Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “PROGNOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 685 records · Page 38Linked to original sources
PubMed1989

[Evaluation and prognosis of periodontally involved teeth].

One of the most difficult parts of the perio- prosthetic treatment is the evaluation and the prognosis. This paper presents the basic factors affecting a successful prognosis. Factors like bone support, mobility, distribution of the remaining teeth, root morphology, etc. as well as factors like the "patient", abilities of the therapist, etc. has been presented. From our clinical experience and from the review of the literature is presented the basic guideline of a successful prognosis. "Prognosis" is not one of the black arts--it is a system of therapeutic projection based upon successes and failures of the past.

Bone Resorption↗
PubMed1989

[Analysis of 293 cases of hepatocellular carcinoma of recent ten years--II. Diagnosis, therapy and prognosis].

Two hundred and ninety-three cases of hepatocellular carcinoma (HCC) of recent ten years during 1979 and 1988 were analysed on its diagnosis, therapy and prognosis. Angiography was the most useful diagnostic method for the first 5 years. During recent 5 years and for the tumor with size less than 2 cm, however, ultrasonography was the best method. 24.7% cases showed negative AFP and only 42.5% cases showed the level over 400 ng/ml. According to the tumor occupying-rate at the diagnosis, the number of cases of E1 had increased annually, the other cases being unchanged. 88.6% cases had liver cirrhosis microscopically as being reported previously. As a therapy TAE was most frequently performed, followed by operation, arterial infusion of antitumor drugs et al. The prognosis of the patients depended on the tumor occupying-rate. For the case of E1, the prognosis was the best by the therapy of ethanol injection therapy, operation and TAE. For the cases with tumor of larger than E1, frequent TAE was the best. From these results we concluded that we must make efforts to find small tumors to get the good prognosis.

Adult↗
PubMed1989

[Individual long-term social and work capacity prognosis in paroxysmal schizophrenia (informative value of the criteria and structure of classification)].

A clinico-epidemiologic research method combined with a multi-dimensional analysis was applied in patients suffering from attack-like schizophrenia. This made it possible to distinguish the most informative criteria for a long-term social and work fitness prognosis: premorbid adaptation, age by the disease onset, duration of the initial period, the first remission syndrome, the intensity of negative disturbances occurring in the course of the first remission, duration of the first remission, exogenous injuries in the premorbid and in the pre-manifest++ periods of psychosis. The prognosis classifier developed with regard to the above criteria provides a correct forecasting of the social and work fitness status of patients in 81.19% of cases (when patients are attributed to the favourable prognosis group) and in 69.64% of cases (when patients are attributed to the unfavourable prognosis group).

Adult↗
PubMed1989

[Prognosis in patients in intensive care from the aspect of renal function].

The authors evaluated in 82 patients 228 findings of renal functions. Twenty-nine patients with a total number of 113 findings died. In those who died frequently the values of renal functional parameters were beyond the reference limits, indicating various failures (high serum creatinine, high serum urea, elevated fractional osmolal and water excretion, reduced creatinine clearance). In those who died tubular osmotic diuresis was more frequent, while overflow osmotic diuresis was found mostly in the surviving patients. By means of linear discrimination analysis vectors of parameters were assessed suitable for evaluation of the relationship of renal functions and the prognosis and functional shapes of so-called renal prognostic indicators. In the calculation of renal prognostic parameters the following ones prove useful: serum creatinine (SKrea), creatinine clearance (CKrea), serum osmolality (SOsm), osmolality of urine (UOsm), sodium cation in serum (SNa), fractional excretion of water (FeH2o), of potassium (FeK), osmolal (FeOsm), urinary excretion per 24 hours of creatinine (DuKrea), sodium (DuNa) and potassium (DuK). The best prognostic effectiveness was obtained from the calculation of the renal prognostic indicator (RPU) according to the following equation: RPU = SOsm.0.0178--CKrea.0.944 + FeK.0.854 + + DuKrea.0.0665--DuNa.0.0022 + DuK.0.0047--4.931. The RPU value rises with the deteriorating prognosis of the patients; in those who died it reaches more frequently positive values, in surviving patients the values are negative. By reclassification, using this prognostic index, 82% of the patients with a favourable prognosis and 68% with a poor prognosis (those who died) were correctly classified, i. e. a total of 74% patients.

Critical Care↗
PubMed1989

Prognosis of human immunodeficiency virus infection in children and adolescents.

The prognosis of 111 children and adolescents (from 2.5 months to 19.5 years of age) infected with human immunodeficiency virus (HIV) was assessed by survival analysis based on risk factors and clinical status. Risk factors included: maternal HIV infection 93; transfusion 12; both maternal HIV infection and transfusion 2; sexual abuse 1; and intravenous drug use and/or sexual activity 3. Children with perinatal infection survived from 2.5 months to 10.25 years (median, 1.87 years) and had inapparent infection from 6 weeks to 7.3 years (median, 0.75 years). Children who acquired HIV infection via transfusion had inapparent infection from 4 months to 5.7 years (median, 3.6 years). Actuarial survival following infection was not significantly different from maternally and transfusion-acquired infection; however, survival from infection was longer for children infected by transfusion beyond 2 years of age (mean, 7.5 years) than for children infected perinatally (mean, 5.6 years). The case-fatality ratio was 32%, with 25% of subjects succumbing within 1 year of developing an HIV-associated illness. Opportunistic infection was the most common acquired immunodeficiency syndrome-defining illness and the cause of death in 22 of the 35 children who died. Pneumocystis carinii and fungal pneumonias had the worst prognosis. Cryptosporidiosis and other opportunistic infections had a better prognosis. Because of difficulties in case finding, diagnosis of infection and variable survival of HIV-infected children, arge longitudinal studies and pooling of data among centers will be necessary to have an accurate understanding of the prognosis of individual clinical syndromes.(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired Immunodeficiency Syndrome↗
PubMed1989

Prognosis of cervical cancers with reference to steroid receptors.

The relationship among the prognosis of a patient with cancer of the cervix and endocrine background [production of estrogen receptor (ER), progestogen receptor (PR), and androgen receptor (AR)], clinical stage, histological type, lymph node metastasis, age, and treatment was studied. ERs were detected in almost all cases, regardless of the histological type of cancer. The detection rate and level of PR were in the decreasing order of large-cell non-keratinizing (LNK) carcinoma, keratinizing (K) carcinoma, and small-cell non-keratinizing (SNK) carcinoma of the cervix. Thus, the presence and level of PR in squamous cell carcinoma of the cervix were considered to be an indicator of the degree of differentiation. PR was not detected in cases of adenocarcinoma of the cervix. This may explain the poor responsiveness to progestogen treatment in adenocarcinoma of the cervix. There was no relationship between the patient's prognosis and the presence of PR or AR, but the prognosis of patients with lesions rich in ER (greater than or equal to 5 fmol/micrograms DNA) tended to be better than that of patients with lesions poor in ER (less than 5 fmol/micrograms DNA). The prognosis of patients before menopause tended to be better than that postmenopause. These findings indicate a relationship between cancer of the cervix and endocrine background.

Adenocarcinoma↗
PubMed1989

[A scoring system for preoperative evaluation of the prognosis of metastatic spine tumor (a preliminary report)].

A trial of assessment system for the prognosis of metastatic spine tumor was evaluated in 47 cases who underwent surgery. Six parameters were postulated in the evaluation system; 1) general condition, 2) number of extraspinal bone metastasis, 3) number of metastasis in the vertebral body, 4) metastasis to the major internal organs (lung, liver, kidney and brain), 5) primary site of cancer, and 6) severity of spinal cord palsy. Each parameter ranged from 0 to 2 points. Total scores obtained in each patient can correlate with prognosis and are valuable to predict prognosis, however, the prognosis could not predicted from a single parameter. In conclusion, excisional operation should be performed in those cases scored above 11 points, and palliative operation will be indicated for those under 5 points. However, this assessment system will further remain useful with some items modified.

Adolescent↗
PubMed1987

Tumor cell type versus staging in the prognosis of carcinoma of the lung.

From this and other studies, it is clear that the determination of tumor cell type is dependent on cellular and architectural patterns which are fraught with considerable interobserver and even intraobserver variations. Even though determination of cell type is semiobjective at best, previous reports have sought to determine prognosis solely on the basis of cell type or subtype while other studies have made attempts to define the prognosis of the disease based on even less precise terms. In seeking an answer to the question of which is more important for prognosis of lung cancer, cell type or TNM stage, the findings reported herein support the hypothesis that the TNM stage is the single most important factor for survival. This conclusion is substantiated by the following observations: 1. When cell type is stratified by stage, no significant differences can be determined in survival according to tumor cell type. 2. There is a minor difference (not statistically significant) in survival for tumor cell type when considering resected stage I tumors (67 of 99) in terms of adenocarcinomas which had a survival of 38 percent at 5 years versus squamous cell carcinomas which had a survival of 23 percent at 5 years. The numbers of cases in this study were not sufficiently large to comment on the possible difference between surgically resected large cell and small cell carcinomas. 3. TNM staging is a highly significant predictor in the survival of patients with lung cancer. The significance for survival by stage remains even if the data are stratified by the cell type diagnosis. These conclusions apply to the total group of 124 patients, and also to the subgroup of 99 surgically resected patients. Many reports have attempted to determine survival of carcinoma of the lung in terms of cell type without regard to its stage. Consequently, comparison of data from various institutions is difficult. We believe TNM staging of the disease not only allows reasonable comparison of data obtained from different institutions, but also, affords a useful and accurate means of assessing the extent of the disease and its prognosis.

Adenocarcinoma↗
PubMed1988

[Factors affecting the prognosis of brain tumors].

A variety of tumors with different histologic types are included in a group of brain tumors. Although each histologic type of tumor has its own range of malignancy, the prognosis seems to be affected by several clinical, histologic and cell-biological factors. For example, relative survival rate of patients with glioblastoma is lower if the patient is older than 50 or 60 years. The leptomeningeal dissemination of glioma cells is a sign of poor prognosis. The presence of necrotic foci in the astrocytic tumors suggests shorter astrocytic tumors suggests shorter survival. Using a monoclonal antibody to bromodeoxyuridine (BrdU), the growth activity of the tumor can be estimated by BrdU labeling index (BrdU-LI, %). Higher BrdU-LI is correlated with more malignant histologic features in astrocytic tumors. In meningiomas, higher BrdU-LI is correlated with a more frequent or rapid recurrence of the tumor. The significance of growth factor receptors and oncogene of growth factor receptors and oncogene products as a cell-biologic marker of malignancy was investigated with an immunohistochemical method. Transferrin receptor was demonstrated in all tumors, and epidermal growth factor in about 40% of astrocytic tumors. The immunoreaction to c-myc oncogene product was detected in most astrocytic tumors; with higher intensity in anaplastic astrocytomas and glioblastomas than in low-grade astrocytomas. The role of these markers in the prognosis of brain tumors is, however, still unclear. Total or subtotal resection of glioblastoma results in longer resection of glioblastoma results in longer survival. Both postoperative radiotherapy and chemotherapy are effective. However, maintenance of chemotherapy longer than longer than 2 years does not significantly improve the prognosis.

Age Factors↗
PubMed1989

[Malignant salivary gland tumor. Occurrence, histology, prognosis].

The article is based to some extent upon publications from the ear, nose and throat departments at Rikshospitalet and Ullevål sykehus. For a long time, about 25-30 malignant neoplasms of salivary glands have been diagnosed each year in Norway. Some develop in major salivary glands such as glandula parotis and glandula submandibularis; some in minor salivary glands, most typically in the palate. In this respect glandula sublingualis is of little importance. The purpose of this article is to indicate the prognosis for these malignant neoplasms in the light of therapeutic results reported in this country and abroad. Besides therapeutics, other important factors for the prognosis include localization and histological type. These factors are dealt with separately. The prognosis is found to be best for malignant salivary gland neoplasms of the palate, with a reported five years survival of up to 77%. The next best prognosis is for glandula parotis (46-70%), followed by glandula submandibularis (32-50%).

Aged↗
PubMed1988

Prognosis of elderly hospital patients with cerebral thrombosis.

Over 8000 patients with cerebral thrombosis (ICD-8 number 433) hospitalised between 1970 and 1980 were surveyed retrospectively for outcome and additional diseases. The case-fatality rates and long-term prognosis of the patients were strongly affected by age, and the number of patients requiring permanent hospital care rose sharply with increasing age. The case-fatality rates in the different age groups were as follows: under 50 years 6%, 50-64 years 16%, 65-74 years 32%, 75-84 years 48% and over 85 years 66%. The cumulative survival rates at 1 and 5 years were as follows: under 50 years 54 and 46%, 50-64 years and 38%, 65-74 years 60 and 20% and over 75 years 45 and 10%. Clinical manifest coronary heart disease clearly affected the prognosis of patients under 75 years, but the impact diminished with rising age. Although hypertension led to an earlier onset of ischemic stroke, it did not significantly influence the survival prognosis. In patients over 75 years additional diseases, e.g. diabetes, had no significant effect on case-fatality or long-term prognosis underlining the malignant nature of cerebral thrombosis itself.

Age Factors↗
PubMed1988

Left ventricular function and prognosis in patients suspected of acute myocardial infarction but without confirmed diagnosis. The risk of cardiac events related to echocardiography, systolic time intervals, and chest x-ray.

The prognosis following discharge, with cardiac events as endpoint, was related to left ventricular function in 217 patients admitted with a suspicion of acute myocardial infarction (AMI), but in whom the diagnosis was not confirmed (non-AMI patients). The investigations used were echocardiography, systolic time intervals, and chest X-ray. During follow-up (median 14 months, range 12-24 months), 18 cardiac events occurred, i.e. non-fatal AMI or cardiac death. The prognosis for non-AMI patients was only slightly better than for patients with confirmed AMI (p = 0.05). The prognosis for non-AMI patients was significantly related to a decreased left ventricular function. Measurements of relative heart volume or mitral septal separation on echocardiography gave significant information about prognosis. The percentage without cardiac events after one year was 88.0 in patients with cardiomegaly versus 96.8 in those with normal heart size (p = 0.029). We conclude that non-AMI patients with decreased left ventricular function are at increased risk of cardiac events following discharge.

Adult↗
PubMed1987

Relation of ABH blood group antigen expression to prognosis in lung carcinoma.

The ABH blood group antigens were studied in resected specimens from patients with lung cancer employing monoclonal antibodies against A, B and H antigens by the immunoperoxidase technique. There were no differences between paraffin-processed and fresh-frozen materials in detectability of ABH antigens. Comparing specimens at operation with those at autopsy from the same patient, the loss of A and B antigens in the latter was demonstrated more frequently than H antigen. Concerning the relation between the prognoses and the expression of ABH antigens, the group with good prognosis preserved more ABH antigens than that with poor prognosis. In contrast, the group with poor prognosis showed less ABH antigens. There were also statistical differences in antigen detectability and prognosis, particularly in stage 1 patients, adenocarcinomas and well-differentiated lung cancers.

ABO Blood-Group System↗
PubMed1986

Difference in prognosis between T- and B-cell lymphomas: clinical study at Shikoku Cancer Center Hospital.

In order to determine whether the surface marker phenotypes of non-Hodgkin's lymphomas affect the prognosis, we have studied the differences in response rate and duration of survival between T- and B-cell lymphomas. Sixty-four patients who underwent first-line therapy, including combination chemotherapy and/or radiotherapy, from February 1979 to August 1985 were evaluated. With the aid of standard immunological methods and monoclonal antibodies related to T-cells and B-cells, 21 T-cell lymphomas and 21 B-cell lymphomas were identified. In the other 22 cases phenotypes were not determined mainly because of the inability to obtain fresh samples. The complete remission rate was 100% for B-cell lymphomas and 52.3% for T-cell lymphomas. The median survival time for patients with lymphomas of Stage III and IV, excluding those with low-grade histology, was nine months for T-cell lymphomas and 17 months for B-cell lymphomas. T-cell lymphomas were found to have significantly poorer prognosis than B-cell lymphomas. One patient with B-cell lymphoma and six patients in an undetermined phenotype group, who were treated with combination chemotherapy, have been alive more than three years without relapse and these patients are considered potentially cured. Our results suggest that the surface marker phenotype study of lymphoma cells as well as histological subtyping is important in prognosis and that more effective therapy is needed to improve the prognosis of T-cell lymphomas.

Antibodies, Monoclonal↗
PubMedDate not supplied

Study of the prognosis factors in liver cirrhosis.

In a prospective study carried out on a group of 1210 patients with liver cirrhosis (LC), the diagnosis was based on clinical, biological and histological criteria, as well as on the prognostic significance of 20 clinical, biochemical and histological parameters. The group, including 830 males (68.59%) and 380 females (31.41%), with an average age of 49.27 +/- 13.18 years, was studied during periods of 6 to 16 months, the initial investigations being periodically repeated. The statistical significance of the prognosis factors was studied by uni- and multivariative methods, according to the model of Cox, with the help of an IMB computer. The survival rate for the group studied ranged from 6 to 204 months, with an average period of survival of 38.29 months. The multivariative analysis demonstrated that the prognosis factor with a best correlation with the death power is ascites, which has additional predictive significance in association with encephalopathy and/or jaundice. The multivariative analysis selects as clinical factors of unfavourable prognosis the cholestasis, the hepatocytolytic syndrome, the syndrome of liver deficiency and the age over 50. The limits of the biochemical parameters with unfavourable significance were: bilirubinemia level greater than 3 mg%, ASAT/ALAT = 50.24/70.33 u.i., prothrombinemic index less than 50% and albuminemia greater than 3 g%. The multivariative method proved also superior in appreciating the interrelations of the prognostic factors, emphasizing the significance of the clinical parameters (ascites, encephalopathy, jaundice), while the multivariative analysis differentiated the biochemical prognosis factors (bilirubinemia, ASAT/ALAT, prothrombinemic index, albuminemia) and their level of significance.

Adult↗
PubMed1986

[Multivariate analysis of factors affecting the prognosis of renal cell carcinoma].

During the last 10 years, we histologically or clinically diagnosed 36 cases of renal cell carcinoma in our department. Concerning the factors affecting the prognosis of renal cell carcinoma, we analyzed 18 data items by mean of quantification II, one of the methods of multivariate analysis. The results were as follow: 1. Operation, stage, age, ESR and tumor weight were found to be significant factors in evaluating the prognosis. 2. The prognosis group and good prognosis group were clearly divided by this analysis.

Adult↗
PubMed1986

[Expert assessment method in the prognosis of myocardial infarct in unstable stenocardia].

The questioning of highly-qualified cardiologists, using the expert assessment technique, demonstrated that 4 groups of signs could be identified in unstable angina which differed significantly (p less than 0.01) with respect to the risk of myocardial infarction. Nine of 18 signs, associated with the poorest prognosis are listed in order of significance. There is no basic agreement among highly qualified cardiologists as to the assessment of risk signalled by the individual signs. Patients with unstable angina are not a homogeneous sample as regards the short-term prognosis of myocardial infarction where infarction risks seem to increase at a relatively even pace rather than by peaks. Therefore, the assessment of myocardial infarction risks requires that more than 2 groups be identified. Patients with different types of unstable angina may have similar prognosis. The prognosis tended to be particularly poor in patients with spontaneous angina.

Angina Pectoris↗
PubMed1986

[Criteria for the clinical prognosis of slowly-progressive schizophrenia in the very early and late stages of the disease (according to the results of a clinico-epidemiologic study].

In order to determine the criteria of the clinical prognosis at the initial and long-term stages of the disease, the author conducted a clinico-epidemiological study of 156 patients with at least 10-year history of slowly progressive schizophrenia who had fallen ill at the age of 10-20 years. The criteria of the clinical prognosis have been identified, both common and typical of the immediate and long-term stages of the disease. The age factor is a significant criterion of the prognosis of initial manifestations of the clinical picture in patients with slowly progressive schizophrenia. The use of the elaborated criteria of the clinical prognosis with regard to the range and time course of psychopathological manifestations at different stages of the disease will make it possible to conduct rehabilitative measures more effectively and adequately, which will contribute to increasing the number of patients having a socially useful employment.

Adolescent↗