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PubMed1978

Postnatal development of retinogeniculate, retinopretectal and retinotectal projections in the opossum.

The postnatal development of retinogeniculate, retinopretectal and retinotectal projections has been studied by the anterograde transport of proline-labeled proteins in 20 pouch young opossums aged from 10 to 60 days. Radioautographical findings suggest delayed development of uncrossed as compared to crossed projections. There is a phase of overlapping projections from both eyes in thalamic and tectal target sites. Partial segregation of projections to the dorsal lateral geniculate nucleus (GLD) is preceded by differential distribution of crossed and uncrossed terminal fields along its dorsoventral axis (at age 23 days). The quasilaminar pattern of projections in the dorsocaudal region of GLD pars alpha is incipient by 42 days and is fully established at 60 days of age, as eye opening starts. The mature pattern of projections to the ventral lateral geniculate nucleus (GLV) is established much earlier, at 23 days of age. The development of retinopretectal projections is assessed mostly from the analysis of the olivary pretectal nucleus (PO). Distribution of silver grains into discrete areas coextensive with PO is relatively delayed (by 23 days of age) as compared to the nuclei of the lateral geniculate body. Soon after, however, the mature pattern of projections to PO is established (at 33 days of age). The early development of retinotectal projections (from 10 to 23 days) is compatible with an initial tangential course of crossed optic fibers in the superior colliculus (CS) but other alternatives remain open, such as a sequential outside-in arrangement of terminal fields of deeply coursing fibers. Arborization of uncrossed fibers is delayed at extreme rostromedial and caudolateral portion of the territory of the main uncrossed retinotectal projection. Segregation of uncrossed projections at different depths of CS is nearly complete by 42 days. Differences in the development of terminal fields in different target nuclei or in regions of a given target site are discussed in relation to retinal and local factors.

Animals↗
PubMed1994

Mossy fiber projections from the brain stem to the nodulus in the cat. An experimental study comparing the nodulus, the uvula and the flocculus.

Mossy fiber projections from the brainstem to the nodulus were studied by means of the retrograde transport of horseradish peroxidase (HRP) in the cat. The findings indicate exclusive secondary vestibular projections to the nodulus (96.5% of the total number of labeled cells in cat 1). Major sources of such projections include the caudal half of the medial and inferior vestibular nuclei, and the dorsal half of the superior vestibular nucleus. Groups-x and -z of the vestibular nuclei give rise to minor projections. The projections from groups-f and -y, and the interstitial nucleus of the eighth nerve are very few, if any. Minor extravestibular projections originate from the prepositus hypoglossal nucleus and the infratrigeminal nucleus. All these projections are bilateral. No other nuclei in the brainstem were labeled following HRP injection in the nodulus. No indications of mediolateral and dorsoventral differences in mossy fiber projections were found. There are quantitative differences in the sources of projections to the nodulus, the ventral uvula and the flocculus, all of which belong to the vestibulocerebellum. The largest sources for projections to the nodulus and the ventral uvula are from the vestibular nuclei. Among the vestibular nuclei, group-x provides the major projections to the ventral uvula. For the flocculus, in contrast, the major sources of input are the reticular formation and raphe nuclei. These quantitative differences may play an important role for differential functions of the nodulus, the ventral uvula and the flocculus.

Afferent Pathways↗
PubMed1983

Prenatal development of the optic projection in albino and hooded rats.

The development of retinofugal projections has been examined in albino and hooded rat embryos from embryonic day 16 to birth (E21.5). Horseradish peroxidase (HRP) was injected intraocularly through the uterine wall and its anterograde transport revealed with TMB and DAB. The retrograde transport of HRP or the fluorescent dyes Nuclear yellow, Fast blue and propidium iodide from optic tract, superior colliculus (SC) or lateral geniculate body (LG) injections was used to demonstrate the origin of the projections. Superficial projections to the contralateral SC were first identified at E16. A light projection to the entire medio-lateral extent of the ipsilateral SC could be detected a day later. The optic axons grow over the surface of the diencephalon at E16 and it was only at later stages that the fibers were observed to invade successively deeper parts of the LG. A superficial projection to the ipsilateral LG could first be detected at E17. Both the ipsilateral and contralateral projections grew through the entire dorso-ventral extent of the lateral geniculate body: some restriction of the axons to their normal adult termination zones could be detected by E21. No difference in the distribution of projections could be detected between the albino and pigmented rats although the projections were lighter, and possibly because of this were detected later, in the albino rats. At all the ages examined in this study labeled retinal ganglion cells were observed in the non-injected eyes after injection of label into the contralateral eye. The use of persistent fluorescent dyes showed that these retinal ganglion cells did not survive for more than 5 days postnatally. The projection to the uninjected eye came preferentially from ganglion cells in the lower nasal retina while the ipsilateral central projections came predominantly but not exclusively from the lower temporal retina of the injected eye. It appears, therefore, that the initial projections of optic axons in the rat are not limited to their normal termination zones and that the choice of pathway at the chiasm appears to be only loosely controlled.

Animals↗
PubMed1987

Consequences of damage to the sensorimotor cortex in neonatal and adult cats. II. Maintenance of exuberant projections.

After chronic sensorimotor cortex ablations, sparing and greater recovery of function were seen in neonatally operated cats compared with adult operated cats. These results suggested that undamaged cortex in neonatal operates might display projections different from those of adult operates. Injections of horseradish peroxidase-wheat germ agglutinin (HRP-WGA) were made in ipsilateral parietal cortex adjacent to the sensorimotor cortex ablations or in the contralateral sensorimotor cortex. No changes in the projections of the parietal cortex were seen in operated cats or in the projections of the undamaged sensorimotor cortical projections of adult operates. In contrast, the intact sensorimotor cortex of neonatal operates exhibited crossed corticothalamic and corticorubral projections not present in normal or adult operated animals, whereas the corticospinal tract (CST) was unchanged by the ablations. Analysis of neurons within the ventroanterior-ventrolateral nuclear complex of the thalamus ipsilateral to the ablation showed that the surviving cells of neonatal operates were equal in number but were, on average, larger than those of normals and adult operates. Some neurons in neonatal operates were larger than any seen in adult operates and normals. Injections of HRP/WGA were also made into the sensorimotor cortex of normal newborn animals. Dense bilateral corticothalamic and corticorubral projections were present. The CST had extended to lumbar levels by the day of birth but projections to the grey matter were sparse. Thus, bilateral projections seen in neonatal operates probably represent retention of some exuberant projections present in normal neonatal animals. The CST which exhibited no exuberant projection was unchanged by the lesion. The crossed corticothalamic and corticorubral projections are likely to play a role in sparing and recovery of function particularly in sparing of contact placing.

Animals↗
PubMed1990

Ipsilateral interpositorubral projection in the kitten and its relation to post-hemicerebellectomy plasticity.

Hemicerebellectomy has been reported to induce aberrant ipsilateral projection from the nucleus interpositus (IN) of the remaining hemisphere to the red nucleus (RN) in the kitten but not in adult cats. The cellular mechanisms for this age-at-lesion effect were investigated. The experiments were designed to compare interpositorubral (IN-RN) projections in normal kittens and in kittens hemicerebellectomized at corresponding ages. A sparse ipsilateral IN-RN projection was found in normal kittens aged 7-16 postnatal days (PND) with the PHA-L method, but was not found in those aged 26-43 PND. Among the hemicerebellectomized kittens, ipsilateral IN-RN projections were observed only in those which received the lesion on PND 17 or earlier. Such temporal coincidence between the two events strongly suggests that the exuberant ipsilateral IN-RN projection in normal kittens is related to the establishment of the aberrant ipsilateral IN-RN projection observed after hemicerebellectomy. This notion is strengthened by other lines of evidence; the fibers projecting to the ipsilateral RNs appeared to enter the nucleus from the contralateral one by recrossing the midline between them in both the normal and the lesioned animals. In kittens in which hemicerebellectomy induced the aberrant ipsilateral projection, labeling of fibers within the ipsilateral RNs was much more extensive than that in the normal kittens, while labeling on the pathway of the projection was comparable to that in the normal animals. These observations support the interpretation for aberrant projections observed after a neonatal lesion as being terminal proliferations of pre-existing exuberant projections.

Animals↗
PubMed1996

Trigeminocerebellar and trigemino-olivary projections in rats.

Retrograde and anterograde neuronal tracers (HRP, biocytin, biotinylated dextran-amine) were used to study the organisation of trigeminocerebellar and trigemino-olivary connections, focusing on the connectivity between trigeminal nuclear regions and the sagittal zones of the rat cerebellar cortex. Trigeminocerebellar projections were bilateral, but mostly ipsilateral. Direct trigeminocerebellar fibres originated mostly in the principal trigeminal nucleus (VP) and pars oralis (Vo), pars interpolaris (Vi), and to a lesser extent in pars caudalis (Vc) of the spinal trigeminal nucleus. Consistent projections were found from the Vc to cerebellar lobules IX and X. The trigeminal fibres terminated in the cerebellum in an organised fashion. The ventral part of the VP, Vo and Vi projected to the medial A zone and the C3 and D2 subzones, whereas the dorsal part of the nuclei projected to the lateral A zone and the C2, D0 and D1 subzones. In lobules IX and X, the organisation was different. The medial half of the VP, Vo, Vi and Vc projected to the lateral aspects of these lobules whereas their lateral part projected to their medial aspects. Trigeminal projections to the deep cerebellar nuclei were also present. Projections to a given sagittal zone concomitantly reached its corresponding nuclear target. Trigemino-olivary projections were principally contralateral. The Vo, Vi and Vc projected to the rostromedial dorsal accessory olive, the adjacent dorsal leaf and the dorsomedial part of the ventral leaf of the principal olive, which are known to project subzones C3, D0 and D1 of the rat cerebellar cortex.

Animals↗
PubMed1992

Time-dependent neuroplasticity in mesostriatal projections after unilateral removal of vibrissae in the adult rat: compartment-specific effects on horseradish peroxidase transport and cell size.

In adult rats the mystacial vibrissae were clipped on one side of the snout, and the influence of this sensory deprivation on crossed and uncrossed striatal afferents from the substantia nigra, ventral tegmental area, and retrorubral area was examined with the horseradish peroxidase tract tracing technique. Unilateral removal of vibrissae was found to affect crossed and uncrossed nigrostriatal projections in a time-dependent manner. One to three days after hemivibrissotomy an apparent neuronal asymmetry was found in the crossed nigrostriatal projection arising in the rostral part of the substantia nigra, with more labeled neurons in the projection to the caudate-putamen on the side of vibrissae removal. This asymmetry resulted mainly from an asymmetry in the subset of nigrostriatal neurons reported to project to the striatal matrix ("dorsal cell type"). In contrast, 4-20 days after hemivibrissotomy reversed asymmetries were found in crossed and uncrossed nigrostriatal projections, with more labeled neurons in the projections to the caudate-putamen of the hemisphere opposite to vibrissae removal (the sensory deprived hemisphere). The asymmetry in the uncrossed projection was found throughout the substantia nigra, but was also most substantial in the projection from its rostral part. The asymmetry in the crossed projection was again restricted to the rostral substantia nigra; interestingly, however, it was limited to the subset of neurons reported to terminate in the striosomes ("ventral cell type"). Evidence was also found for time-dependent changes in size of neurons of the crossed nigrostriatal projections, as well as for changes in striatal afferents from the ventral tegmental area. The time course of these apparent changes in strength of mesostriatal projections is similar to the known time course of recovery from behavioral asymmetries induced by hemivibrissotomy, which is suggestive of a functional relationship between neuronal and behavioral changes. Moreover, the finding of a differential influence of hemivibrissotomy on nigrostriatal afferents to striosomes and matrix is indicative of a functional dissociation of these two systems.

Analysis of Variance↗
PubMed1996

Cortico-cortical and cortico-amygdaloid projections of the rat occipital cortex: a Phaseolus vulgaris leucoagglutinin study.

The efferent projections of the occipital cortex of the rat were investigated using the Phaseolus vulgaris leucoagglutinin anterograde tract tracing technique. Particular attention was focused on projections to the amygdala and amygdalopetal cortical areas. The primary visual cortex had projections to the medial and lateral portions of occipital area 2 and other cortical regions, but no projections to the amygdala or amygdalopetal cortical areas. The only occipital area that had direct projections to the amygdala was the most ventral portion of lateral occipital area 2, located just dorsal to temporal area 2. This occipitotemporal junction region, which received projections from secondary visual cortical areas but not from the primary visual cortex, had projections to the lateral nucleus, magnocellular basal nucleus, and lateral capsular subdivision of the central nucleus of the amygdala. Occipital area 2 had projections to seven amygdalopetal cortical regions: temporal area 2, temporal area 3, frontal area 2, ventrolateral orbitofrontal area, occipitotemporal junction region, lateral entorhinal area, and the perirhinal cortex. Projections to the perirhinal cortex targeted regions located adjacent to the parietal cortex and caudal temporal cortex, but not regions adjacent to the rostral temporal cortex. Other cortical regions receiving projections from medial and lateral portions of occipital area 2 included the presubiculum, retrosplenial areas, and caudal portions of the parietal cortical areas 1 and 2. The results of the present investigation, in conjunction with previous anatomical and neurobehavioral studies, support the concept that rodent cortical visual pathways, like those of primates, consist of a dorsal system involved with visuospatial functions and a ventral system involved with object recognition. As in primates, the ventral pathway projects to the temporal-perirhinal region in a cascading manner; only highly processed information from tertiary visual cortical areas reaches the amygdala. Unlike primates, however, cortical areas in the rat brain that receive highly processed visual information appear to be regions of multisensory convergence.

Amygdala↗
PubMed1984

Organization of raphe-cortical projections in rat: a quantitative retrograde study.

Retrograde transport of a fluorescent dye was employed to study the projections from raphe nuclei to neocortex in the rat. The spatial distributions of labeled raphe cells were analyzed quantitatively to determine whether the nuclei are topographically organized with respect to different cortical targets. The dorsal raphe nucleus (DRN), exclusive of the lateral wing regions, has a predominantly (3:1) ipsilateral projection with decreasing numbers of cells projecting to frontal, parietal, and occipital cortex. Overlapping cell groups within the DRN project differentially to these three cortical areas: DRN cells innervating frontal cortex extend more rostrally and laterally than those to either parietal or occipital cortex. The medium raphe and B9 projections are bilaterally symmetric, with equal cell numbers projecting to frontal, parietal, and occipital cortex. The rostro-caudal distributions of cells that project to disparate cortical areas differ in B9 but not in MR. The percentage of cortically projecting cells that are serotonergic is 80% for the DRN, 60% in the MR and 33% in the B9 cell group. The dorsal raphe nucleus and the B9 cell group are organized heterogeneously, and overlapping sets of neurons project differentially upon particular areas of neocortex. In contrast, the median raphe nucleus projects uniformly upon the neocortex and does not exhibit topographic organization. The three rostral raphe nuclei (DR, MR and B9) are each organized according to different rules with regard to their efferent projections to cortex. The differential organization of the raphe nuclei suggests that groups of cells within these three raphe nuclei are likely to innervate different combinations of cortical targets and thus to have different functional effects.

Animals↗
PubMed2005

Commitment of project participants to developing health care services based on the internet technology.

BACKGROUND: When developing Information and Communication Technology (ICT), such as services for the decision-making process, skilled health care professionals with their comprehensive knowledge of patients/clients are essential contributors to the project. Careful evaluation is needed to assess the effectiveness of project management as well as to analyze the commitment of the personnel to goal attainment. OBJECTIVE: In the course of the development of integrated maternity care services, the commitment of project participants (n=48) was evaluated. What factors enhanced or impaired their commitment to the project work? METHODS: Questionnaire (n=80, response rate 60%) with quantitative analysis as well as open-ended questions with qualitative content analysis. RESULTS: Positive commitment was related to a confidential and open atmosphere during the project. The utilization of personal skills and experience was appreciated. Differences in the working principles and cultures between the participating organizations complicated fluent collaboration. To encourage commitment, a lot of attention should be paid to internal communication as well as the effective realization of project tasks. CONCLUSION: The strength of the project was the highly innovative and confidential atmosphere. The well-established project goals, the highly inspired project team, and the effective co-operation between the project manager and the core group helped to deepen overall commitment in the project.

Attitude of Health Personnel↗
PubMed1998

Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study.

The nucleus accumbens (Acb) of the rat has been divided immunohistochemically into shell and core, and further, it was subdivided into several portions in relation to functional significance. In this report, the efferent projection of each subdivision of the Acb was examined using biotinylated dextran amine as an anterograde tracer. In rostral Acb, the dorsomedial shell mainly projected to the dorsomedial ventral pallidum (VP), lateral hypothalamus (LH) and substantia nigra pars compacta (SNc), while the ventromedial shell projected to the ventromedial VP, lateral preoptic area, LH and ventral tegmental area (VTA). The dorsal core of rostral Acb projected to the caudate putamen, dorsolateral VP, globus pallidus (GP), LH, and substantia nigra pars reticulata (SNr). In the middle to caudal Acb, the dorsomedial shell mainly projected to the dorsomedial VP, LH and VTA, the ventromedial shell projected to the ventromedial VP, substantia innominata, VTA, SNc and retrorubral area, and the ventrolateral shell projected to the ventrolateral VP and SNc. Furthermore, the ventromedial shell projected to the parabrachial nucleus (PB). The dorsomedial core projected to the dorsal VP, LH, SNc and SNr, and the ventral and lateral core sent axons to the dorsolateral VP, GP and SNc. From the point of view of projection patterns, shell and core are distinct throughout the rostro-caudal extent of the Acb. The ventrolateral shell at the caudal Acb was clearly differentiated. A direct projection from the ventromedial shell of the Acb to PB was also recognised.

Animals↗
PubMed2000

Organization of retrosplenial cortical projections to the laterodorsal thalamic nucleus in the rat.

The organization of the projections from the retrosplenial cortex (areas 29a--d) to the laterodorsal thalamic nucleus (LD) was examined in the rat with axonal transport of the cholera toxin B subunit and biotinylated dextran amine. The results showed that an area of the retrosplenial cortex provides ipsilateral projections to a distinct part of the LD at the level of its rostral two-thirds. The projections originate from layer VI and, to a lesser extent, layer V cells of the retrosplenial cortex. Area 29a and area 29b project, respectively, to the dorsolateral and the dorsomedial part of the LD. Area 29c projects to the ventromedial two-thirds of the LD, in a topographic pattern such that the rostral part of area 29c projects more ventromedially within the projection field than the caudal part of area 29c. Area 29d projects to the ventrolateral two-thirds of the LD in a topographic pattern similar to area 29c; the rostral part of area 29d projects more ventromedially within the projection field than the caudal part. These precise topographic projections from the retrosplenial cortex to the LD may constitute part of the circuitry underlying spatial navigation and various memory and emotional functions.

Animals↗
PubMed2004

[Quality analysis of the statistical used resources (material and methods section) in thesis projects of a university department].

INTRODUCTION AND OBJECTIVES: Studies about quality in thesis and investigation projects in biomedical sciences are unusual, but very important in university teaching because is necessary to improve the quality elaboration of the thesis. The objectives the study were to determine the project's quality of thesis in our department, according to the fulfillment of the scientific methodology and to establish, if it exists, a relation between the global quality of the project and the statistical used resources. MATERIAL AND METHODS: Descriptive study of 273 thesis projects performed between 1995-2002 in surgery department of the Zaragoza University. The review realized for 15 observers that they analyzed 28 indicators of every project. Giving a value to each of the indicators, the projects qualified in a scale from 1 to 10 according to the quality in the fulfillment of the scientific methodology. RESULTS: The mean of the project's quality was 5.53 (D.E: 1.77). In 13.9% the thesis projects was concluded with the reading of the work. The three indicators of statistical used resources had a significant difference with the value of the quality projects. DISCUSSION: The quality of the statistical resources is very important when a project of thesis wants to be realized by good methodology, because it assures to come to certain conclusions. In our study we have thought that more of the third part of the variability in the quality of the project of thesis explains for three statistical above-mentioned articles.

Academic Dissertations as Topic↗
PubMed2003

Auditory thalamic nuclei projections to the temporal cortex in the rat.

Thalamocortical projections from the auditory thalamic nuclei were examined systematically in the rat, including those from the dorsal division (MGD) of the medial geniculate body (MG), which were less clearly determined in previous studies. Injections of biocytin confined in each thalamic nucleus revealed characteristic features of projections in terms of cortical areas and layers of termination. In contrast to exclusively selective projections to cortical area Te1 from the ventral division (MGV) of the MG, diffuse and selective terminations were observed in the projections from the dorsal (MGD) and medial divisions (MGM) of the MG and the suprageniculate nucleus (SG). Diffuse termination was continuous in layer I or VI of the temporal cortex, while selective termination was in layers III and IV of discrete cortical areas. In addition to diffuse termination in the upper half of layer I of cortical areas Te1, Te2d and Te3v, the MGD and SG projections formed plexuses of axons selectively in lower layer III and layer IV of Te2d and Te3v. The SG projections targeted further the dorsal bank of the perirhinal cortex (PRh), while the MGD projections targeted in part the ventral fringe of Te1. The MGM projections terminated diffusely in layer VI of Te1 and Te3v, and selectively in lower layer III and layer IV of the rostral part of Te3v. Diffuse projections to layers I and VI from the SG and MGM extended in cortical regions over the dorsal fringe of Te1. Selective dense projections to middle cortical layers of Te2d and Te3v (especially its rostral part) indicate the existence of auditory areas, which could be involved in cross-modal interaction with visual and somatosensory system, respectively. Diffuse projections are supposed to bind information processings in these areas and the primary auditory area (Te1).

Animals↗
PubMed1997

Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus.

Fetal hippocampal cells grafted into the excitotoxically lesioned hippocampus of adult rats are capable of extending axonal projections into the host brain. We hypothesize that the axonal growth of grafted fetal cells into specific host targets, and the establishment of robust long-distance efferent graft projections, require placement of fetal cells in close proximity to appropriate axon guidance pathways. Intracerebroventricular administration of kainic acid in adult rats leads to a specific loss of hippocampal CA3 pyramidal neurons. We grafted 5'-bromodeoxyuridine-labeled embryonic day 19 hippocampal cells into adult hippocampus at four days post-kainic acid lesion, and quantitatively measured the projection of grafted cells into the contralateral hippocampus and the septum after three to four months survival using Fluoro-Gold and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine (Dil) tracing. Grafts located in or near the degenerated CA3 cell layer exhibited numerous neurons which established commissural projections with the contralateral hippocampus. However, such projection did not occur in intrahippocampal grafts located away from the CA3 cell layer. In contrast, neurons in all grafts established robust projections into the septum regardless of location within hippocampus although grafts located near the degenerated CA3 cell layer displayed more neurons with such projections. Location of grafted cells clearly influences the development of efferent graft projections into distant targets in the adult host brain, particularly access to axon guidance pathways to facilitate the formation of projections. The establishment of robust long-distance commissural projections of fetal hippocampal grafts is clearly dependent on their placement in or near the degenerated CA3 cell layer, suggesting that appropriate axon guidance pathways for commissural pathways are tightly focussed near this cell layer. However, the establishment of septal projections of these grafts was not dependent on specific location within the CA3 cell layer, suggesting that axonal guidance mechanisms to the septum are more diffuse and not limited to the CA3 dendritic layers. The results underscore that fetal hippocampal grafts are capable of partly restoring lesioned hippocampal circuitry in adult animals when appropriately placed in the host hippocampus.

Animals↗
PubMed1999

Health promotion projects: skill and attitude learning for medical students.

OBJECTIVES: The aim of this health promotion project is to introduce students to appropriate skills and attitudes--as well as knowledge about health promotion strategies and methods. As part of this process, standardized procedures have been established to ensure that the projects are scientifically and ethically appropriate and adequately supervised. This project-centred course introduces the discipline of health promotion to third-year medical students at Monash University. It is aimed at introducing students to the range of health promotion concepts, providing them with experience of health promotion activities and involving them in consideration of the scientific, political and ethical issues arising from doctors' participation in health promotion. DESIGN: As the major learning and assessment component of the unit, students participate in self-selected project groups of three to five students. Each group develops a topic for a health promotion activity in the community, carries out that project and presents the results as a poster as well as a written report. SETTING: Monash University. SUBJECTS: Third-year medical students. RESULTS: Sixty per cent of each student's mark for the unit is based on the project. The posters produced by the project groups are placed on public display in a major teaching hospital for a week at the end of the unit. Public display of the posters helps each student to appreciate the variety of possible health promotion activities, and to appreciate health promotion as a scientific discipline. It also makes the project findings available to the public. CONCLUSIONS: Student evaluation of the project, and community response to the projects--especially the poster display-- indicate that the project is both a highly effective learning experience and a health-promoting activity in its own right.

Attitude↗
PubMed1998

Origin and terminal distribution of the trigeminal projections to the inferior and superior colliculi in the lesser hedgehog tenrec.

The trigemino-tectal projections were investigated with anterograde and retrograde tracing techniques in the Madagascan lesser hedgehog tenrec, Echinops telfairi. There were prominent contralateral projections to the inferior colliculus (CoI) and the superior colliculus (CoS), each showing its own characteristic pattern of terminations. While the projections to the CoI were confined consistently to a circumscribed region in its ventrolateral, external portion, the projections from particularly the rostral trigeminal subdivision to the CoS were distributed inhomogenously across almost the entire rostro-caudal and mediolateral extents. Comparing these data with the spino-tectal projections published previously, it demonstrates that the somatotopic organization of ascending tectal afferents is more distinct in the CoI than in the CoS. There were roughly twice as many trigeminal neurones projecting to the CoS than to the CoI. This difference might be due to the fact that the cells projecting to CoS were distributed extensively across the trigeminal nuclear complex (peak densities in the principal and interpolar subdivisions), while the neurones projecting to the CoI were largely confined to the interpolar and caudal trigeminal subdivisions. The latter cells were located adjacent to the spinal trigeminal tract; the neurones projecting to the CoS occupied preferentially the ventral trigeminal regions at rostral levels, while from the interpolar subdivision caudalward the labelled cells shifted dorsolaterally. In comparison to other mammals the trigeminal projection to the tenrec's CoI is unique. There is evidence for such a projection in other species too, but it is poorly documented, presumably due to technical reasons.

Animals↗
PubMed1996

The projection of the lateral sacral mass on the outer table of the posterior ilium.

STUDY DESIGN: This study was designed to construct the projection of the lateral sacral mass on the posterior ilium using cadaveric pelves and to measure the dimensions of the projection. OBJECTIVES: The present study was undertaken to determine quantitatively the location of the lateral sacral mass on the outer table of the ilium. SUMMARY OF BACKGROUND DATA: Anatomic studies relative to instrumentation of the posterior iliosacral region are few. No previous anatomic studies with regard to the projection of the lateral sacral mass have been reported. METHODS: Twelve cadaveric pelves were used for this study. To determine the projection of the lateral sacral mass on the outer table of the posterior ilium, several Kirschner wires were drilled along the outermost peripheral edge of the lateral sacral mass from the inner table of the ilium through the outer table. A triangle projection on the outer table of the posterior ilium was then constructed according to the placed Kirschner wires. The widths and height of the projection, and the distances from the axis of the projection to posterior superior iliac spine and posterior inferior iliac spine were measured bilaterally. RESULTS: The average height of the projection of the lateral sacral mass was 61.4 mm. The average base width of the projection was 56.8 mm. The average distances from posterior superior iliac spine and posterior interior iliac spine to the longitudinal axis of the projection of the lateral mass were 30 mm and 27.4 mm, respectively. CONCLUSIONS: This study reported the average location of the lateral sacral mass on the outer table of the ilium. The superior area of the projection may be an ideal zone for transiliosacral screw placement.

Adult↗