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At least 685 records · Page 38Linked to original sources

New coaxial ureteral stricture knife.

Open surgical repair of upper urinary collecting system strictures or obstructions is difficult and is less likely to be accepted by the patient than an endoscopic or ureteroscopic approach. In the hands of an experienced urologic endoscopist the use of our cold blade has the advantage of less trauma to the ureter, already compromised by poor blood supply, than blind dilation; there is visual control of the procedure and acceptance by the patient that the urologic surgeon is doing the procedure; and it is adaptable to rigid or flexible endoscopes and ureterorenoscopes. Furthermore, there is information that the results are better, at least in the short term, than the more traumatic endoscopic procedures associated with dilation. However, only long-term future series will give us an evolving view of this resistant problem. Finally, the ureteral knife we have developed has the potential to be converted to an electrosurgical device for incision or coagulation, when appropriate. An application is pending with the US Food and Drug Administration concerning electrosurgical applications of the ureteral knife (in conjunction with J.R. La Course, PhD, and G.C. Gerhard, PhD, Department of Electrical Engineering and Computer Sciences, University of New Hampshire, Durham). The high dielectric constant of the sheath, combined with hemostatic or incisional properties in this latter mode, would likely prove advantageous.

Endoscopes↗

[The cortical column, a new processing unit for cortex-like networks].

We propose in this paper a new connectionnist model which is the result of a collaboration between computer science and neurobiology researchers. This model is based upon a cortical-like network close to cortical function simulation. We present its functional and architectural characteristics together with the very encouraging results obtained for the first simulations on the visual and auditory cortical functions in speech and character recognition.

Auditory Cortex↗

Software engineering education in medical informatics.

Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) educational status and needs in computer science education influenced by the controversy "theoretical versus practical education". Special attention is directed toward the growing importance of analysis, design methods, and techniques in the professional spectrum of Medical Informatics, the relevance of general principles of systems engineering in health care, the potential of non-procedural programming paradigms, and the intersection of Artificial Intelligence and education. Realizations of and experiences with programs in the field of Software Engineering are reported with respect to special requirements in Medical Informatics.

Artificial Intelligence↗

[The use of large morbidity data bases in the evaluation of health services].

The major developments of recent years in computer sciences have led to the creation of large morbidity data bases. Although these data sets are not compiled expressly for research, they serve researchers if certain precautions are taken. These concern definition of the study population, unit of analysis, record linkage and both reliability and validity of the data.

Canada↗

[Current computerized support for vestibular function tests.I. Expert systems and their clinical applications].

Expert Systems are a new method developed by the branch of Computer Science known as Artificial Intelligence in order to make available the knowledge and the expertise of the specialists in a certain domain of the science to other operators in the same field. Most of their applications belong to the medical domain. In this paper the main features of the expert systems are briefly described. As an example the structure and the characteristics of the shell EXPERT (Weiss and Kulikowski, 1979) are presented in detail. This shell has already been used to develop several expert systems. It is the tool by which we constructed a consultation system (VERTIGO) aimed to classify different types of vertigo.

Expert Systems↗

[Various abuses of statistics in medical research].

Statistics has become an indispensable tool in biomedical research. Thanks, in particular, to computer science, the researcher has easy access to elementary "classical" procedures. These are often of a "confirmatory" nature: their aim is to test hypotheses (for example the efficacy of a treatment) prior to experimentation. However, doctors often use them in situations more complex than foreseen, to discover interesting data structures and formulate hypotheses. This inverse process may lead to misuse which increases the number of "statistically proven" results in medical publications. The help of a professional statistician thus becomes necessary. Moreover, good, simple "exploratory" techniques are now available. In addition, medical data contain quite a high percentage of outliers (data that deviate from the majority). With classical methods it is often very difficult (even for a statistician!) to detect them and the reliability of results becomes questionable. New, reliable ("robust") procedures have been the subject of research for the past two decades. Their practical introduction is one of the activities of the Statistics and Data Processing Department of the University of Social and Preventive Medicine, Lausanne.

Humans↗

Graduate program in biomedical communication.

The need for harnessing the achievements of communication technology to the burgeoning mass of biomedical information is critical. Recognizing this problem and aware of the short supply of professionals with the skills necessary for the job, a group of leaders from the fields of medicine and communications formed a consortium in 1967 and have developed a twelve month graduate program in biomedical communication. Designed to ground the advanced student in the development and administration of biomedical communication programs, the curriculum focuses on the principles and practice of communication and the development of communications media. Courses are given in the control and communication of information; the printed and spoken word; visual media of photographic arts, television, and motion pictures; computer science; and administration and systems analysis.

Communication↗

The MEDLARS project at the UCLA Biomedical Library.

The National Library of Medicine has established at the Biomedical Library, UCLA, a remote MEDLARS search station. The agreement between the libraries provided that the Biomedical Library in cooperation with the UCLA Health Sciences Computing Facility would reprogram MEDLARS for the IBM 7094 computer, provide personnel to be trained in machine searching at NLM, and engage in a pilot demonstration of search service to the medical staff of UCLA. This paper describes the place of the search section in the organization of the Biomedical Library and the training of personnel at NLM (the article by Garvis in this issue of the Bulletin relates the problems encountered in making two different computer systems compatible). Search service had not begun when this paper was written; it was scheduled to begin late in 1965. Plans for the future include the enlargement of the UCLA MEDLARS staff and extension of search service to a larger geographical area.

California↗

Research needs and priorities for ruminant internal parasites in the United States.

The management-chemotherapy approach is currently the most applicable means of effectively and practically controlling parasites of ruminants. Knowledge of regional patterns for major ruminant parasites, especially seasonal transmission dynamics, promises to lead to major improvements in management-chemotherapy systems. This knowledge also provides the fundamental context for design of new integrated control strategies that include other approaches such as immunization, chemical and biological control, and the interaction of environmental, physiologic, and nutritional factors. Greatly needed is a change in the protracted government regulatory process that obviates the availability of new, more effective drugs until years after they are available in other developed nations and that creates a dearth of "minor species, minor use" antiparasitic compounds. It is necessary to recognize both the need for product safety and the realities of investment limitations in the pharmaceutical industry. Also needed are new formulations and better methods of mass treatment for inaccessible herds of ruminants that will allow flexibility in strategic treatment programs based on seasonal transmission and other factors. More reliable cost-benefit assessments, more sensitive diagnostic indicators, and better knowledge of pathophysiologic mechanisms of damage by parasites will assist greatly in identifying the economically important effects against which economical control programs can be targeted. The opportunities for development and evaluation of novel prophylactic, diagnostic, and management approaches for animal parasitism are close at hand if the spectacular advances in molecular biology, immunology, computer science, and ecologic methodologies are assimilated in present research efforts. Although the emphasis of this report is on applied research and identification of approaches for the immediate future, the importance of more basic research on animal parasites and discoveries in other areas of modern biology and medicine are recognized as the essential pacesetters of the future. There is increasing concern by agricultural research workers that renewal of this base of fundamental knowledge is greatly needed. In this context, studies on the physiology, behavior, antigenicity, and genetic makeup of parasites, protective host responses, and mechanisms of tissue destruction and invasion by veterinary parasites are essential. Veterinary parasitologists must study host-parasite interactions directly with minimal reliance on rodent model systems; although this has disadvantages it offers special opportunities for research that is concurrently applied and fundamental. While the livestock industry can expect continuous progress on current problems, a long-term investment in basic research must be made for the future.

Animals↗

Taxonomies for application in rheumatic diseases: quests for uniformity.

The technologic explosion in computer science and communications has made possible the development of scientific databases for longterm use, and global applications are becoming feasible. The eventual achievement of maximal utility of such databases dictates the need for uniform terminologies and definitions. A number of prominent efforts toward such uniformity are identified and reviewed with respect to their potential applicability to the arthritis and musculoskeletal disorders.

Disability Evaluation↗

The cardiac diagnostic unit. A new approach to patient care.

The Cardiac Diagnostic Unit at Duke University Hospital brings together multiple diagnostic services for evaluation of patients with cardiovascular disease. This Unit is a combined effort of the departments of Medicine, Radiology, Surgery, Bioengineering, and Computer Sciences. The reasons for the establishment of the Unit are discussed, along with some illustrative case studies.

Aged↗

[Biology yesterday, today and tomorrow].

Throughout the history of the biological disciplines from the 18th to the 20th centuries, there has been a succession of predominating fields of interest: morphology, physiology, genetics, biochemistry, ecology and ethology, while statistics, biometry and computer sciences were developing as powerful means of imposing rigor on research. In all sciences, there is a fundamental empiricism which has often been criticized as prescientific. However, it is unavoidable, especially in biology owing to the unusual wealth and complexity of the facts to be reported. Explaining in the natural sciences first requires the discovery of relationships between facts. Biological explanation has many levels. One of the main avenues leading to true explanation is the multidisciplinary approach, which is in reality an attempt at synthesis. Another characteristic of biological work is the equilibrium between pragmatism and idealism, usually expressed as a balance between application and theory. Both modalities are necessary because of their complementarity. The emergence of ecology demonstrates this duality in the recent past. The equilibrium between theory and application should be decided by the biologists themselves, not by the funding public agencies, although competent administrators are necessary for the welfare of researchers. Applied and theoretical research should be kept separate to a large extent, even though they remain interdependent. In biology, theoretical work has suffered considerable neglect as compared to the situation in physics and chemistry. Biology has few explanatory theories and the few it possesses have often been put forward by physicists in the field of biophysics.(ABSTRACT TRUNCATED AT 250 WORDS)

Biology↗

Building large knowledge bases in molecular biology.

Large scale genome sequencing projects are now producing hugh amounts of data which can be readily stored and managed within data base management systems, and analyzed using dedicated software packages. The results of these analyzes should also be stored with the input DNA sequences. The increasing complexity and size of the objects to be described and managed have led biologists to rely on advanced data models such as the object-oriented model. As a joint effort between our computer science and molecular biology research projects, the knowledge bases we have developed in molecular genetics have shown however that the basic object-oriented model is not fully adapted to the complexity of some biological situations encountered. Advanced descriptive capabilities, provided only by knowledge models originated from the AI field, are required. Composite or evolving objects, multiple viewpoints, constraints, tasks and methods, textual annotations are some examples of such capabilities. They are illustrated by biological situations for which they appeared to be necessary. Supporting powerful reasoning mechanisms (e.g. object classification, constraint propagation or qualitative simulators), they allow the development of large knowledge bases in molecular biology. These knowledge bases are expected to become the adequate support for co-operative distributed research efforts.

Artificial Intelligence↗

Representation of medical concepts of the thyroid gland by physicians in anatomy and pathology.

An experimental study in cognitive psychology is described, concerning the categorization of medical concepts into specific classes, expressed by physicians specialized in anatomic pathology consultations of the thyroid gland. This study belongs to a medical computer science project, called ARISTOTLE, concerning Natural Language Processing of specialized medical reports in anatomic pathology of the thyroid gland. This research has been done for two reasons; first, to specify the characteristics of human expert categorization in an area of medical knowledge and, secondly, to validate the hierarchical organization of a prototype declarative knowledge base. In this experiment, physicians were asked to categorize 121 concepts into 10 proposed classes. These classes and concepts belong to expert knowledge represented in a conceptual graph that was constructed before the experiment. Results show variable semantic distances between concepts of a same class, and dynamic variations of these distances due to contextual representation.

Artificial Intelligence↗

Databases save time and improve the quality of the design, management and processing of ecopathological surveys.

The example of an ecopathological survey on nursing ewe mastitis shows that data bases have 4 complementary functions: assistance during the conception of surveys; follow-up of surveys; management and quality control of data; and data organization for statistical analysis. This is made possible by the simultaneous conception of both the data base and the survey, and by the integration of computer science into the work of the task group that conducts the survey. This methodology helps save time and improve the quality of data in ecopathological surveys.

Animals↗

New approaches: innovations in cancer prevention, diagnosis, treatment, and support.

PURPOSE/OBJECTIVE: To discuss and project changes in cancer care in the 21st century. DATA SOURCES: Projections are based on synthesis of multiple scholarly, professional, and governmental information sources. DATA SYNTHESIS: Changes will be reflected in the areas of patient subgrouping for more effective prevention and treatment; a redesigned therapeutic paradigm; a mind-body renaissance emphasizing holism and quality of life; and an accentuated influence of ethics on oncology nursing practice arising from healthcare reform and new scientific understanding of the human gene. CONCLUSIONS: Opportunities for nurses resulting from these changes include roles as genetic-risk analysts, health-education media designers, patient readiness evaluators, technology accessors, partners in a holistic care center, and treatment options advisors. IMPLICATIONS FOR NURSING PRACTICE: Nurses will need to respond to these challenges by expanding their knowledge base with respect to genetics and computer science, refining the interactive skills that are necessary to address the psychosocial aspects of cancer care, and assimilating new technology while designing strategies to minimize the dehumanizing consequences of technology dependency.

Delivery of Health Care↗

Validation of the CSA accelerometer for assessing children's physical activity.

The Computer Science Application (CSA) accelerometer is designed to detect the acceleration and deceleration of human movement. The purpose of this study was to evaluate its validity and utility for measuring children's activity in field settings. The criterion measure was heart rate telemetry. This study also examined the between-day stability of children's physical activity. Thirty-one children (7-15 yr) wore a CSA accelerometer and a heart rate telemetry monitor for 12 h.d-1 for 3 consecutive days. The validity correlation coefficients between accelerometry and heart rate telemetry for each monitored day ranged from r = 0.50-0.74. All children reported the accelerometer to be comfortable to wear. The moderate to high validity correlations and the subjects' favorable response to wearing the accelerometer support its validity and utility as an objective method for monitoring activity in children in field settings. However, the between-day stability of individual physical activity measures was low to moderate (r = -0.23 to 0.53), indicating that when using accelerometry or heart rate telemetry more than 3 d of monitoring is needed to assess usual activity.

Adolescent↗

The stability of children's physical activity as measured by accelerometry and self-report.

The Computer Science Application (CSA) accelerometer uses integrated circuitry and memory to provide a continuous recording of minute-by-minute movement counts. It has been previously validated as an objective monitor of children's physical activity in field and laboratory settings. Our purpose was to derive accelerometry summary variables reflective of different physical activity intensity levels, evaluate the stability of these summary variables, and define the number of days needed to adequately measure usual physical activity. A secondary study purpose was to compare three self-report questionnaires to accelerometry. Thirty children (7-15 yr) wore accelerometers for 12 h.d-1 for 6 d. Daily summary variables of average movement count (total physical activity) and daily frequency of sedentary through vigorous activity were constructed. Intraclass correlation coefficients (R) and 95% confidence intervals (CI) were used to analyze the data. Accelerometry stability using 1 monitored day to represent usual physical activity was R = 0.42-0.47. When 6 d were used, stability increased to R = 0.81-0.84. Acceptable intraclass correlations and CI were achieved with 4 d of monitoring (R = 0.75-0.78, CI = 0.60-0.88). The self-report questionnaires were poorly to moderately correlated to accelerometry variables (r = -0.03-0.51). Data indicate that in field settings: 1) accelerometry can be used to assess the intensity of children's activity and 2) 4 or more days of activity monitoring are needed to achieve satisfactory reliability.

Adolescent↗