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PubMed1993

Effect of differential rearing on synapses and soma size in rat medial amygdaloid nucleus.

The effects of differential rearing on synaptic morphology and neuronal size were examined in the medial amygdaloid nucleus (MAN) of adult rats. Forty-day-old male rats were housed in one of three ways: individually (isolated condition, IC); with four males per cage (unisexual condition, UC); or with two males and two females per cage (social condition, SC). After 2 months, the animals were prepared for electron and light microscopy. Although there was no statistically significant difference in number of synapses per unit volume in MAN, the number of perforated (P) synapses, which are characterized by discontinuities in the postsynaptic density, were significantly greater in the UC and the SC than in the IC. The length of synaptic contact zone of P synapses was also longer in both the UC and the SC compared with the IC, whereas the length of nonperforated synapses was longer only in the SC. Soma area was also larger in the SC compared with the IC. These results demonstrate that exposure to different rearing conditions, in which the pheromonal environment can be substantially different, can induce striking morphological changes in both synapses and neurons in the MAN of adult rats.

Amygdala↗
PubMed2006

Job control, job demands, or social class? The impact of working conditions on the relation between social class and health.

BACKGROUND: The aim of the study was to investigate (1) how much of the association between health and social class is accounted by psychosocial working conditions, and (2) whether health is related to working conditions after controlling for social class. METHODS: The data derive from the surveys of the Helsinki health study, collected in 2000, 2001, and 2002 from 40-60 year old employees working for the City of Helsinki (n=8970, response rate 67%). The study measured occupation based social class and Karasek's demand-control model. The health outcomes were self rated health as less than good and limiting longstanding illness. Age adjusted prevalence percentages and fitted logistic regression models were calculated. RESULTS: The individual effects of social class and psychosocial working conditions on self rated health and limiting longstanding illness were strong among both men and women. The relation between social class and both health outcomes considerably attenuated when job control was controlled for, but was reinforced when controlling for job demands. Controlling for both job control and job demands attenuated the relation between social class and self rated health and limiting longstanding illness among women, however, was reinforced among men. CONCLUSIONS: A substantial part of the relation between social class and health could be attributed to job control, however, job demands reinforced the relation. Although the effect of social class is mediated by psychosocial working conditions, both social class and working conditions were related to health after mutual adjustments.

Adult↗
PubMed2003

Effects of exercise on cardiovascular outcomes in monkeys with risk factors for coronary heart disease.

OBJECTIVE: Exercise reduces the risk for coronary heart disease. However, the mechanisms mediating the beneficial effects of exercise remain ambiguous. In particular, it is uncertain whether exercise inhibits the development of atherosclerosis, a major pathobiologic process underlying heart disease. METHODS AND RESULTS: To address this question, adult male monkeys were fed an atherogenic diet while assigned to one of four experimental conditions for 34 months: 1) runner/no group disruption, ie, "stable" (n=19); 2) runner plus frequent social group disruption, ie, "unstable" (n=19); 3) sedentary/stable (n=15); or 4) sedentary/unstable (n=18). Neither exposure to exercise nor social group disruption significantly affected the resulting coronary artery atherosclerosis extent or lumen areas (all ANOVA values, P>0.05). When compared with sedentary individuals, exercise animals had lower resting heart rates (119.0+/-3 vs 132.0+/-3 bpm, P=0.002), greater echocardiographically measured left ventricular ejection fractions (77.2+/-0.01% vs 73.8+/-0.01%, P=0.02), greater quantitative angiographically measured dilation of coronary arteries to phenylephrine (2.6+/-1% vs -3.7+/-1% change from baseline diameter, P=0.003), and a reduced cortisol response to an adrenocorticotropin challenge. These measures were not significantly affected by social condition. CONCLUSIONS: Thus, exercise improved some measures of cardiovascular health and reduced stress responsivity but did not inhibit progression of coronary artery atherosclerosis or promote positive artery remodeling. It is concluded that exercise may exert cardioprotective effects without influencing atherosclerosis extent.

Adrenocorticotropic Hormone↗
PubMed2002

Illuminating social determinants of women's health using grounded theory.

Emphasis in health policy has shifted from curative intervention to prevention and health promotion through personal responsibility for lifestyle choices and, most recently, to the social determination of health. These shifts draw attention to and legitimize women's health research that moves beyond biomedical, epidemiological, and subjective knowledge to question previously unquestioned societal norms and structures that influence women's health. The challenge is to avoid relying solely on population-based studies that support relationships between social determinants and indicators of women's health and to find ways to illuminate the processes by which social determinants interact with the health of specific groups of women. Without such research, our knowledge of how social factors that underpin women's health interact will be faceless and will not address the interplay of health and social policy within women's lives. One research method that may be useful for exploring the interplay between such policies and women's health is grounded theory. Grounded theory is a widely used approach in women's health research. The goal of grounded theory is the discovery of dominant social and structural processes that account for most of the variation in behavior in a particular situation. Despite the usefulness of this method for capturing the interaction between social conditions and women's health experiences, many grounded theory researchers restrict themselves to women's subjective experiences as a source of data for theory development. Consequently, the resultant theory's capacity to illuminate the effects of the social determinants of health is limited. The purpose of this article is to discuss how the grounded theory method can be used in a participatory way to theoretically sample structural conditions at many levels. Using examples from completed and ongoing women's health research where data have and have not been collected primarily from women themselves, we outline the benefits and process for using grounded theory to influence health and public policy in women's health.

Female↗
PubMed1993

Effects of differential rearing on the structure of perforated synapses in the granule cell layer of the rat's accessory olfactory bulb.

The effects of differential rearing on synaptic morphology in the granule cell layer of the accessory olfactory bulb (AOB) were examined in adult rats. Forty-day-old male rats were housed in one of three ways: individually (isolated condition, IC); with four males per cage (unisexual condition, UC); or with two males and two females per cage (social condition, SC). After 2 months, the animals were killed for electron microscopy. Two types of synapses were classified: (1) perforated synapses, which are characterized by discontinuities in their postsynaptic thickenings, and (2) non-perforated synapses. The length of the synaptic contact zone as well as the area and the length of the perimeter of both the pre- and postsynaptic terminals were measured in each observed synapse. For perforated synapses, the length of the synaptic contact zone was significantly greater in the UC and the SC than in the IC. For the presynaptic terminals of perforated synapses, the area was greater in the UC and the SC than in the IC, and the length of the perimeter was greater in the UC than in the IC. In contrast, there was no difference in the area and the length of the perimeter among the three groups for postsynaptic terminals. For non-perforated synapses, there was no statistically significant difference in either the area or the length of the perimeter of pre- and postsynaptic terminals among the three experimental groups, although the length of the synaptic contact zone was greater in the SC than in the IC.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMed1989

Exposure, susceptibility, and breast cancer risk: a hypothesis regarding exogenous carcinogens, breast tissue development, and social gradients, including black/white differences, in breast cancer incidence.

At present, known risk factors account for only one-third of breast cancer cases diagnosed in the United States. They explain an even smaller fraction of the ten-fold variation in international breast cancer incidence rates. The low population-attributable risk of these identified risk factors, plus the existence of phenomena that cannot be easily explained by current etiologic hypotheses (such as the higher rate of breast cancer among black as compared to white women under age 40 within the United States), suggests that unidentified risk factors contribute substantially to breast cancer causation. This paper summarizes evidence to propose that two socially-conditioned factors determine a society's breast cancer incidence and its social gradients in risk: 1) the extent of exposure to exogenous carcinogens, and 2) breast tissue susceptibility to these exposures. It is further hypothesized that breast tissue susceptibility is inversely related to breast tissue differentiation, and that socially-mediated reproductive patterns (involving both early-terminated and full-term pregnancies) affect susceptibility both by altering (via hormonally-mediated mechanisms) the number and ratio of undifferentiated and differentiated cells, and by stimulating the growth of initiated and transformed cells. This view is presented in contrast to hypotheses that propose exposure to endogenous hormones as the major determinant of breast cancer risk.

Abortion, Spontaneous↗
PubMed2006

Ethnographically informed community evaluation: a framework and approach for evaluating community-based initiatives.

OBJECTIVES: This paper describes ethnographically informed community evaluation (EICE), a framework for evaluating complex community-based interventions, and illustrates its use in the evaluation of Baltimore City Healthy Start, a federally funded infant mortality prevention project. EICE, which is influenced by cultural anthropology and assets-based community assessment, supports continuous program improvement, resident involvement, and measurement of community-level change. This approach takes into account both individual and contextual levels of analysis. METHODS: The evaluation coupled a participatory approach with qualitative and survey research methods to study community context and how it might contribute to infant mortality and influence program implementation, and to assess community change resulting from the program. Data collection included focus groups, key informant interviews, surveys, neighborhood mapping, journaling, and a study of community problem-solving. RESULTS: The evaluation provided program-related feedback to staff, contributed to a collective understanding of the local context, validated and augmented outcome findings, and imparted skills and a sense of empowerment to the neighborhood. Results reveal a community burdened by crime and social problems, yet showing great diversity in physical and social conditions when examined at the census block group level. Nevertheless, these social and physical hazards in the community are more salient than any specific health issue such as infant mortality. CONCLUSIONS: EICE is a powerful evaluation approach able to respond to the complexities of community-based maternal and child health initiatives designed to institute changes across multiple domains. EICE may be used, in whole or in part, as a supplement to traditional designs.

Anthropology, Cultural↗
PubMed2001

Service to the poor: the foundations of community nursing in England, Ireland and New South Wales.

This paper describes the foundations of community nursing in England, Ireland and New South Wales. It is guided by Foucault's work on power, discourse and knowledge, and argues that the common discourse of poverty coupled with the influence of socially advantaged women in the nineteenth century was the impetus for the development of community nursing in England, Ireland and New South Wales. Throughout the nineteenth century in Great Britain, economic and industrial development, coupled with an unprecedented growth in the population (particularly among the poor) inspired socially advantaged women to extend traditional gender-specific roles to address the needs of the poor. Protestant women in England advanced professional nursing as a career for women and in Ireland and New South Wales; Catholic women pioneered professional nursing, targeting the poor as the focus of their practice. These women used prevailing social conditions to enhance their life options within the limits prescribed by social norms.

Catholicism↗
PubMed2005

Social sustainability and collaborative learning.

The social dimension is central to sustainable development of agri-food systems. If farmers are not satisfied with their situation or motivated to continue farming, many of today's environmental goals will be impossible to achieve. Between 1997 and 2003, several case studies were carried out on social sustainability, the importance of recognition in the farming system, and the potential role of increased collaboration between actors. The main hypothesis was that improved recognition is a basis for sustainable social conditions. Our findings show that many farmers today perceive an impoverished social situation. They believe they lack control over decisions, which hinders their ability to continue farming. Public images and political decisions show a lack of respect for farmers' skills and knowledge. However, increased collaboration among actors is believed to be one important way forward, creating stronger relationships and networks, as well as a stronger identity for farmers. Our findings emphasize the need for authorities and other organizations to support farmers and to facilitate collaborative learning and decision-making processes for socioecological sustainability.

Agriculture↗
PubMedDate not supplied

[The level of social support parameters in relation to coping with stress caused by a disease among female patients suffering from depression].

INTRODUCTION: Social support issues have their permanent position in the studies of socio-psychological changes influencing people's health. Social support has been treated as one of the factors guarding against disease symptoms occurrence and supporting the stable health state. AIM: The purpose the study was to determine how female patients suffering from depression function in society in relation to the social support they receive. METHOD: 60 female patients with a diagnosed depression and 60 mentally ordered female patients were tested with the use of Uchnast's Sense of Security Questionnaire (KPB). The social support aspects such as the sense of security, sense of closeness, stability and self-confidence were analysed. The participants of the analysis were both women with diagnosed depression and women without any indicators of a depression. RESULTS: The analysis of the result indicated the existence of differences in the intensity of all the social support parameters in both studied groups of women. CONCLUSIONS: Women with depression are characterised by a lower sense of closeness, lower stability and lower self-confidence. Among the female patients with depression there is a lower level of the need of safety, and this is the symptom characteristic for the individuals not properly adjusted to social conditions. Lower sense of security staunches and deteriorates the perception of social support, both perceived and expected.

Adaptation, Psychological↗
PubMed1980

[Social causes and social therapy].

Sociogenesis is divided into primary sociogenesis (direct connection between social conditions and mental disorders), secondary sociogenesis (indirect connection), and tertiary sociogenesis (social consequences of a disorder according to the degree of acceptance). It has to be interpreted in a system network with organo- and psychogenesis. Social therapy is, according to that, an integration of social work, psychotherapy and pedagogics. Its main instrument is the therapeutic community.

Community Mental Health Services↗
PubMed1998

Is our work dangerous? Should it be?

Three case histories show how work in the medical social sciences--to the extent that such work reveals the origins of health problems in social structures of wealth and power--can become dangerous enough to threaten one's livelihood and in some instances one's very life. In this presentation, I encourage critical and engaged scholarship by referring to examples of dangerous work that should receive more attention: social medicine in Latin America and the critique of managerial ideology in the United States. Although social medicine has become a widely respected field of research, teaching, and clinical practice in Latin America, its accomplishments remain little known in the English-speaking world. For centuries, indigenous cultures in Latin America have held belief systems linking social conditions to patterns of illness and death. Latin American accounts of social medicine's history emphasize its European origins, especially in the contributions of Rudolf Virchow. In the United States, with the impact of the Flexner Report (1910) and its supporters, Virchow's vision of social medicine went into decline. On the other hand, in Latin America, social medicine flourished as a focus of education and research. Since social medicine's "golden age" during the 1930s, teachers, researchers, and practitioners have produced major achievements despite the dangers of this work, which in several instances have included torture, imprisonment, or death. An ideology favoring managerial decision making in the United States has influenced crucial policy decisions, and the justifications for these decisions have manifested symbolic politics in addition to the evaluation of factual evidence. With ambiguous empirical support, managerial ideology has fostered the general growth of managed care, the implementation of Medicaid managed care by state governments, the expansion of managed care in rural areas, and the impact of "evidence-based medicine" on policy and clinical decisions. If the occupational risks of critical work in the medical social sciences are not taken, we forfeit some of the most important gifts offered by "the sociological imagination."

Awards and Prizes↗
PubMed1989

[Current empirical data on conditions in relation to death in the hospital].

This survey-study represents the psycho-social conditions of death in West-German hospitals as seen from different occupational groups. The test, developed for this task, has been applied in 70 hospitals of different federal states, medical-departments and supporters. It is shown that following factors have an essential influence on the attitudes of people to the needs of the dying patient: amount of medical engineering at ward, time of professional activity and status of the personnel. In sum, the study gives a dark picture of death situation. Most helpers hold that situation inhumane. This is a burden for the helpers themselves. The results of the study tell against the efficiency of actual engagement in dying patients. The author develops some proposals, how the requests of thanatology that were adequat to improve the actual situation, could better be transferred to the practice.

Attitude of Health Personnel↗
PubMed2003

Study of Health in Pomerania (SHIP): a health survey in an East German region. Objectives and design of the oral health section.

The goal of the Study of Health in Pomerania (SHIP) was to estimate the prevalence of diseases, identify potential risk factors in a defined region in northeast Germany, and examine the particular living situation of this population after the reunification of East and West Germany. One of the main concerns of the SHIP design is the analysis of the relationships between dental, medical, social, and environmentally and behaviorally determined health factors. SHIP is a cross-sectional study (clinical findings and sociologic interviews). The sample was drawn in two steps: Thirty-two communities in the region were selected, and within these communities, a simple random sample was drawn from residence registries, stratified by gender and age. The final sample included 4,310 males and females, aged 20 to 79 years. This is equivalent to a participation rate of 68.8%. Data collection was completed in May 2001. The data collection and items comprised four parts: oral health examination, medical examination, health-related interview, and a health- and risk-factor-related questionnaire. The oral health examination included the teeth, periodontium, oral mucosa, morphology and function of the craniomandibular system, and prosthodontics. The medical examination included blood pressure measurements; electrocardiography; echocardiography; carotid, thyroid, and liver ultrasound examinations; neurologic screening; and blood and urine sampling. The computer-assisted interview consisted of questions on symptoms of disease, utilization of medical and dental services, self-assessment of general and oral health, health behavior and knowledge, and socioeconomic variables. The self-administered questionnaire comprised housing conditions, social network, work conditions, subjective well-being, and individual consequences of the German reunification.

Adult↗
PubMed2003

[The access to care of underserved populations: a research among free clinics patients in the Paris area].

BACKGROUND: Over the last decade, the increasing number of people experiencing difficult social conditions--especially in urban areas--has led to the implementation of free (health and social care) clinics for uninsured and/or poor people. METHODS: In this paper, we give some results of multidisciplinary (sociological and epidemiological) research conducted among patients attending five of these free clinics in the Paris area. RESULTS: The statistical and qualitative analyses revealed the diversity of the studied population, as well as the conditions in which these consultants attended such clinics, what kind of services and help they used and, furthermore, what kind of social ties were strengthened. CONCLUSION: These results lead us to discuss our present knowledge of the determinants of the utilization of the healthcare system, not only among vulnerable people, but perhaps also amongst the general population.

Adult↗
PubMed2005

A life-span developmental perspective on social status and health.

This article presents a life-span developmental (LSD) perspective on the linkages between social status and health. The objective is to develop a conceptual framework that is useful in understanding why people are differentially exposed to risks of disease or protective factors and the social conditions that link the effects of risk and protective factors to the social environment over the life span. The discussion distinguishes between the complementary concepts of "life span," "life cycle," and "life course," critical theoretical distinctions that may help refine hypotheses about the relationship between health and social status. We argue that life-cycle and life-course concepts can be viewed as embedded in a more general LSD perspective. Using the theoretical principles derived from this perspective, the review examines (a) gender differences, (b) race-ethnic experiences, (c) childhood experiences, (d) educational levels, (e) socioeconomic differences, and (f) age differences. The emphasis in the review is to highlight the value of a broader LSD perspective in the study of health inequalities. The article ends with a brief summary of where future research is headed and novel developments in the study of social status and health.

Health Status↗
PubMed2007

Heart rate measurements as an index of energy expenditure and energy balance in ruminants: a review.

A major part of the ME consumed by ruminants (MEI) is dissipated as heat. This fraction, called heat production or energy expenditure (EE), is assayed largely by measuring O2 consumption (VO2). Conventional measurement of EE in controlled conditions in chambers does not reflect the complexity of natural, environmental, and social conditions of free-ranging animals. In mammals, most of the measured VO2 is transferred to the tissues through the heart; therefore, regression of heart rate (HR) against VO2 can be used to estimate the EE of free-ranging animals. The present article reviews the current knowledge on the use of HR for estimating EE. Energy expenditure can be determined from HR measurements, recorded daily over the course of several days, multiplied by the VO2 per beat. When an animal does not perform significant exercise, a constant value of VO2 per beat [O2 pulse (O2P)] measured over a short period (10 to 15 min) is used; during exercise, O2P increases, and the regression equation of VO2 against HR is used. Under extreme heat load, HR increases to improve heat dissipation, and O2P decreases; therefore, the effect of heat load on O2P needs to be taken into account. Cold stress that doubles heat production does not affect O2P. Heart rate and EE are highly correlated with MEI, but there is significant individual variation in the relationship; therefore, the daily change in the HR of individual animals can be used as an indicator of changes in the individual energy status of a ruminant, and the average HR of the group can serve in the estimation of the energy status of the group. When O2P is measured, the average group EE is an indication of the energy balance of the whole group. Because the MEI of nondraft animals is the sum of EE and retained energy (RE), the MEI of free-ranging ruminants can be determined by measurement of EE by the HR method and adding the RE. Similarly, the RE can be determined without slaughtering the animals from measurements of EE and MEI. Soon when devices for automatic HR monitoring of domestic ruminants become available at a reasonable price, continuous monitoring of HR might provide producers with a sensitive tool for identifying changes in the energy status of their animals. This will also significantly help to shorten the time needed to identify health problems of individual animals.

Animals↗
PubMed1984

Tubal sterilization. A prospective long term investigation of 218 sterilized women.

The present study is a long-term investigation of 218 consecutively sterilized women in Akershus County, Norway. The operations were performed in 1973-74, when the access to sterilization was regulated by a legislation from 1934. The women were interviewed personally, and a clinical examination was performed before sterilization, at discharge from hospital, three months, one and six years later. At each occasion the participation was about 95%, and only one woman was lost to follow-up. The women in this series lived in stable social conditions, their average age was 33.7, their parity 2.8. They were not socially distinguishable from women of the same age in the county at large, but there were important socially and age related differences within the series. Their contraceptive usage was widespread, but inconsistent. Family planning was the all-dominant motive. Forty per cent of the women had been suggested the sterilization by a doctor, 30% at abortion application. The operations were performed as laparoscopic electrocoagulation of the tubes or as a Pomeroy resection. Five pregnancies were recognized in the study period, four of these in the laparoscopy group. There were few serious complications, but 20% had a diversity of complaints at the three month interview. At six years seven women had complaints attributed to the operation. The large majority of the series was satisfied with the sterilization. Almost half the women would have preferred an even earlier operation, and six years after the sterilization 85% of the women had told friends about it, and 71% of these had directly recommended sterilization to someone. Six years after the sterilization 74% said the operation should be more widespread, 69% believed postoperative regret was uncommon, and the impact on postoperative marital life was mainly positive. However, during the study period, 18% of the women had experienced regret, ambivalence or periodic depression because of their sterilization. The rate of, and reasons for regret varied with time. The rate increased; at six years 6% of the women would have preferred the sterilization undone, and in 10% of the couples at least one of the partners held that view. At one year, the primary reason for regret was a feeling of having been persuaded by the doctor at abortion application. Six years after the sterilization the desire for a child with a new spouse was the principle reason. There was no association between regret and age or parity at operation.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗