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[Kilovolt-megavolt irradiation techniques for malignant tumors. Characteristics, indication and limits (author's transl)].

For curative effects of irradiation tumour doses of 5000 to 7000 rd are needed. They can be achieved in depth-therapy with conventional kilo-volt techniques only in carcinoma of the larynx and - via additional gamma rays - in radium-X-ray irradiation of the cervix. For all other indications mega-volt techniques are needed. If properly used, their side-effects are less. The kilo-volt technique for malignant tumors remains for palliative indications. Training will have to be undertaken in centres equipped for all types of therapy.

Cobalt Radioisotopes↗

Effect of X rays on virus production and DNA synthesis in adenovirus-infected cells.

The effect of X rays on the process of type 10 adenovirus infection in HeLa cells was tested. CPE development and virus infections titer were lower in the irradiated cells, while CF titer remained unchanged. The rate of DNA synthesis, as measured by 3H-thymidine incorporation, was higher in the infected cells and radiosensitivity of the process was higher in the infected cells compared with uninfected controls.

Adenoviruses, Human↗

Inflammatory disease of the brain diagnosed by computed tomography.

Inflammatory disease of the brain, particularly of pyogenic etiology, may be most accurately assessed by the use of computed tomography and contrast enhancement. Examples of cerebritis, evolving and mature intracerebral abcesses, and inflammatory extracerebral collections are presented and discussed, particularly with reference to differential diagnosis and the problem of infectious versus neoplastic etiology. Ancillary studies, particulary selective arteriography, are reviewed where appropriate. The residual changes of inflammatory disease of the brain after medical and/or surgical therapy are illustrated, and the value of serial examinations is emphasized. The rural indigent patient population (American Indian) served by the University of New Mexico Medical Center is a source of case material providing several examples of severe and untreated intracerebral infectious processes heretofore not described in the literature.

Adult↗

Mechanism of T-cell suppression in tolerance to HGG: arguments in favor of a T-cell-T-cell interaction.

The specific soluble factor from suppressor T cells of CBA mice rendered tolerant to human gammaglobulin was further investigated. Immunochemical analysis proved the low zone tolerance (LZT) factor to be similar as the one described in high zone (HZT), e. g. absorbed by anti-Iak or IGG but not anti-HGG or anti-IgG. Molecular weight was ascribed as 45--55,000 by Sephadex chromatography and "Amicon" ultrafiltration. The HZT factor acts only if administered early after challenge, and on T cell as judged by double transfer experiments, suggesting impairment of early T-cell function (helper?) by suppressor cells.

Animals↗