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PubMedDate not supplied

[Characterization of cardiovascular system function in children from the Issyk-Kul Rregion].

The age-specific features of the cardiovascular system in a child and the pattern of adaptive responses to the long-term impact the mountain-and-maritime climate of the Issyk-Kul Region. All the children were found to have bradycardia (43-61 beats per min), which corresponds to the parasympathetic predominance of their nervous system. They also showed a short pulse recovery (60 seconds), unlike the children of the plains and a statistically significant pulse rate reduction at rest minute 5 (p < 0.05) as compared with the base-line level. In the settlement of Kadji-Sai, there was a decrease in all functional parameters: pressure, the time of a response to light and sound stimuli. It was ascertained that the following features were characteristic for mountain dwellers: bradycardia associated with the predominance of the parasympathetic nervous system and the tendency towards lowered systolic pressure without a significant change in diastolic pressure.

Bradycardia↗
PubMed1997

Two patients with asymmetric crying facies, normal cardiovascular systems and deletion of chromosome 22q11.

We report two unrelated patients with Asymmetric Crying Facies (ACF) and 22q11 deletion. In the first case ACF was the presenting feature. Fluorescent In Situ Hybridization (FISH) revealed 22q11 deletion and subsequent echocardiography demonstrated a normal cardiovascular system. The second presented with hypoparathyroidism, shown on FISH to be secondary to 22q11 deletion. Echocardiography was normal and ACF was found incidentally. Deletion of 22q11 has been reported with ACF occurring as part of the Cardiofacial syndrome (CFS) [Giannotti A, Mingarelli R, (1994): Am J Med Genet 53: 303-304] but this is the first report of ACF with 22q11 deletion in the absence of cardiac abnormalities. A review of the literature pertaining to ACF is presented.

Cardiovascular System↗
PubMedDate not supplied

[Effect of pharmacological agents to prevent the motion sickness syndrome on the cardiovascular system in simulating the early period of adaptation to weightlessness].

The application of pharmacological agents, preventing the motion sickness syndrome in modelling the early stages of adaptation to weightlessness by means of 6-hour antiorthostatic influence (-15 degrees), does not exert a negative action on the human cardiovascular system. The given agents normalize partially cerebral circulation, eliminating changes induced by antiorthostatic influence.

Adaptation, Physiological↗
PubMed1978

Some preliminary observations on the effects of kola nut on the cardiovascular system.

The prevalence of kola nut chewing and the effects attributed to it are briefly reviewed. Except for a generalisation that its effects are probably due to its caffeine content, no attempts have been made to quantify its specific actions. Preliminary observations on the cardiovascular system of the cat show that aqueous extracts of the nut evoke a dose dependent differential response - the 8 - 9% hypertensive effect of 0.01 ug - 1mg/ml doses contrasting with the 18--71% hypotensive response of 10--1000mgs/ml doses. Adrenergic receptor blockade showed no significant alteration of the response. With larger doses a bradycardia developed and cardiac arrythmias were observed as a terminal event. These results are compatible with the action of xanthines on the heart and peripheral vasculature. The possible role of the habitually chewed kola nut in the pathophysiology of cardiovascular disease and its implications have been briefly discussed.

Animals↗
PubMed2001

Cardiovascular genomics: estimating the total number of genes expressed in the human cardiovascular system.

The number of genes encoded by the human genome has long sought to be determined. With the recent publications of the complete sequence of the human genome, the number of genes encoded by the human genome has now been estimated to be approximately 32,000-38,000. Now the next step will be to determine which of these genes are expressed in a given cell, tissue or organ. Using three unique approaches taking advantage of our current cardiovascular EST database and the complete nucleotide sequence of human chromosomes 21 and 22 as well as cDNA microarray hybridization, we estimate that between 20,930-27,160 genes are expressed in the cardiovascular system.

Cardiovascular System↗
PubMedDate not supplied

Numeric modeling of the cardiovascular system with a left ventricular assist device.

A numeric model consisting of a lump-parameter cardiovascular system (CVS) model and a model for the Cleveland Clinic Implantable Ventricular Assist System (IVAS), a nonpulsatile rotary pump designed to augment the failing left ventricle, are described in this paper. The purposes of this study were to 1) observe the hemodynamic interactions between CVS and IVAS under various physiologic and pathophysiologic conditions running at different speeds; and 2) allow testing and optimization of various IVAS control algorithms. An existing numeric model of CVS (24 coupled differential equations, representing all cardiac chambers and systemic and pulmonary vasculature) was modified to add the IVAS pump as an auxiliary chamber between the left ventricle and aorta with pressure-flow-speed characteristics derived from in vitro testing. Simulations were conducted for ventricles with normal and abnormal systolic and diastolic dysfunction at different exercise levels with the pump running at various speeds. Computer simulations show that 1) numeric modeling is useful for predicting hemodynamic response of CVS to IVAS in various circumstances; 2) IVAS results in normalization of cardiac output, especially in failing hearts, although with reduced pulse pressure; and 3) various control algorithms allowing adaptation of IVAS to physiologic demands of CVS could be developed based on the simulation study.

Blood Pressure↗
PubMed1986

Aging and the cardiovascular system.

What has preceded has been largely a listing of contradictory data: what follows is an attempt to gleam a pattern from all of this. In general, responsiveness is either reduced or unchanged by aging; reduced responsiveness has been demonstrated most frequently for cardiac beta-adrenoreceptors, cardiac muscarinic receptors, vascular beta-adrenoreceptors and vascular alpha 2-adrenoreceptors. A reduced ability of the amine uptake system has been demonstrated in some but not all studies: any reduction in re-uptake would tend to potentiate the effects of NA and counteract the reduced receptor responsiveness (or vice versa). This may explain why the most consistent cardiovascular alteration reported in the elderly is an increased plasma NA. While there are clinical reports that beta-blockers and converting enzyme inhibitors are less effective in elderly hypertensives at lowering blood pressure, this may reflect more the pathological development of hypertension with time rather than a true aging phenomenon. Overall, it appears that resting function of the cardiovascular system is near normal in the aged, but since the mode of control is somewhat altered, in particular with a blunted baroreflex, perturbations in the system produced by drugs may cause a higher incidence of adverse effects.

Aging↗
PubMed1979

[Status of the cardiovascular system in children with acute diffused peritonitis].

67 patients with acute diffused peritonitis aged from 2 to 15 years were examined. The arterial and central venous blood pressure, contractile function of the myocardium, peripheral and central blood flow were estimated. It has been found that functional shifts of the cardiovascular system occur at the early stage of the disease and advances as it develops.

Acute Disease↗
PubMed1999

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system.

OBJECTIVE: Methylation of the promoter region of the estrogen receptor gene alpha (ER alpha) occurs as a function of age in human colon, and results in inactivation of gene transcription. In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease. METHODS: We used Southern blot analysis to determine the methylation state of the ER alpha gene in human right atrium, aorta, internal mammary artery, saphenous vein, coronary atherectomy samples, as well as cultured aortic endothelial cells and smooth muscle cells. RESULTS: An age related increase in ER alpha gene methylation occurs in the right atrium (range 6 to 19%, R = 0.36, P < 0.05). Significant levels of ER alpha methylation were detected in both veins and arteries. In addition, ER alpha gene methylation appears to be increased in coronary atherosclerotic plaques when compared to normal proximal aorta (10 +/- 2% versus 4 +/- 1%, P < 0.01). In endothelial cells explanted from human aorta and grown in vitro, ER alpha gene methylation remains low. In contrast, cultured aortic smooth muscle cells contain a high level of ER alpha gene methylation (19-99%). CONCLUSIONS: Methylation associated inactivation of the ER alpha gene in vascular tissue may play a role in atherogenesis and aging of the vascular system. This potentially reversible defect may provide a new target for intervention in heart disease.

Aging↗
PubMed2006

Nitric oxide signaling in the cardiovascular system: implications for heart failure.

PURPOSE OF REVIEW: The role played by nitric oxide (NO) in cardiovascular physiology remains highly controversial. Following the discovery that NO is the prototypic endothelium-derived relaxing factor, this signaling molecule was implicated as possessing many other biological actions within the cardiovascular system, including effects on cardiac contraction, relaxation, and energetics. Here, we discuss new concepts regarding NO signaling, its effector pathways, and interactions between NO and the redox milieu within a framework of cardiac physiology and pathophysiology. RECENT FINDINGS: Major recent insights that have advanced understanding of the mechanisms of NO bioactivity include the following. (1) NO acts in subcellular signaling compartments or modules. (2) S-nitrosylation (covalent modification of cysteine thiol moieties) of proteins represents a prototypic second messenger signaling mode in biologic systems. (3) Reactive oxygen and nitrogen species work together to facilitate signaling. (4) Disruption of physiologic signaling can occur by either increased formation of reactive oxygen species or decreased production of reactive nitrogen species, a situation of nitroso-redox imbalance. SUMMARY: These insights, which challenge classically held views that NO acts as a freely diffusible molecule regulated primarily by concentration and exerting signaling primarily through cyclic GMP production, offer a new perspective on the pathophysiology and treatment of congestive heart failure.

Alcohol Dehydrogenase↗
PubMed2006

[Hyperhydration and the cardiovascular system in patients receiving hemodialysis].

In order to evaluate the influence of volume overload on the cardiovascular system, patients on program hemodialysis were examined using ultrasonography and isotope ventriculography. The study revealed a doubtless correlation between hyperhydration, on the one hand, and arterial hypertension, an increased minute volume, and left ventricular hypertrophy, on the other. A growing left atrial contribution was shown to play an important role for the maintenance of an adequate left ventricular filling during a session of hemodialysis with ultrafiltration. The study also found paradoxal blood sequestration in the venous system during the process of ultrafiltration in patients with high parathyroid hormone levels.

Adult↗
PubMed1985

Effect of nifedipine treatment on cardiac myosin ATPase activity and responsiveness of cardiovascular system in the dog.

Effects of nifedipine treatment on cardiac myosin ATPase activity and responsiveness of cardiovascular system to catecholamine have been studied. Eight mongrel dogs weighing 7.5 to 13.5 kg were given nifedipine orally twice daily (60 mg/day) for 2 weeks. Ten minutes after the first administration of nifedipine (30 mg p.o.) the heart rate increased significantly and it lasted for, at least, 4 hours. Two-week treatment of nifedipine caused a decrease of the resting heart rate, but the maximal heart rate increase by nifedipine administration was almost the same as the one on the first day. The effects of norepinephrine on heart rate and blood pressure, responsiveness of isolated coronary arteries to some agents inducing a contraction and, Ca2+-activated and K+-activated cardiac myosin ATPase activities were not significantly different between control and nifedipine treatment groups.

Adenosine Triphosphatases↗
PubMed1987

The impact of butyric acid on the cardiovascular system.

The influence of sodium salt of butyric acid (C4H7NaO2) on the functional state of the cardiovascular system was studied on 12 guinea-pigs and 15 rabbits by the thermodilution method. The following parameters were determined: cardiac output (CO), arterial blood pressure (AP), total peripheral vascular resistance (TPVR), and in rabbits the heart rate (HR). It was found that butyric acid induces significant changes in TPVR, which correlate with changes in CO and AP. These changes could to a considerable extent be prevented by the administration of indomethacin. Haemodynamic changes induced by butyric acid are primarily connected with changes in vascular tonus, induced by the action of F2 alpha prostaglandins whose synthesis is intensified by the influence of butyric acid.

Animals↗
PubMed2006

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

The renin-angiotensin system is a central component of the physiological and pathological responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not only mediates immediate physiological effects of vasoconstriction and blood pressure regulation, but is also implicated in inflammation, endothelial dysfunction, atherosclerosis, hypertension, and congestive heart failure. The myriad effects of ANG II depend on time (acute vs. chronic) and on the cells/tissues upon which it acts. In addition to inducing G protein- and non-G protein-related signaling pathways, ANG II, via AT(1) receptors, carries out its functions via MAP kinases (ERK 1/2, JNK, p38MAPK), receptor tyrosine kinases [PDGF, EGFR, insulin receptor], and nonreceptor tyrosine kinases [Src, JAK/STAT, focal adhesion kinase (FAK)]. AT(1)R-mediated NAD(P)H oxidase activation leads to generation of reactive oxygen species, widely implicated in vascular inflammation and fibrosis. ANG II also promotes the association of scaffolding proteins, such as paxillin, talin, and p130Cas, leading to focal adhesion and extracellular matrix formation. These signaling cascades lead to contraction, smooth muscle cell growth, hypertrophy, and cell migration, events that contribute to normal vascular function, and to disease progression. This review focuses on the structure and function of AT(1) receptors and the major signaling mechanisms by which angiotensin influences cardiovascular physiology and pathology.

Angiotensin II↗
PubMed1994

Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system.

A human fetal heart cDNA library was constructed in the lambda gt22A expression vector. Polymerase chain reaction (PCR) was used to amplify the cDNA inserts. PCR products were purified and used in cycle sequencing reactions in the presence of a fluorescein-conjugated primer and electrophoresed on a Pharmacia A.L.F. Sequencer. Partial cDNA sequences, or expressed sequence tags (ESTs) were searched against the Genbank and EMBL databases to identify novel genes expressed in the human cardiovascular system.

Base Sequence↗
PubMed2006

Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system.

Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450 epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing factors in some vascular beds. EETs are rapidly metabolized by soluble epoxide hydrolase to form dihydroxyeicosatrienoic acids (DHETs). Recent reports indicate that EETs have several important non-vasomotor regulatory roles in the cardiovascular system. EETs are potent anti-inflammatory agents and might function as endogenous anti-atherogenic compounds. In addition, EETs and DHETs might stimulate lipid metabolism and regulate insulin sensitivity. Thus, pharmacological inhibition of soluble epoxide hydrolase might be useful not only for hypertension but also for abating atherosclerosis, diabetes mellitus and the metabolic syndrome. Finally, although usually protective in the systemic circulation, EETs might adversely affect the pulmonary circulation.

8,11,14-Eicosatrienoic Acid↗