist for evaluating reports of expression profiling for treatment selection.

Oncologists need improved tools for selecting the right treatment for a given patient because many patients do not benefit from administered therapies. The use of expression profiling of tumors has increased dramatically and many claims are made for the value of expression signatures in treatment selection. It is difficult, however, for oncologists to critically evaluate published results in this technology- and statistics-intensive field. A checklist is presented to help oncologists evaluate publications on expression profiling of human tumors to determine whether the results are ready for use with their patients.

Gene Expression Profiling↗

Calibration and reliability of a school food checklist: a new tool for assessing school food and beverage consumption.

There is a pressing need in Australia and other countries to develop systems for monitoring secular trends in childhood obesity and related behavioural and environmental determinants. Energy from foods and beverages consumed at school is an accessible indicator of children's eating patterns and we have developed a school food checklist (SFC) to measure this. The SFC records the number of serves and source (home, canteen, vending machine) of 20 food and beverage categories. This study aims to assess the accuracy and to calibrate the SFC by comparing it to a weighed record (WR) and to evaluate inter-recorder reliability. Participants were 910 primary school children aged 5 to 12 years from a rural township in Victoria, Australia. WR were collected from a non-random sub-sample of 106 and a second sub-sample (n=46) had intake measured twice using the SFC to assess inter-recorder reliability. Mean energy values were 2992 kJ +/- 924 and 3008 kJ +/- 952 for the SFC and WR respectively and the correlation coefficient was strong (Pearson r = 0.77). The mean difference between the WR and SFC methods was 15 kJ (95% CI, -107 kJ to 138 kJ) and the limits of agreement (+2 standard deviations) were +/- 1270 kJ. The SFC overestimated the energy/serve of breads and fruit drinks and under-estimated energy/serve from fat spreads, biscuits/crackers, muesli/fruit bars and fruit. Inter-recorder reliability was good (kappa 0.51). The SFC was designed to measure energy from food and beverages in schools. It has good accuracy and reliability and the revised version should further improve accuracy of the instrument.

Beverages↗

Oral behaviors checklist: reliability of performance in targeted waking-state behaviors.

AIMS: To assess the consistency of intentional behavioral performance as an index of whether individuals understood the meanings of the behavioral terms of the Oral Behaviors Checklist, which is a self-report scale for identifying and quantifying the frequency of jaw overuse behaviors. METHODS: Surface electromyography was used to measure bilaterally the activity of the masseter, temporalis, and suprahyoid muscles (for assessment of oral behaviors) and the biceps muscles (reference task of biceps curl) in 27 temporomandibular disorder (TMD) cases and 27 controls. Subjects were asked to perform (1) biceps curls to lift 5 weights, with explanation, and (2) 10 oral behaviors (e.g., "clench", "yawn") without explanation. RESULTS: Biceps-curl performance resulted in assignments of excellent or very good for linearity-reliability based on inspection and correlation. Test-retest reliability of the 10 performed oral behaviors generally ranged from 0.6 to 0.98 for all 3 muscle groups, and many tasks had reliability coefficients comparable to those for the biceps curl. Across tasks, elevator muscle reliability of cases was 0.87, compared to 0.75 for controls; group values for opening muscles were similar. CONCLUSION: Individual subjects performed each task at a high level of consistency. Performance was not appreciably altered by being a TMD case versus a control and was not significantly different from the performance level of a reference task, indicating that each individual understood well the meaning of each oral behavior-related word.

Adult↗

Concurrent validity of a Crime-Related Post-Traumatic Stress Disorder scale for women within the Symptom Checklist-90-Revised.

Using a structured interview to obtain a lifetime history of criminal victimization, a community sample of 266 adult women who had experienced at least one incident of victimization was identified. These women were administered the Symptom Checklist-90-Revised, the Impact of Event Scale, and a structured clinical interview was used to identify Crime-Related Post-Traumatic Stress Disorder (CR-PTSD). A recently derived scale based on responses to items on the SCL-90-R was compared to the IES for predicting current diagnosis of Crime-Related PostTraumatic Disorder. Both the scale and the IES were found to improve prediction of CR-PTSD above base rates and to perform in a similar manner. The utility of each of these scales as a screening measure is discussed.

Adult↗

Cross-validation of the factor structure of the Aberrant Behavior Checklist for persons with mental retardation.

The original factor structure of the Aberrant Behavior Checklist was cross-validated with an American sample of 470 persons with moderate to profound mental retardation, including nonambulatory individuals. The results of the factor analysis with varimax rotation essentially replicated previous findings, suggesting that the original five factors (Irritability, Lethargy, Stereotypic Behavior, Hyperactivity, and Inappropriate Speech) could be cross-validated by factor loadings of individual items. The original five scales continue to show high internal consistency. These factors are easily interpretable and should continue to provide valuable research and clinical information.

Adult↗

Assessing differences in chemically dependent adolescent males using the Child Behavior Checklist.

A study was conducted with 59 chemically dependent (CD) male adolescents (ages 13 to 16) using the Child Behavior Checklist (CBC). The CD sample was compared to a normative group on four adaptive behavior scales and twelve behavior problem scales, and was found to be significantly different on all measures. The CD sample was also compared to a general clinical group on nine behavior problem scales, and was found to score significantly higher on scales measuring delinquent and uncommunicative behaviors, and significantly lower on scales measuring immature and hostile-withdrawn behaviors. Summary profile types were compared with the clinical population and a separate assaultive/aggressive population. More of the CD population fit an uncommunicative/delinquent profile type and relatively fewer fit schizoid and immature/aggressive profile types as compared to the two other groups. The CBC differentiated subgroups in the CD sample with respect to completion of treatment and type of drug used, but not motivation for treatment at admission.

Adolescent↗

Evaluating CD-ROM versions of the MEDLINE database: a checklist.

The emergence of CD-ROM (compact disc/read-only memory) versions of the MEDLINE database requires experienced MEDLINE searchers to examine assumptions about searching MEDLINE, since some expectations may not be fulfilled by this new technology. When applied to a particular CD-ROM MEDLINE product, the evaluation procedure involves testing assumptions concerning database contents; mechanics of searching; display, print, and download capabilities; and user-friendly features. The extent to which a CD-ROM product preserves and exploits important MEDLINE strengths should be assessed, e.g., the MeSH controlled vocabulary, the designation of major and minor MeSH emphasis, and the use of subheadings. Search software characteristics that affect ease of searching and quality of results also need to be examined, e.g., the ability to truncate search terms and the order of precedence in which Boolean operators are evaluated. A checklist to assist in the evaluation process is presented, including search examples for use in testing search functions.

Abstracting and Indexing↗

The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects.

The development of a scale to assess drug and other treatment effects on severely mentally retarded individuals was described. In the first stage of the project, an initial scale encompassing a large number of behavior problems was used to rate 418 residents. The scale was then reduced to an intermediate version, and in the second stage, 509 moderately to profoundly retarded individuals were rated. Separate factor analyses of the data from the two samples resulted in a five-factor scale comprising 58 items. The factors of the Aberrant Behavior Checklist have been labeled as follows: (I) Irritability, Agitation, Crying; (II) Lethargy, Social Withdrawal; (III) Stereotypic Behavior; (IV) Hyperactivity, Noncompliance; and (V) Inappropriate Speech. Average subscale scores were presented for the instrument, and the results were compared with empirically derived rating scales of childhood psychopathology and with factor analytic work in the field of mental retardation.

Adult↗

Nineteenth century medical journalism in Texas: with a journal checklist.

Texas medical journals prior to 1900 have been incompletely (sometimes incorrectly) recorded in periodical checklists. This paper attempts to provide a short account of the purposes and achievements of the more significant journals and to list all names and related name changes, in so far as it has been possible to do so.

History, 19th Century↗

Improving the MEDLARS search interview: a checklist approach.

An analogy is drawn between searching a computer data base and conducting laboratory research: the crucial process in both is phrasing the question to the system to obtain meaningful and useful results. The searcher must act as an intermediary for the library user in questioning the data base; for this reason every effort must be made to maximize the efficiency with which a query is transferred from requester to searcher. Studies reported in the literature tend to distribute themselves into one of two categories: flowchart analyses or nonverbal communication approaches. Because message transfer in an interview is an entirely human process, the flowchart approach, while perhaps providing a correct analysis, is rejected as a means of improvement. Similarly, emphasis on nonverbal cues and communication inhibitors is assessed as misplaced. Rather, the method recommended is guided practice, using a checklist of areas to be covered in an interview for a MEDLARS search. Topic appropriateness, form design, and postsearch follow-through are included in the discussion.

MEDLARS↗

[Validity and reliability of a symptom checklist (FSCL): use in psychogeriatrics].

The incidence of psychogenic (depressive) disturbances in the elderly (greater than or equal to 65 years) is estimated to be 20--64%. In contrast to this, the systematic, exact and broad evaluation of the psychic condition is astonishingly rare in geriatric patients. --The FSCL is a sensitive, reliable, valid and practicable instrument for the quantitative rating of 40 clinical symptoms by the doctor. It is an attendant addition to the specific geriatric scales. The time required to complete the checklist is 2--5 minutes. --The interrater- and intrarater reliability has been analysed for 34 untrained raters previously unfamiliar with the FSCL, using simultaneously video-recorded interviews. The results showed a high homogeneity (reproducibility) resp. correlation (rtt = .58--.95). The sensibility to changes and differences between drugs or against placebo was demonstrated by e.g. double-blind multicenter trials (geriatrics N = 420, depression N = 450, chronic anxiety N = 643). --Concurrent validity has been demonstrated by the good correlation between the percentage improvements in the symptoms and the 4-point overall clinical ratings (r = .81, N = 240). The construct validity has been confirmed by means of factor analysis. Six orthogonal, clinical relevant factors were obtained (item loading greater than or equal to .40) which accounted for 50% of the total variance: anxiety--excitation, inhibition--depression, inhibited social behaviour, disturbed thought process and content, agitation--aggression, auto-aggressive thoughts.

Aged↗

Ethical checklist for dental practice.

A checklist for verification of unethical business practices, originally formulated by Drs. Blanchard and Peale, is adapted to dental practice. A scenario is used as a model to demonstrate the applicability of this instrument to dental practice. The instrument asks three questions in regards to an ethical dilemma: 1) Is it legal? 2) Is it fair? 3) How does it make you feel? The paper concludes the giving of gifts to general dentists by dental specialists for the referral of patients is unethical.

Clinical Competence↗