Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ARTERIOSCLEROSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 703 records · Page 39Linked to original sources
PubMedDate not supplied

Studies of the pathogenesis of arteriosclerosis induced in rats by intrarenal injection of a carcinogen, nickel subsulfide.

Widespread arteriosclerotic lesions were detected by histological examinations of rats killed at seven or nine weeks after an intrarenal (ir) injection of nickel subsulfide (Ni3S2, 5 mg per rat). Arteriosclerotic plaques were readily visualized by administering hematoporphyrin derivative (HPD) iv to rats at 24 hours before sacrifice. At necropsy, the major arteries were inspected under ultraviolet light, revealing patches of intense HPD-fluorescence in the arterial endothelium of Ni3S2-treated rats, but not in control rats. Consistent with previous reports, the Ni3S2-treated rats developed pronounced erythrocytosis; blood hematocrit values averaged 70 +/- 4 percent at seven weeks after ir injection of Ni3S2 (P less than 0.001 vs corresponding value of 49 +/- 2 percent in vehicle controls). At seven weeks, blood platelet counts averaged 17 percent lower and serum glucose concentrations averaged 23 percent lower in Ni3S2-treated rats than in controls; serum lipids, lipoproteins, non-protein nitrogen constituents, electrolytes, proteins, and enzymes were not significantly affected. Body weights and systolic blood pressures of rats at two, four, and six weeks after ir injection of Ni3S2 did not differ from corresponding values in controls. Addition of egg yolk to the diet caused mild hypercholesterolemia, but it did not enhance the incidence or severity of arterial lesions in Ni3S2-treated rats. These findings exclude hypertension and hyperlipidemia as pathogenic factors in Ni3S2-induced arteriosclerosis.

Animals↗
PubMed1983

Fibrinolytic activity and the effects of beta-pyridylcarbinol (Ronicol) in patients with arteriosclerosis obliterans.

Twenty-one patients with arteriosclerosis obliterans of lower extremities were treated with beta-pyridylcarbinol (Ronicol) for five weeks. The long-term therapy with beta-pyridylcarbinol did not influence platelet aggregability. Activation of the fibrinolytic system was observed. This fibrinolytic effect of Ronicol was abolished in patients treated with aspirin. In most cases a slight clinical improvement was seen, manifested by elongation of pain-free walking distance and increased blood flow in affected limbs. It is concluded that the therapeutic effect of Ronicol in humans may be partly mediated by the release of endogenous prostacyclin.

Arteriosclerosis Obliterans↗
PubMed1984

[Nutrition--a factor in preventing arteriosclerosis, coronary disease and disorders of the blood coagulation system. I. An imbalance in food fats and carbohydrates and atherogenesis].

The analysis of the literary data and the results of own research testifies that the lipids and carbohydrates metabolism disturbance in food is one of the decisive factors of pathogenetic arteriosclerosis and coronary disease. A long balanced diet in particular in fats and carbohydrates favours the normalization of the metabolic processes in stabilization of the organism.

Adult↗
PubMed1984

[Experimental immune arteriosclerosis of rabbits. Immunoenzymatic study].

The immunization of rabbits with aorta homogenates, constituants of the arterial tissue, serum glycoproteins, or lipopolysaccharides from enterobacteria, leads to the production of cross-reacting antibodies and to identical arteriosclerotic lesions. The incubation of aortic slices with anti-rabbit IgG sheep Fab, or anti-rabbit complement sheep IgG, labelled with peroxidase, shows that IgG and complement are bound on prenecrotic cells and on sheaths of elastic fibers. The binding sites are the same, whatever the immunizing agent. The antigenic site blockade prevents the response. The indirect immunoenzymatic test, performed on aortic slices of young control rabbits, shows that the different immune sera obtained with the various antigens bind on the same arterial structures, that is the sheath of elastic fibers, the cellular membrane and cytoplasm. The response to this test is clearly decreased, if not suppressed, by absorption of the immune sera with one of the three following sugars: mannose, NA glucosamine, and sialic acid. These data confirm that the arteriosclerosis induced in the rabbit by immunization is actually of an immune nature and show that the antibodies thus formed are bound on the same arterial structures, independently of the immunizing agent. They suggest that the sugars could be haptens, taking part in cross-reactions and antibody binding.

Animals↗
PubMed1984

Extraanatomic vascular reconstruction in patients with aorto-iliac arteriosclerosis.

During an 11-year period 117 extraanatomic reconstructions were made for aorto-iliac arteriosclerosis; 36 axillofemoral and 81 femorofemoral crossover bypasses. The patients were old and had several factors making them poor risks for surgery. Axillofemoral grafts were more often used in patients with malignant disease. Postoperative mortality was 10% without difference between the two types of reconstruction. Both early and late complications were significantly more frequent in patients with axillofemoral bypass. Reoperations for occlusion and symptoms from the donor side also were significantly more common among axillofemoral patients. Life table analysis showed a higher survival and patency rate among patients with crossover grafts.

Aged↗
PubMed1984

Dirofilariasis with arteriosclerosis in a horse.

Arteriosclerosis caused by Dirofilaria immitis adult parasites was diagnosed in a 20-month-old Quarter horse stallion that died from cantharidin toxicosis. Microscopically, the pulmonary vascular changes were typical of those described as "proliferative endarteritis" in D immitis-infected dogs.

Animals↗
PubMed1978

Survival after arterial reconstruction in arteriosclerosis obliterans of the lower limbs. Follow-up after 10-20 years.

Cumulative survival rates were calculated for 144 patients subjected, 10-20 years previously, to vascular surgery for arteriosclerosis obliterans of the lower limbs. The five-, ten-, and fifteen-year survival rates were 71%, 49%, and 30% respectively, when calculated from the time of operation. The five-, ten-, fifteen, and twenty-year survival rates were 85%, 65%, 44%, and 23% respectively, when calculated from the onset of symptoms. This represents a considerable excess mortality, mainly among men, and mainly caused by arteriosclerotic diseases. However, the median survival time is 13 years from the onset of symptoms, and during this period it is of decisive importance, that patients with disabling symptoms get access to vascular surgical evaluation.

Adult↗
PubMed1982

Systolic hypertension in arteriosclerosis obliterans of the lower limbs.

Hemodynamic parameters were measured in 24 patients with arteriosclerosis obliterans of the lower limbs (AOLL) in comparison with 16 normal subjects of same age. Systemic artérial compliance was estimated from a simple visco-elastic model. In patients with (AOLL), systolic pressure was significantly increased (P less than 0.001) while diastolic pressure remained within normal ranges. Arterial compliance was reduced (P less than 0.01) and was negatively correlated with systolic pressure (r = - 0.72). Intravenous administration of nitroglycerin significantly decreased systolic pressure (P less than 0.05) and increased arterial compliance (P less than 0.01) without any change in mean arterial pressure. The study provided evidence that, in patients with AOLL the reduced systemic arterial compliance contributes in the increase in systolic pressure largely.

Arteries↗
PubMed1978

[Experimental investigation of thoracic aorta myocytes in mice. Contribution to the problem of the cause of arteriosclerosis].

The reactivity of myocytes has been ultrastructurally investigated. Pieces of aorta thoracic from mice were organ-cultured on the chorioallantoic membrane of chicken eggs incubated for 14 days. The outstanding finding were individual myocytes of the media--probably in a particular cytoenergetic stage--undergoing necrosis. They were enclosed from almost unaffected myocytes. Transferred to in vivo conditions, these findings may serve as a model for a participation of myocytes in the devleopment of disseminated multifocal arteriosclerotic plaques. The reactivity of the myocytes as to their ability of proteoglycan and lipid synthesis was opposed to Benditt's hypothesis of the genesis of an arteriosclerotic plaque caused by a monoclonal cell line originating from a mutated myocyte of the artery wall near the site of the plaque. The hypothesis of Kaunitz has been discussed, according to which the high serum cholesterin level with severe arteriosclerosis may be rather a consequence of cholesterin synthesis by the 'reparative' tissue of the arteriosclerotic lesion than its reason.

Animals↗
PubMed1981

Arteriosclerosis in severe hemophilia. A postmortem study.

The clinical histories, risk factors, and autopsy findings were reviewed for five deceased hemophiliacs over the age of 40 years to determine the prevalence and severity of arteriosclerosis. The presence of a severe, congenital, hypocoagulative state did not prevent these five men from displaying typical arteriosclerotic vascular disease. One patient actually died of severe, multivessel, coronary artery disease.

Acute Disease↗
PubMed1980

Inhibition of vitamin D2-induced arteriosclerosis in rats by depletion of complement with cobra venom factor.

Widespread calcerous deposits developed in the aorta, heart and kidneys of rats fed for 4 days with purina chow and high doses of vitamin D2 (200,000 IU/kg body wt/day). Decomplementation of rats with highly purified cobra venom factor (CoF) prior to vitamin D2 feeding, almost completely prevented calcium deposition in the aorta and arteritis. The mortality rate in the CoF-treated vitamin D2-fed rats was much lower than in untreated rats. These findings suggest that the complement system may be recruited in the pathogenesis of vitamin D2-induced arteriosclerosis.

Animals↗
PubMed1978

[Foundations of arteriosclerosis therapy].

Since for the time being there might not be a causal therapy of arteriosclerosis one depends on recognition and influence upon the so-called factors of risk. Up to now these factors have only a statistical but no inevitably causal significance. The aim should be to comprehend groups of endangered persons in the stage of health or, respectively, in the still repairable early stage of the disease to perform a true primary and secondary prevention. In the later stages in the best way a cure of the defect or possible a retardation of the course of the disease and prevention of complications may be achieved.

Arteriosclerosis↗
PubMed1982

[Differential diagnosis of endangiitis and arteriosclerosis obliterans].

41 males at the age from 20 to 40 years with chronic obstruction of the arteries of the extremities were on the basis of anamnestic and clinical findings subdivided into the groups obliterating endangiitis (group I = 20 patients) and obliterating arteriosclerosis (group II = 11 patients). In 10 patients in this way no decision for one of the two diagnoses could be made (group III). By multidimensional variance and discriminance analysis of various clinico-chemical parameters the separation of the groups I and II could be proved. The efficiency was 93.6% in the discrimination with 10 characteristics. With the help of the calculated non-elementary, linear characteristics of discriminance the patients could be classified into the group III. 7 patients could be classified into the group II and 3 patients into the group I. Thus we succeeded in differing 23 patients with obliterating endangiitis from 18 patients who as arteriosclerotics belong to the metabolic syndrome.

Adult↗
PubMed1982

[Animal experiments on predilection of the superficial femoral artery of the adductor canal for arteriosclerosis].

The premature manifestation of the arteriosclerosis in the adductor canal makes this vascular region to a first-class site of predilection. These localised mechanical morphological factors were malingered by means of polyvinylchloride splinting in animal experiment. All degrees of severity of the arteriosclerotic vascular wall changes were shown histologically. The changes of the arteries were developed essentially slighter under medication of pyridinolcarbamat, however, they could not be prevented.

Animals↗
PubMed1980

[Incidence of spontaneous arteriosclerosis in Lowland Black-and-White (LBW) and Simentaler cows from selected regions of Poland].

Studies on the occurrence of spontaneous arteriosclerosis in the arteries of the uterus were conducted on Lowland Black-and-White (LBW) and Simentaler (S) cows. The material studied had been collected from the genital organs of heifers and cows slaughtered in the abattoirs of Gdańsk (LBW) and Rzeszów (S). The animals had been found free from disease, both clinically and on post-mortem examination. Pathological changes in the arteries of the uterus were diagnosed by post-mortem angiography, and identified histologically and histochemically. In both breeds studied, high intensity of the occurrence of arteriosclerotic changes was found, both in heifers and in multiparae cows (LBW 81.9%, S 33.3%). Histochemical examination of the walls of pathologically changed vessels failed to reveal any accumulation of fatty bodies.

Angiography↗
PubMedDate not supplied

[Cerebral arteriosclerosis: neurologic and psychiatric consequences].

Cerebral arteriosclerosis is a frequent, often not sufficiently diagnosed disease in the second half of the life span. Possible causes, diagnosis, and therapy are explicitly shown of its somatic and psycho-pathological symptoms, often acute, and chronically persistent. Particular emphasis is put on acute-care and the therapeutic relevance of socio-and psychotherapy. Finally, consequences for forensic medical opinions are shown.

Aged↗
PubMed1981

High density lipoprotein and arteriosclerosis. Different patterns in primary hypothyroidism and type IIa hyperlipoproteinemia.

Concentrations of high density lipoprotein (HDL) and its subfractions were contrasted in two groups of patients with hypercholesterolemia and a control group of normocholesterolemic subjects. HDL-cholesterol and HDL-protein were low in patients with Type IIa hyperlipoproteinemia, but elevated in patients with primary hypothyroidism. HDL-3 levels were low whereas those of HDL-2 remained unchanged in patients with Type IIa hyperlipoproteinemia. In contrast, in the hypothyroid patients, HDL-3 remained unchanged, while HDL-2 levels were high. The role of HDL in the development of arteriosclerosis in patients with primary hypothyroidism is therefore questioned. Our findings also suggest that measurement of HDL-cholesterol alone cannot be regarded as an accurate indicator of changes in total HDL concentration in different clinical situations.

Arteriosclerosis↗
PubMed1980

[Blood circulation in the lower extremities after reconstructive operations on the vessels in arteriosclerosis obliterans of the aorta and major arteries].

Circulation in the lower limbs of 22 patients with obliterating arteriosclerosis of the aorta and main arteries was studied during operation by means of occlusion plethysmography and from the results of manometry and flow measurement. All patients underwent reconstructive operations on the vessels. Ejection of blood into the limb with a large volume of the contributing vascular bed was encountered immediately and in the first few days after the operation; the specific blood flow (ml/min/100 cm3 tissue) sharply increased in the limb most affected by ischemia. Circulation in the lower limbs was gradually normalized by the 5 th--7 th day. Some indices obtained during the study are important for understanding the course of the postoperative period in patients with the pathological condition discussed.

Adult↗